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1-(2-Bromoethoxy)-4-Chlorobenzene
Linshang Chemical
|
HS Code |
826834 |
| Name | 1-(2-Bromoethoxy)-4-Chlorobenzene |
| Molecular Formula | C8H8BrClO |
| Molar Mass | 235.505 g/mol |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Approximately 260 - 265 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
As an accredited 1-(2-Bromoethoxy)-4-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(2 - bromoethoxy)-4 - chlorobenzene in a sealed, labeled chemical - grade bottle. |
| Storage | 1-(2 - bromoethoxy)-4 - chlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to chemical reactions or degradation. |
| Shipping | 1-(2 - bromoethoxy)-4 - chlorobenzene is shipped in accordance with strict chemical transport regulations. It's packaged securely in corrosion - resistant containers to prevent leakage during transit, ensuring safety. |
Competitive 1-(2-Bromoethoxy)-4-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-(2-Bromoethoxy)-4-Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1- (2-bromoethoxy) -4-chlorobenzene?
The chemical properties of 1 - (2-hydroxyethyl) - 4 -chlorobenzene are an important part of the study, which has a general property.
First of all, its physical properties, this compound is usually solid under normal conditions, color or white to white, melting, boiling and other physical conditions, all depend on the characteristics of the molecule. Its melting or depending on the magnitude of the molecular force, depending on a certain degree of resistance, the amount of molecular phase and molecular interaction are closely related.
and chemical reaction activity, the chlorine atom of 1 - (2-hydroxyethyl) - 4 -chlorobenzene has phase reaction activity. Due to the chlorine atom's resistance, the carbon-chlorine content of the benzene phase is resistant, and it is susceptible to nuclear attack. For example, in the presence of a benzene component, the benzene nucleus and other benzene nuclei can replace the chlorine atom, and the benzene nucleus can replace the anti-benzene to form the alcohol derivative of the benzene phase.
Furthermore, the benzene part also has characteristics. Benzene is aromatic and easy to generate benzene substitution and anti-benzene. Due to the high density of the benzene phase, new substituents can be introduced into the benzene in the presence of benzene catalysis.
And the benzene group of the 2-hydroxyethyl moiety can also react like benzene. It can be esterified by carboxylic acid to form ester compounds. This reaction can be used in acid catalysis. Moreover, the solubility and melt boiling of the carboxylic acid compounds also affect the physical properties of the carboxylic acid, so that it has good solubility in some soluble compounds.
Therefore, 1- (2-hydroxyethyl) -4-chlorobenzene has important uses in various fields such as synthesis, and can be used for the synthesis of more complex compounds.
First of all, its physical properties, this compound is usually solid under normal conditions, color or white to white, melting, boiling and other physical conditions, all depend on the characteristics of the molecule. Its melting or depending on the magnitude of the molecular force, depending on a certain degree of resistance, the amount of molecular phase and molecular interaction are closely related.
and chemical reaction activity, the chlorine atom of 1 - (2-hydroxyethyl) - 4 -chlorobenzene has phase reaction activity. Due to the chlorine atom's resistance, the carbon-chlorine content of the benzene phase is resistant, and it is susceptible to nuclear attack. For example, in the presence of a benzene component, the benzene nucleus and other benzene nuclei can replace the chlorine atom, and the benzene nucleus can replace the anti-benzene to form the alcohol derivative of the benzene phase.
Furthermore, the benzene part also has characteristics. Benzene is aromatic and easy to generate benzene substitution and anti-benzene. Due to the high density of the benzene phase, new substituents can be introduced into the benzene in the presence of benzene catalysis.
And the benzene group of the 2-hydroxyethyl moiety can also react like benzene. It can be esterified by carboxylic acid to form ester compounds. This reaction can be used in acid catalysis. Moreover, the solubility and melt boiling of the carboxylic acid compounds also affect the physical properties of the carboxylic acid, so that it has good solubility in some soluble compounds.
Therefore, 1- (2-hydroxyethyl) -4-chlorobenzene has important uses in various fields such as synthesis, and can be used for the synthesis of more complex compounds.
What are the physical properties of 1- (2-bromoethoxy) -4-chlorobenzene?
The physical properties of 1 - (2-hydroxyethyl) - 4-bromobenzene are as follows:
The outer properties of this compound are usually solid and have a specific melting property. The melting property of this compound is determined by the degree of solid-phase melting and liquid-phase melting, and for 1 - (2-hydroxyethyl) - 4-bromobenzene, the melting value of the fine is determined by factors such as its degree. In general, the immobilization of this melt phase can be used to determine one of the important properties of this compound.
Its density is also important for physical properties. The density of 1- (2-hydroxyethyl) -4-bromobenzene is the density of its molecules. Because the molecule contains bromine atoms, the amount of bromine atoms in the phase is large, which increases the overall amount of the molecule, so the density of the phase is high.
In terms of solubility, 1- (2-hydroxyethyl) -4-bromobenzene is different in different solubility. In some soluble molecules such as ethanol, ether, etc., because their molecules have both groups, they have a certain solubility. In water, due to the large phase of the non-toxic part of the molecule, water molecules form strong interactions, so the solubility is limited.
In addition, the refractive index of 1- (2-hydroxyethyl) -4-bromobenzene is also one of its physical properties. The refractive index reflects the degree of refraction of light in the material, the distribution of the sub-cloud of the molecules of the material, the molecular arrangement, etc. The specific refractive index can be used for qualitative determination and degree analysis of the material.
Therefore, the physical properties of 1- (2-hydroxyethyl) -4-bromobenzene, such as melting, density, solubility, refractive index, etc., are essential for its application in the fields of chemical synthesis and analysis, helping chemists to understand its properties in depth, and better control the reaction and application of the phase.
The outer properties of this compound are usually solid and have a specific melting property. The melting property of this compound is determined by the degree of solid-phase melting and liquid-phase melting, and for 1 - (2-hydroxyethyl) - 4-bromobenzene, the melting value of the fine is determined by factors such as its degree. In general, the immobilization of this melt phase can be used to determine one of the important properties of this compound.
Its density is also important for physical properties. The density of 1- (2-hydroxyethyl) -4-bromobenzene is the density of its molecules. Because the molecule contains bromine atoms, the amount of bromine atoms in the phase is large, which increases the overall amount of the molecule, so the density of the phase is high.
In terms of solubility, 1- (2-hydroxyethyl) -4-bromobenzene is different in different solubility. In some soluble molecules such as ethanol, ether, etc., because their molecules have both groups, they have a certain solubility. In water, due to the large phase of the non-toxic part of the molecule, water molecules form strong interactions, so the solubility is limited.
In addition, the refractive index of 1- (2-hydroxyethyl) -4-bromobenzene is also one of its physical properties. The refractive index reflects the degree of refraction of light in the material, the distribution of the sub-cloud of the molecules of the material, the molecular arrangement, etc. The specific refractive index can be used for qualitative determination and degree analysis of the material.
Therefore, the physical properties of 1- (2-hydroxyethyl) -4-bromobenzene, such as melting, density, solubility, refractive index, etc., are essential for its application in the fields of chemical synthesis and analysis, helping chemists to understand its properties in depth, and better control the reaction and application of the phase.
What are the synthesis methods of 1- (2-bromoethoxy) -4-chlorobenzene?
The synthesis of 1 - (2 -hydroxyethyl) - 4 -chlorobenzene has various methods today, which are described in detail as follows:
First, it can be started by halogenation reaction. Select the appropriate benzene derivative, use chlorine as the halogenating agent, and under suitable reaction conditions, such as the presence of catalysts (such as iron filings, ferric chloride, etc.) and heating, chlorination reaction occurs at a specific position on the benzene ring, and chlorine atoms are introduced to obtain 4-chlorobenzene derivatives. Then, through the hydroxyethylation reaction, a reagent such as ethylene oxide is selected, and under the action of a basic catalyst (such as sodium hydroxide, etc.), it reacts with 4-chlorobenzene derivatives to introduce the hydroxyethyl group into the molecule, thereby obtaining the target product 1- (2-hydroxyethyl) -4-chlorobenzene.
Second, the etherification reaction begins. Compounds containing hydroxyethyl groups are first prepared, such as ethanol and halogenated hydrocarbons (halogen atom activity needs to be suitable) in an alkaline environment to form hydroxyethyl ether intermediates. Then, the intermediate is nucleophilized with 4-chlorophenol under basic conditions, and ether bonds are connected to achieve the synthesis of 1- (2-hydroxyethyl) -4-chlorobenzene. In this way, the reaction temperature, the amount of base and the proportion of reactants need to be carefully controlled to ensure the high efficiency of the reaction and the purity of the product.
Third, with the help of Grignard reagent method. First prepare 4-chlorophenyl magnesium halide (Grignard reagent), and react magnesium chips with 4-chlorohalobenzene in anhydrous ether or tetrahydrofuran and other inert solvents. Then, ethylene oxide is added to the Grignard reagent to undergo a nucleophilic addition reaction, and then the addition product is converted into 1- (2-hydroxyethyl) -4-chlorobenzene through a hydrolysis step. This method requires strict anhydrous and anaerobic conditions in the reaction environment, and the preparation and use of Grignard reagents need to be carefully handled to avoid danger and ensure the smooth progress of the reaction.
The above synthetic methods have their own advantages and disadvantages. In practical application, the choice needs to be weighed according to various factors such as the availability of raw materials, the difficulty of achieving reaction conditions, and the purity requirements of the product.
First, it can be started by halogenation reaction. Select the appropriate benzene derivative, use chlorine as the halogenating agent, and under suitable reaction conditions, such as the presence of catalysts (such as iron filings, ferric chloride, etc.) and heating, chlorination reaction occurs at a specific position on the benzene ring, and chlorine atoms are introduced to obtain 4-chlorobenzene derivatives. Then, through the hydroxyethylation reaction, a reagent such as ethylene oxide is selected, and under the action of a basic catalyst (such as sodium hydroxide, etc.), it reacts with 4-chlorobenzene derivatives to introduce the hydroxyethyl group into the molecule, thereby obtaining the target product 1- (2-hydroxyethyl) -4-chlorobenzene.
Second, the etherification reaction begins. Compounds containing hydroxyethyl groups are first prepared, such as ethanol and halogenated hydrocarbons (halogen atom activity needs to be suitable) in an alkaline environment to form hydroxyethyl ether intermediates. Then, the intermediate is nucleophilized with 4-chlorophenol under basic conditions, and ether bonds are connected to achieve the synthesis of 1- (2-hydroxyethyl) -4-chlorobenzene. In this way, the reaction temperature, the amount of base and the proportion of reactants need to be carefully controlled to ensure the high efficiency of the reaction and the purity of the product.
Third, with the help of Grignard reagent method. First prepare 4-chlorophenyl magnesium halide (Grignard reagent), and react magnesium chips with 4-chlorohalobenzene in anhydrous ether or tetrahydrofuran and other inert solvents. Then, ethylene oxide is added to the Grignard reagent to undergo a nucleophilic addition reaction, and then the addition product is converted into 1- (2-hydroxyethyl) -4-chlorobenzene through a hydrolysis step. This method requires strict anhydrous and anaerobic conditions in the reaction environment, and the preparation and use of Grignard reagents need to be carefully handled to avoid danger and ensure the smooth progress of the reaction.
The above synthetic methods have their own advantages and disadvantages. In practical application, the choice needs to be weighed according to various factors such as the availability of raw materials, the difficulty of achieving reaction conditions, and the purity requirements of the product.
In what fields is 1- (2-bromoethoxy) -4-chlorobenzene used?
1 - (2 - hydroxyethyl) - 4 - chlorobenzene is used in many fields, which is a very important organic compound.
In the field of medicine, it is a key intermediate for drug synthesis. In the preparation of many drugs, 1 - (2 - hydroxyethyl) - 4 - chlorobenzene plays an indispensable role. For example, in the synthesis path of some antibacterial drugs, it can be used as a starting material through a series of chemical reactions to construct molecular structures with specific pharmacological activities, which help to improve the inhibition and killing ability of drugs against bacteria, so as to provide effective drugs for the treatment of infectious diseases.
In the field of materials science, it also has important uses. It can participate in the synthesis of polymer materials. By polymerizing with other monomers, it can give polymer materials specific properties. For example, it can improve the solubility, thermal stability and mechanical properties of materials. The synthesized materials can be applied to coatings, plastics and other fields to meet the diverse needs of material properties in different scenarios.
In the field of fine chemicals, 1- (2-hydroxyethyl) -4-chlorobenzene is often used to prepare various fine chemicals. Such as special surfactants, fragrances, etc. The surfactants synthesized on its basis may have unique interfacial activities, which can play an excellent role in emulsifying, dispersing, and solubilizing in emulsions, detergents, and other products; the synthesized fragrances may have unique aroma characteristics, which can be used in perfumes, flavors, and other products to add unique fragrance.
In summary, although 1- (2-hydroxyethyl) -4-chlorobenzene is an organic compound, it is widely used in many fields such as medicine, materials science, and fine chemicals, and is of great significance for promoting technological development and product innovation in various fields.
In the field of medicine, it is a key intermediate for drug synthesis. In the preparation of many drugs, 1 - (2 - hydroxyethyl) - 4 - chlorobenzene plays an indispensable role. For example, in the synthesis path of some antibacterial drugs, it can be used as a starting material through a series of chemical reactions to construct molecular structures with specific pharmacological activities, which help to improve the inhibition and killing ability of drugs against bacteria, so as to provide effective drugs for the treatment of infectious diseases.
In the field of materials science, it also has important uses. It can participate in the synthesis of polymer materials. By polymerizing with other monomers, it can give polymer materials specific properties. For example, it can improve the solubility, thermal stability and mechanical properties of materials. The synthesized materials can be applied to coatings, plastics and other fields to meet the diverse needs of material properties in different scenarios.
In the field of fine chemicals, 1- (2-hydroxyethyl) -4-chlorobenzene is often used to prepare various fine chemicals. Such as special surfactants, fragrances, etc. The surfactants synthesized on its basis may have unique interfacial activities, which can play an excellent role in emulsifying, dispersing, and solubilizing in emulsions, detergents, and other products; the synthesized fragrances may have unique aroma characteristics, which can be used in perfumes, flavors, and other products to add unique fragrance.
In summary, although 1- (2-hydroxyethyl) -4-chlorobenzene is an organic compound, it is widely used in many fields such as medicine, materials science, and fine chemicals, and is of great significance for promoting technological development and product innovation in various fields.
What are the storage conditions for 1- (2-bromoethoxy) -4-chlorobenzene?
The storage conditions of 1- (2-hydroxyethyl) -4-chlorobenzene are crucial to the maintenance of its quality and utility. According to the techniques and physical properties of Tiangong Kaiwu, the following points should be paid attention to:
Temperature and humidity of the first environment. This compound should be placed in a cool place to avoid high temperature baking. High temperature can easily cause its molecular structure to be restless, or cause changes, which will damage its inherent properties. If it is under the hot summer sun, it is afraid of qualitative change, so the room temperature should not exceed 20 degrees. Humidity should not be ignored. In places that are too humid, water vapor is easy to attach, or cause hydrolysis and other changes. When choosing a dry place, it will not be damp and keep it pure.
Times and the influence of light. 1 - (2 - hydroxyethyl) - 4 - chlorobenzene is quite sensitive to light. Energy in light or stimulate its chemical reaction, so that the composition changes. Therefore, when storing, use a light-shielding device, such as a brown glass bottle, to block light intrusion and protect its essence.
Furthermore, the packaging should be tight. Isolated from the outside world, to prevent oxygen and impurities from the air from mixing. Oxygen can cause oxidation, impurities or promote side reactions. To seal the volume, keep its internal environment stable and maintain its chemical purity.
In addition, it should also be kept away from fire sources and strong oxidants. 1 - (2 - hydroxyethyl) - 4 - chlorobenzene has certain chemical activity, and it may be exposed to fire or oxidants, or react violently, which endangers safety.
In short, the storage of 1 - (2 - hydroxyethyl) - 4 - chlorobenzene should be in a cool, dry, shaded and sealed place, protected from fire and oxidants, so as to ensure its quality and effectiveness for subsequent use.
Temperature and humidity of the first environment. This compound should be placed in a cool place to avoid high temperature baking. High temperature can easily cause its molecular structure to be restless, or cause changes, which will damage its inherent properties. If it is under the hot summer sun, it is afraid of qualitative change, so the room temperature should not exceed 20 degrees. Humidity should not be ignored. In places that are too humid, water vapor is easy to attach, or cause hydrolysis and other changes. When choosing a dry place, it will not be damp and keep it pure.
Times and the influence of light. 1 - (2 - hydroxyethyl) - 4 - chlorobenzene is quite sensitive to light. Energy in light or stimulate its chemical reaction, so that the composition changes. Therefore, when storing, use a light-shielding device, such as a brown glass bottle, to block light intrusion and protect its essence.
Furthermore, the packaging should be tight. Isolated from the outside world, to prevent oxygen and impurities from the air from mixing. Oxygen can cause oxidation, impurities or promote side reactions. To seal the volume, keep its internal environment stable and maintain its chemical purity.
In addition, it should also be kept away from fire sources and strong oxidants. 1 - (2 - hydroxyethyl) - 4 - chlorobenzene has certain chemical activity, and it may be exposed to fire or oxidants, or react violently, which endangers safety.
In short, the storage of 1 - (2 - hydroxyethyl) - 4 - chlorobenzene should be in a cool, dry, shaded and sealed place, protected from fire and oxidants, so as to ensure its quality and effectiveness for subsequent use.
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