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1-[(4-Chlorophenyl)Sulfanyl]-2-Nitrobenzene
Linshang Chemical
|
HS Code |
269116 |
| Chemical Formula | C12H8ClNO2S |
| Molar Mass | 265.72 g/mol |
| Appearance | Solid (predicted) |
| Physical State At Room Temp | Solid |
| Solubility In Water | Low (predicted) |
| Solubility In Organic Solvents | Soluble in common organic solvents (predicted) |
| Stability | Stable under normal conditions (predicted) |
| Hazard Class | Potential irritant (predicted) |
As an accredited 1-[(4-Chlorophenyl)Sulfanyl]-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-[(4 - chlorophenyl)sulfanyl]-2 - nitrobenzene in sealed chemical - grade packaging. |
| Storage | 1 - [(4 - chlorophenyl)sulfanyl]-2 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air or moisture. Avoid storing near incompatible substances to prevent potential chemical reactions. |
| Shipping | 1 - [(4 - chlorophenyl)sulfanyl]-2 - nitrobenzene is shipped in accordance with chemical transportation regulations. Packed securely in suitable containers, transported by approved carriers to ensure safe delivery. |
Competitive 1-[(4-Chlorophenyl)Sulfanyl]-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1- [ (4-chlorophenyl) thio] -2-nitrobenzene?
(1) Preparation of (4-cyanophenyl) boric acid
Preparation of (4-cyanophenyl) boric acid, often with halogenated aromatic hydrocarbons as starting materials, by reacting with metal reagents and borate esters. For example, 4-halogenated benzonitrile is used as a starting material, and at low temperatures, it interacts with strong bases such as butyl lithium to form phenyllithium intermediates. This intermediate has high activity and can undergo nucleophilic substitution reactions with borate ester reagents such as trimethyl borate, followed by hydrolysis to obtain (4-halogenated benzonitrile) boric acid.
Or using 4-halogenated benzonitrile as raw material, under the action of transition metal catalysts such as palladium, boronation reaction with diphenol borate can also achieve the synthesis of the target product. With the help of transition metal catalysis, this method has relatively mild conditions and good selectivity, and is widely used in the field of organic synthesis.
Chemical properties of (di) cyanophenylboronic acid
Cyanophenylboronic acid has the chemical properties of both cyanobenzene and boric acid.
1. ** Characteristics of boric acid **:
- ** Acidic **: The boric acid is partially weakly acidic and can undergo weak ionization in water, and its hydroxyl hydrogen can be partially dissociated. This acidity allows cyanophenylboronic acid to neutralize with bases to form corresponding borates. For example, when reacted with sodium hydroxide, the hydroxyl hydrogen borate combines with hydroxide to form water and cyanophenylborate ions.
- ** Reaction with alcohols **: Boric acid can complex with polyols to form stable cyclic borate esters. Cyanophenylboronic acid also has this property. In organic synthesis, this property can be used to selectively identify and separate hydroxyl-containing compounds. If reacted with glycerol, a stable five-membered cyclic borate structure can be formed.
2. ** Characteristics of cyanyl groups **:
- ** Hydrolysis **: Cyanyl groups can be hydrolyzed under the catalysis of acids or bases. Under acidic conditions, the cyanyl group is gradually hydrolyzed to amide, and then hydrolyzed to carboxylic acid. When cyanophenylboronic acid is hydrolyzed by acid, the cyanyl group is first converted to amidophenylboronic acid. If the hydrolysis is complete, carboxyphenylboronic acid can be obtained. Under basic conditions, the hydrolysis process is similar, but the reaction intermediates and product forms are different.
- ** Nucleophilic addition **: Cyanyl groups are electrophilic and can be added to nucleophilic reagents. If reacted with Grignard reagent, the negatively charged hydrocarbons in the Grignard reagent attack the cyanocarbon atom to form imide intermediates, which can be hydrolyzed to obtain ketones. If cyanophenylboronic acid reacts with suitable Grignard reagents, new compounds containing cyanide and ketone groups can be formed, providing a variety of structural units for organic synthesis.
Preparation of (4-cyanophenyl) boric acid, often with halogenated aromatic hydrocarbons as starting materials, by reacting with metal reagents and borate esters. For example, 4-halogenated benzonitrile is used as a starting material, and at low temperatures, it interacts with strong bases such as butyl lithium to form phenyllithium intermediates. This intermediate has high activity and can undergo nucleophilic substitution reactions with borate ester reagents such as trimethyl borate, followed by hydrolysis to obtain (4-halogenated benzonitrile) boric acid.
Or using 4-halogenated benzonitrile as raw material, under the action of transition metal catalysts such as palladium, boronation reaction with diphenol borate can also achieve the synthesis of the target product. With the help of transition metal catalysis, this method has relatively mild conditions and good selectivity, and is widely used in the field of organic synthesis.
Chemical properties of (di) cyanophenylboronic acid
Cyanophenylboronic acid has the chemical properties of both cyanobenzene and boric acid.
1. ** Characteristics of boric acid **:
- ** Acidic **: The boric acid is partially weakly acidic and can undergo weak ionization in water, and its hydroxyl hydrogen can be partially dissociated. This acidity allows cyanophenylboronic acid to neutralize with bases to form corresponding borates. For example, when reacted with sodium hydroxide, the hydroxyl hydrogen borate combines with hydroxide to form water and cyanophenylborate ions.
- ** Reaction with alcohols **: Boric acid can complex with polyols to form stable cyclic borate esters. Cyanophenylboronic acid also has this property. In organic synthesis, this property can be used to selectively identify and separate hydroxyl-containing compounds. If reacted with glycerol, a stable five-membered cyclic borate structure can be formed.
2. ** Characteristics of cyanyl groups **:
- ** Hydrolysis **: Cyanyl groups can be hydrolyzed under the catalysis of acids or bases. Under acidic conditions, the cyanyl group is gradually hydrolyzed to amide, and then hydrolyzed to carboxylic acid. When cyanophenylboronic acid is hydrolyzed by acid, the cyanyl group is first converted to amidophenylboronic acid. If the hydrolysis is complete, carboxyphenylboronic acid can be obtained. Under basic conditions, the hydrolysis process is similar, but the reaction intermediates and product forms are different.
- ** Nucleophilic addition **: Cyanyl groups are electrophilic and can be added to nucleophilic reagents. If reacted with Grignard reagent, the negatively charged hydrocarbons in the Grignard reagent attack the cyanocarbon atom to form imide intermediates, which can be hydrolyzed to obtain ketones. If cyanophenylboronic acid reacts with suitable Grignard reagents, new compounds containing cyanide and ketone groups can be formed, providing a variety of structural units for organic synthesis.
What are the common methods for synthesizing 1- [ (4-chlorophenyl) thio] -2-nitrobenzene?
(1) Regarding (4-cyanobenzyl) carbonate
(4-cyanobenzyl) carbonate, this substance is occasionally involved in the field of organic synthesis. In its structure, cyanobenzyl is connected to carbonate, and cyano (-CN) has certain reactivity and can participate in a variety of chemical reactions, such as nucleophilic addition, hydrolysis, etc. The carbonate part also has unique chemical properties, which can occur transesterification and other reactions under suitable conditions. In the route design of organic synthesis, (4-cyanobenzyl) carbonate can be used as a key intermediate to construct more complex organic molecular structures through the transformation and modification of its functional groups. Common Synthesis Methods of
(II) Benzyl Ether
Benzyl ether is an important class of ether substances in organic compounds. The common synthesis methods are as follows:
1. ** Williamson Synthesis Method **: This is a classic method. React with alcohol or phenol and halogenated benzyl under basic conditions. For example, the alcohol first interacts with a strong base (such as sodium hydride, sodium hydroxide, etc.) to form an alcohol negative ion. The negative ion has strong nucleophilicity and can attack the carbon atom of halogenated benzyl, and the halogenated atom leaves to form benzyl ether. During the reaction, attention should be paid to the activity of halogenated benzyl. Usually, the activity of benzyl halogen is higher, and the reaction is easier to carry out. This method has relatively mild conditions and is widely used.
2. ** Phase Transfer Catalytic Synthesis Method **: In the presence of a phase transfer catalyst, the reaction can be promoted. The phase transfer catalyst can transfer the nucleophile in the aqueous phase to the organic phase and react with halobenzyl. Commonly used phase transfer catalysts include quaternary ammonium salts (such as tetrabutylammonium bromide). This method can overcome the problem of different solubility of the reactants in different solvents and improve the reaction efficiency. It is especially suitable for the reaction of some insoluble reactants. The reaction conditions are relatively mild and the operation is simple.
3. ** Dehydration and condensation of benzyl alcohol and alcohol under acid catalysis **: Under the action of acidic catalysts (such as p-toluenesulfonic acid, etc.), benzyl alcohol dehydrates with another molecule of alcohol to form benzyl ether. This reaction is an equilibrium reaction. In order to improve the yield, measures such as removing the generated water in time can be taken, such as using a water separator. However, this method requires attention to the reaction temperature and the amount of acid to avoid side reactions, such as intramolecular dehydration of alcohols to form olefins.
(4-cyanobenzyl) carbonate, this substance is occasionally involved in the field of organic synthesis. In its structure, cyanobenzyl is connected to carbonate, and cyano (-CN) has certain reactivity and can participate in a variety of chemical reactions, such as nucleophilic addition, hydrolysis, etc. The carbonate part also has unique chemical properties, which can occur transesterification and other reactions under suitable conditions. In the route design of organic synthesis, (4-cyanobenzyl) carbonate can be used as a key intermediate to construct more complex organic molecular structures through the transformation and modification of its functional groups. Common Synthesis Methods of
(II) Benzyl Ether
Benzyl ether is an important class of ether substances in organic compounds. The common synthesis methods are as follows:
1. ** Williamson Synthesis Method **: This is a classic method. React with alcohol or phenol and halogenated benzyl under basic conditions. For example, the alcohol first interacts with a strong base (such as sodium hydride, sodium hydroxide, etc.) to form an alcohol negative ion. The negative ion has strong nucleophilicity and can attack the carbon atom of halogenated benzyl, and the halogenated atom leaves to form benzyl ether. During the reaction, attention should be paid to the activity of halogenated benzyl. Usually, the activity of benzyl halogen is higher, and the reaction is easier to carry out. This method has relatively mild conditions and is widely used.
2. ** Phase Transfer Catalytic Synthesis Method **: In the presence of a phase transfer catalyst, the reaction can be promoted. The phase transfer catalyst can transfer the nucleophile in the aqueous phase to the organic phase and react with halobenzyl. Commonly used phase transfer catalysts include quaternary ammonium salts (such as tetrabutylammonium bromide). This method can overcome the problem of different solubility of the reactants in different solvents and improve the reaction efficiency. It is especially suitable for the reaction of some insoluble reactants. The reaction conditions are relatively mild and the operation is simple.
3. ** Dehydration and condensation of benzyl alcohol and alcohol under acid catalysis **: Under the action of acidic catalysts (such as p-toluenesulfonic acid, etc.), benzyl alcohol dehydrates with another molecule of alcohol to form benzyl ether. This reaction is an equilibrium reaction. In order to improve the yield, measures such as removing the generated water in time can be taken, such as using a water separator. However, this method requires attention to the reaction temperature and the amount of acid to avoid side reactions, such as intramolecular dehydration of alcohols to form olefins.
In what fields is 1- [ (4-chlorophenyl) thio] -2-nitrobenzene used?
(1) About " (4-cyanobenzyl) boronic acid": This is a key chemical substance in the field of organic synthesis. Its structure contains cyano and benzyl groups, and is connected with boric acid groups. In organic synthesis reactions, boric acid groups have unique properties and are often used as key activity check points. For example, in the Suzuki coupling reaction, " (4-cyanobenzyl) boric acid" can be coupled with haloaromatic hydrocarbons under the action of suitable catalysts and bases to form cyanobenzyl-containing biaryl compounds. This is a common strategy for constructing complex organic molecular structures. In the field of medicinal chemistry, it is helpful to synthesize lead compounds with specific biological activities.
(2) Cyanobenzyl ether application field:
- ** Medicinal Chemistry **: Cyanobenzyl ether has unique electronic effects and biological activities. The introduction of cyanobenzyl ether structure can change the lipid solubility, electrical properties and interaction with biological targets of drug molecules. In the development of many anti-cancer drugs, compounds containing cyanobenzyl ether fragments have shown good tumor cell inhibitory activity. For example, some tyrosine kinase inhibitors are anti-cancer drugs. Cyanobenzyl ether structure is involved in the precise combination of kinase activity checking point to block abnormal proliferation of cancer cells.
- ** Materials Science Field **: Cyanobenzyl ether compounds can be used to prepare functional polymer materials. Because of its structure, the cyanyl group can participate in the polymerization reaction to form polymers with special properties. For example, the synthesis of liquid crystal polymers containing cyanobenzyl ether structure, such polymers exhibit unique liquid crystal phase behavior due to cyanobenzyl polarity and benzyl ether structure rigidity, and may have potential applications in the field of display materials, such as the preparation of high-performance liquid crystal display materials.
- ** Total Synthesis of Natural Products **: Many natural products have complex molecular structures and similar structural units containing cyanobenzyl ethers. In the total synthesis of natural products, cyanobenzyl ethers are often used as key intermediates to construct the carbon skeleton and functional groups of target molecules. Through ingenious organic synthesis strategy, cyanobenzyl ether fragments were gradually assembled to achieve total synthesis of natural products, and then their biological activities and pharmacological effects were studied, laying the foundation for the development of new drugs and the development and utilization of natural product resources.
(2) Cyanobenzyl ether application field:
- ** Medicinal Chemistry **: Cyanobenzyl ether has unique electronic effects and biological activities. The introduction of cyanobenzyl ether structure can change the lipid solubility, electrical properties and interaction with biological targets of drug molecules. In the development of many anti-cancer drugs, compounds containing cyanobenzyl ether fragments have shown good tumor cell inhibitory activity. For example, some tyrosine kinase inhibitors are anti-cancer drugs. Cyanobenzyl ether structure is involved in the precise combination of kinase activity checking point to block abnormal proliferation of cancer cells.
- ** Materials Science Field **: Cyanobenzyl ether compounds can be used to prepare functional polymer materials. Because of its structure, the cyanyl group can participate in the polymerization reaction to form polymers with special properties. For example, the synthesis of liquid crystal polymers containing cyanobenzyl ether structure, such polymers exhibit unique liquid crystal phase behavior due to cyanobenzyl polarity and benzyl ether structure rigidity, and may have potential applications in the field of display materials, such as the preparation of high-performance liquid crystal display materials.
- ** Total Synthesis of Natural Products **: Many natural products have complex molecular structures and similar structural units containing cyanobenzyl ethers. In the total synthesis of natural products, cyanobenzyl ethers are often used as key intermediates to construct the carbon skeleton and functional groups of target molecules. Through ingenious organic synthesis strategy, cyanobenzyl ether fragments were gradually assembled to achieve total synthesis of natural products, and then their biological activities and pharmacological effects were studied, laying the foundation for the development of new drugs and the development and utilization of natural product resources.
What are the physical properties of 1- [ (4-chlorophenyl) thio] -2-nitrobenzene?
(1) Regarding "1- [ (4-aminophenyl) sulfonyl] -2-naphthalenesulfonic acid"
This is a naming expression for an organic compound. From a structural point of view, it takes the naphthalene ring as the basic skeleton, and is connected with a sulfonic acid group (-SO-H) at the 2-position of the naphthalene ring, and a more complex substituent is connected at the 1-position. The substituent is connected to the naphthalene ring by a benzene ring through the 4-position, and the 4-position of the benzene ring is also connected with an amino group (-NH-2), and the 1-position of the benzene ring is connected to a sulfonic group (-SO-H). This structure makes the compound have a certain acidity, and the reactivity of the sulfonic acid group and the possible amino group also determines its potential reactivity in organic synthesis and related fields. In organic synthesis, sulfonic acid groups can participate in reactions such as nucleophilic substitution, and amino groups can undergo various reactions such as acylation and alkylation, which provides the possibility for the construction of more complex organic structures.
(II) Physical Properties of 2-Naphthalene Sulfonic Acid
2-Naphthalene Sulfonic Acid is usually in solid form. In terms of solubility, due to the strong hydrophilicity of sulfonic acid groups, it has a certain solubility in water and can partially ionize hydrogen ions, making the solution acidic. In appearance, it is mostly white to light yellow crystalline powder. From the perspective of melting point, it has a relatively high melting point, which is related to its strong intermolecular interaction forces, including hydrogen bonding between sulfonic acid groups and intermolecular van der Waals forces caused by the planar structure of naphthalene rings. Its density is comparable to that of ordinary organic compounds, and it is relatively stable at room temperature and pressure. However, under extreme conditions such as high temperature, strong acid and alkali, the molecular structure may change, and the sulfonic acid groups may be removed or other chemical reactions may occur. At the same time, it has a certain degree of hygroscopicity, which may absorb water in a humid environment, affecting its physical state and purity.
This is a naming expression for an organic compound. From a structural point of view, it takes the naphthalene ring as the basic skeleton, and is connected with a sulfonic acid group (-SO-H) at the 2-position of the naphthalene ring, and a more complex substituent is connected at the 1-position. The substituent is connected to the naphthalene ring by a benzene ring through the 4-position, and the 4-position of the benzene ring is also connected with an amino group (-NH-2), and the 1-position of the benzene ring is connected to a sulfonic group (-SO-H). This structure makes the compound have a certain acidity, and the reactivity of the sulfonic acid group and the possible amino group also determines its potential reactivity in organic synthesis and related fields. In organic synthesis, sulfonic acid groups can participate in reactions such as nucleophilic substitution, and amino groups can undergo various reactions such as acylation and alkylation, which provides the possibility for the construction of more complex organic structures.
(II) Physical Properties of 2-Naphthalene Sulfonic Acid
2-Naphthalene Sulfonic Acid is usually in solid form. In terms of solubility, due to the strong hydrophilicity of sulfonic acid groups, it has a certain solubility in water and can partially ionize hydrogen ions, making the solution acidic. In appearance, it is mostly white to light yellow crystalline powder. From the perspective of melting point, it has a relatively high melting point, which is related to its strong intermolecular interaction forces, including hydrogen bonding between sulfonic acid groups and intermolecular van der Waals forces caused by the planar structure of naphthalene rings. Its density is comparable to that of ordinary organic compounds, and it is relatively stable at room temperature and pressure. However, under extreme conditions such as high temperature, strong acid and alkali, the molecular structure may change, and the sulfonic acid groups may be removed or other chemical reactions may occur. At the same time, it has a certain degree of hygroscopicity, which may absorb water in a humid environment, affecting its physical state and purity.
What is the market price of 1- [ (4-chlorophenyl) thio] -2-nitrobenzene?
Today there is a question, what is the market price of (4-cyanobenzyl) pyridine-2-carbonylbenzonitrile? In the commercial market, the price of these two is related to various factors, and it is difficult to determine the constant value with the change of the market.
Fu (4-cyanobenzyl) pyridine-2-carbonylbenzonitrile are all important materials in organic chemistry, often used in medicine, materials and other fields. Its market value depends primarily on the situation of supply and demand. If at some point, the pharmaceutical R & D industry needs it very much, and the demand exceeds the supply, the price will rise; on the contrary, if there are many products, but there are few people using it, and the supply exceeds the demand, the price will decline.
Second, the cost of its production is also the key. The price of raw materials, the production process, the amount of energy consumption, etc., all affect the cost. If the raw materials are rare and expensive, or the production process is complicated and laborious, the cost will be high, and the market price will also be high; if the raw materials are easy to cause, the process is advanced, the cost will drop, and the price will fall accordingly.
Furthermore, the competitive situation of the market cannot be ignored. If there are many businesses and intense competition between the two, each wants to win by price, and the price may be lowered; if there are few operators, it is almost a monopoly, and the price may be higher.
In addition, changes in the current situation and policy regulations also affect the price. Such as tariff adjustment, environmental protection regulations, etc., can change the cost and supply and demand, resulting in fluctuations in the price.
Therefore, in order to know the current market price of (4-cyanobenzyl) pyridine-2-carbonylbenzonitrile, it is necessary to carefully observe the supply and demand of the market, the cost of nuclear production, understand the state of competition, and pay attention to changes in the current situation and policy. It is difficult to say in a word that it refers to a certain price.
Fu (4-cyanobenzyl) pyridine-2-carbonylbenzonitrile are all important materials in organic chemistry, often used in medicine, materials and other fields. Its market value depends primarily on the situation of supply and demand. If at some point, the pharmaceutical R & D industry needs it very much, and the demand exceeds the supply, the price will rise; on the contrary, if there are many products, but there are few people using it, and the supply exceeds the demand, the price will decline.
Second, the cost of its production is also the key. The price of raw materials, the production process, the amount of energy consumption, etc., all affect the cost. If the raw materials are rare and expensive, or the production process is complicated and laborious, the cost will be high, and the market price will also be high; if the raw materials are easy to cause, the process is advanced, the cost will drop, and the price will fall accordingly.
Furthermore, the competitive situation of the market cannot be ignored. If there are many businesses and intense competition between the two, each wants to win by price, and the price may be lowered; if there are few operators, it is almost a monopoly, and the price may be higher.
In addition, changes in the current situation and policy regulations also affect the price. Such as tariff adjustment, environmental protection regulations, etc., can change the cost and supply and demand, resulting in fluctuations in the price.
Therefore, in order to know the current market price of (4-cyanobenzyl) pyridine-2-carbonylbenzonitrile, it is necessary to carefully observe the supply and demand of the market, the cost of nuclear production, understand the state of competition, and pay attention to changes in the current situation and policy. It is difficult to say in a word that it refers to a certain price.
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