Linshang Chemical
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1,2-Dichloro-4-Fluorobenzene
Linshang Chemical
|
HS Code |
458395 |
| Chemical Formula | C6H3Cl2F |
| Molar Mass | 166.99 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 172 - 174 °C |
| Melting Point | -17.5 °C |
| Density | 1.458 g/cm³ at 20 °C |
| Vapor Pressure | 1.33 hPa at 25.4 °C |
| Water Solubility | Insoluble |
| Logp | 3.41 |
| Flash Point | 62 °C |
| Refractive Index | 1.5250 - 1.5270 |
As an accredited 1,2-Dichloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1,2 - dichloro - 4 - fluorobenzene: Packed in 5 - liter containers for chemical storage. |
| Storage | 1,2 - Dichloro - 4 - fluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. The storage site should also be dry to prevent any moisture - induced degradation. |
| Shipping | 1,2 - Dichloro - 4 - fluorobenzene is shipped in sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical transport regulations, protecting it from external factors during transit. |
Competitive 1,2-Dichloro-4-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a trusted 1,2-Dichloro-4-Fluorobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1,2-Dichloro-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1,2-dichloro-4-fluorobenzene?
1,2-Dichloro-4-ethylbenzene is an organic compound with a wide range of uses. In the field of chemical synthesis, it is often used as a key intermediate. This substance can be converted into a variety of high-value-added products through a series of chemical reactions, such as specific medicines, pesticides and dyes.
Taking the field of medicine as an example, it can be used as a starting material to synthesize drugs with specific therapeutic effects after multi-step reactions. In the field of pesticide manufacturing, it can be used as a basis to prepare efficient and environmentally friendly pesticides, fungicides, etc., to help agricultural production of pest control. In the dye industry, the dyes synthesized by it are brightly colored and have good stability and light resistance, and are widely used in textile, printing and dyeing and other industries.
Furthermore, in the study of organic synthesis chemistry, 1,2-dichloro-4-ethylbenzene can provide chemists with novel reaction check points and synthesis paths due to its unique chemical structure, which is helpful for exploring new organic reaction mechanisms, expanding the methods and strategies of organic synthesis, and promoting the development of organic chemistry.
Taking the field of medicine as an example, it can be used as a starting material to synthesize drugs with specific therapeutic effects after multi-step reactions. In the field of pesticide manufacturing, it can be used as a basis to prepare efficient and environmentally friendly pesticides, fungicides, etc., to help agricultural production of pest control. In the dye industry, the dyes synthesized by it are brightly colored and have good stability and light resistance, and are widely used in textile, printing and dyeing and other industries.
Furthermore, in the study of organic synthesis chemistry, 1,2-dichloro-4-ethylbenzene can provide chemists with novel reaction check points and synthesis paths due to its unique chemical structure, which is helpful for exploring new organic reaction mechanisms, expanding the methods and strategies of organic synthesis, and promoting the development of organic chemistry.
What are the physical properties of 1,2-dichloro-4-fluorobenzene?
1% 2C2-dideuterium-4-pentenonitrile is an organic compound, and its physical properties are quite unique. The details are as follows:
1. ** Properties **: Under normal conditions, this substance may be a colorless to light yellow liquid, and the appearance is clear and transparent. Its appearance characteristics are of great significance for the identification and preliminary judgment of the state of the substance. In experimental and industrial application scenarios, its purity and the presence of impurities can be preliminarily determined by its appearance.
2. ** Boiling point **: The boiling point is one of the important physical properties of a substance. The boiling point of 1% 2C2-dideuterium-4-pentenonitrile is in a specific temperature range. The boiling point is closely related to the intermolecular force, which determines the energy required for the material to convert from liquid to gaseous state. Accurately knowing the boiling point is of great significance in chemical operations such as distillation and separation, so as to realize the effective separation of the substance from other substances with different boiling points.
3. ** Melting point **: The melting point is also a key physical property. 1% 2C2-dideuterium-4-pentenonitrile changes from solid to liquid at a specific temperature. The melting point is affected by the molecular structure and lattice energy. Understanding the melting point helps to control the physical state of the substance at different temperatures, which is of great significance for storage and transportation. For example, if the storage temperature is close to or higher than the melting point, the substance may change from solid to liquid, which affects the storage stability.
4. ** Density **: Its density refers to the mass of the substance per unit volume. This physical property reflects the compactness of the substance. Density data is extremely important when it comes to processes such as mixing and reaction. Through density, the mass of the substance in a specific volume can be calculated, providing a basis for precise batching and reaction control.
5. ** Solubility **: 1% 2C2-dideuterium-4-pentenonitrile has different solubility in different solvents. Generally speaking, it has better solubility in organic solvents such as ethanol and ether, but poor solubility in water. Solubility is related to molecular polarity, which determines its ability to interact with different solvents. This property is widely used in extraction, purification and other operations. It can be separated from the mixture by taking advantage of the difference in solubility in different solvents.
6. ** Refractive index **: The refractive index is a measure of the degree of refraction of light when passing through the substance, and is the characteristic constant of the substance. The refractive index is affected by the molecular structure and concentration of the substance. In the field of analytical chemistry, the purity and concentration of the substance are often identified by measuring the refractive index. For 1% 2C2-dideuterium-4-pentenonitrile, accurate refractive index data can be used to judge its quality and composition.
1. ** Properties **: Under normal conditions, this substance may be a colorless to light yellow liquid, and the appearance is clear and transparent. Its appearance characteristics are of great significance for the identification and preliminary judgment of the state of the substance. In experimental and industrial application scenarios, its purity and the presence of impurities can be preliminarily determined by its appearance.
2. ** Boiling point **: The boiling point is one of the important physical properties of a substance. The boiling point of 1% 2C2-dideuterium-4-pentenonitrile is in a specific temperature range. The boiling point is closely related to the intermolecular force, which determines the energy required for the material to convert from liquid to gaseous state. Accurately knowing the boiling point is of great significance in chemical operations such as distillation and separation, so as to realize the effective separation of the substance from other substances with different boiling points.
3. ** Melting point **: The melting point is also a key physical property. 1% 2C2-dideuterium-4-pentenonitrile changes from solid to liquid at a specific temperature. The melting point is affected by the molecular structure and lattice energy. Understanding the melting point helps to control the physical state of the substance at different temperatures, which is of great significance for storage and transportation. For example, if the storage temperature is close to or higher than the melting point, the substance may change from solid to liquid, which affects the storage stability.
4. ** Density **: Its density refers to the mass of the substance per unit volume. This physical property reflects the compactness of the substance. Density data is extremely important when it comes to processes such as mixing and reaction. Through density, the mass of the substance in a specific volume can be calculated, providing a basis for precise batching and reaction control.
5. ** Solubility **: 1% 2C2-dideuterium-4-pentenonitrile has different solubility in different solvents. Generally speaking, it has better solubility in organic solvents such as ethanol and ether, but poor solubility in water. Solubility is related to molecular polarity, which determines its ability to interact with different solvents. This property is widely used in extraction, purification and other operations. It can be separated from the mixture by taking advantage of the difference in solubility in different solvents.
6. ** Refractive index **: The refractive index is a measure of the degree of refraction of light when passing through the substance, and is the characteristic constant of the substance. The refractive index is affected by the molecular structure and concentration of the substance. In the field of analytical chemistry, the purity and concentration of the substance are often identified by measuring the refractive index. For 1% 2C2-dideuterium-4-pentenonitrile, accurate refractive index data can be used to judge its quality and composition.
What are the production methods of 1,2-dichloro-4-fluorobenzene?
1% 2C2-dibromo-4-vinylbenzene is an organic compound. The common preparation methods are as follows:
First, vinylbenzene is used as the starting material and prepared by bromination reaction. Vinylbenzene is placed in an appropriate reaction vessel, and bromine is slowly added dropwise under the condition of light or the addition of an initiator such as benzoyl peroxide. Light or the initiator can cause the bromine molecule to cleave into bromine free radicals, which can then undergo free radical addition reaction with vinylbenzene. This reaction needs to be carefully controlled to control the reaction temperature and the drop rate of bromine to prevent the formation of polybrominated products. The reaction is roughly as follows:
$C_6H_5CH = CH_2 + 2Br_2\ xrightarrow {light or initiator} C_6H_3Br_2CH = CH_2 + 2HBr $
Second, the benzene ring can be brominated first to obtain dibromobenzene, and then vinyl is introduced. First, benzene is used as a raw material, and the electrophilic substitution reaction with bromine is carried out under the catalysis of iron powder or iron tribromide to generate 1,2-dibromobenzene. Next, 1,2-dibromobenzene is reacted with vinyl Grignard reagents (such as $CH_2 = CHMgBr $), and vinyl is introduced on the benzene ring by the nucleophilic substitution of Grignard reagents for halogenated aromatics. This method requires attention to the preparation and use conditions of Grignard reagents, and must be operated in an anhydrous and anaerobic environment. The relevant reactions are as follows:
$C_6H_6 + 2Br_2\ xrightarrow {FeBr_3} C_6H_4Br_2 + 2HBr $
$C_6H_4Br_2 + CH_2 = CHMgBr\ xrightarrow {anhydrous ether} C_6H_3Br_2CH = CH_2 + MgBr_2 $
Third, palladium-catalyzed cross-coupling reaction. The reaction is carried out in a suitable solvent (such as a mixed solvent of dioxane and water) in the presence of a palladium catalyst (such as tetra (triphenylphosphine) palladium) and a base (such as potassium carbonate). Palladium catalysts can activate halogenated aromatics and boric acid or borate esters to cross-couple the two to form the target product 1% 2C2 -dibromo-4 -vinylbenzene. This method has relatively mild conditions and high selectivity. The reaction formula is as follows:
$C_6H_4Br_2 + CH_2 = CHB (OH) _2\ xrightarrow {Pd (PPh_3) _4, K_2CO_3} C_6H_3Br_2CH = CH_2 + B (OH) _3 + KBr $
First, vinylbenzene is used as the starting material and prepared by bromination reaction. Vinylbenzene is placed in an appropriate reaction vessel, and bromine is slowly added dropwise under the condition of light or the addition of an initiator such as benzoyl peroxide. Light or the initiator can cause the bromine molecule to cleave into bromine free radicals, which can then undergo free radical addition reaction with vinylbenzene. This reaction needs to be carefully controlled to control the reaction temperature and the drop rate of bromine to prevent the formation of polybrominated products. The reaction is roughly as follows:
$C_6H_5CH = CH_2 + 2Br_2\ xrightarrow {light or initiator} C_6H_3Br_2CH = CH_2 + 2HBr $
Second, the benzene ring can be brominated first to obtain dibromobenzene, and then vinyl is introduced. First, benzene is used as a raw material, and the electrophilic substitution reaction with bromine is carried out under the catalysis of iron powder or iron tribromide to generate 1,2-dibromobenzene. Next, 1,2-dibromobenzene is reacted with vinyl Grignard reagents (such as $CH_2 = CHMgBr $), and vinyl is introduced on the benzene ring by the nucleophilic substitution of Grignard reagents for halogenated aromatics. This method requires attention to the preparation and use conditions of Grignard reagents, and must be operated in an anhydrous and anaerobic environment. The relevant reactions are as follows:
$C_6H_6 + 2Br_2\ xrightarrow {FeBr_3} C_6H_4Br_2 + 2HBr $
$C_6H_4Br_2 + CH_2 = CHMgBr\ xrightarrow {anhydrous ether} C_6H_3Br_2CH = CH_2 + MgBr_2 $
Third, palladium-catalyzed cross-coupling reaction. The reaction is carried out in a suitable solvent (such as a mixed solvent of dioxane and water) in the presence of a palladium catalyst (such as tetra (triphenylphosphine) palladium) and a base (such as potassium carbonate). Palladium catalysts can activate halogenated aromatics and boric acid or borate esters to cross-couple the two to form the target product 1% 2C2 -dibromo-4 -vinylbenzene. This method has relatively mild conditions and high selectivity. The reaction formula is as follows:
$C_6H_4Br_2 + CH_2 = CHB (OH) _2\ xrightarrow {Pd (PPh_3) _4, K_2CO_3} C_6H_3Br_2CH = CH_2 + B (OH) _3 + KBr $
What are the precautions for storing and transporting 1,2-dichloro-4-fluorobenzene?
1% 2C2-dibromo-4-vinylbenzene is a chemical substance. When storing and transporting it, you need to pay more attention to the following things:
First, the storage place must be cool and dry. When this chemical is hot or wet, it may deteriorate, or even cause dangerous reactions. "Tiangong Kaiwu" says: "Dry and humid, things are hidden for a long time." If the storage environment is hot and its quality is variable, it is essential to find a cool and dry place.
Second, it is necessary to keep away from fire sources and oxidants. 1% 2C2-dibromo-4-vinyl benzene is flammable, and it is easy to react violently when it encounters oxidants. For example, "Tiangong Kaiwu" talks about the relationship between fire and various things. If there is a little carelessness, it will cause disasters. Therefore, the source of fire and the oxidant must not be similar to it.
Third, the packaging must be tight. If the chemical leaks, it will not only pollute the environment, but also endanger personal safety. Tight packaging to prevent leakage, just like the caution of packaging materials in "Tiangong Kaiwu" to ensure its safety.
Fourth, when transporting, specific regulations should be followed. According to its chemical characteristics, suitable transportation methods and tools should be selected, and must not be mixed with contraindicated items. This is just like the attention paid to the transportation of various materials in "Tiangong Kaiwu", each one is safe and sound.
Fifth, the operator must undergo professional training. Knowing the characteristics of this object, the danger location and the emergency response method, in case of emergencies, can calmly deal with and save the danger, just like the craftsmen in "Tiangong Kaiwu" who are familiar with the craftsmanship, can ensure everything goes smoothly.
First, the storage place must be cool and dry. When this chemical is hot or wet, it may deteriorate, or even cause dangerous reactions. "Tiangong Kaiwu" says: "Dry and humid, things are hidden for a long time." If the storage environment is hot and its quality is variable, it is essential to find a cool and dry place.
Second, it is necessary to keep away from fire sources and oxidants. 1% 2C2-dibromo-4-vinyl benzene is flammable, and it is easy to react violently when it encounters oxidants. For example, "Tiangong Kaiwu" talks about the relationship between fire and various things. If there is a little carelessness, it will cause disasters. Therefore, the source of fire and the oxidant must not be similar to it.
Third, the packaging must be tight. If the chemical leaks, it will not only pollute the environment, but also endanger personal safety. Tight packaging to prevent leakage, just like the caution of packaging materials in "Tiangong Kaiwu" to ensure its safety.
Fourth, when transporting, specific regulations should be followed. According to its chemical characteristics, suitable transportation methods and tools should be selected, and must not be mixed with contraindicated items. This is just like the attention paid to the transportation of various materials in "Tiangong Kaiwu", each one is safe and sound.
Fifth, the operator must undergo professional training. Knowing the characteristics of this object, the danger location and the emergency response method, in case of emergencies, can calmly deal with and save the danger, just like the craftsmen in "Tiangong Kaiwu" who are familiar with the craftsmanship, can ensure everything goes smoothly.
What are the effects of 1,2-dichloro-4-fluorobenzene on the environment and human health?
1,2-Dichloro-4-ethylbenzene is an organic compound. Its impact on the environment and human health is detailed as follows:
Environmental impact
1. ** Soil pollution **: If this compound is released into the soil, it is difficult to be rapidly decomposed by soil microorganisms because of its certain chemical stability. Over time, it will cause the accumulation of harmful substances in the soil, change the physical and chemical properties of the soil, affect the balance of soil ecosystems, hinder the absorption of nutrients and moisture by plant roots, and then affect plant growth and development.
2. ** Water pollution **: If it enters the water body, it will deteriorate the water quality. Because it is slightly soluble in water but fat-soluble, it is easy to accumulate in aquatic organisms. Transmission and amplification through the food chain can cause damage to the entire aquatic ecosystem, affecting the reproduction, survival and behavior of aquatic organisms, and even leading to a decrease in the number of species, destroying the aquatic ecological balance.
3. ** Air pollution **: Under certain conditions, such as high temperature or combustion process, 1,2-dichloro-4-ethylbenzene may evaporate into the atmosphere and become part of volatile organic compounds (VOCs). It will participate in photochemical reactions in the atmosphere, generate secondary pollutants such as ozone, aggravate air pollution, affect air quality, and cause environmental problems such as smog.
Effects on human health
1. ** Respiratory System **: Inhalation of air containing 1,2-dichloro-4-ethylbenzene can irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure may damage the respiratory defense function and increase the risk of respiratory infections and chronic diseases such as bronchitis and emphysema.
2. ** Nervous System **: The compound may be neurotoxic. After entering the human body, it can pass through the blood-brain barrier and affect the normal function of the nervous system. In the early stage, there may be symptoms such as headache, dizziness, fatigue, and drowsiness. In severe cases, it may damage nerve cells, cause memory loss, cognitive dysfunction, and especially affect fetuses and children in the development of the nervous system, or affect intellectual development.
3. ** Carcinogenic risk **: Although the current evidence on the direct carcinogenicity of 1,2-dichloro-4-ethylbenzene is not conclusive, it is classified as a potential carcinogen by organizations such as the International Agency for Research on Cancer (IARC) because of its structural similarity to some known carcinogens. Long-term exposure may increase the risk of cancer, especially liver cancer and lung cancer.
Environmental impact
1. ** Soil pollution **: If this compound is released into the soil, it is difficult to be rapidly decomposed by soil microorganisms because of its certain chemical stability. Over time, it will cause the accumulation of harmful substances in the soil, change the physical and chemical properties of the soil, affect the balance of soil ecosystems, hinder the absorption of nutrients and moisture by plant roots, and then affect plant growth and development.
2. ** Water pollution **: If it enters the water body, it will deteriorate the water quality. Because it is slightly soluble in water but fat-soluble, it is easy to accumulate in aquatic organisms. Transmission and amplification through the food chain can cause damage to the entire aquatic ecosystem, affecting the reproduction, survival and behavior of aquatic organisms, and even leading to a decrease in the number of species, destroying the aquatic ecological balance.
3. ** Air pollution **: Under certain conditions, such as high temperature or combustion process, 1,2-dichloro-4-ethylbenzene may evaporate into the atmosphere and become part of volatile organic compounds (VOCs). It will participate in photochemical reactions in the atmosphere, generate secondary pollutants such as ozone, aggravate air pollution, affect air quality, and cause environmental problems such as smog.
Effects on human health
1. ** Respiratory System **: Inhalation of air containing 1,2-dichloro-4-ethylbenzene can irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure may damage the respiratory defense function and increase the risk of respiratory infections and chronic diseases such as bronchitis and emphysema.
2. ** Nervous System **: The compound may be neurotoxic. After entering the human body, it can pass through the blood-brain barrier and affect the normal function of the nervous system. In the early stage, there may be symptoms such as headache, dizziness, fatigue, and drowsiness. In severe cases, it may damage nerve cells, cause memory loss, cognitive dysfunction, and especially affect fetuses and children in the development of the nervous system, or affect intellectual development.
3. ** Carcinogenic risk **: Although the current evidence on the direct carcinogenicity of 1,2-dichloro-4-ethylbenzene is not conclusive, it is classified as a potential carcinogen by organizations such as the International Agency for Research on Cancer (IARC) because of its structural similarity to some known carcinogens. Long-term exposure may increase the risk of cancer, especially liver cancer and lung cancer.
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