Linshang Chemical
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1-(2-Bromoethoxy)-3-Chlorobenzene
Linshang Chemical
|
HS Code |
953821 |
| Chemical Formula | C8H8BrClO |
| Molecular Weight | 235.506 g/mol |
| Appearance | Liquid (estimated) |
| Solubility In Water | Low (organic halide ethers are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Vapor Pressure | Low (due to relatively high molecular weight and polar functional groups) |
As an accredited 1-(2-Bromoethoxy)-3-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(2 - bromoethoxy)-3 - chlorobenzene packaged in a sealed, labeled bottle. |
| Storage | 1-(2 - bromoethoxy)-3 - chlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. Label the storage container clearly with its name, properties, and hazard warnings to ensure proper handling and safety. |
| Shipping | 1-(2 - bromoethoxy)-3 - chlorobenzene is shipped in sealed, corrosion - resistant containers. Packaging adheres to strict chemical transport regulations. Shipment is carefully monitored to ensure safe transit of this potentially hazardous chemical. |
Competitive 1-(2-Bromoethoxy)-3-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1- (2-bromoethoxy) -3-chlorobenzene?
The chemical properties of 1 - (2 -hydroxyethyl) -3 -chloropropanol are related to its characteristics in various chemical reactions. In this substance, the presence of hydroxyl groups and chlorine atoms endows it with unique chemical activities.
Hydroxy (OH) is nucleophilic and easily participates in substitution reactions. For example, under appropriate conditions, it can undergo nucleophilic substitution with halogenated hydrocarbons. The oxygen atom in the hydroxyl group attacks the carbon atom of the halogenated hydrocarbon with its lone pair electron, and the halogen atom leaves to form ether compounds. This is an important path for building carbon-oxygen bonds in organic synthesis.
And the chlorine atom (-Cl) is also active. In an alkaline environment, chlorine atoms are easily replaced by nucleophiles. For example, when co-heated with sodium hydroxide solution, chlorine atoms will be replaced by hydroxyl groups to form corresponding alcohols. In this process, hydroxide ions act as nucleophiles to attack carbon atoms containing chlorine atoms, and chloride ions are separated to achieve functional group conversion.
1 - (2 - hydroxyethyl) - 3 - chloropropanol can also participate in esterification reactions. Because of its hydroxyl group, it can react with carboxylic acids to form esters under acid catalysis. In this reaction, the carboxyl group of the carboxylic acid and the hydroxyl group of the alcohol are dehydrated and condensed to form ester bonds, which are widely used in organic synthesis, fragrance, drug preparation and other fields.
In addition, there are two different functional groups in the molecule of this substance, which can undergo intramolecular reactions. Under specific conditions, the hydroxyl group interacts with the carbon atom where the chlorine atom is located, triggering a cyclization reaction to form a cyclic compound, further expanding its application in organic synthesis. These chemical properties make it an important intermediate in the field of organic synthesis chemistry, which can be used to construct a variety of complex organic molecular structures.
Hydroxy (OH) is nucleophilic and easily participates in substitution reactions. For example, under appropriate conditions, it can undergo nucleophilic substitution with halogenated hydrocarbons. The oxygen atom in the hydroxyl group attacks the carbon atom of the halogenated hydrocarbon with its lone pair electron, and the halogen atom leaves to form ether compounds. This is an important path for building carbon-oxygen bonds in organic synthesis.
And the chlorine atom (-Cl) is also active. In an alkaline environment, chlorine atoms are easily replaced by nucleophiles. For example, when co-heated with sodium hydroxide solution, chlorine atoms will be replaced by hydroxyl groups to form corresponding alcohols. In this process, hydroxide ions act as nucleophiles to attack carbon atoms containing chlorine atoms, and chloride ions are separated to achieve functional group conversion.
1 - (2 - hydroxyethyl) - 3 - chloropropanol can also participate in esterification reactions. Because of its hydroxyl group, it can react with carboxylic acids to form esters under acid catalysis. In this reaction, the carboxyl group of the carboxylic acid and the hydroxyl group of the alcohol are dehydrated and condensed to form ester bonds, which are widely used in organic synthesis, fragrance, drug preparation and other fields.
In addition, there are two different functional groups in the molecule of this substance, which can undergo intramolecular reactions. Under specific conditions, the hydroxyl group interacts with the carbon atom where the chlorine atom is located, triggering a cyclization reaction to form a cyclic compound, further expanding its application in organic synthesis. These chemical properties make it an important intermediate in the field of organic synthesis chemistry, which can be used to construct a variety of complex organic molecular structures.
What are the main uses of 1- (2-bromoethoxy) -3-chlorobenzene?
(1) This substance has a wide range of uses.
1- (2-hydroxyethyl) -3-methoxyphenol is often found in medicine, chemical industry and many other fields.
In the field of medicine, its function is significant. It can be used as a key intermediate in drug synthesis. For example, in the preparation of some anti-inflammatory and antibacterial drugs, it plays an indispensable role. With its unique chemical structure, it can participate in a series of complex chemical reactions, help build drug molecular structures with specific pharmacological activities, thereby enhancing drug efficacy and improving the therapeutic effect of diseases.
In the chemical industry, it also has extraordinary performance. In the cosmetic industry, it can be used as an antioxidant. It can effectively resist the oxidation of the skin and delay the aging process of the skin. Like some high-end skin care products, after adding this substance, it can prevent the oil and other ingredients from deteriorating due to oxidation, prolong the shelf life of the product, and at the same time protect the skin from free radicals, so that the skin remains youthful. In the paint industry, it can enhance the stability and durability of the paint. During the film formation process of the paint, it interacts with other ingredients in the paint to form a more stable structure, thereby enhancing the tolerance of the paint to environmental factors (such as light, temperature changes, etc.), prolonging the service life of the paint on the surface of the object, and maintaining its good decorative and protective properties.
1- (2-hydroxyethyl) -3-methoxyphenol is often found in medicine, chemical industry and many other fields.
In the field of medicine, its function is significant. It can be used as a key intermediate in drug synthesis. For example, in the preparation of some anti-inflammatory and antibacterial drugs, it plays an indispensable role. With its unique chemical structure, it can participate in a series of complex chemical reactions, help build drug molecular structures with specific pharmacological activities, thereby enhancing drug efficacy and improving the therapeutic effect of diseases.
In the chemical industry, it also has extraordinary performance. In the cosmetic industry, it can be used as an antioxidant. It can effectively resist the oxidation of the skin and delay the aging process of the skin. Like some high-end skin care products, after adding this substance, it can prevent the oil and other ingredients from deteriorating due to oxidation, prolong the shelf life of the product, and at the same time protect the skin from free radicals, so that the skin remains youthful. In the paint industry, it can enhance the stability and durability of the paint. During the film formation process of the paint, it interacts with other ingredients in the paint to form a more stable structure, thereby enhancing the tolerance of the paint to environmental factors (such as light, temperature changes, etc.), prolonging the service life of the paint on the surface of the object, and maintaining its good decorative and protective properties.
What are the synthesis methods of 1- (2-bromoethoxy) -3-chlorobenzene?
The synthesis of 1 - (2 - hydroxyethyl) - 3 - methoxybenzene is a key issue in the field of organic synthesis. Although it is not directly described in detail in "Tiangong Kaiwu", it can be derived from the wisdom of the ancients and the principle of organic synthesis.
One of its synthesis paths may be derived from benzene. First, benzene and halogenated alkanes are alkylated by Fu-g under the catalysis of Lewis acid, and methyl groups are introduced to obtain toluene. Under specific conditions, toluene is oxidized with an appropriate oxidant to convert methyl groups into carboxyl groups to obtain benzoic acid. Benzoic acid is treated with acylation reagents to become benzoyl chloride.
At the same time, ethylene is added to water to obtain ethanol, and ethanol reacts with hydrogen halide to form haloethane. Haloethane reacts with compounds containing hydroxyl groups and with appropriate protective groups to introduce hydroxyethyl groups.
After that, benzoyl chloride and compounds containing hydroxyethyl groups are acylated under the catalysis of bases to form key carbon-oxygen bonds. Then through the step of deprotecting the group, the target product precursor is obtained. Finally, phenolic hydroxyl is methylated with appropriate methylation reagents, such as iodomethane and base, to obtain 1 - (2-hydroxyethyl) - 3-methoxybenzene.
Another path may be started from m-cresol. M-cresol is first reacted with halogenated alkanes under basic conditions to achieve methylation of phenolic hydroxyl groups to form m-methoxyphenol. M-methoxyphenol reacts with ethylene oxide under the action of a catalyst, ethylene oxide opens the ring, and hydroxyethyl is introduced at the ortho-position of the benzene ring to obtain the target product. Although these two methods have not been found in ancient books, they all follow the basic principles of organic synthesis and can be used as a reference for the synthesis of this compound.
One of its synthesis paths may be derived from benzene. First, benzene and halogenated alkanes are alkylated by Fu-g under the catalysis of Lewis acid, and methyl groups are introduced to obtain toluene. Under specific conditions, toluene is oxidized with an appropriate oxidant to convert methyl groups into carboxyl groups to obtain benzoic acid. Benzoic acid is treated with acylation reagents to become benzoyl chloride.
At the same time, ethylene is added to water to obtain ethanol, and ethanol reacts with hydrogen halide to form haloethane. Haloethane reacts with compounds containing hydroxyl groups and with appropriate protective groups to introduce hydroxyethyl groups.
After that, benzoyl chloride and compounds containing hydroxyethyl groups are acylated under the catalysis of bases to form key carbon-oxygen bonds. Then through the step of deprotecting the group, the target product precursor is obtained. Finally, phenolic hydroxyl is methylated with appropriate methylation reagents, such as iodomethane and base, to obtain 1 - (2-hydroxyethyl) - 3-methoxybenzene.
Another path may be started from m-cresol. M-cresol is first reacted with halogenated alkanes under basic conditions to achieve methylation of phenolic hydroxyl groups to form m-methoxyphenol. M-methoxyphenol reacts with ethylene oxide under the action of a catalyst, ethylene oxide opens the ring, and hydroxyethyl is introduced at the ortho-position of the benzene ring to obtain the target product. Although these two methods have not been found in ancient books, they all follow the basic principles of organic synthesis and can be used as a reference for the synthesis of this compound.
What should be paid attention to when storing and transporting 1- (2-bromoethoxy) -3-chlorobenzene?
When storing and transporting 1 - (2 -hydroxyethyl) -3 -bromobenzene, there are many key things to pay attention to.
First, the storage environment is extremely important. It should be placed in a cool, dry and well-ventilated place. Because the substance may be sensitive to temperature and humidity, if the environment is humid, it may cause deliquescence or chemical reaction with water vapor, which may affect its quality; if the temperature is too high, it may cause the substance to evaporate or accelerate its chemical changes, reducing stability. This is why the storage must be kept away from heat sources and water sources to maintain proper temperature and humidity.
Second, the packaging must be tight. Use high-quality, well-sealed packaging materials to prevent its leakage. Due to its certain chemical activity, once it leaks, it may not only cause pollution to the surrounding environment, but also cause dangerous reactions due to contact with external substances. Moreover, the packaging needs to have a certain degree of pressure resistance to prevent damage due to extrusion during storage and transportation.
Third, vibration and collision should be avoided during transportation. The chemical structure of the substance determines that when it is subject to strong vibration or collision, it may cause the molecular structure to change and trigger unstable reactions. Therefore, the transportation vehicle should run smoothly to reduce bumps.
Fourth, fireworks must be strictly prohibited at storage and transportation sites. 1 - (2-hydroxyethyl) -3-bromobenzene may be flammable or cause severe reactions in the presence of fire sources, posing a serious safety hazard. At the same time, it should also be stored and transported separately from oxidants, acids, bases and other substances, as it may react chemically with these substances, resulting in dangerous conditions.
Finally, the storage and transportation area should be equipped with professional emergency treatment equipment and personnel. In the event of an emergency situation such as leakage or fire, it can be responded quickly and effectively to reduce the degree of harm.
First, the storage environment is extremely important. It should be placed in a cool, dry and well-ventilated place. Because the substance may be sensitive to temperature and humidity, if the environment is humid, it may cause deliquescence or chemical reaction with water vapor, which may affect its quality; if the temperature is too high, it may cause the substance to evaporate or accelerate its chemical changes, reducing stability. This is why the storage must be kept away from heat sources and water sources to maintain proper temperature and humidity.
Second, the packaging must be tight. Use high-quality, well-sealed packaging materials to prevent its leakage. Due to its certain chemical activity, once it leaks, it may not only cause pollution to the surrounding environment, but also cause dangerous reactions due to contact with external substances. Moreover, the packaging needs to have a certain degree of pressure resistance to prevent damage due to extrusion during storage and transportation.
Third, vibration and collision should be avoided during transportation. The chemical structure of the substance determines that when it is subject to strong vibration or collision, it may cause the molecular structure to change and trigger unstable reactions. Therefore, the transportation vehicle should run smoothly to reduce bumps.
Fourth, fireworks must be strictly prohibited at storage and transportation sites. 1 - (2-hydroxyethyl) -3-bromobenzene may be flammable or cause severe reactions in the presence of fire sources, posing a serious safety hazard. At the same time, it should also be stored and transported separately from oxidants, acids, bases and other substances, as it may react chemically with these substances, resulting in dangerous conditions.
Finally, the storage and transportation area should be equipped with professional emergency treatment equipment and personnel. In the event of an emergency situation such as leakage or fire, it can be responded quickly and effectively to reduce the degree of harm.
What are the effects of 1- (2-bromoethoxy) -3-chlorobenzene on the environment and human health?
"Tiangong Kaiwu" is a masterpiece of science and technology written by Song Yingxing in the Ming Dynasty. It describes the principles of all things and the wonders of craftsmanship in simple classical Chinese. Today, on the question "What is the impact of 1- (2-hydroxyethyl) -3-methoxy on the environment and human health", the answer in ancient classical Chinese is as follows:
Fu 1- (2-hydroxyethyl) -3-methoxy This substance may be useful in various industrial fields in the modern world. However, its impact on the environment and human health should not be underestimated.
At one end of the environment, if this substance is not properly disposed of and spread out in the world, enter the water of rivers, lakes and seas, or cause water quality to change. Aquatic spirits, such as fish, turtles, shrimp and crabs, depend on water to live, and the change of water endangers their habitat. It may hinder the reproduction of aquatic animals and plants, causing ecological imbalance. Entering the soil, or interfering with various elements in the soil, changes the fertility and structure of the soil, and then harms the growth of plants and plants.
As for human health, if people come into contact with this thing through breathing, diet or skin, they may have a bad response. Entering through the respiratory tract, or irritating the lungs, causing shortness of breath, cough and asthma. Entering the stomach, or disturbing the digestive system, causing abdominal pain and diarrhea. If penetrated through the skin, or causing skin allergies, redness, swelling and itching. And this substance may be potentially toxic, long-term exposure to it, or damage the function of human organs, such as the genus of liver and kidney, or even cause disease.
Therefore, in 1- (2-hydroxyethyl) -3-methoxy, it should be carefully observed and properly disposed of to protect the beauty of the environment and the safety of the human body.
Fu 1- (2-hydroxyethyl) -3-methoxy This substance may be useful in various industrial fields in the modern world. However, its impact on the environment and human health should not be underestimated.
At one end of the environment, if this substance is not properly disposed of and spread out in the world, enter the water of rivers, lakes and seas, or cause water quality to change. Aquatic spirits, such as fish, turtles, shrimp and crabs, depend on water to live, and the change of water endangers their habitat. It may hinder the reproduction of aquatic animals and plants, causing ecological imbalance. Entering the soil, or interfering with various elements in the soil, changes the fertility and structure of the soil, and then harms the growth of plants and plants.
As for human health, if people come into contact with this thing through breathing, diet or skin, they may have a bad response. Entering through the respiratory tract, or irritating the lungs, causing shortness of breath, cough and asthma. Entering the stomach, or disturbing the digestive system, causing abdominal pain and diarrhea. If penetrated through the skin, or causing skin allergies, redness, swelling and itching. And this substance may be potentially toxic, long-term exposure to it, or damage the function of human organs, such as the genus of liver and kidney, or even cause disease.
Therefore, in 1- (2-hydroxyethyl) -3-methoxy, it should be carefully observed and properly disposed of to protect the beauty of the environment and the safety of the human body.
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