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1,5-Dichloro-3-Fluoro-2-(4-Nitrophenoxy)Benzene
Linshang Chemical
|
HS Code |
640217 |
| Chemical Formula | C12H6Cl2FNO3 |
| Molar Mass | 304.086 g/mol |
| Appearance | Solid (usually) |
| Physical State At Room Temperature | Solid |
| Melting Point | Data - specific value needed |
| Boiling Point | Data - specific value needed |
| Solubility In Water | Low (expected, due to non - polar nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Data - specific value needed |
| Vapor Pressure | Low (expected for a solid at room temperature) |
| Flash Point | Data - specific value needed |
| Chemical Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1,5-Dichloro-3-Fluoro-2-(4-Nitrophenoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1,5 - Dichloro - 3 - fluoro - 2 - (4 - nitrophenoxy)benzene, 500g, packed in a sealed plastic - lined carton. |
| Storage | 1,5 - Dichloro - 3 - fluoro - 2 - (4 - nitrophenoxy)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of heat, ignition, and incompatible substances like strong oxidizers. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially affect its chemical stability. |
| Shipping | 1,5 - dichloro - 3 - fluoro - 2 - (4 - nitrophenoxy)benzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and secure handling during transit. |
Competitive 1,5-Dichloro-3-Fluoro-2-(4-Nitrophenoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Where to Buy 1,5-Dichloro-3-Fluoro-2-(4-Nitrophenoxy)Benzene in China?
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As a leading 1,5-Dichloro-3-Fluoro-2-(4-Nitrophenoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1,5-dichloro-3-fluoro-2 - (4-nitrophenoxy) benzene?
1% 2C5 + - + dioxy-3-alkane-2- (4-aminophenoxy) benzene, this substance was not recorded in the era covered by Tiangong Kaiwu, but from today's scientific perspective, its use is quite extensive.
In the field of materials science, due to the unique chemical structure of this compound, it can be used as a monomer for high-performance polymer synthesis. Through carefully designed polymerization reactions, polymer materials with excellent mechanical properties, thermal stability and chemical stability can be prepared. In industries with strict material performance requirements such as aerospace and automotive manufacturing, such materials can meet their high performance requirements for components.
In the field of medicinal chemistry, because it contains specific functional groups, or has potential biological activities. Scientists can use it as a lead compound to conduct in-depth research, and through structural modification and optimization, develop new drug molecules. It may act on specific biological targets for disease treatment, such as anti-tumor, anti-inflammatory and other fields, and contribute to human health.
In the field of organic synthetic chemistry, this compound can act as a key intermediate and participate in the construction of complex organic molecules. Chemists can use a variety of organic reactions, such as nucleophilic substitution, coupling reactions, etc., to build various organic compounds with novel structures, expand the boundaries of organic synthetic chemistry, and provide a rich material basis for the development of new materials and new drugs.
In the field of materials science, due to the unique chemical structure of this compound, it can be used as a monomer for high-performance polymer synthesis. Through carefully designed polymerization reactions, polymer materials with excellent mechanical properties, thermal stability and chemical stability can be prepared. In industries with strict material performance requirements such as aerospace and automotive manufacturing, such materials can meet their high performance requirements for components.
In the field of medicinal chemistry, because it contains specific functional groups, or has potential biological activities. Scientists can use it as a lead compound to conduct in-depth research, and through structural modification and optimization, develop new drug molecules. It may act on specific biological targets for disease treatment, such as anti-tumor, anti-inflammatory and other fields, and contribute to human health.
In the field of organic synthetic chemistry, this compound can act as a key intermediate and participate in the construction of complex organic molecules. Chemists can use a variety of organic reactions, such as nucleophilic substitution, coupling reactions, etc., to build various organic compounds with novel structures, expand the boundaries of organic synthetic chemistry, and provide a rich material basis for the development of new materials and new drugs.
What are the synthesis methods of 1,5-dichloro-3-fluoro-2 - (4-nitrophenoxy) benzene?
To prepare 1,5-dialdehyde-3-ene-2- (4-cyanophenoxy) benzene, the synthesis method is as follows:
First, a suitable aryl halide and a cyano- containing phenoxy compound are combined by palladium-catalyzed coupling reaction, such as Suzuki coupling or Stille coupling. Suzuki coupling requires the selection of an appropriate aryl boric acid or borate ester and a halogenated aromatic hydrocarbon. Under the action of base and palladium catalyst, the reaction is heated in a suitable solvent such as dioxane, toluene and water mixed system. The reaction conditions are mild, the selectivity is good, and the carbon-carbon bond can be accurately constructed, which lays the foundation for the introduction of cyanophenoxy groups.
Furthermore, for the introduction of alkenyl and aldehyde groups, the Wittig reaction or the Horner-Wadsworth-Emmons reaction can be used. Taking the Wittig reaction as an example, the phosphorus-containing Yellide reagent is first prepared. It reacts with the corresponding carbonyl compound under the action of a base to efficiently generate a carbon-carbon double bond and skillfully introduce an aldehyde group. If the Horner-Wadsworth-Emmons reaction is selected, the reaction conditions are relatively mild, and the substrate requirements also have their own characteristics, which can achieve the similar purpose of constructing the structure of alkenaldehyde.
Oxidation reaction can also be used to form aldehyde groups. For example, selecting a suitable alcohol substrate and treating it with mild oxidation reagents, such as Dess-Martin oxidant or Swern oxidation system, can oxidize alcohol hydroxyl groups to aldehyde groups, and can better control the reaction selectivity and avoid excessive oxidation to carboxylic acids.
During the entire synthesis process, the reaction sequence needs to be carefully planned, and the interaction and compatibility of each functional group need to be considered. After each step of the reaction, the product should be purified by methods such as column chromatography and recrystallization to ensure the smooth progress of the reaction, and finally the target product 1,5-dialdehyde-3-ene-2 - (4-cyanophenoxy) benzene should be obtained efficiently.
First, a suitable aryl halide and a cyano- containing phenoxy compound are combined by palladium-catalyzed coupling reaction, such as Suzuki coupling or Stille coupling. Suzuki coupling requires the selection of an appropriate aryl boric acid or borate ester and a halogenated aromatic hydrocarbon. Under the action of base and palladium catalyst, the reaction is heated in a suitable solvent such as dioxane, toluene and water mixed system. The reaction conditions are mild, the selectivity is good, and the carbon-carbon bond can be accurately constructed, which lays the foundation for the introduction of cyanophenoxy groups.
Furthermore, for the introduction of alkenyl and aldehyde groups, the Wittig reaction or the Horner-Wadsworth-Emmons reaction can be used. Taking the Wittig reaction as an example, the phosphorus-containing Yellide reagent is first prepared. It reacts with the corresponding carbonyl compound under the action of a base to efficiently generate a carbon-carbon double bond and skillfully introduce an aldehyde group. If the Horner-Wadsworth-Emmons reaction is selected, the reaction conditions are relatively mild, and the substrate requirements also have their own characteristics, which can achieve the similar purpose of constructing the structure of alkenaldehyde.
Oxidation reaction can also be used to form aldehyde groups. For example, selecting a suitable alcohol substrate and treating it with mild oxidation reagents, such as Dess-Martin oxidant or Swern oxidation system, can oxidize alcohol hydroxyl groups to aldehyde groups, and can better control the reaction selectivity and avoid excessive oxidation to carboxylic acids.
During the entire synthesis process, the reaction sequence needs to be carefully planned, and the interaction and compatibility of each functional group need to be considered. After each step of the reaction, the product should be purified by methods such as column chromatography and recrystallization to ensure the smooth progress of the reaction, and finally the target product 1,5-dialdehyde-3-ene-2 - (4-cyanophenoxy) benzene should be obtained efficiently.
What are the physical properties of 1,5-dichloro-3-fluoro-2 - (4-nitrophenoxy) benzene
The physical properties of 1% 2C5-dioxy-3-alkyne-2- (4-cyanophenoxy) benzene are as follows:
In appearance, it is often in the state of white to light yellow crystalline powder. This morphology is easy to recognize by the naked eye. In many chemical reaction systems, this morphology is conducive to its dispersion and participation in the reaction.
The melting point is quite critical, between about 130-135 ° C. As an important physical constant of a substance, the melting point can not only be used to identify the purity of the substance, but also to guide its phase state changes at different temperatures. When it is below the melting point, it is stable in a solid state; when it is near or reaches the melting point, it gradually melts into a liquid state. This property has far-reaching implications in the fields of material processing and preparation.
The solubility of this substance cannot be ignored. It is slightly soluble in water, but soluble in common organic solvents such as dichloromethane, N, N-dimethylformamide, etc. This difference in solubility is due to its molecular structure and polarity. Water molecules are strongly polar, while the molecular polarity of this substance is relatively weak. According to the principle of "similar compatibility", it is difficult to dissolve in water, but easily soluble in organic solvents with similar polarities. This property is conducive to the selection of suitable solvents to promote the reaction in chemical synthesis; in separation and purification, effective separation can be achieved by means of differences in solubility.
In addition, its density is about 1.3 - 1.4g/cm ³, which is of great significance for material measurement, storage and transportation planning. When storing, it is necessary to consider the storage capacity per unit volume according to its density to ensure the security of the storage container; when transporting, the density affects the transportation cost and method choice.
In summary, these physical properties of 1% 2C5 -dioxy-3 -alkynyl-2 - (4 -cyanophenoxy) benzene are indispensable basic information in chemical research, industrial production and related application fields, and profoundly affect various operations and processes related to them.
In appearance, it is often in the state of white to light yellow crystalline powder. This morphology is easy to recognize by the naked eye. In many chemical reaction systems, this morphology is conducive to its dispersion and participation in the reaction.
The melting point is quite critical, between about 130-135 ° C. As an important physical constant of a substance, the melting point can not only be used to identify the purity of the substance, but also to guide its phase state changes at different temperatures. When it is below the melting point, it is stable in a solid state; when it is near or reaches the melting point, it gradually melts into a liquid state. This property has far-reaching implications in the fields of material processing and preparation.
The solubility of this substance cannot be ignored. It is slightly soluble in water, but soluble in common organic solvents such as dichloromethane, N, N-dimethylformamide, etc. This difference in solubility is due to its molecular structure and polarity. Water molecules are strongly polar, while the molecular polarity of this substance is relatively weak. According to the principle of "similar compatibility", it is difficult to dissolve in water, but easily soluble in organic solvents with similar polarities. This property is conducive to the selection of suitable solvents to promote the reaction in chemical synthesis; in separation and purification, effective separation can be achieved by means of differences in solubility.
In addition, its density is about 1.3 - 1.4g/cm ³, which is of great significance for material measurement, storage and transportation planning. When storing, it is necessary to consider the storage capacity per unit volume according to its density to ensure the security of the storage container; when transporting, the density affects the transportation cost and method choice.
In summary, these physical properties of 1% 2C5 -dioxy-3 -alkynyl-2 - (4 -cyanophenoxy) benzene are indispensable basic information in chemical research, industrial production and related application fields, and profoundly affect various operations and processes related to them.
What are the chemical properties of 1,5-dichloro-3-fluoro-2- (4-nitrophenoxy) benzene
1% 2C5-dioxy-3-alkyne-2- (4-aminophenoxy) benzene. The chemical properties of this compound are quite complex. It has aromatic properties and is due to the existence of the benzene ring structure. The benzene ring is a stable conjugated system, resulting in certain thermal and chemical stability.
The compound contains a dioxy structure, which affects its electron cloud distribution and reactivity. The high electronegativity of oxygen atoms makes the surrounding electron cloud biased, causing the charge distribution of neighboring atoms to change, which is unique in nucleophilic and electrophilic reactions. The introduction of
3-alkynyl groups adds active reaction check points to molecules. The alkynyl group is unsaturated and can undergo addition reactions, such as addition with hydrogen, halogen, hydrogen halide and other electrophilic reagents. This addition reaction condition is related to the electron cloud density of the alkynyl group and the surrounding groups.
2- (4-aminophenoxy) moiety, the amino group is the power supply sub-group, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. Oxygen atoms in the phenoxy group also participate in electron conjugation, which affects the activity of the benzene ring.
In summary, 1% 2C5-dioxy-3-alkyne-2 - (4-aminophenoxy) benzene contains a variety of special structures, which have chemical properties such as thermal stability, unsaturated addition reaction activity and benzene ring electrophilic substitution reaction activity. It may have important applications in organic synthesis and medicinal chemistry.
The compound contains a dioxy structure, which affects its electron cloud distribution and reactivity. The high electronegativity of oxygen atoms makes the surrounding electron cloud biased, causing the charge distribution of neighboring atoms to change, which is unique in nucleophilic and electrophilic reactions. The introduction of
3-alkynyl groups adds active reaction check points to molecules. The alkynyl group is unsaturated and can undergo addition reactions, such as addition with hydrogen, halogen, hydrogen halide and other electrophilic reagents. This addition reaction condition is related to the electron cloud density of the alkynyl group and the surrounding groups.
2- (4-aminophenoxy) moiety, the amino group is the power supply sub-group, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. Oxygen atoms in the phenoxy group also participate in electron conjugation, which affects the activity of the benzene ring.
In summary, 1% 2C5-dioxy-3-alkyne-2 - (4-aminophenoxy) benzene contains a variety of special structures, which have chemical properties such as thermal stability, unsaturated addition reaction activity and benzene ring electrophilic substitution reaction activity. It may have important applications in organic synthesis and medicinal chemistry.
What are the precautions for the use of 1,5-dichloro-3-fluoro-2 - (4-nitrophenoxy) benzene?
1% 2C5-dioxy-3-ene-2- (4-aminophenoxy) benzene requires attention to many key matters during use.
First, this substance has specific chemical activity. When storing, be sure to ensure that the environment is dry and cool. Because it may react with humid air and moisture, causing its chemical properties to change, it should be stored in a well-sealed container, away from water sources and moisture.
Second, protective measures are indispensable when using. Because of its chemical structure characteristics, or potential hazards such as sensitization and irritation to the human body. Wear suitable protective equipment during operation, such as protective gloves, goggles and protective clothing, to prevent skin contact and eye splashing. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the specific situation.
Third, in view of its chemical properties, the use environment should be well ventilated. Avoid use in closed, airless places to prevent the accumulation of volatile gases and cause safety problems such as poisoning. Excellent ventilation conditions can disperse volatile substances in time and maintain the air quality of the operating environment.
Fourth, the operation process should strictly follow the established norms and procedures. Precisely control the dosage and reaction conditions. Due to improper dosage or deviation of reaction conditions, not only the expected effect will be affected, but also unexpected chemical reactions may be triggered, such as violent reactions, explosions, etc.
Fifth, this compound should be fully understood before mixing or reacting with other chemical substances. Blind mixing or cause uncontrollable chemical reactions, produce harmful substances or damage experimental equipment.
Finally, after use, properly dispose of the remaining substances and waste. Follow relevant environmental protection and safety regulations, and do not discard at will to avoid polluting the environment or causing safety hazards.
In short, when using 1% 2C5-dioxy-3-ene-2- (4-aminophenoxy) benzene, careful operation, strict protection, and compliance with regulations can ensure the safety of personnel, the smooth progress of experiments and production.
First, this substance has specific chemical activity. When storing, be sure to ensure that the environment is dry and cool. Because it may react with humid air and moisture, causing its chemical properties to change, it should be stored in a well-sealed container, away from water sources and moisture.
Second, protective measures are indispensable when using. Because of its chemical structure characteristics, or potential hazards such as sensitization and irritation to the human body. Wear suitable protective equipment during operation, such as protective gloves, goggles and protective clothing, to prevent skin contact and eye splashing. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the specific situation.
Third, in view of its chemical properties, the use environment should be well ventilated. Avoid use in closed, airless places to prevent the accumulation of volatile gases and cause safety problems such as poisoning. Excellent ventilation conditions can disperse volatile substances in time and maintain the air quality of the operating environment.
Fourth, the operation process should strictly follow the established norms and procedures. Precisely control the dosage and reaction conditions. Due to improper dosage or deviation of reaction conditions, not only the expected effect will be affected, but also unexpected chemical reactions may be triggered, such as violent reactions, explosions, etc.
Fifth, this compound should be fully understood before mixing or reacting with other chemical substances. Blind mixing or cause uncontrollable chemical reactions, produce harmful substances or damage experimental equipment.
Finally, after use, properly dispose of the remaining substances and waste. Follow relevant environmental protection and safety regulations, and do not discard at will to avoid polluting the environment or causing safety hazards.
In short, when using 1% 2C5-dioxy-3-ene-2- (4-aminophenoxy) benzene, careful operation, strict protection, and compliance with regulations can ensure the safety of personnel, the smooth progress of experiments and production.
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