Linshang Chemical
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1,3,5-Trichloro-2-Isothiocyanatobenzene
Linshang Chemical
|
HS Code |
432675 |
| Chemical Formula | C7H2Cl3NS |
| Molecular Weight | 236.52 g/mol |
| Appearance | Solid (usually) |
| Odor | Pungent |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like dichloromethane |
| Melting Point | Typically in a certain range (data may vary) |
| Boiling Point | Relevant value (data may vary) |
| Density | Specific value (data may vary) |
| Toxicity | Toxic, harmful to health |
As an accredited 1,3,5-Trichloro-2-Isothiocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 1,3,5 - trichloro - 2 - isothiocyanatobenzene packaged in air - tight plastic bags. |
| Storage | 1,3,5 - trichloro - 2 - isothiocyanatobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, ignition sources, and incompatible substances such as strong acids, bases, and reducing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially cause decomposition or reaction. |
| Shipping | 1,3,5 - Trichloro - 2 - isothiocyanatobenzene is a chemical. Shipping requires proper containment in sealed, corrosion - resistant containers. It must follow hazardous material regulations, with clear labeling for safe and compliant transportation. |
Competitive 1,3,5-Trichloro-2-Isothiocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1,3,5-Trichloro-2-Isothiocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1, 3, 5 - trichloro - 2 - isothiocyanatobenzene?
1% 2C3% 2C5 - trichloro - 2 - isothiocyanatobenzene, Chinese name 1,3,5 - phenyl trichloro - 2 - isothiocyanate, this is an organic compound. Its chemical properties are unique and play a key role in many chemical reactions.
The chemical properties of this compound are first and foremost the activity of its isothiocyanate group. This group is easily nucleophilic addition reaction with compounds containing active hydrogen, such as alcohols and amines. When it encounters alcohols, it can form corresponding thiocarbamates; when it encounters amines, it can form thiourea derivatives. This reaction property is often used in the field of organic synthesis to construct the structure of complex compounds containing nitrogen and sulfur.
1,3,5-Trichloro-2-isothiocyanate on the benzene ring, due to the presence of three chlorine atoms, the electron cloud density of the benzene ring decreases, which weakens the electrophilic substitution activity of the benzene ring. However, chlorine atoms can undergo substitution reactions under specific conditions. For example, in the presence of strong bases and suitable catalysts, chlorine atoms can be replaced by other nucleophiles, thereby realizing the transformation of substituents on the benzene ring, providing the possibility for the synthesis of various benzene derivatives.
In terms of physical properties, the compound is usually a solid with a certain melting point and boiling point. Due to the presence of polar groups isothiocyanate and more electronegative chlorine atoms, its solubility in polar solvents is better than that in non-polar solvents. This solubility characteristic has important practical significance in separation, purification and reaction operations.
1,3,5-Trichloro-2-isothiocyanate phenyl ester has wide application prospects in the fields of medicine, pesticides and materials due to its unique chemical properties. In pharmaceutical research and development, it participates in the synthesis of sulfur-containing and nitrogen-containing compounds, or has specific biological activities; in the creation of pesticides, it can be used as a key intermediate to build high-efficiency and low-toxicity new pesticides; in the field of materials, with the help of its reactivity, it may be able to prepare functional materials with unique properties.
The chemical properties of this compound are first and foremost the activity of its isothiocyanate group. This group is easily nucleophilic addition reaction with compounds containing active hydrogen, such as alcohols and amines. When it encounters alcohols, it can form corresponding thiocarbamates; when it encounters amines, it can form thiourea derivatives. This reaction property is often used in the field of organic synthesis to construct the structure of complex compounds containing nitrogen and sulfur.
1,3,5-Trichloro-2-isothiocyanate on the benzene ring, due to the presence of three chlorine atoms, the electron cloud density of the benzene ring decreases, which weakens the electrophilic substitution activity of the benzene ring. However, chlorine atoms can undergo substitution reactions under specific conditions. For example, in the presence of strong bases and suitable catalysts, chlorine atoms can be replaced by other nucleophiles, thereby realizing the transformation of substituents on the benzene ring, providing the possibility for the synthesis of various benzene derivatives.
In terms of physical properties, the compound is usually a solid with a certain melting point and boiling point. Due to the presence of polar groups isothiocyanate and more electronegative chlorine atoms, its solubility in polar solvents is better than that in non-polar solvents. This solubility characteristic has important practical significance in separation, purification and reaction operations.
1,3,5-Trichloro-2-isothiocyanate phenyl ester has wide application prospects in the fields of medicine, pesticides and materials due to its unique chemical properties. In pharmaceutical research and development, it participates in the synthesis of sulfur-containing and nitrogen-containing compounds, or has specific biological activities; in the creation of pesticides, it can be used as a key intermediate to build high-efficiency and low-toxicity new pesticides; in the field of materials, with the help of its reactivity, it may be able to prepare functional materials with unique properties.
What are the main uses of 1, 3, 5 - trichloro - 2 - isothiocyanatobenzene?
1% 2C3% 2C5 - trichloro - 2 - isothiocyanatobenzene is 1,3,5 - trichloro - 2 - isothiocyanate phenyl ester, which is widely used.
One is often used as a key intermediate in the field of organic synthesis. Because its structure contains isothiocyanate groups and chlorine atoms, it is chemically active and can react with many nucleophiles, such as alcohols, amines, etc. For example, when it encounters alcohols, it can form carbamate compounds, which are widely used in the fields of medicine and pesticides. When reacted with amines, thiourea derivatives can be formed. These derivatives are extremely important structural units in medicinal chemistry, and some of them have biological activities such as antibacterial and antiviral.
Second, in the field of materials science, it also has its own shadow. With its reactive activity, it can be used to prepare functional polymer materials. For example, by reacting with polymers containing hydroxyl or amino groups, specific functional groups can be introduced into the polymer backbone, thereby imparting unique properties such as antibacterial and corrosion resistance to the material.
Third, in the field of agriculture, 1,3,5-trichloro-2-isothiocyanate phenyl ester also plays a role. Because of its certain biological activity, it can be used as a soil disinfectant. It can effectively inhibit harmful microorganisms in the soil, such as fungi, bacteria and nematodes, thereby improving the soil environment, reducing the probability of soil-borne diseases of crops, and helping to improve crop yield and quality.
Fourth, in the field of pharmaceutical research, as a lead compound, scientists modify and modify its structure, and then develop new drugs with higher activity and selectivity. By studying the interaction mechanism between it and biological macromolecules, it provides a key theoretical basis for drug design.
One is often used as a key intermediate in the field of organic synthesis. Because its structure contains isothiocyanate groups and chlorine atoms, it is chemically active and can react with many nucleophiles, such as alcohols, amines, etc. For example, when it encounters alcohols, it can form carbamate compounds, which are widely used in the fields of medicine and pesticides. When reacted with amines, thiourea derivatives can be formed. These derivatives are extremely important structural units in medicinal chemistry, and some of them have biological activities such as antibacterial and antiviral.
Second, in the field of materials science, it also has its own shadow. With its reactive activity, it can be used to prepare functional polymer materials. For example, by reacting with polymers containing hydroxyl or amino groups, specific functional groups can be introduced into the polymer backbone, thereby imparting unique properties such as antibacterial and corrosion resistance to the material.
Third, in the field of agriculture, 1,3,5-trichloro-2-isothiocyanate phenyl ester also plays a role. Because of its certain biological activity, it can be used as a soil disinfectant. It can effectively inhibit harmful microorganisms in the soil, such as fungi, bacteria and nematodes, thereby improving the soil environment, reducing the probability of soil-borne diseases of crops, and helping to improve crop yield and quality.
Fourth, in the field of pharmaceutical research, as a lead compound, scientists modify and modify its structure, and then develop new drugs with higher activity and selectivity. By studying the interaction mechanism between it and biological macromolecules, it provides a key theoretical basis for drug design.
What is the preparation method of 1, 3, 5 - trichloro - 2 - isothiocyanatobenzene?
1% 2C3% 2C5 - trichloro - 2 - isothiocyanatobenzene is phenyl 1,3,5 - trichloro - 2 - isothiocyanate, which is prepared as follows:
First take an appropriate amount of 3,5 - dichloroaniline, place it in a reactor, and dissolve it with an organic solvent such as dichloromethane. In this solution, slowly add sulfur phosgene dropwise, while maintaining a low temperature environment, such as 0 - 5 ° C, and continue to stir. The molar ratio of sulfur phosgene to 3,5 - dichloroaniline should be controlled between 1.0 - 1.2:1. After the dropwise addition is completed, slowly raise the temperature of the reaction system to room temperature, and continue to stir for 2 - 3 hours.
After the reaction is completed, the reaction mixture is washed with an appropriate amount of dilute alkali solution, such as sodium bicarbonate solution, to remove unreacted sulfur phosgene and generated acidic impurities. After washing, the organic phase is separated and dried with anhydrous sodium sulfate. After drying is completed, the desiccant is filtered to remove the desiccant, and the filtrate is distilled under reduced pressure to remove the organic solvent.
Collect the fractions within a specific temperature range to obtain a crude product of 1,3,5-trichloro-2-isothiocyanate. Crude products can be further purified by column chromatography, using silica gel as the stationary phase and the mixture of petroleum ether and ethyl acetate as the mobile phase, and adjusting the ratio of the two according to the actual situation to obtain high-purity 1,3,5-trichloro-2-isothiocyanate phenyl ester products. Throughout the preparation process, attention should be paid to the precise control of reaction conditions, the appropriate proportion of each material, and the operation specifications to ensure high yield and purity.
First take an appropriate amount of 3,5 - dichloroaniline, place it in a reactor, and dissolve it with an organic solvent such as dichloromethane. In this solution, slowly add sulfur phosgene dropwise, while maintaining a low temperature environment, such as 0 - 5 ° C, and continue to stir. The molar ratio of sulfur phosgene to 3,5 - dichloroaniline should be controlled between 1.0 - 1.2:1. After the dropwise addition is completed, slowly raise the temperature of the reaction system to room temperature, and continue to stir for 2 - 3 hours.
After the reaction is completed, the reaction mixture is washed with an appropriate amount of dilute alkali solution, such as sodium bicarbonate solution, to remove unreacted sulfur phosgene and generated acidic impurities. After washing, the organic phase is separated and dried with anhydrous sodium sulfate. After drying is completed, the desiccant is filtered to remove the desiccant, and the filtrate is distilled under reduced pressure to remove the organic solvent.
Collect the fractions within a specific temperature range to obtain a crude product of 1,3,5-trichloro-2-isothiocyanate. Crude products can be further purified by column chromatography, using silica gel as the stationary phase and the mixture of petroleum ether and ethyl acetate as the mobile phase, and adjusting the ratio of the two according to the actual situation to obtain high-purity 1,3,5-trichloro-2-isothiocyanate phenyl ester products. Throughout the preparation process, attention should be paid to the precise control of reaction conditions, the appropriate proportion of each material, and the operation specifications to ensure high yield and purity.
1, 3, 5 - trichloro - 2 - isothiocyanatobenzene what are the precautions during use?
1% 2C3% 2C5 - trichloro - 2 - isothiocyanatobenzene, it is a special chemical substance. When using, many precautions should not be ignored.
Bear the brunt, and safety protection must be comprehensive. This substance may be toxic and irritating, and protective equipment is essential when it comes into contact. Apply protective clothing to cover the body and skin; wear protective gloves to keep the skin from touching it; wear protective glasses and masks, protect the eyes and respiratory organs to prevent the volatile gas or splash fluid from hurting people.
Furthermore, the operating environment should also be paid attention to. Work in a well-ventilated place so that the volatile gas can dissipate quickly and not gather in the space. If used in a closed place, gas accumulation, fear of poisoning and other risks. And the operation site should be away from fire and heat sources, because it may be flammable, in case of open flames, hot topics, easy to cause fire or even explosion.
During use, accurate operation is essential. Strictly follow the established procedures to control the dosage and reaction conditions. When weighing, strive for accuracy; reaction temperature, time and other factors need to be strictly controlled. If there is a slight difference, or the reaction is abnormal, it will not only affect the product, but also pose a safety hazard.
After use, proper disposal should not be underestimated. The remaining substances cannot be discarded at will, and they should be disposed of in the correct way in accordance with relevant regulations. The utensils used should also be thoroughly cleaned to avoid subsequent contamination or reactions caused by residual substances.
All of these are what should be paid attention to when using 1% 2C3% 2C5 - trichloro - 2 - isothiocyanatobenzene, and must not be negligent to ensure the safety and smoothness of the operation.
Bear the brunt, and safety protection must be comprehensive. This substance may be toxic and irritating, and protective equipment is essential when it comes into contact. Apply protective clothing to cover the body and skin; wear protective gloves to keep the skin from touching it; wear protective glasses and masks, protect the eyes and respiratory organs to prevent the volatile gas or splash fluid from hurting people.
Furthermore, the operating environment should also be paid attention to. Work in a well-ventilated place so that the volatile gas can dissipate quickly and not gather in the space. If used in a closed place, gas accumulation, fear of poisoning and other risks. And the operation site should be away from fire and heat sources, because it may be flammable, in case of open flames, hot topics, easy to cause fire or even explosion.
During use, accurate operation is essential. Strictly follow the established procedures to control the dosage and reaction conditions. When weighing, strive for accuracy; reaction temperature, time and other factors need to be strictly controlled. If there is a slight difference, or the reaction is abnormal, it will not only affect the product, but also pose a safety hazard.
After use, proper disposal should not be underestimated. The remaining substances cannot be discarded at will, and they should be disposed of in the correct way in accordance with relevant regulations. The utensils used should also be thoroughly cleaned to avoid subsequent contamination or reactions caused by residual substances.
All of these are what should be paid attention to when using 1% 2C3% 2C5 - trichloro - 2 - isothiocyanatobenzene, and must not be negligent to ensure the safety and smoothness of the operation.
What is the market outlook for 1, 3, 5 - trichloro - 2 - isothiocyanatobenzene?
1% 2C3% 2C5 - trichloro - 2 - isothiocyanatobenzene, that is, 1,3,5 - trichloro - 2 - isothiocyanate phenyl ester, due to its special chemical structure, has emerged in the field of chemical industry and scientific research. Its market prospect is worth exploring.
In the field of chemical synthesis, 1,3,5 - trichloro - 2 - isothiocyanate phenyl ester is a key intermediate. A series of high value-added compounds can be prepared through various organic reactions. With the increasing demand for novel materials and fine chemicals in the chemical industry, the demand for such intermediates is also rising. Many high-end coatings, pesticides, and pharmaceutical synthesis processes rely on their participation to achieve the desired chemical properties and biological activities.
At the forefront of scientific research, phenyl 1,3,5-trichloro-2-isothiocyanate has also attracted attention. Scientists use its unique reactivity to explore novel organic synthesis paths and expand the boundaries of chemical synthesis. In the field of materials science, it helps to develop new materials with special properties, such as materials with high selective adsorption or separation functions for specific substances, contributing to material innovation.
Looking at its market, there are also challenges. The synthesis process of this compound may be more complex, and cost control is the key. Furthermore, due to chlorine and isothiocyanate and other groups, its production and use must strictly follow environmental protection and safety standards, and the compliance cost should not be underestimated.
In summary, although 1,3,5-trichloro-2-isothiocyanate phenyl ester faces cost and compliance challenges, it is expected to create a new situation in related fields due to its important position in chemical synthesis and scientific research. It will continue to shine in the fine chemical industry and cutting-edge scientific research stage.
In the field of chemical synthesis, 1,3,5 - trichloro - 2 - isothiocyanate phenyl ester is a key intermediate. A series of high value-added compounds can be prepared through various organic reactions. With the increasing demand for novel materials and fine chemicals in the chemical industry, the demand for such intermediates is also rising. Many high-end coatings, pesticides, and pharmaceutical synthesis processes rely on their participation to achieve the desired chemical properties and biological activities.
At the forefront of scientific research, phenyl 1,3,5-trichloro-2-isothiocyanate has also attracted attention. Scientists use its unique reactivity to explore novel organic synthesis paths and expand the boundaries of chemical synthesis. In the field of materials science, it helps to develop new materials with special properties, such as materials with high selective adsorption or separation functions for specific substances, contributing to material innovation.
Looking at its market, there are also challenges. The synthesis process of this compound may be more complex, and cost control is the key. Furthermore, due to chlorine and isothiocyanate and other groups, its production and use must strictly follow environmental protection and safety standards, and the compliance cost should not be underestimated.
In summary, although 1,3,5-trichloro-2-isothiocyanate phenyl ester faces cost and compliance challenges, it is expected to create a new situation in related fields due to its important position in chemical synthesis and scientific research. It will continue to shine in the fine chemical industry and cutting-edge scientific research stage.
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