Linshang Chemical
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1,4-Bis(Chloromethyl)-2,3,5,6-Tetrafluorobenzene
Linshang Chemical
|
HS Code |
525452 |
| Chemical Formula | C8H4Cl2F4 |
| Molecular Weight | 259.016 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 195 - 197 °C |
| Density | 1.57 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents like dichloromethane |
| Vapor Pressure | Low vapor pressure |
| Flash Point | 87 °C |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 1,4-Bis(Chloromethyl)-2,3,5,6-Tetrafluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1,4 - bis(chloromethyl)-2,3,5,6 - tetrafluorobenzene in a sealed chemical - grade bottle. |
| Storage | 1,4 - bis(chloromethyl)-2,3,5,6 - tetrafluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. Label the storage clearly for easy identification. |
| Shipping | 1,4 - bis(chloromethyl)-2,3,5,6 - tetrafluorobenzene is a chemical. Shipping requires compliance with hazardous material regulations. It must be properly packaged to prevent leakage and transported by carriers approved for such chemicals. |
Competitive 1,4-Bis(Chloromethyl)-2,3,5,6-Tetrafluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Where to Buy 1,4-Bis(Chloromethyl)-2,3,5,6-Tetrafluorobenzene in China?
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As a leading 1,4-Bis(Chloromethyl)-2,3,5,6-Tetrafluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1,4-bis (chloromethyl) -2,3,5,6-tetrafluorobenzene?
1,4-Bis (cyanomethyl) - 2,3,5,6-tetrafluorobenzene is an organic compound with a wide range of main uses.
In the field of materials science, it is often used as a key monomer in the synthesis of special polymer materials. After clever polymerization, polymers with excellent heat resistance, chemical stability and electrical properties can be formed. Such polymers are of great significance in high-end industries such as aerospace and electronics. For example, in aerospace equipment, they can help to create components that are both lightweight and strong and can withstand extreme environments. In the field of electronics and electrical, they can be used to make high-performance insulating materials and circuit board substrates, which greatly enhance the stability and reliability of electronic products.
In the field of organic synthesis chemistry, this compound is an extremely important intermediate. With its special molecular structure, it can derive many organic compounds with unique functions and structures through various chemical reactions. For example, with the help of nucleophilic substitution, addition and other reactions, organic molecules with complex structures and specific biological activities or optical properties can be synthesized, providing a rich material basis for the development of new drugs and the creation of new dyes.
In the field of medicinal chemistry, some derivatives synthesized based on 1,4-bis (cyanomethyl) -2,3,5,6-tetrafluorobenzene show potential biological activities. Researchers are actively exploring the possibility of its use in the development of anti-cancer, antibacterial and other drugs, which is expected to bring new breakthroughs and hope for human health.
In the field of materials science, it is often used as a key monomer in the synthesis of special polymer materials. After clever polymerization, polymers with excellent heat resistance, chemical stability and electrical properties can be formed. Such polymers are of great significance in high-end industries such as aerospace and electronics. For example, in aerospace equipment, they can help to create components that are both lightweight and strong and can withstand extreme environments. In the field of electronics and electrical, they can be used to make high-performance insulating materials and circuit board substrates, which greatly enhance the stability and reliability of electronic products.
In the field of organic synthesis chemistry, this compound is an extremely important intermediate. With its special molecular structure, it can derive many organic compounds with unique functions and structures through various chemical reactions. For example, with the help of nucleophilic substitution, addition and other reactions, organic molecules with complex structures and specific biological activities or optical properties can be synthesized, providing a rich material basis for the development of new drugs and the creation of new dyes.
In the field of medicinal chemistry, some derivatives synthesized based on 1,4-bis (cyanomethyl) -2,3,5,6-tetrafluorobenzene show potential biological activities. Researchers are actively exploring the possibility of its use in the development of anti-cancer, antibacterial and other drugs, which is expected to bring new breakthroughs and hope for human health.
What are the physical properties of 1,4-bis (chloromethyl) -2,3,5,6-tetrafluorobenzene
1% 2C4 - bis (cyanoethyl) - 2% 2C3% 2C5% 2C6 - tetrafluorobenzene is an organic compound with the following physical properties:
Its properties are often white to slightly yellow crystalline powder, which is easy to distinguish. The melting point is in a specific range, about [X] ° C. This temperature characteristic is a key indicator of its change in heat, and it is very important for the study of its phase transition under specific conditions.
The compound is insoluble in water, and this solubility characteristic makes its behavior in the aqueous environment different from that of soluble substances. In many chemical reactions or systems involving the aqueous phase, it mostly exists as an independent phase. However, it can be soluble in some organic solvents, such as common acetone, chloroform, etc. In acetone, at [specific temperature], the solubility can reach [X] g/100mL, and in chloroform, under similar conditions, the solubility is also [X] g/100mL. This solubility property provides a basis for the separation and purification of reactants or products in organic synthesis.
Its density is about [X] g/cm ³, which reflects the mass of the substance per unit volume. It is of great significance in terms of material balance and density calculation of mixed systems. In actual production or experimental operations, it is indispensable for determining the amount and volume of the required substance.
In addition, the vapor pressure of the compound is about [X] Pa at [specific temperature], and the vapor pressure reflects the tendency of the substance to evaporate into a gaseous state. This value indicates that the degree of volatilization at this temperature is moderate, and it is neither extremely volatile and difficult to store, nor extremely difficult to volatilize and difficult to function in some processes that require the participation of the gas phase. These physical properties are interrelated and together determine the performance and application of 1% 2C4-bis (cyanoethyl) -2% 2C3% 2C5% 2C6-tetrafluorobenzene in various chemical and physical processes.
Its properties are often white to slightly yellow crystalline powder, which is easy to distinguish. The melting point is in a specific range, about [X] ° C. This temperature characteristic is a key indicator of its change in heat, and it is very important for the study of its phase transition under specific conditions.
The compound is insoluble in water, and this solubility characteristic makes its behavior in the aqueous environment different from that of soluble substances. In many chemical reactions or systems involving the aqueous phase, it mostly exists as an independent phase. However, it can be soluble in some organic solvents, such as common acetone, chloroform, etc. In acetone, at [specific temperature], the solubility can reach [X] g/100mL, and in chloroform, under similar conditions, the solubility is also [X] g/100mL. This solubility property provides a basis for the separation and purification of reactants or products in organic synthesis.
Its density is about [X] g/cm ³, which reflects the mass of the substance per unit volume. It is of great significance in terms of material balance and density calculation of mixed systems. In actual production or experimental operations, it is indispensable for determining the amount and volume of the required substance.
In addition, the vapor pressure of the compound is about [X] Pa at [specific temperature], and the vapor pressure reflects the tendency of the substance to evaporate into a gaseous state. This value indicates that the degree of volatilization at this temperature is moderate, and it is neither extremely volatile and difficult to store, nor extremely difficult to volatilize and difficult to function in some processes that require the participation of the gas phase. These physical properties are interrelated and together determine the performance and application of 1% 2C4-bis (cyanoethyl) -2% 2C3% 2C5% 2C6-tetrafluorobenzene in various chemical and physical processes.
What are the chemical properties of 1,4-bis (chloromethyl) -2,3,5,6-tetrafluorobenzene?
1% 2C4 - bis (cyanomethyl) -2% 2C3% 2C5% 2C6 - tetrafluorobenzene is an organic compound with unique chemical properties.
In this compound, cyanomethyl coexists with tetrafluorobenzene, giving it many special properties. Cyanomethyl has certain reactivity and can participate in many nucleophilic substitution reactions because of its cyanyl group. Under suitable conditions, cyanyl can be hydrolyzed to carboxyl groups or reduced to amine groups, resulting in a variety of compounds, which are widely used in the field of organic synthesis.
The tetrafluorobenzene part changes the distribution of molecular electron clouds due to the strong electronegativity of fluorine atoms. The presence of fluorine atoms enhances the stability of molecules and affects their physical properties, such as boiling point, melting point, etc. Fluorine atoms make molecules highly fat-soluble. In the field of medicinal chemistry, this property may improve the transmembrane transport ability of drugs and enhance bioavailability.
From the perspective of reactivity, the benzene ring of the compound can undergo aromatic electrophilic substitution. Although the electron cloud density of the tetrafluorobenzene ring decreases due to the electron-absorbing effect of fluorine atoms, the reactive activity is slightly lower than that of benzene, but under suitable catalyst and reaction conditions, halogenation, nitrification, sulfonation and other reactions can still occur. And the reaction check point may be affected by the localization effect of cyanomethyl and fluorine atoms, which has a certain selectivity.
In addition, the interaction between different groups in the molecule may affect the overall chemical properties. The synergy of electronic and spatial effects between cyanomethyl and tetrafluorobenzene may have subtle effects on their reactivity and selectivity. The unique chemical properties of this compound offer broad application prospects in the fields of organic synthesis, materials science and drug development, and it is a compound worthy of further investigation.
In this compound, cyanomethyl coexists with tetrafluorobenzene, giving it many special properties. Cyanomethyl has certain reactivity and can participate in many nucleophilic substitution reactions because of its cyanyl group. Under suitable conditions, cyanyl can be hydrolyzed to carboxyl groups or reduced to amine groups, resulting in a variety of compounds, which are widely used in the field of organic synthesis.
The tetrafluorobenzene part changes the distribution of molecular electron clouds due to the strong electronegativity of fluorine atoms. The presence of fluorine atoms enhances the stability of molecules and affects their physical properties, such as boiling point, melting point, etc. Fluorine atoms make molecules highly fat-soluble. In the field of medicinal chemistry, this property may improve the transmembrane transport ability of drugs and enhance bioavailability.
From the perspective of reactivity, the benzene ring of the compound can undergo aromatic electrophilic substitution. Although the electron cloud density of the tetrafluorobenzene ring decreases due to the electron-absorbing effect of fluorine atoms, the reactive activity is slightly lower than that of benzene, but under suitable catalyst and reaction conditions, halogenation, nitrification, sulfonation and other reactions can still occur. And the reaction check point may be affected by the localization effect of cyanomethyl and fluorine atoms, which has a certain selectivity.
In addition, the interaction between different groups in the molecule may affect the overall chemical properties. The synergy of electronic and spatial effects between cyanomethyl and tetrafluorobenzene may have subtle effects on their reactivity and selectivity. The unique chemical properties of this compound offer broad application prospects in the fields of organic synthesis, materials science and drug development, and it is a compound worthy of further investigation.
What are the synthesis methods of 1,4-bis (chloromethyl) -2,3,5,6-tetrafluorobenzene
The synthesis of 1% 2C4-bis (cyanoethyl) -2% 2C3% 2C5% 2C6-tetrafluorobenzene is an important topic in the field of organic synthesis. This compound has potential applications in materials science, medicinal chemistry and other fields, and its synthesis method is of great significance.
There are methods for synthesis, one of which is the nucleophilic substitution reaction path. Using tetrafluorobenzene as the starting material, in an appropriate solvent, such as N, N-dimethylformamide (DMF), add a base, such as potassium carbonate, heat up to a certain temperature, and then dropwise add cyanoethylation reagents, such as 3-bromopropionitrile, through nucleophilic substitution reaction, the cyanoethyl group is introduced into the benzene ring to obtain the target product. This process requires attention to the regulation of the reaction temperature and the proportion of reagents. If the temperature is too high or side reactions occur, improper proportions will affect the yield.
The second is the transition metal catalysis method. Under mild reaction conditions, tetrafluorobenzene is coupled to the cyanoethylation reagent under mild reaction conditions with transition metals such as palladium or nickel as cataly The advantage of this method is that the selectivity is good, the yield is higher or higher, but the cost of the catalyst is higher, and the recovery and repurpose are the problems to be solved.
Another method is to construct fluorine-containing blocks. The specific blocks containing cyanoethyl and fluorine atoms are synthesized first, and then the target benzene ring structure is constructed by cyclization reaction. This strategy can effectively control the position and number of substituents, and has unique advantages for the synthesis of complex structures. However, the block synthesis steps may be cumbersome and require multi-step reactions and purification operations.
All synthetic methods have their own advantages and disadvantages. In practical applications, it is necessary to choose an appropriate method according to specific needs, considering factors such as cost, yield, and selectivity, in order to achieve the efficient synthesis of 1% 2C4-bis (cyanoethyl) -2% 2C3% 2C5% 2C6-tetrafluorobenzene.
There are methods for synthesis, one of which is the nucleophilic substitution reaction path. Using tetrafluorobenzene as the starting material, in an appropriate solvent, such as N, N-dimethylformamide (DMF), add a base, such as potassium carbonate, heat up to a certain temperature, and then dropwise add cyanoethylation reagents, such as 3-bromopropionitrile, through nucleophilic substitution reaction, the cyanoethyl group is introduced into the benzene ring to obtain the target product. This process requires attention to the regulation of the reaction temperature and the proportion of reagents. If the temperature is too high or side reactions occur, improper proportions will affect the yield.
The second is the transition metal catalysis method. Under mild reaction conditions, tetrafluorobenzene is coupled to the cyanoethylation reagent under mild reaction conditions with transition metals such as palladium or nickel as cataly The advantage of this method is that the selectivity is good, the yield is higher or higher, but the cost of the catalyst is higher, and the recovery and repurpose are the problems to be solved.
Another method is to construct fluorine-containing blocks. The specific blocks containing cyanoethyl and fluorine atoms are synthesized first, and then the target benzene ring structure is constructed by cyclization reaction. This strategy can effectively control the position and number of substituents, and has unique advantages for the synthesis of complex structures. However, the block synthesis steps may be cumbersome and require multi-step reactions and purification operations.
All synthetic methods have their own advantages and disadvantages. In practical applications, it is necessary to choose an appropriate method according to specific needs, considering factors such as cost, yield, and selectivity, in order to achieve the efficient synthesis of 1% 2C4-bis (cyanoethyl) -2% 2C3% 2C5% 2C6-tetrafluorobenzene.
What should be paid attention to when storing and transporting 1,4-bis (chloromethyl) -2,3,5,6-tetrafluorobenzene?
1% 2C4-bis (hydroxyethyl) -2% 2C3% 2C5% 2C6-tetrafluorobenzene is a highly toxic product. When storing and transporting, the following things must be paid attention to:
First, the storage place must be cool, dry and well ventilated. This medicine is afraid of moisture and heat. If it is in a high temperature and humid place, it may cause changes in drug properties or cause dangerous chemical reactions. Therefore, the temperature of the warehouse should be controlled within a specific range, and the humidity should not be too high.
Second, when storing, it must be isolated from other objects. Because of its strong toxicity, it should not be mixed with food, medicine, feed, etc., to prevent accidental pollution and harm to humans and animals. And it should be kept away from fire and heat sources to avoid accidental explosion and cause disaster.
Third, during transportation, the packaging must be solid and stable. Choose appropriate packaging materials to ensure that it will not be damaged and leaked during bumps and collisions. At the same time, the transportation vehicle should also be clean and have no other objects that may react with it.
Fourth, relevant operators must undergo professional training. Familiar with the characteristics, hazards and emergency response methods of this object. When working, be sure to wear protective clothing and protective equipment, and do not take it lightly.
Fifth, whether it is stored or transported, it is necessary to strictly abide by relevant laws and regulations. Record the quantity, flow direction and other information in detail for inspection. If an accident such as a leak occurs, immediately activate an emergency plan, evacuate the crowd, handle it properly, and try to reduce the harm.
Such highly toxic substances are related to human life and environmental safety, and must not be slack and negligent. Only by treating them with caution can they be safe.
First, the storage place must be cool, dry and well ventilated. This medicine is afraid of moisture and heat. If it is in a high temperature and humid place, it may cause changes in drug properties or cause dangerous chemical reactions. Therefore, the temperature of the warehouse should be controlled within a specific range, and the humidity should not be too high.
Second, when storing, it must be isolated from other objects. Because of its strong toxicity, it should not be mixed with food, medicine, feed, etc., to prevent accidental pollution and harm to humans and animals. And it should be kept away from fire and heat sources to avoid accidental explosion and cause disaster.
Third, during transportation, the packaging must be solid and stable. Choose appropriate packaging materials to ensure that it will not be damaged and leaked during bumps and collisions. At the same time, the transportation vehicle should also be clean and have no other objects that may react with it.
Fourth, relevant operators must undergo professional training. Familiar with the characteristics, hazards and emergency response methods of this object. When working, be sure to wear protective clothing and protective equipment, and do not take it lightly.
Fifth, whether it is stored or transported, it is necessary to strictly abide by relevant laws and regulations. Record the quantity, flow direction and other information in detail for inspection. If an accident such as a leak occurs, immediately activate an emergency plan, evacuate the crowd, handle it properly, and try to reduce the harm.
Such highly toxic substances are related to human life and environmental safety, and must not be slack and negligent. Only by treating them with caution can they be safe.
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