Linshang Chemical
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1,5-Dibromo-2-Chloro-3-Fluorobenzene
Linshang Chemical
|
HS Code |
184755 |
| Chemical Formula | C6H2Br2ClF |
| Molar Mass | 289.34 g/mol |
| Appearance | Solid (predicted, based on similar halogenated benzenes) |
| Density | Estimated around 2.0 - 2.5 g/cm³ (comparable to other poly - halogenated benzenes) |
| Solubility In Water | Very low, likely less than 0.1 g/L (hydrophobic due to halogen substitution) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, toluene |
| Vapor Pressure | Low, as it is a relatively high - molecular - weight halogenated aromatic compound |
| Stability | Stable under normal conditions, but can react under strong reducing or oxidizing agents |
As an accredited 1,5-Dibromo-2-Chloro-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1,5 - dibromo - 2 - chloro - 3 - fluorobenzene packaged in a sealed glass bottle. |
| Storage | 1,5 - Dibromo - 2 - chloro - 3 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to avoid potential reactions. |
| Shipping | 1,5 - dibromo - 2 - chloro - 3 - fluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported via regulated freight services, ensuring compliance with chemical shipping safety regulations to prevent leakage and ensure safe transit. |
Competitive 1,5-Dibromo-2-Chloro-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 1,5-dibromo-2-chloro-3-fluorobenzene?
1% 2C5-dibromo-2-fluoro-3-chloropyridine is a kind of organic compound. Its physical properties are particularly important, and it is related to the properties of this compound in various environments and chemical reactions.
In terms of its physical state, it is mostly solid at room temperature and pressure. Due to the strong intermolecular force, the molecules are closely arranged to form a stable solid structure. The determination of its melting point can be used as a key indicator for discrimination and purity evaluation. After experimental investigation, its melting point is roughly within a specific temperature range, which varies slightly due to the purity of the compound and experimental conditions.
Its solubility shows different degrees of solubility in organic solvents. For example, in common polar organic solvents, such as dichloromethane, N, N-dimethylformamide, it can be well dissolved. Due to the existence of intermolecular forces between the molecular structure of the compound and the polar organic solvent molecules, such as hydrogen bonds, van der Waals forces, etc., it promotes the interaction and dissolution of the compound. However, in water, its solubility is poor, and the hydrogen bond network between water molecules is difficult to accept due to the poor matching of the molecular polarity and the polarity of water molecules.
Its density is also an important physical property. After precise measurement, its density value can be known. This value is helpful to consider its distribution in the mixed system, and is also of great significance to the design of related chemical processes.
In addition, the color state of the compound is usually white to light yellow solid, and this color characteristic may be affected by electronic transitions and impurities in its molecular structure. Its appearance can be the basis for preliminary identification, and during storage and use, color changes may also suggest changes in chemical properties.
All these physical properties play a key role in the synthesis, separation, purification and application of the compound, and researchers and producers must consider them carefully.
In terms of its physical state, it is mostly solid at room temperature and pressure. Due to the strong intermolecular force, the molecules are closely arranged to form a stable solid structure. The determination of its melting point can be used as a key indicator for discrimination and purity evaluation. After experimental investigation, its melting point is roughly within a specific temperature range, which varies slightly due to the purity of the compound and experimental conditions.
Its solubility shows different degrees of solubility in organic solvents. For example, in common polar organic solvents, such as dichloromethane, N, N-dimethylformamide, it can be well dissolved. Due to the existence of intermolecular forces between the molecular structure of the compound and the polar organic solvent molecules, such as hydrogen bonds, van der Waals forces, etc., it promotes the interaction and dissolution of the compound. However, in water, its solubility is poor, and the hydrogen bond network between water molecules is difficult to accept due to the poor matching of the molecular polarity and the polarity of water molecules.
Its density is also an important physical property. After precise measurement, its density value can be known. This value is helpful to consider its distribution in the mixed system, and is also of great significance to the design of related chemical processes.
In addition, the color state of the compound is usually white to light yellow solid, and this color characteristic may be affected by electronic transitions and impurities in its molecular structure. Its appearance can be the basis for preliminary identification, and during storage and use, color changes may also suggest changes in chemical properties.
All these physical properties play a key role in the synthesis, separation, purification and application of the compound, and researchers and producers must consider them carefully.
What are the chemical properties of 1,5-dibromo-2-chloro-3-fluorobenzene?
1% 2C5-dibromo-2-chloro-3-iodobenzoic acid, which is an organic halogenated compound with unique chemical properties.
Its chemical activity is quite high. Due to the existence of bromine, chlorine, iodine and other halogen atoms in the molecule, the halogen atom is highly electronegative, resulting in strong polarity of C-X (X is a halogen atom) bonds, making the molecule prone to nucleophilic substitution reactions. In case of nucleophilic reagents, halogen atoms can be replaced by nucleophilic groups. This reaction is often used in organic synthesis to construct new carbon-heteroatom bonds, laying the foundation for the preparation of various organic compounds.
And because it contains multiple halogen atoms, it can participate in the elimination reaction. Under suitable conditions, the halogen and hydrogen atoms on adjacent carbon atoms can be removed to form unsaturated compounds containing carbon-carbon double bonds or triple bonds. This process is of great significance for the synthesis of organic molecules with specific structures and functions.
In addition, the compound has an effect on the electron cloud density distribution of the benzene ring due to the electronic effect of the halogen atom, which in turn changes the activity and selectivity of the electrophilic substitution reaction of the benzene ring. The electron-absorbing induction effect of the halogen atom reduces the electron cloud density of the benzene ring, weakens the activity of the electrophilic substitution reaction, and the reaction conditions may be more severe. However, different halogen atoms have different localization effects on the benzene ring. In the electrophilic substitution reaction, the substituent can be guided into the specific position of the benz
This compound is widely used in the field of organic synthesis, and can be used as an intermediate to synthesize complex organic molecules through a series of reactions. It plays a key role in many fields such as medicinal chemistry and materials science.
Its chemical activity is quite high. Due to the existence of bromine, chlorine, iodine and other halogen atoms in the molecule, the halogen atom is highly electronegative, resulting in strong polarity of C-X (X is a halogen atom) bonds, making the molecule prone to nucleophilic substitution reactions. In case of nucleophilic reagents, halogen atoms can be replaced by nucleophilic groups. This reaction is often used in organic synthesis to construct new carbon-heteroatom bonds, laying the foundation for the preparation of various organic compounds.
And because it contains multiple halogen atoms, it can participate in the elimination reaction. Under suitable conditions, the halogen and hydrogen atoms on adjacent carbon atoms can be removed to form unsaturated compounds containing carbon-carbon double bonds or triple bonds. This process is of great significance for the synthesis of organic molecules with specific structures and functions.
In addition, the compound has an effect on the electron cloud density distribution of the benzene ring due to the electronic effect of the halogen atom, which in turn changes the activity and selectivity of the electrophilic substitution reaction of the benzene ring. The electron-absorbing induction effect of the halogen atom reduces the electron cloud density of the benzene ring, weakens the activity of the electrophilic substitution reaction, and the reaction conditions may be more severe. However, different halogen atoms have different localization effects on the benzene ring. In the electrophilic substitution reaction, the substituent can be guided into the specific position of the benz
This compound is widely used in the field of organic synthesis, and can be used as an intermediate to synthesize complex organic molecules through a series of reactions. It plays a key role in many fields such as medicinal chemistry and materials science.
What are the common methods for synthesizing 1,5-dibromo-2-chloro-3-fluorobenzene?
The common synthesis method of 1% 2C5-dibromo-2-chloro-3-iodobenzoic acid involves many delicate chemical techniques. In the past, Fang family followed the classical organic synthesis method to produce this product.
One method is based on benzoic acid and borrows the technique of halogenation. The method of bromination is first applied, and the benzoic acid is placed in a suitable reaction environment. Under the condition of heating or light, the bromine atom is selectively attached to the 1% 2C5 position of the benzene ring to obtain 1% 2C5-dibromobenzoic acid. The key to this step is to precisely control the temperature, dosage, and reaction time, so as to ensure that the bromination position is accurate, and to prevent excessive bromination from generating heterogeneous side products.
Next, chlorine atoms are introduced. React with 1% 2C5-dibromobenzoic acid in a suitable chlorination reagent, such as thionyl chloride or phosphorus oxychloride, in a specific solvent, such as dichloromethane or N, N-dimethylformamide, so that the chlorine atom occupies 2 positions. This process requires attention to the nature of the solvent and the acid-base environment of the reaction, which are all related to the rate of the chlorination reaction and the purity of the product.
Finally, to add iodine atoms, iodide, such as potassium iodide or iodine elemental substance, is often used, accompanied by appropriate oxidation reagents, such as hydrogen peroxide or potassium persulfate, in a suitable buffer system, so that the iodine atoms fall into 3 positions, and finally 1% 2C5-dibromo-2-chloro-3-iodobenzoic acid is obtained. The key to this stage lies in the amount of oxidation reagents. Too much can easily cause excessive oxidation of iodine atoms, and too little can make the reaction difficult to complete.
There are other methods, or starting from other derivatives of benzene ring, through multi-step conversion and modification of functional groups, this purpose can also be achieved. However, no matter what method is used, it is necessary to study the mechanism of the reaction carefully and observe the conditions of each step in order to obtain pure 1% 2C5-dibromo-2-chloro-3-iodobenzoic acid for scientific research, medicine and other purposes.
One method is based on benzoic acid and borrows the technique of halogenation. The method of bromination is first applied, and the benzoic acid is placed in a suitable reaction environment. Under the condition of heating or light, the bromine atom is selectively attached to the 1% 2C5 position of the benzene ring to obtain 1% 2C5-dibromobenzoic acid. The key to this step is to precisely control the temperature, dosage, and reaction time, so as to ensure that the bromination position is accurate, and to prevent excessive bromination from generating heterogeneous side products.
Next, chlorine atoms are introduced. React with 1% 2C5-dibromobenzoic acid in a suitable chlorination reagent, such as thionyl chloride or phosphorus oxychloride, in a specific solvent, such as dichloromethane or N, N-dimethylformamide, so that the chlorine atom occupies 2 positions. This process requires attention to the nature of the solvent and the acid-base environment of the reaction, which are all related to the rate of the chlorination reaction and the purity of the product.
Finally, to add iodine atoms, iodide, such as potassium iodide or iodine elemental substance, is often used, accompanied by appropriate oxidation reagents, such as hydrogen peroxide or potassium persulfate, in a suitable buffer system, so that the iodine atoms fall into 3 positions, and finally 1% 2C5-dibromo-2-chloro-3-iodobenzoic acid is obtained. The key to this stage lies in the amount of oxidation reagents. Too much can easily cause excessive oxidation of iodine atoms, and too little can make the reaction difficult to complete.
There are other methods, or starting from other derivatives of benzene ring, through multi-step conversion and modification of functional groups, this purpose can also be achieved. However, no matter what method is used, it is necessary to study the mechanism of the reaction carefully and observe the conditions of each step in order to obtain pure 1% 2C5-dibromo-2-chloro-3-iodobenzoic acid for scientific research, medicine and other purposes.
In what fields is 1,5-dibromo-2-chloro-3-fluorobenzene used?
1% 2C5-dibromo-2-fluoro-3-chloropyridine is used in the fields of chemical industry, medicine and pesticides.
In the chemical industry, it is a key intermediate in organic synthesis. It can interact with many reagents through various chemical reactions to construct organic compounds with more complex structures. The special functional groups of this compound can enable the reaction to proceed in a specific direction, assisting chemists in accurately creating the required molecular structure. It may play an important role in the research and development of new materials and lay the foundation for the preparation of polymer materials and functional materials with special properties.
In the field of medicine, its application is also quite wide. Due to the presence of specific halogen atoms, it can affect the physicochemical properties and biological activities of drug molecules. Or it can participate in the design and synthesis of drug molecules to develop new therapeutic drugs. For example, after modification, it can enhance the affinity and selectivity of drugs to specific targets, enhance drug efficacy, and reduce toxic and side effects. In the research and development of antibacterial, antiviral, and anti-tumor drugs, it may be a potentially important raw material.
In the field of pesticides, 1% 2C5-dibromo-2-fluoro-3-chloropyridine can be used as a starting material for the creation of new pesticides. Its halogenated structure endows the molecule with unique chemical and biological activities, or it can be used to synthesize high-efficiency, low-toxicity, and environmentally friendly pesticide products. It can effectively kill pests, control diseases, ensure the growth and yield of crops, and has relatively little adverse impact on the environment, meeting the current needs of green agriculture development.
In the chemical industry, it is a key intermediate in organic synthesis. It can interact with many reagents through various chemical reactions to construct organic compounds with more complex structures. The special functional groups of this compound can enable the reaction to proceed in a specific direction, assisting chemists in accurately creating the required molecular structure. It may play an important role in the research and development of new materials and lay the foundation for the preparation of polymer materials and functional materials with special properties.
In the field of medicine, its application is also quite wide. Due to the presence of specific halogen atoms, it can affect the physicochemical properties and biological activities of drug molecules. Or it can participate in the design and synthesis of drug molecules to develop new therapeutic drugs. For example, after modification, it can enhance the affinity and selectivity of drugs to specific targets, enhance drug efficacy, and reduce toxic and side effects. In the research and development of antibacterial, antiviral, and anti-tumor drugs, it may be a potentially important raw material.
In the field of pesticides, 1% 2C5-dibromo-2-fluoro-3-chloropyridine can be used as a starting material for the creation of new pesticides. Its halogenated structure endows the molecule with unique chemical and biological activities, or it can be used to synthesize high-efficiency, low-toxicity, and environmentally friendly pesticide products. It can effectively kill pests, control diseases, ensure the growth and yield of crops, and has relatively little adverse impact on the environment, meeting the current needs of green agriculture development.
What are the precautions in the preparation of 1,5-dibromo-2-chloro-3-fluorobenzene?
When preparing 1,5-dibromo-2-chloro-3-fluorobenzene, all precautions must be kept in mind.
The starting material needs to be carefully selected, the purity must be up to standard, impurities are mixed, and the reaction must be skewed and the product is impure. When weighing, it is accurate to the millimeter, the balance check is correct, the dosage is correct, and the reaction can proceed as expected.
The choice of reaction solvent is a matter of success or failure. Consider the reaction characteristics, substrate solubility and reaction conditions, and choose the appropriate solvent. Its properties affect the reaction rate and selectivity, and should not be ignored.
The amount of catalyst is appropriate. Many reactions are too fast and difficult to control; few are slow and time-consuming. Temperature control is also critical, either high or low, can cause side reactions, and the yield and purity of the product are damaged. Monitor with a precise thermometer, adjust it with a temperature control device, and keep the reaction at a suitable temperature.
During the reaction process, close monitoring should not be slack. Or use thin-layer chromatography, gas chromatography, etc. to know the degree of reaction. After reaching expectations, stop in time to avoid overreaction.
Separation and purification stage, the technical method is appropriate. Extraction, distillation, column chromatography, etc., selected according to the characteristics of the product. The operation is delicate to avoid product loss and secondary pollution.
The protective measures are comprehensive, and this compound is toxic and corrosive. The experimenter operates in a well-ventilated place in front of protective clothing, gloves and goggles. The waste is handled according to regulations to ensure environmental safety. In this way, the process of preparing 1,5-dibromo-2-chloro-3-fluorobenzene can obtain a pure product, which meets the experimental expectations.
The starting material needs to be carefully selected, the purity must be up to standard, impurities are mixed, and the reaction must be skewed and the product is impure. When weighing, it is accurate to the millimeter, the balance check is correct, the dosage is correct, and the reaction can proceed as expected.
The choice of reaction solvent is a matter of success or failure. Consider the reaction characteristics, substrate solubility and reaction conditions, and choose the appropriate solvent. Its properties affect the reaction rate and selectivity, and should not be ignored.
The amount of catalyst is appropriate. Many reactions are too fast and difficult to control; few are slow and time-consuming. Temperature control is also critical, either high or low, can cause side reactions, and the yield and purity of the product are damaged. Monitor with a precise thermometer, adjust it with a temperature control device, and keep the reaction at a suitable temperature.
During the reaction process, close monitoring should not be slack. Or use thin-layer chromatography, gas chromatography, etc. to know the degree of reaction. After reaching expectations, stop in time to avoid overreaction.
Separation and purification stage, the technical method is appropriate. Extraction, distillation, column chromatography, etc., selected according to the characteristics of the product. The operation is delicate to avoid product loss and secondary pollution.
The protective measures are comprehensive, and this compound is toxic and corrosive. The experimenter operates in a well-ventilated place in front of protective clothing, gloves and goggles. The waste is handled according to regulations to ensure environmental safety. In this way, the process of preparing 1,5-dibromo-2-chloro-3-fluorobenzene can obtain a pure product, which meets the experimental expectations.
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