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1,2-Dichloro-3-Methyl-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
540342 |
| Chemical Formula | C8H5Cl2F3 |
| Molecular Weight | 229.026 g/mol |
| Solubility In Water | Low, as it is a non - polar aromatic compound, likely less than 0.1 g/L |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene, etc. |
| Vapor Pressure | Low, aromatic halides generally have low vapor pressures at room temperature |
As an accredited 1,2-Dichloro-3-Methyl-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 1,2 - dichloro - 3 - methyl - 4 - (trifluoromethyl)benzene. |
| Storage | 1,2 - dichloro - 3 - methyl - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air and moisture, which could potentially lead to chemical reactions or degradation. |
| Shipping | 1,2 - Dichloro - 3 - methyl - 4 - (trifluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transport to prevent spills and environmental harm. |
Competitive 1,2-Dichloro-3-Methyl-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1,2-Dichloro-3-Methyl-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1,2-dichloro-3-methyl-4- (trifluoromethyl) benzene?
1% 2C2-dibromo-3-methyl-4- (trifluoromethyl) benzene, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help develop drugs with specific curative effects. Due to its unique chemical structure, it can participate in a variety of chemical reactions. After ingenious design and transformation, it can construct molecular structures with specific pharmacological activities, laying the foundation for the birth of innovative drugs.
In the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of functional materials. After a series of chemical modifications and polymerization reactions, materials with special properties can be prepared. Polymer materials with excellent thermal stability, chemical stability or optical properties can be used in high-end fields such as aerospace and electronic devices.
1% 2C2-dibromo-3-methyl-4 - (trifluoromethyl) benzene also plays a key role in the research and development of pesticides. It can be used as a lead compound to develop new pesticides with high efficiency, low toxicity and environmental friendliness through structural optimization and modification. Its special structure helps to enhance the activity and selectivity of pesticides to target organisms, improve the control effect, and reduce the impact on non-target organisms and the environment.
In the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of functional materials. After a series of chemical modifications and polymerization reactions, materials with special properties can be prepared. Polymer materials with excellent thermal stability, chemical stability or optical properties can be used in high-end fields such as aerospace and electronic devices.
1% 2C2-dibromo-3-methyl-4 - (trifluoromethyl) benzene also plays a key role in the research and development of pesticides. It can be used as a lead compound to develop new pesticides with high efficiency, low toxicity and environmental friendliness through structural optimization and modification. Its special structure helps to enhance the activity and selectivity of pesticides to target organisms, improve the control effect, and reduce the impact on non-target organisms and the environment.
What are the physical properties of 1,2-dichloro-3-methyl-4- (trifluoromethyl) benzene?
1% 2C2-dichloro-3-methyl-4- (trichloromethyl) benzene, this substance is an organic halide with specific physical and chemical properties. Its properties are mostly liquid or solid at room temperature. Due to the presence of halogen atoms, the molecular polarity is enhanced, resulting in its boiling point and melting point being affected. Compared with hydrocarbons with similar structures, halogen-containing atoms change the intermolecular force, and the melting boiling point is usually higher.
The density of this compound is greater than that of water. The relative mass of halogen atoms is large, resulting in an increase in molecular weight and a tight arrangement. Therefore, the density is higher, and it will sink to the bottom in water. In terms of solubility, due to its own polarity, it is slightly soluble in water, but easily soluble in organic solvents, such as common ethanol, ether, chloroform, etc. This characteristic is derived from the principle of "similar phase dissolution", that is, polar solutes are easily soluble in polar solvents, and non-polar solutes are easily soluble in non-polar solvents.
Its chemical properties are active, and the halogen atom is highly active, which is prone to substitution reactions. If under appropriate conditions, the chlorine atom on the benzene ring can be replaced by other nucleophilic reagents to form new organic compounds. And due to the electron-absorbing effect of halogen atoms, the electron cloud density of the benzene ring is reduced, which affects the electrophilic substitution In addition, the substance is toxic to a certain extent, and halogenated aromatics are toxic to organisms. After entering the human body, they can interfere with physiological processes and damage health. Therefore, safety procedures must be strictly followed when using and handling.
The density of this compound is greater than that of water. The relative mass of halogen atoms is large, resulting in an increase in molecular weight and a tight arrangement. Therefore, the density is higher, and it will sink to the bottom in water. In terms of solubility, due to its own polarity, it is slightly soluble in water, but easily soluble in organic solvents, such as common ethanol, ether, chloroform, etc. This characteristic is derived from the principle of "similar phase dissolution", that is, polar solutes are easily soluble in polar solvents, and non-polar solutes are easily soluble in non-polar solvents.
Its chemical properties are active, and the halogen atom is highly active, which is prone to substitution reactions. If under appropriate conditions, the chlorine atom on the benzene ring can be replaced by other nucleophilic reagents to form new organic compounds. And due to the electron-absorbing effect of halogen atoms, the electron cloud density of the benzene ring is reduced, which affects the electrophilic substitution In addition, the substance is toxic to a certain extent, and halogenated aromatics are toxic to organisms. After entering the human body, they can interfere with physiological processes and damage health. Therefore, safety procedures must be strictly followed when using and handling.
Is the chemical property of 1,2-dichloro-3-methyl-4- (trifluoromethyl) benzene stable?
1% 2C2 -dibromo-3 -methyl-4 - (trifluoromethyl) benzene This compound has relatively stable properties. Its stability is attributed to many aspects. From the structural point of view, the benzene ring itself has a special conjugate system. This conjugate structure endows the benzene ring with high stability, making the benzene ring less prone to ring opening and other structural destruction reactions.
In this compound, methyl (-CH 🥰) is connected to the benzene ring. Methyl is an electron-supplying group. It provides electrons to the benzene ring through induction effect and super-conjugation effect, which can stabilize the electron cloud structure of the benzene ring to a certain extent and enhance the stability of the molecule.
Trifluoromethyl (-CF 🥰) is an electron-withdrawing group, but when it is connected to the benzene ring, its strong electron-withdrawing property mainly affects the distribution of electron clouds on the benzene ring, which reduces the electron cloud density on the benzene ring. However, this is not enough to destroy the conjugation stability of the benzene ring. On the contrary, due to its electron-withdrawing effect, the reactivity of the benzene ring to the electrophilic reagent is reduced, further reducing the possibility of structural changes caused by electrophilic reactions, thereby enhancing the stability of the whole compound.
At the same time, two bromine atoms (-Br) are connected to the benzene ring, and the electronegativity of the bromine atom is relatively large. It reduces the electron cloud density of the benzene ring through induction effect, but at the same time, the lone pair electrons of the bromine atom can form p-π conjugation with the large π bond of the benzene ring, and this conjugation effect can stabilize the benzene ring structure to a certain extent. Overall, the interaction between various substituents of the compound and the benzene ring makes 1% 2C2-dibromo-3-methyl-4- (trifluoromethyl) benzene have good chemical stability under normal conditions.
In this compound, methyl (-CH 🥰) is connected to the benzene ring. Methyl is an electron-supplying group. It provides electrons to the benzene ring through induction effect and super-conjugation effect, which can stabilize the electron cloud structure of the benzene ring to a certain extent and enhance the stability of the molecule.
Trifluoromethyl (-CF 🥰) is an electron-withdrawing group, but when it is connected to the benzene ring, its strong electron-withdrawing property mainly affects the distribution of electron clouds on the benzene ring, which reduces the electron cloud density on the benzene ring. However, this is not enough to destroy the conjugation stability of the benzene ring. On the contrary, due to its electron-withdrawing effect, the reactivity of the benzene ring to the electrophilic reagent is reduced, further reducing the possibility of structural changes caused by electrophilic reactions, thereby enhancing the stability of the whole compound.
At the same time, two bromine atoms (-Br) are connected to the benzene ring, and the electronegativity of the bromine atom is relatively large. It reduces the electron cloud density of the benzene ring through induction effect, but at the same time, the lone pair electrons of the bromine atom can form p-π conjugation with the large π bond of the benzene ring, and this conjugation effect can stabilize the benzene ring structure to a certain extent. Overall, the interaction between various substituents of the compound and the benzene ring makes 1% 2C2-dibromo-3-methyl-4- (trifluoromethyl) benzene have good chemical stability under normal conditions.
What are the synthesis methods of 1,2-dichloro-3-methyl-4- (trifluoromethyl) benzene?
The synthesis method of 1% 2C2-dibromo-3-methyl-4- (trifluoromethyl) benzene can follow the following paths:
First, benzene compounds containing methyl groups and halogens are used as starting materials. First, the nucleophilic substitution reaction is used to make the starting material and bromine-containing reagents (such as potassium bromide, bromine, etc.) in appropriate solvents (such as dichloromethane, carbon tetrachloride, etc.) and catalysts (such as iron filings, iron tribromide, etc.) to introduce bromine atoms into specific positions in the benzene ring to generate bromine-containing intermediates. Then, through the nucleophilic substitution reaction of halogenated hydrocarbons, trifluoromethyl Trifluoromethylation reagents (such as trifluoromethyl magnesium halide, lithium trifluoromethylation reagents, etc.) can be selected to react with intermediates in an anhydrous and oxygen-free environment and low temperature conditions to obtain the target product 1% 2C2-dibromo-3-methyl-4 - (trifluoromethyl) benzene.
Second, a benzene derivative containing bromine and methyl is used as the starting material. First, a metal-catalyzed coupling reaction, such as Suzuki coupling, Stille coupling, etc. Taking Suzuki coupling as an example, the starter and the boric acid derivative containing trifluoromethyl are heated and reacted in an organic solvent (such as toluene, dioxane, etc.) in the presence of a palladium catalyst (such as tetra (triphenylphosphine) palladium, etc.) and a base (such as potassium carbonate, sodium carbonate, etc.) to form an intermediate containing trifluoromethyl. After that, through a halogenation reaction, such as the use of bromine and a suitable catalyst, further bromination under suitable reaction conditions is used to obtain the target product.
Third, benzene is used as the starting material and is synthesized by stepwise functionalization. First, through the Fu-gram alkylation reaction, benzene and halomethane (such as chloromethane, bromomethane, etc.) are introduced into methyl to form toluene under the action of Lewis acid catalysts such as anhydrous aluminum trichloride. Toluene is brominated by selectively introducing bromine atoms at the ortho or meta sites to form monobromotoluene. Then, trifluoromethyl is introduced by nucleophilic substitution or free radical reaction using trifluoromethylation reagents, and then brominated again to achieve the synthesis of the target product.
First, benzene compounds containing methyl groups and halogens are used as starting materials. First, the nucleophilic substitution reaction is used to make the starting material and bromine-containing reagents (such as potassium bromide, bromine, etc.) in appropriate solvents (such as dichloromethane, carbon tetrachloride, etc.) and catalysts (such as iron filings, iron tribromide, etc.) to introduce bromine atoms into specific positions in the benzene ring to generate bromine-containing intermediates. Then, through the nucleophilic substitution reaction of halogenated hydrocarbons, trifluoromethyl Trifluoromethylation reagents (such as trifluoromethyl magnesium halide, lithium trifluoromethylation reagents, etc.) can be selected to react with intermediates in an anhydrous and oxygen-free environment and low temperature conditions to obtain the target product 1% 2C2-dibromo-3-methyl-4 - (trifluoromethyl) benzene.
Second, a benzene derivative containing bromine and methyl is used as the starting material. First, a metal-catalyzed coupling reaction, such as Suzuki coupling, Stille coupling, etc. Taking Suzuki coupling as an example, the starter and the boric acid derivative containing trifluoromethyl are heated and reacted in an organic solvent (such as toluene, dioxane, etc.) in the presence of a palladium catalyst (such as tetra (triphenylphosphine) palladium, etc.) and a base (such as potassium carbonate, sodium carbonate, etc.) to form an intermediate containing trifluoromethyl. After that, through a halogenation reaction, such as the use of bromine and a suitable catalyst, further bromination under suitable reaction conditions is used to obtain the target product.
Third, benzene is used as the starting material and is synthesized by stepwise functionalization. First, through the Fu-gram alkylation reaction, benzene and halomethane (such as chloromethane, bromomethane, etc.) are introduced into methyl to form toluene under the action of Lewis acid catalysts such as anhydrous aluminum trichloride. Toluene is brominated by selectively introducing bromine atoms at the ortho or meta sites to form monobromotoluene. Then, trifluoromethyl is introduced by nucleophilic substitution or free radical reaction using trifluoromethylation reagents, and then brominated again to achieve the synthesis of the target product.
What are the precautions for storing and transporting 1,2-dichloro-3-methyl-4- (trifluoromethyl) benzene?
1% 2C2-dideuterium-3-methyl-4- (trideuterium-methyl) naphthalene is an organic compound. During storage and transportation, many matters need to be paid special attention to:
First, because of its nature or temperature sensitivity, the storage temperature must be strictly controlled. A cool, dry and well-ventilated place should be selected to avoid direct sunlight and high temperature environments. If the temperature is too high, it may cause the compound to decompose, deteriorate, or even cause safety accidents. If the warehouse temperature is too high in summer, it may cause changes in its internal structure, which will affect the quality.
Second, humidity cannot be ignored. High humidity environments may cause compounds to absorb moisture, which in turn affects their purity and stability. It is necessary to use desiccants and other means to maintain the dry storage environment. For example, an appropriate amount of desiccant is placed in the storage container to monitor the environmental humidity in real time and adjust it.
Third, this compound may be toxic, corrosive or irritating. When storing and transporting, it is necessary to take comprehensive protective measures. Operators should wear protective clothing, protective gloves and goggles, etc., to prevent physical damage caused by contact. Handling process should be handled with care to avoid material leakage caused by damage to the container.
Fourth, this compound is a chemical, and relevant regulations and standards must be followed when transporting. Professional qualified transportation enterprises and transportation tools should be selected. Transportation documents should be detailed and accurate, indicating the name, nature, emergency treatment methods and other information of the compound. In the event of an accident such as a leak during transportation, the surrounding personnel should be evacuated quickly, and professionals should properly handle it according to its characteristics.
Fifth, the storage area should be kept away from fire sources, heat sources and oxidants. Because it may be flammable or react violently with oxidants, causing serious consequences such as fire or explosion. Storage sites should be equipped with complete fire protection facilities and emergency treatment equipment so that they can respond in time in case of emergencies.
First, because of its nature or temperature sensitivity, the storage temperature must be strictly controlled. A cool, dry and well-ventilated place should be selected to avoid direct sunlight and high temperature environments. If the temperature is too high, it may cause the compound to decompose, deteriorate, or even cause safety accidents. If the warehouse temperature is too high in summer, it may cause changes in its internal structure, which will affect the quality.
Second, humidity cannot be ignored. High humidity environments may cause compounds to absorb moisture, which in turn affects their purity and stability. It is necessary to use desiccants and other means to maintain the dry storage environment. For example, an appropriate amount of desiccant is placed in the storage container to monitor the environmental humidity in real time and adjust it.
Third, this compound may be toxic, corrosive or irritating. When storing and transporting, it is necessary to take comprehensive protective measures. Operators should wear protective clothing, protective gloves and goggles, etc., to prevent physical damage caused by contact. Handling process should be handled with care to avoid material leakage caused by damage to the container.
Fourth, this compound is a chemical, and relevant regulations and standards must be followed when transporting. Professional qualified transportation enterprises and transportation tools should be selected. Transportation documents should be detailed and accurate, indicating the name, nature, emergency treatment methods and other information of the compound. In the event of an accident such as a leak during transportation, the surrounding personnel should be evacuated quickly, and professionals should properly handle it according to its characteristics.
Fifth, the storage area should be kept away from fire sources, heat sources and oxidants. Because it may be flammable or react violently with oxidants, causing serious consequences such as fire or explosion. Storage sites should be equipped with complete fire protection facilities and emergency treatment equipment so that they can respond in time in case of emergencies.
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