Linshang Chemical
PRODUCTS
1,2-Dibromo-5-Chloro-3-Fluorobenzene
Linshang Chemical
|
HS Code |
490378 |
| Chemical Formula | C6H2Br2ClF |
| Molar Mass | 304.34 g/mol |
| Appearance | Solid (predicted) |
| Boiling Point | Estimated around 250 - 280 °C (predicted) |
| Density | Estimated around 2.2 - 2.5 g/cm³ (predicted) |
| Solubility In Water | Insoluble (aromatic halides are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, etc. |
| Vapor Pressure | Low at room temperature (predicted) |
| Stability | Stable under normal conditions, but may react with strong bases, reducing agents |
As an accredited 1,2-Dibromo-5-Chloro-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1,2 - dibromo - 5 - chloro - 3 - fluorobenzene in a sealed chemical - grade bottle. |
| Storage | 1,2 - dibromo - 5 - chloro - 3 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container made of materials resistant to corrosion, such as glass or certain plastics. This helps prevent leakage, decomposition, and potential reactions that could pose safety risks. |
| Shipping | 1,2 - dibromo - 5 - chloro - 3 - fluorobenzene, being a chemical, is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous material shipping regulations, ensuring secure transit to prevent any leakage or environmental risk. |
Competitive 1,2-Dibromo-5-Chloro-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1,2-Dibromo-5-Chloro-3-Fluorobenzene in China?
As a trusted 1,2-Dibromo-5-Chloro-3-Fluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1,2-Dibromo-5-Chloro-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1,2-dibromo-5-chloro-3-fluorobenzene?
1,2-Dichloro-5-fluoro-3-bromobenzene, which is not detailed in the books involved in "Tiangong Kaiwu", is widely used in modern chemistry.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. The introduction of halogen atoms can change the physical, chemical properties and biological activities of compounds. For example, through specific reaction steps, it can construct molecular structures with unique pharmacological activities, or can be used to develop new antibacterial and antiviral drugs to treat various diseases and save patients from pain.
In the field of materials science, its status should not be underestimated. It can be used as a starting material for the synthesis of special polymer materials. Through polymerization reaction, it is connected with other monomers to give the material special properties, such as excellent heat resistance, chemical corrosion resistance, etc. These materials may be used in high-end fields such as aerospace, electronics and electrical appliances to meet their strict requirements for materials.
In the field of pesticide chemistry, it is also an important component in the creation of new and efficient pesticides. After rational design and synthesis, the derived compounds may have high selectivity and strong lethality to specific pests, and are environmentally friendly, can effectively prevent and control pests and diseases, maintain the prosperity of farmers and mulberry, and promote the yield of agriculture.
Although this is not mentioned in Tiangong Kaiwu, from today's scientific and technological perspective, 1,2-dichloro-5-fluoro-3-bromobenzene plays an indispensable role in many key fields and is an important substance for promoting the development of modern technology and industry.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. The introduction of halogen atoms can change the physical, chemical properties and biological activities of compounds. For example, through specific reaction steps, it can construct molecular structures with unique pharmacological activities, or can be used to develop new antibacterial and antiviral drugs to treat various diseases and save patients from pain.
In the field of materials science, its status should not be underestimated. It can be used as a starting material for the synthesis of special polymer materials. Through polymerization reaction, it is connected with other monomers to give the material special properties, such as excellent heat resistance, chemical corrosion resistance, etc. These materials may be used in high-end fields such as aerospace, electronics and electrical appliances to meet their strict requirements for materials.
In the field of pesticide chemistry, it is also an important component in the creation of new and efficient pesticides. After rational design and synthesis, the derived compounds may have high selectivity and strong lethality to specific pests, and are environmentally friendly, can effectively prevent and control pests and diseases, maintain the prosperity of farmers and mulberry, and promote the yield of agriculture.
Although this is not mentioned in Tiangong Kaiwu, from today's scientific and technological perspective, 1,2-dichloro-5-fluoro-3-bromobenzene plays an indispensable role in many key fields and is an important substance for promoting the development of modern technology and industry.
What are the physical properties of 1,2-dibromo-5-chloro-3-fluorobenzene?
1,2-Dichloro-5-fluoro-3-bromopyridine is an organic compound with the following physical properties:
In terms of appearance, it is mostly colorless to light yellow liquid at room temperature and pressure. When it is pure, it is clear and transparent, but it contains impurities. It may change color and turbidity. This state is related to its molecular structure, which makes the intermolecular forces reach a specific balance, resulting in this state at room temperature and pressure.
In terms of boiling point, it is about 180-200 ° C. Due to the presence of chlorine, fluorine, bromine and other halogen atoms in the molecule, the electronegativity of the halogen atom is large, resulting in a strong dipole-dipole force between the molecules. To make it boil, more energy is required to overcome this force, so the boiling point is higher.
The melting point is about -20-0 ° C. The degree of orderly arrangement of molecules and the interaction force determine the melting point. Its molecular structure makes the intermolecular force equilibrium break in this temperature range, and the substance changes from solid to liquid.
In terms of solubility, it is slightly soluble in water and soluble in most organic solvents, such as ethanol, ether, dichloromethane, etc. Because it is an organic compound, the molecule has certain hydrophobicity, and it is difficult to form strong interactions such as hydrogen bonds with water, so it is slightly soluble in water; while it can interact with organic solvents through Van der Waals forces to achieve mutual solubility.
In terms of density, it is relatively large relative to water, about 1.6-1.8 g/cm ³. The halogen atom has a large atomic weight and a tight molecular structure, resulting in an increase in mass per unit volume and a density greater than that of water.
In terms of odor, there is usually an irritating odor. Halogen atoms and pyridine rings work together to stimulate olfactory receptors and make people feel irritating odor. This odor may vary in strength due to purity and concentration.
In terms of appearance, it is mostly colorless to light yellow liquid at room temperature and pressure. When it is pure, it is clear and transparent, but it contains impurities. It may change color and turbidity. This state is related to its molecular structure, which makes the intermolecular forces reach a specific balance, resulting in this state at room temperature and pressure.
In terms of boiling point, it is about 180-200 ° C. Due to the presence of chlorine, fluorine, bromine and other halogen atoms in the molecule, the electronegativity of the halogen atom is large, resulting in a strong dipole-dipole force between the molecules. To make it boil, more energy is required to overcome this force, so the boiling point is higher.
The melting point is about -20-0 ° C. The degree of orderly arrangement of molecules and the interaction force determine the melting point. Its molecular structure makes the intermolecular force equilibrium break in this temperature range, and the substance changes from solid to liquid.
In terms of solubility, it is slightly soluble in water and soluble in most organic solvents, such as ethanol, ether, dichloromethane, etc. Because it is an organic compound, the molecule has certain hydrophobicity, and it is difficult to form strong interactions such as hydrogen bonds with water, so it is slightly soluble in water; while it can interact with organic solvents through Van der Waals forces to achieve mutual solubility.
In terms of density, it is relatively large relative to water, about 1.6-1.8 g/cm ³. The halogen atom has a large atomic weight and a tight molecular structure, resulting in an increase in mass per unit volume and a density greater than that of water.
In terms of odor, there is usually an irritating odor. Halogen atoms and pyridine rings work together to stimulate olfactory receptors and make people feel irritating odor. This odor may vary in strength due to purity and concentration.
What are the chemical properties of 1,2-dibromo-5-chloro-3-fluorobenzene?
1% 2C2-dibromo-5-fluoro-3-chloropyridine is heterogeneous in nature. It is halogenated and very active.
Bromine, in the reaction of nucleophilic substitution, is often the leaving group. If it is a nucleophilic reagent, it is easy to be replaced by other groups. When encountering electron-rich reagents, such as alkoxides, amines, etc., bromine atoms can be mixed with them to form different compounds. This reaction depends on the activity of the reagent, the properties of the solvent and the temperature.
Although fluorine is a small atom, it is extremely electronegative. In molecules, it can change the cloud of electrons, change the electron density of the pyridine ring, and then affect the activity of the ring reaction. It can cause the localization and rate of the electrophilic substitution reaction on the ring to be different from usual. And because of its high carbon-fluorine bond energy, the chemical stability of fluorine-containing compounds is increased.
A member of the chlorine-halogen group, in the reaction, can participate in various chemical changes. In some metal-catalyzed reactions, chlorine atoms can coordinate with metals to initiate unique reaction paths. For example, in the coupling reaction catalyzed by palladium, chlorine atoms may be the key starting point. After a series of transformations, a complex organic structure is finally obtained.
And because of the coexistence of polyhalogen atoms in the molecule, the electronic effects of each other interfere with each other, making the overall chemical properties more complex. In the field of organic synthesis, this compound is often an important medium. Through ingenious design and reaction, it can derive many substances with biological activity and pharmacological functions, paving the way for the creation of new drugs, material research and development, etc. It is one of the focuses of organic chemistry research.
Bromine, in the reaction of nucleophilic substitution, is often the leaving group. If it is a nucleophilic reagent, it is easy to be replaced by other groups. When encountering electron-rich reagents, such as alkoxides, amines, etc., bromine atoms can be mixed with them to form different compounds. This reaction depends on the activity of the reagent, the properties of the solvent and the temperature.
Although fluorine is a small atom, it is extremely electronegative. In molecules, it can change the cloud of electrons, change the electron density of the pyridine ring, and then affect the activity of the ring reaction. It can cause the localization and rate of the electrophilic substitution reaction on the ring to be different from usual. And because of its high carbon-fluorine bond energy, the chemical stability of fluorine-containing compounds is increased.
A member of the chlorine-halogen group, in the reaction, can participate in various chemical changes. In some metal-catalyzed reactions, chlorine atoms can coordinate with metals to initiate unique reaction paths. For example, in the coupling reaction catalyzed by palladium, chlorine atoms may be the key starting point. After a series of transformations, a complex organic structure is finally obtained.
And because of the coexistence of polyhalogen atoms in the molecule, the electronic effects of each other interfere with each other, making the overall chemical properties more complex. In the field of organic synthesis, this compound is often an important medium. Through ingenious design and reaction, it can derive many substances with biological activity and pharmacological functions, paving the way for the creation of new drugs, material research and development, etc. It is one of the focuses of organic chemistry research.
What are the synthesis methods of 1,2-dibromo-5-chloro-3-fluorobenzene?
For the synthesis of 1% 2C2-dibromo-5-fluoro-3-chloropyridine, please refer to the ancient method of "Tiangong Kaiwu", which is described as follows:
Starting materials, when carefully selected. To obtain 1% 2C2-dibromo-5-fluoro-3-chloropyridine, first take pyridine as the base material, pyridine is a cyclic nitrogen-containing compound, which is aromatic and has a wide range of uses in the field of organic synthesis. Choosing pyridine requires high purity, few impurities, and smooth synthesis.
The step of halogenation is crucial. A brominating agent, such as liquid bromine or N-bromosuccinimide (NBS), is used in the presence of a brominating agent and pyridine. If liquid bromine is used, it needs to be in a low temperature and catalyst environment. Catalyzed by iron powder or iron tribromide, the liquid bromine gradually enters the pyridine, and the bromine atoms replace the hydrogen atoms on the pyridine ring in sequence. During this process, the temperature needs to be stable, and the stirring should be uniform to make the reaction comprehensive and orderly. As for the substitution of 5-fluoro-3-chlorine, it is also necessary to find suitable fluorinating agents and chlorinating agents. Fluorinating agents such as potassium fluoride, chlorinating agents such as phosphorus trichloride, etc. When introducing fluorine and chlorine atoms, the reaction conditions should be reviewed, either high temperature and high pressure are required, or the force of a phase transfer catalyst is used to make the fluorine and chlorine atoms fall precisely at the 5th and 3rd positions of the pyridine ring.
The reaction process should be closely monitored. Observe it by thin layer chromatography (TLC) or gas chromatography-mass spectrometry (GC-MS). For TLC, the reaction process and product purity can be visually seen by using a silica gel plate and a suitable development agent; GC-MS can analyze the structure and impurity composition of the product in detail. If the reaction is not as expected, or the rate is slow, or the product is impure, the reaction conditions need to be reviewed, and the temperature and reagent ratio need to be adjusted.
Purification of the product is also the key. After the reaction is completed, the crude product is obtained, which may contain unreacted raw materials, by-products, etc. By distillation, according to the boiling point difference of each component, volatile and high boiling impurities are removed first. Next, column chromatography is used to select suitable silica gel fillers and eluents to separate the product from impurities. After these steps, a relatively pure 1% 2C2-dibromo-5-fluoro-3-chloropyridine can be obtained.
The road of synthesis is interconnected, and the selection of materials, the control of reactions, and the purity of products are all related to success or failure. It is necessary to follow the essence of ancient methods, in line with modern technology, and be cautious to get a good product.
Starting materials, when carefully selected. To obtain 1% 2C2-dibromo-5-fluoro-3-chloropyridine, first take pyridine as the base material, pyridine is a cyclic nitrogen-containing compound, which is aromatic and has a wide range of uses in the field of organic synthesis. Choosing pyridine requires high purity, few impurities, and smooth synthesis.
The step of halogenation is crucial. A brominating agent, such as liquid bromine or N-bromosuccinimide (NBS), is used in the presence of a brominating agent and pyridine. If liquid bromine is used, it needs to be in a low temperature and catalyst environment. Catalyzed by iron powder or iron tribromide, the liquid bromine gradually enters the pyridine, and the bromine atoms replace the hydrogen atoms on the pyridine ring in sequence. During this process, the temperature needs to be stable, and the stirring should be uniform to make the reaction comprehensive and orderly. As for the substitution of 5-fluoro-3-chlorine, it is also necessary to find suitable fluorinating agents and chlorinating agents. Fluorinating agents such as potassium fluoride, chlorinating agents such as phosphorus trichloride, etc. When introducing fluorine and chlorine atoms, the reaction conditions should be reviewed, either high temperature and high pressure are required, or the force of a phase transfer catalyst is used to make the fluorine and chlorine atoms fall precisely at the 5th and 3rd positions of the pyridine ring.
The reaction process should be closely monitored. Observe it by thin layer chromatography (TLC) or gas chromatography-mass spectrometry (GC-MS). For TLC, the reaction process and product purity can be visually seen by using a silica gel plate and a suitable development agent; GC-MS can analyze the structure and impurity composition of the product in detail. If the reaction is not as expected, or the rate is slow, or the product is impure, the reaction conditions need to be reviewed, and the temperature and reagent ratio need to be adjusted.
Purification of the product is also the key. After the reaction is completed, the crude product is obtained, which may contain unreacted raw materials, by-products, etc. By distillation, according to the boiling point difference of each component, volatile and high boiling impurities are removed first. Next, column chromatography is used to select suitable silica gel fillers and eluents to separate the product from impurities. After these steps, a relatively pure 1% 2C2-dibromo-5-fluoro-3-chloropyridine can be obtained.
The road of synthesis is interconnected, and the selection of materials, the control of reactions, and the purity of products are all related to success or failure. It is necessary to follow the essence of ancient methods, in line with modern technology, and be cautious to get a good product.
What are the precautions for storing and transporting 1,2-dibromo-5-chloro-3-fluorobenzene?
1% 2C2-dibromo-5-fluoro-3-chloropyridine is an organic compound. When storing and transporting, you must pay attention to the following matters:
First, when storing, you should choose a dry, cool and well-ventilated place. This compound is quite sensitive to humidity, and humid environment can easily cause it to react, which in turn affects the quality. And high temperature may also cause decomposition or other chemical reactions, so a suitable cool environment is indispensable.
Second, it must be stored separately from oxidants, acids, bases and other substances. Due to its active chemical properties, contact with these substances is very likely to cause violent chemical reactions, which can even lead to serious consequences such as combustion and explosion.
Third, the storage container must have a good seal. To prevent the compound from evaporating into the air, it will not only cause material loss, but also may cause harm to the environment and human health. At the same time, the material of the container should be compatible with the compound to avoid reaction between the two.
Fourth, during transportation, ensure that the packaging is complete and firm. Prevent package damage due to bumps and collisions, resulting in compound leakage.
Fifth, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment. In the event of an unexpected situation such as leakage, it can be treated in time to reduce the harm.
Sixth, transportation and storage personnel must be professionally trained and familiar with the characteristics, hazards and corresponding emergency treatment measures of the compound. Only in this way can we achieve standardization and safety during operation to avoid accidents caused by improper operation.
First, when storing, you should choose a dry, cool and well-ventilated place. This compound is quite sensitive to humidity, and humid environment can easily cause it to react, which in turn affects the quality. And high temperature may also cause decomposition or other chemical reactions, so a suitable cool environment is indispensable.
Second, it must be stored separately from oxidants, acids, bases and other substances. Due to its active chemical properties, contact with these substances is very likely to cause violent chemical reactions, which can even lead to serious consequences such as combustion and explosion.
Third, the storage container must have a good seal. To prevent the compound from evaporating into the air, it will not only cause material loss, but also may cause harm to the environment and human health. At the same time, the material of the container should be compatible with the compound to avoid reaction between the two.
Fourth, during transportation, ensure that the packaging is complete and firm. Prevent package damage due to bumps and collisions, resulting in compound leakage.
Fifth, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment. In the event of an unexpected situation such as leakage, it can be treated in time to reduce the harm.
Sixth, transportation and storage personnel must be professionally trained and familiar with the characteristics, hazards and corresponding emergency treatment measures of the compound. Only in this way can we achieve standardization and safety during operation to avoid accidents caused by improper operation.
Scan to WhatsApp
