Linshang Chemical
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1,3-Dinitro-2-Chloro-5-Trifluoromethylbenzene
Linshang Chemical
|
HS Code |
581485 |
| Chemical Formula | C7H2ClF3N2O4 |
| Molecular Weight | 272.55 |
| Appearance | Solid (Typically) |
| Physical State At Room Temperature | Solid |
| Boiling Point | Data may vary, often high due to nitro groups |
| Melting Point | Data may vary |
| Solubility In Water | Low (due to non - polar groups like trifluoromethyl and nitro) |
| Solubility In Organic Solvents | Soluble in some organic solvents like dichloromethane, toluene |
| Density | Data may vary depending on purity and measurement conditions |
| Vapor Pressure | Low at room temperature |
| Stability | Can be unstable due to nitro groups, sensitive to heat and shock |
| Odor | May have a pungent or characteristic odor |
As an accredited 1,3-Dinitro-2-Chloro-5-Trifluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 1,3 - dinitro - 2 - chloro - 5 - trifluoromethylbenzene packaged in a sealed plastic drum. |
| Storage | 1,3 - dinitro - 2 - chloro - 5 - trifluoromethylbenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, ignition sources, and incompatible substances like reducing agents, bases, and metals. Store in a tightly - sealed container to prevent leakage and vapor release, ensuring compliance with safety regulations. |
| Shipping | 1,3 - dinitro - 2 - chloro - 5 - trifluoromethylbenzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It should be transported in a secure, well - labeled container to prevent leakage and ensure safety during transit. |
Competitive 1,3-Dinitro-2-Chloro-5-Trifluoromethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1,3-Dinitro-2-Chloro-5-Trifluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1,3-dinitro-2-chloro-5-trifluoromethylbenzene?
1% 2C3-dihydroxy-2-amino-5-trifluoromethylbenzene has important uses in many fields. In the field of medicine, it is a key intermediate for drug synthesis. With it, drugs with unique pharmacological activities can be synthesized. For example, in the development of antidepressant drugs, its special chemical structure can precisely regulate the transmission of neurotransmitters, thus playing a role in relieving depression symptoms. The hydroxyl and amino groups in its structure can interact with specific targets in the body, while trifluoromethyl can enhance the lipid solubility of drug molecules, improve the ability of drugs to penetrate biological membranes, and promote drug absorption and distribution.
In the field of pesticides, this compound also plays an important role. It can be used to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. Due to its unique chemical properties, it can have specific effects on the physiological functions of pests. For example, it interferes with the nervous system of pests or hinders their growth and development process to achieve effective pest control. And the presence of trifluoromethyl enhances the stability and durability of pesticides, reduces the frequency of administration, and reduces environmental pollution.
In the field of materials science, 1% 2C3-dihydroxy-2-amino-5-trifluoromethylbenzene can be used as a functional monomer to participate in the synthesis of polymer materials. With its special structure, materials are endowed with unique properties such as excellent thermal stability, chemical stability, and optical properties. For example, in the preparation of high-performance engineering plastics, the introduction of this compound can enhance the corrosion resistance and high temperature resistance of plastics, broadening their application range in extreme environments.
In the field of pesticides, this compound also plays an important role. It can be used to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. Due to its unique chemical properties, it can have specific effects on the physiological functions of pests. For example, it interferes with the nervous system of pests or hinders their growth and development process to achieve effective pest control. And the presence of trifluoromethyl enhances the stability and durability of pesticides, reduces the frequency of administration, and reduces environmental pollution.
In the field of materials science, 1% 2C3-dihydroxy-2-amino-5-trifluoromethylbenzene can be used as a functional monomer to participate in the synthesis of polymer materials. With its special structure, materials are endowed with unique properties such as excellent thermal stability, chemical stability, and optical properties. For example, in the preparation of high-performance engineering plastics, the introduction of this compound can enhance the corrosion resistance and high temperature resistance of plastics, broadening their application range in extreme environments.
What are the physical properties of 1,3-dinitro-2-chloro-5-trifluoromethylbenzene?
1% 2C3-diamino-2-chloro-5-trifluoromethylbenzene is an organic compound, and its physical properties are related to many aspects.
Looking at its properties, it is often a crystalline solid state, which is due to the force between molecules, so that the molecules are arranged in an orderly manner and then crystallized. Its melting point is also a key property. Due to the specific molecular structure, the melting point or at a specific temperature range, the energy required for the molecules to break free from the lattice is fixed.
In terms of solubility, due to its polar amino group and chlorine atom, and non-polar trifluoromethyl group, it may have a certain solubility in polar solvents such as alcohols, but the solubility in non-polar solvents such as alkanes may be limited. This follows the principle of similar phase dissolution, the polar part interacts with the polar solvent, and the non-polar part interacts with the non-polar solvent.
The boiling point cannot be ignored, and the intermolecular force determines the boiling point. The amino group containing hydrogen bonds enhances the intermolecular force, and more energy is required to boil it, so the boiling point is higher.
The density is also one of its physical properties, which depends on the molecular weight and the degree of molecular packing. The molecular weight of this compound is determined by the specific type and quantity of atoms it contains, and the way of packing is also determined by the molecular structure, so the density is a specific value.
In addition, its color may be colorless to light yellow, which is caused by the absorption and reflection characteristics of the molecule to light. Some groups can absorb specific wavelengths of light, and the unabsorbed light is reflected into the human eye, presenting a corresponding color.
Looking at its properties, it is often a crystalline solid state, which is due to the force between molecules, so that the molecules are arranged in an orderly manner and then crystallized. Its melting point is also a key property. Due to the specific molecular structure, the melting point or at a specific temperature range, the energy required for the molecules to break free from the lattice is fixed.
In terms of solubility, due to its polar amino group and chlorine atom, and non-polar trifluoromethyl group, it may have a certain solubility in polar solvents such as alcohols, but the solubility in non-polar solvents such as alkanes may be limited. This follows the principle of similar phase dissolution, the polar part interacts with the polar solvent, and the non-polar part interacts with the non-polar solvent.
The boiling point cannot be ignored, and the intermolecular force determines the boiling point. The amino group containing hydrogen bonds enhances the intermolecular force, and more energy is required to boil it, so the boiling point is higher.
The density is also one of its physical properties, which depends on the molecular weight and the degree of molecular packing. The molecular weight of this compound is determined by the specific type and quantity of atoms it contains, and the way of packing is also determined by the molecular structure, so the density is a specific value.
In addition, its color may be colorless to light yellow, which is caused by the absorption and reflection characteristics of the molecule to light. Some groups can absorb specific wavelengths of light, and the unabsorbed light is reflected into the human eye, presenting a corresponding color.
What are the chemical properties of 1,3-dinitro-2-chloro-5-trifluoromethylbenzene?
1% 2C3-diamino-2-chloro-5-trifluoromethylbenzene is an organic compound with unique chemical properties.
In this compound, the presence of amino group (-NH ²) endows it with a certain alkalinity. The nitrogen atom in the amino group has a lone pair of electrons, which can be combined with protons and easily form ammonium ions in an acidic environment. At the same time, the amino group is also a good power supply group, which can increase the electron cloud density of the benzene ring through the conjugation effect, making the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc.
The chlorine atom (-Cl) is an electron-withdrawing group, which will reduce the electron cloud density of the benzene ring through induction effect. However, when it is conjugated with the benzene ring, there is a weak electron-fed conjugation effect. Overall, the chlorine atom has a complex effect on the electrophilic substitution activity of the benzene ring, which generally decreases its activity slightly, and makes the substitution reaction mainly occur in the ortho and para-sites.
Trifluoromethyl (-CF 🥰) has strong electron-absorbing properties, which significantly reduces the electron cloud density of the benzene ring by induction effect, greatly weakens the electrophilic substitution activity of the benzene ring, making the reaction conditions more harsh, and mainly guides the substituent into the meta-site.
In addition, the compound can participate in many organic reactions because it contains a variety of different functional groups. For example, amino groups can be acylated with acyl chloride, acid anhydride, etc., to form amide compounds; they can also be condensed with aldides and ketones to form nitrogen-containing heterocycles or Schiff bases. Under appropriate conditions, chlorine atoms can undergo nucleophilic substitution reactions, which can be replaced by other nucleophilic reagents such as hydroxyl, alkoxy, amino, etc., and then a variety of organic compounds can be derived.
In this compound, the presence of amino group (-NH ²) endows it with a certain alkalinity. The nitrogen atom in the amino group has a lone pair of electrons, which can be combined with protons and easily form ammonium ions in an acidic environment. At the same time, the amino group is also a good power supply group, which can increase the electron cloud density of the benzene ring through the conjugation effect, making the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc.
The chlorine atom (-Cl) is an electron-withdrawing group, which will reduce the electron cloud density of the benzene ring through induction effect. However, when it is conjugated with the benzene ring, there is a weak electron-fed conjugation effect. Overall, the chlorine atom has a complex effect on the electrophilic substitution activity of the benzene ring, which generally decreases its activity slightly, and makes the substitution reaction mainly occur in the ortho and para-sites.
Trifluoromethyl (-CF 🥰) has strong electron-absorbing properties, which significantly reduces the electron cloud density of the benzene ring by induction effect, greatly weakens the electrophilic substitution activity of the benzene ring, making the reaction conditions more harsh, and mainly guides the substituent into the meta-site.
In addition, the compound can participate in many organic reactions because it contains a variety of different functional groups. For example, amino groups can be acylated with acyl chloride, acid anhydride, etc., to form amide compounds; they can also be condensed with aldides and ketones to form nitrogen-containing heterocycles or Schiff bases. Under appropriate conditions, chlorine atoms can undergo nucleophilic substitution reactions, which can be replaced by other nucleophilic reagents such as hydroxyl, alkoxy, amino, etc., and then a variety of organic compounds can be derived.
What are the synthesis methods of 1,3-dinitro-2-chloro-5-trifluoromethylbenzene?
1% 2C3-diamino-2-chloro-5-trifluoromethylpyridine is a crucial compound in the field of organic synthesis. There are many synthesis methods. The following are the common ones:
First, with 2,3-dichloro-5-trifluoromethylpyridine as the starting material, under specific reaction conditions, ammonia and the raw material undergo a nucleophilic substitution reaction. This reaction can replace the chlorine atom with an amino group, and then generate the target product 1,3-diamino-2-chloro-5-trifluoromethylpyridine. The advantage of this path is that the starting material is relatively easy to obtain, and the reaction steps are concise and clear. However, its shortcomings cannot be ignored. The conditions of nucleophilic substitution reaction may be relatively strict, and the reaction temperature, pressure and the ratio of reactants need to be precisely controlled to improve the yield and purity of the product.
Second, the specific functionalization reaction of suitable pyridine derivatives is first carried out, and then the structure of 1,3-diamino-2-chloro-5-trifluoromethyl pyridine is gradually constructed through multi-step reaction. For example, trifluoromethyl is introduced first, followed by chlorination reaction, and finally amino is introduced. The advantage of this strategy is that the reaction steps can be flexibly designed and adjusted, and the reaction conditions can be optimized according to actual needs to improve the quality of the product. However, there are many reaction steps in this method, and the synthesis route is complicated. Each step of the reaction may lead to product loss, overall yield or be affected, and a variety of reagents and catalysts are required in the reaction process, which is relatively expensive.
Third, the synthesis is achieved by means of transition metal catalysis. Transition metal catalysts can effectively promote the formation and fracture of various chemical bonds, and can achieve the synthesis of target compounds under relatively mild conditions. For example, a suitable metal catalyst is used to catalyze the reaction of pyridine derivatives with amino-containing reagents and chlorine-containing reagents, so that the reaction precisely generates 1,3-diamino-2-chloro-5-trifluoromethylpyridine. The outstanding advantages of this method are that the reaction conditions are mild and the selectivity is high, which can greatly reduce the occurrence of side reactions and improve the purity of the product. However, transition metal catalysts are usually expensive, and the separation and recovery after the reaction are also difficult, which limits the large-scale application of this method to a certain extent.
Synthesis of 1,3-diamino-2-chloro-5-trifluoromethylpyridine has its own advantages and disadvantages. In the actual synthesis process, it is necessary to consider the cost of raw materials, reaction conditions, yield, purity and environmental protection and many other factors, and carefully select the most suitable synthesis method.
First, with 2,3-dichloro-5-trifluoromethylpyridine as the starting material, under specific reaction conditions, ammonia and the raw material undergo a nucleophilic substitution reaction. This reaction can replace the chlorine atom with an amino group, and then generate the target product 1,3-diamino-2-chloro-5-trifluoromethylpyridine. The advantage of this path is that the starting material is relatively easy to obtain, and the reaction steps are concise and clear. However, its shortcomings cannot be ignored. The conditions of nucleophilic substitution reaction may be relatively strict, and the reaction temperature, pressure and the ratio of reactants need to be precisely controlled to improve the yield and purity of the product.
Second, the specific functionalization reaction of suitable pyridine derivatives is first carried out, and then the structure of 1,3-diamino-2-chloro-5-trifluoromethyl pyridine is gradually constructed through multi-step reaction. For example, trifluoromethyl is introduced first, followed by chlorination reaction, and finally amino is introduced. The advantage of this strategy is that the reaction steps can be flexibly designed and adjusted, and the reaction conditions can be optimized according to actual needs to improve the quality of the product. However, there are many reaction steps in this method, and the synthesis route is complicated. Each step of the reaction may lead to product loss, overall yield or be affected, and a variety of reagents and catalysts are required in the reaction process, which is relatively expensive.
Third, the synthesis is achieved by means of transition metal catalysis. Transition metal catalysts can effectively promote the formation and fracture of various chemical bonds, and can achieve the synthesis of target compounds under relatively mild conditions. For example, a suitable metal catalyst is used to catalyze the reaction of pyridine derivatives with amino-containing reagents and chlorine-containing reagents, so that the reaction precisely generates 1,3-diamino-2-chloro-5-trifluoromethylpyridine. The outstanding advantages of this method are that the reaction conditions are mild and the selectivity is high, which can greatly reduce the occurrence of side reactions and improve the purity of the product. However, transition metal catalysts are usually expensive, and the separation and recovery after the reaction are also difficult, which limits the large-scale application of this method to a certain extent.
Synthesis of 1,3-diamino-2-chloro-5-trifluoromethylpyridine has its own advantages and disadvantages. In the actual synthesis process, it is necessary to consider the cost of raw materials, reaction conditions, yield, purity and environmental protection and many other factors, and carefully select the most suitable synthesis method.
What are the precautions for using 1,3-dinitro-2-chloro-5-trifluoromethylbenzene?
1% 2C3-diamino-2-chloro-5-trifluoromethylbenzene is a special substance in the chemical synthesis. The following items must be paid attention to during use:
First, comprehensive protection is essential. This substance contains groups such as chlorine and trifluoromethyl, or may be toxic and irritating. Before starting to use, protective equipment must be worn neatly, such as protective gloves, and chemical-resistant materials should be selected to prevent contact with the hand skin. Protective masks are also indispensable, which can effectively block their volatile gases or tiny particles from entering the eyes and respiratory tract, and avoid damage to the eyes and respiratory mucosa.
Second, choose the operating environment carefully. The relevant operation should be carried out in a well-ventilated place. Because of its use or volatilization of irritating gases, good ventilation can discharge harmful gases in time, reduce the concentration of harmful substances in the air, and protect the health of operators. If conditions permit, it is more suitable to operate in a fume hood, which can further enhance the control and emission of harmful gases.
Third, storage is treated strictly. It needs to be stored in a cool, dry and ventilated place, away from fire and heat sources. The chemical properties of this substance may be affected by changes in temperature and humidity. If it is not stored properly, it may deteriorate or even cause safety accidents. And it should be stored separately from oxidants, acids and other substances. Due to the particularity of its chemical structure, contact with these substances or severe chemical reactions occur.
Fourth, take precise operation. Due to its complex structure and special nature, when taking it, the measuring tool must be accurate and operated strictly according to the dosage required for experiment or production. If you take too much, it will not only cause material waste, but also may cause uncontrollable conditions in subsequent reactions or use; if you take too little, you will not be able to achieve the desired effect.
Fifth, emergency response is prepared. The use site should be prepared with corresponding emergency treatment equipment and drugs. In the event of a leak, effective measures should be taken immediately, such as covering the adsorption with inert materials such as sand to prevent its spread; if someone comes into contact or inhales, immediate emergency measures should be taken and medical treatment should be taken in time.
First, comprehensive protection is essential. This substance contains groups such as chlorine and trifluoromethyl, or may be toxic and irritating. Before starting to use, protective equipment must be worn neatly, such as protective gloves, and chemical-resistant materials should be selected to prevent contact with the hand skin. Protective masks are also indispensable, which can effectively block their volatile gases or tiny particles from entering the eyes and respiratory tract, and avoid damage to the eyes and respiratory mucosa.
Second, choose the operating environment carefully. The relevant operation should be carried out in a well-ventilated place. Because of its use or volatilization of irritating gases, good ventilation can discharge harmful gases in time, reduce the concentration of harmful substances in the air, and protect the health of operators. If conditions permit, it is more suitable to operate in a fume hood, which can further enhance the control and emission of harmful gases.
Third, storage is treated strictly. It needs to be stored in a cool, dry and ventilated place, away from fire and heat sources. The chemical properties of this substance may be affected by changes in temperature and humidity. If it is not stored properly, it may deteriorate or even cause safety accidents. And it should be stored separately from oxidants, acids and other substances. Due to the particularity of its chemical structure, contact with these substances or severe chemical reactions occur.
Fourth, take precise operation. Due to its complex structure and special nature, when taking it, the measuring tool must be accurate and operated strictly according to the dosage required for experiment or production. If you take too much, it will not only cause material waste, but also may cause uncontrollable conditions in subsequent reactions or use; if you take too little, you will not be able to achieve the desired effect.
Fifth, emergency response is prepared. The use site should be prepared with corresponding emergency treatment equipment and drugs. In the event of a leak, effective measures should be taken immediately, such as covering the adsorption with inert materials such as sand to prevent its spread; if someone comes into contact or inhales, immediate emergency measures should be taken and medical treatment should be taken in time.
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