Linshang Chemical
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1,3-Dibromo-5-Chloro-2-Fluorobenzene
Linshang Chemical
|
HS Code |
221552 |
| Chemical Formula | C6H2Br2ClF |
| Appearance | Solid (Typical for such aromatic halides) |
| Melting Point | Data might vary, needs experimental determination |
| Boiling Point | Data might vary, needs experimental determination |
| Density | Data might vary, needs experimental determination |
| Solubility In Water | Low (Aromatic halides are generally hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Data might vary, needs experimental determination |
| Vapor Pressure | Low (due to its relatively high molecular weight and non - volatile nature) |
As an accredited 1,3-Dibromo-5-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1,3 - dibromo - 5 - chloro - 2 - fluorobenzene packaged in a sealed glass bottle. |
| Storage | 1,3 - Dibromo - 5 - chloro - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent potential fire or decomposition. It should be stored in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics, to avoid leakage and exposure to air and moisture, which could affect its chemical properties. |
| Shipping | 1,3 - dibromo - 5 - chloro - 2 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It's handled as a hazardous chemical, following strict regulations to ensure safe transportation from origin to destination. |
Competitive 1,3-Dibromo-5-Chloro-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1,3-Dibromo-5-Chloro-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1,3-dibromo-5-chloro-2-fluorobenzene?
1,3-Dibromo-5-chloro-2-fluorobenzene is an important raw material in organic synthesis. This compound plays a key role in the field of drug research and development. Due to its unique chemical structure, it can be used as a key intermediate to create a variety of specific drugs. For example, in the synthesis of some antibacterial drugs, it can participate in the construction of core pharmacoactive groups. With its halogen atom properties, it precisely reacts with other molecules, giving the drug excellent antibacterial activity and pharmacokinetic properties.
In the field of materials science, 1,3-dibromo-5-chloro-2-fluorobenzene also has important uses. It can be used to prepare special functional polymer materials. Through its polymerization with monomers containing specific functional groups, unique structures can be introduced into the polymer backbone, imparting properties such as high stability and special optical or electrical properties to the material. For example, in the preparation of organic optoelectronic materials, with the participation of this compound, the energy level structure of the material can be adjusted, the photoelectric conversion efficiency of the material can be improved, and it is used in the fields of organic Light Emitting Diode, solar cells, etc.
Furthermore, in the field of fine chemistry, this compound is often used as a starting material for the synthesis of high value-added fine chemicals. Such as special fragrances, pesticide synergists, etc. Due to the difference in the activity of halogen atoms in the structure, it can selectively undergo reactions such as substitution and coupling, and realize the synthesis of diverse fine chemicals to meet the needs of different industries. In conclusion, 1,3-dibromo-5-chloro-2-fluorobenzene, with its unique chemical structure, is indispensable in many fields such as drug development, materials science, and fine chemistry.
In the field of materials science, 1,3-dibromo-5-chloro-2-fluorobenzene also has important uses. It can be used to prepare special functional polymer materials. Through its polymerization with monomers containing specific functional groups, unique structures can be introduced into the polymer backbone, imparting properties such as high stability and special optical or electrical properties to the material. For example, in the preparation of organic optoelectronic materials, with the participation of this compound, the energy level structure of the material can be adjusted, the photoelectric conversion efficiency of the material can be improved, and it is used in the fields of organic Light Emitting Diode, solar cells, etc.
Furthermore, in the field of fine chemistry, this compound is often used as a starting material for the synthesis of high value-added fine chemicals. Such as special fragrances, pesticide synergists, etc. Due to the difference in the activity of halogen atoms in the structure, it can selectively undergo reactions such as substitution and coupling, and realize the synthesis of diverse fine chemicals to meet the needs of different industries. In conclusion, 1,3-dibromo-5-chloro-2-fluorobenzene, with its unique chemical structure, is indispensable in many fields such as drug development, materials science, and fine chemistry.
What are the physical properties of 1,3-dibromo-5-chloro-2-fluorobenzene?
1% 2C3-dibromo-5-fluoro-2-chlorotoluene, which is a genus of organohalogenated aromatics. Its physical properties are quite characteristic, and the following are detailed by Jun:
- ** Appearance and Properties **: Under normal conditions, it is mostly colorless to light yellow liquid with clear texture. However, it is not absolute, or the appearance is slightly different due to factors such as purity and impurities.
- ** Melting Point and Boiling Point **: The melting point is relatively low, about - [X] ° C. This characteristic makes it difficult to solidify at room temperature and can maintain a liquid state. The boiling point is higher, roughly [X] ° C. Due to the presence of halogen atoms between molecules, the intermolecular force is increased, and more energy is required to vaporize it.
- ** Density **: The density is greater than that of water, about [X] g/cm ³. If in water, this substance will sink to the bottom, because the halogen atoms in the molecule are heavier, resulting in an increase in the overall density.
- ** Solubility **: Poor solubility in water, because water is a polar solvent, and the molecular polarity of this substance is weak. According to the principle of "similar compatibility", the two are insoluble. However, in organic solvents, such as ether, chloroform, dichloromethane, etc., the solubility is quite good. Because organic solvents are mostly non-polar or weakly polar, they are similar to the molecular polarity of the substance.
- ** Odor **: Usually has a special smell, but the exact smell is difficult to describe accurately, and your mileage may vary. Its smell may be irritating, if inhaled in excess, or irritate the human respiratory tract, eyes and other parts.
- ** Appearance and Properties **: Under normal conditions, it is mostly colorless to light yellow liquid with clear texture. However, it is not absolute, or the appearance is slightly different due to factors such as purity and impurities.
- ** Melting Point and Boiling Point **: The melting point is relatively low, about - [X] ° C. This characteristic makes it difficult to solidify at room temperature and can maintain a liquid state. The boiling point is higher, roughly [X] ° C. Due to the presence of halogen atoms between molecules, the intermolecular force is increased, and more energy is required to vaporize it.
- ** Density **: The density is greater than that of water, about [X] g/cm ³. If in water, this substance will sink to the bottom, because the halogen atoms in the molecule are heavier, resulting in an increase in the overall density.
- ** Solubility **: Poor solubility in water, because water is a polar solvent, and the molecular polarity of this substance is weak. According to the principle of "similar compatibility", the two are insoluble. However, in organic solvents, such as ether, chloroform, dichloromethane, etc., the solubility is quite good. Because organic solvents are mostly non-polar or weakly polar, they are similar to the molecular polarity of the substance.
- ** Odor **: Usually has a special smell, but the exact smell is difficult to describe accurately, and your mileage may vary. Its smell may be irritating, if inhaled in excess, or irritate the human respiratory tract, eyes and other parts.
What are the chemical properties of 1,3-dibromo-5-chloro-2-fluorobenzene?
1% 2C3-dibromo-5-fluoro-2-chlorotoluene is an organic halogen with rich chemical properties. The presence of bromine, fluorine, chlorine and other halogen atoms in this compound endows it with unique reactivity.
From the perspective of nucleophilic substitution reaction, halogen atoms can be used as leaving groups and replaced by various nucleophilic reagents. For example, when encountering hydroxyl negative ions (OH~), halogen atoms may be replaced by hydroxyl groups to generate corresponding alcohol derivatives; if the nucleophilic reagent is an amine, the lone pair electrons on the nitrogen atom will attack the carbon atom connected to the halogen atom and undergo nucleophilic substitution to form a new nitrogen-containing compound. This reaction is quite commonly used in the preparation of nitrogen-containing heterocyclic or amine compounds in organic synthesis.
Because it contains multiple halogen atoms, 1% 2C3-dibromo-5-fluoro-2-chlorotoluene can also exhibit a unique role in metal-catalyzed coupling reactions. For example, in palladium-catalyzed cross-coupling reactions, it can react with metal-organic reagents containing boron and tin to form carbon-carbon bonds, thereby expanding the molecular skeleton and synthesizing organic compounds with more complex structures. This process is of great significance in the fields of medicinal chemistry and materials science, and can help create new materials or drug molecules with specific functions.
In addition, the electronegativity differences of different halogen atoms in 1% 2C3-dibromo-5-fluoro-2-chlorotoluene lead to uneven distribution of molecular electron clouds, which affects their physical properties and chemical activities. The high electronegativity of fluorine atoms will reduce the electron cloud density of ortho-carbon atoms, making this location more susceptible to attack by electrophilic reagents; while bromine and chlorine atoms are slightly less electronegative, they still have an impact on the distribution of molecular electron clouds, and the three work together to make this compound exhibit a unique law of reactivity. At the same time, due to the presence of halogen atoms, the relative density of the compound is greater than that of water, and it has good solubility in organic solvents, which needs to be taken into account in the separation and purification steps of organic synthesis.
From the perspective of nucleophilic substitution reaction, halogen atoms can be used as leaving groups and replaced by various nucleophilic reagents. For example, when encountering hydroxyl negative ions (OH~), halogen atoms may be replaced by hydroxyl groups to generate corresponding alcohol derivatives; if the nucleophilic reagent is an amine, the lone pair electrons on the nitrogen atom will attack the carbon atom connected to the halogen atom and undergo nucleophilic substitution to form a new nitrogen-containing compound. This reaction is quite commonly used in the preparation of nitrogen-containing heterocyclic or amine compounds in organic synthesis.
Because it contains multiple halogen atoms, 1% 2C3-dibromo-5-fluoro-2-chlorotoluene can also exhibit a unique role in metal-catalyzed coupling reactions. For example, in palladium-catalyzed cross-coupling reactions, it can react with metal-organic reagents containing boron and tin to form carbon-carbon bonds, thereby expanding the molecular skeleton and synthesizing organic compounds with more complex structures. This process is of great significance in the fields of medicinal chemistry and materials science, and can help create new materials or drug molecules with specific functions.
In addition, the electronegativity differences of different halogen atoms in 1% 2C3-dibromo-5-fluoro-2-chlorotoluene lead to uneven distribution of molecular electron clouds, which affects their physical properties and chemical activities. The high electronegativity of fluorine atoms will reduce the electron cloud density of ortho-carbon atoms, making this location more susceptible to attack by electrophilic reagents; while bromine and chlorine atoms are slightly less electronegative, they still have an impact on the distribution of molecular electron clouds, and the three work together to make this compound exhibit a unique law of reactivity. At the same time, due to the presence of halogen atoms, the relative density of the compound is greater than that of water, and it has good solubility in organic solvents, which needs to be taken into account in the separation and purification steps of organic synthesis.
What are the methods for preparing 1,3-dibromo-5-chloro-2-fluorobenzene?
1% 2C3-dibromo-5-fluoro-2-chlorobenzene is an important intermediate in organic synthesis. There are many preparation methods. The following are the common ones:
1. ** Halogenation method **:
- Using suitable benzene derivatives as starting materials, bromine, fluorine and chlorine atoms are introduced in sequence through halogenation reaction. For example, first using benzene as the starting material, bromination reaction with bromine under specific conditions can be carried out. Liquid bromine and Lewis acid (such as FeBr) can be used as catalysts to generate bromobenzene. Then, through the guidance of specific positioning groups, a second bromine atom is re-brominated and introduced at a suitable position. Subsequently, suitable fluorination reagents (such as Selectfluor, etc.) are used to achieve fluorine atom substitution under appropriate conditions, and finally chlorine atoms are introduced through chlorination reaction. This process requires fine control of the reaction conditions and the reaction selectivity of each step. Due to different halogenation reaction conditions, the substitution position and degree vary.
- The reaction conditions are quite critical, and the temperature, reaction time, and proportion of reactants need to be precisely regulated. If the bromination reaction is too high, the temperature may cause the formation of polybrominated products, affecting the purity and yield of the target product.
2. ** Diazotization Reaction Method **:
- If the starting material contains amino groups, halogen atoms can be introduced through diazotization reaction first, and then a displacement reaction with halides. For example, the raw material is nitrified and reduced to obtain the corresponding aniline compounds, and the aniline compounds are diazotized with sodium nitrite under acidic conditions to form diazonium salts. Diazonium salts are active in nature and can react with halides such as copper bromide and cuprous chloride to introduce bromine and chlorine atoms, respectively, while fluorine atoms can be introduced by reacting with fluoroboronic acid after similar diazotization, and then decomposed by heating to obtain fluorine-containing products. After appropriate reaction combinations reach the target product structure.
- This method requires attention to the strict conditions of diazotization reaction. Improper control of the amount of sodium nitrite and reaction temperature can easily lead to side reactions or even dangerous.
3. ** Metal catalytic coupling reaction method **:
- Catalyze the coupling reaction between halogenated aromatics and halogen-containing reagents with the help of metal catalysts (such as palladium, copper, etc.). For example, using bromine or chlorine-containing benzene derivatives as substrates, fluorine atoms are introduced by coupling reaction with fluorine-containing reagents in the presence of palladium catalysts (such as Pd (PPh)) and suitable ligands. At the same time, the substitution structures of bromine, fluorine and chlorine in the target molecule can be constructed sequentially through multi-step coupling reactions by selecting suitable halogenated aromatics and halogenated reagents. The
-metal catalytic coupling reaction has high requirements on the reaction system, and the catalyst activity, ligand selection and reaction solvent all have a significant impact on the success or failure of the reaction and the yield.
The above methods have their own advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider factors such as raw material availability, cost, target product purity and yield requirements, and carefully select suitable preparation methods.
1. ** Halogenation method **:
- Using suitable benzene derivatives as starting materials, bromine, fluorine and chlorine atoms are introduced in sequence through halogenation reaction. For example, first using benzene as the starting material, bromination reaction with bromine under specific conditions can be carried out. Liquid bromine and Lewis acid (such as FeBr) can be used as catalysts to generate bromobenzene. Then, through the guidance of specific positioning groups, a second bromine atom is re-brominated and introduced at a suitable position. Subsequently, suitable fluorination reagents (such as Selectfluor, etc.) are used to achieve fluorine atom substitution under appropriate conditions, and finally chlorine atoms are introduced through chlorination reaction. This process requires fine control of the reaction conditions and the reaction selectivity of each step. Due to different halogenation reaction conditions, the substitution position and degree vary.
- The reaction conditions are quite critical, and the temperature, reaction time, and proportion of reactants need to be precisely regulated. If the bromination reaction is too high, the temperature may cause the formation of polybrominated products, affecting the purity and yield of the target product.
2. ** Diazotization Reaction Method **:
- If the starting material contains amino groups, halogen atoms can be introduced through diazotization reaction first, and then a displacement reaction with halides. For example, the raw material is nitrified and reduced to obtain the corresponding aniline compounds, and the aniline compounds are diazotized with sodium nitrite under acidic conditions to form diazonium salts. Diazonium salts are active in nature and can react with halides such as copper bromide and cuprous chloride to introduce bromine and chlorine atoms, respectively, while fluorine atoms can be introduced by reacting with fluoroboronic acid after similar diazotization, and then decomposed by heating to obtain fluorine-containing products. After appropriate reaction combinations reach the target product structure.
- This method requires attention to the strict conditions of diazotization reaction. Improper control of the amount of sodium nitrite and reaction temperature can easily lead to side reactions or even dangerous.
3. ** Metal catalytic coupling reaction method **:
- Catalyze the coupling reaction between halogenated aromatics and halogen-containing reagents with the help of metal catalysts (such as palladium, copper, etc.). For example, using bromine or chlorine-containing benzene derivatives as substrates, fluorine atoms are introduced by coupling reaction with fluorine-containing reagents in the presence of palladium catalysts (such as Pd (PPh)) and suitable ligands. At the same time, the substitution structures of bromine, fluorine and chlorine in the target molecule can be constructed sequentially through multi-step coupling reactions by selecting suitable halogenated aromatics and halogenated reagents. The
-metal catalytic coupling reaction has high requirements on the reaction system, and the catalyst activity, ligand selection and reaction solvent all have a significant impact on the success or failure of the reaction and the yield.
The above methods have their own advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider factors such as raw material availability, cost, target product purity and yield requirements, and carefully select suitable preparation methods.
What are the precautions for storing and transporting 1,3-dibromo-5-chloro-2-fluorobenzene?
1% 2C3-dibromo-5-fluoro-2-chlorotoluene is very rare, and many matters need to be treated with caution during storage and transportation.
It is active and sensitive to heat. When storing, keep it in a cool and dry place, away from heat sources and open flames. If heated, it may cause its chemical properties to change or cause dangerous reactions. The temperature of the warehouse should be controlled within a specific range to prevent it from decomposing due to excessive temperature.
Because it is corrosive and toxic, it can damage the skin, eyes and respiratory tract in contact with the human body. When transporting, be sure to pack it tightly to prevent leakage. The loading and unloading process must be handled with care, and the operator should wear protective equipment, such as protective clothing, gloves and goggles, to avoid direct contact.
During transportation, it should be avoided to mix with oxidizing agents and alkali substances. When these two meet, it is easy to trigger violent chemical reactions, resulting in the risk of fire or explosion. Route planning also needs to be careful to avoid densely populated areas and traffic points.
In addition, transportation vehicles should be equipped with emergency treatment equipment, such as fire extinguishers, adsorption materials, etc. In the event of a leak, it can be disposed of immediately to reduce the harm. Storage places should also have corresponding leakage emergency equipment and suitable containment materials for emergencies. In this way, the safety of 1% 2C3-dibromo-5-fluoro-2-chlorotoluene during storage and transportation is guaranteed.
It is active and sensitive to heat. When storing, keep it in a cool and dry place, away from heat sources and open flames. If heated, it may cause its chemical properties to change or cause dangerous reactions. The temperature of the warehouse should be controlled within a specific range to prevent it from decomposing due to excessive temperature.
Because it is corrosive and toxic, it can damage the skin, eyes and respiratory tract in contact with the human body. When transporting, be sure to pack it tightly to prevent leakage. The loading and unloading process must be handled with care, and the operator should wear protective equipment, such as protective clothing, gloves and goggles, to avoid direct contact.
During transportation, it should be avoided to mix with oxidizing agents and alkali substances. When these two meet, it is easy to trigger violent chemical reactions, resulting in the risk of fire or explosion. Route planning also needs to be careful to avoid densely populated areas and traffic points.
In addition, transportation vehicles should be equipped with emergency treatment equipment, such as fire extinguishers, adsorption materials, etc. In the event of a leak, it can be disposed of immediately to reduce the harm. Storage places should also have corresponding leakage emergency equipment and suitable containment materials for emergencies. In this way, the safety of 1% 2C3-dibromo-5-fluoro-2-chlorotoluene during storage and transportation is guaranteed.
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