Linshang Chemical
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1-Benzyl-4-Chlorobenzene
Linshang Chemical
|
HS Code |
377339 |
| Chemical Formula | C14H13Cl |
| Molecular Weight | 216.706 g/mol |
| Appearance | Solid (presumed, typical for aromatic compounds) |
| Odor | Aromatic odor (expected due to benzene rings) |
| Solubility In Water | Low solubility (hydrophobic due to non - polar aromatic structure) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, toluene |
| Stability | Stable under normal conditions, but can react under strong oxidizing or reducing agents |
As an accredited 1-Benzyl-4-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - benzyl - 4 - chlorobenzene packaged in 1 - kg containers. |
| Storage | 1 - benzyl - 4 - chlorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be placed in a tightly sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents, acids, and bases to avoid potential chemical reactions. Keep the storage area out of reach of children and unauthorized personnel. |
| Shipping | 1 - benzyl - 4 - chlorobenzene should be shipped in tightly - sealed containers, compliant with chemical transport regulations. Ensure proper labeling for identification and safety. Ship via carriers experienced in handling such chemicals, with precautions against spills and exposure. |
Competitive 1-Benzyl-4-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 1-benzyl-4-chlorobenzene?
1-Benzyl-4-chlorobenzene is 1-benzyl-4-chlorobenzene, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique chemical structure, it can participate in many organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Through these reactions, many organic compounds with specific functions and structures can be synthesized. In the field of medicinal chemistry, it can be used to prepare drug molecules with specific biological activities, laying the foundation for the creation of new drugs.
In the field of materials science, 1-benzyl-4-chlorobenzene also plays an important role. After a series of chemical reactions, it can be introduced into the structure of polymer materials, thereby changing the properties of the materials, such as improving the solubility, thermal stability and mechanical properties of the materials. In this way, high-performance materials suitable for different scenarios can be prepared, such as special materials used in electronic devices, aerospace and other fields.
Furthermore, in the production of fine chemical products, 1-benzyl-4-chlorobenzene is also indispensable. It can be used to synthesize fine chemicals such as fragrances and dyes, giving the product a unique color and aroma, and enhancing the added value and market competitiveness of the product.
In conclusion, 1-benzyl-4-chlorobenzene has had a profound impact on the development of the modern chemical industry due to its wide range of uses in organic synthesis, materials science, and fine chemicals, and has made remarkable achievements in promoting technological progress and product innovation in various related fields.
In the field of materials science, 1-benzyl-4-chlorobenzene also plays an important role. After a series of chemical reactions, it can be introduced into the structure of polymer materials, thereby changing the properties of the materials, such as improving the solubility, thermal stability and mechanical properties of the materials. In this way, high-performance materials suitable for different scenarios can be prepared, such as special materials used in electronic devices, aerospace and other fields.
Furthermore, in the production of fine chemical products, 1-benzyl-4-chlorobenzene is also indispensable. It can be used to synthesize fine chemicals such as fragrances and dyes, giving the product a unique color and aroma, and enhancing the added value and market competitiveness of the product.
In conclusion, 1-benzyl-4-chlorobenzene has had a profound impact on the development of the modern chemical industry due to its wide range of uses in organic synthesis, materials science, and fine chemicals, and has made remarkable achievements in promoting technological progress and product innovation in various related fields.
What are the physical properties of 1-benzyl-4-chlorobenzene?
1-Benzyl-4-chlorobenzene is one of the organic compounds. It has unique physical properties and is very important for chemical researchers and industrial applications.
Looking at its appearance, under room temperature and pressure, 1-benzyl-4-chlorobenzene is mostly colorless to light yellow liquid, with a clear texture, which is easy to identify intuitively. Its smell has a specific aromatic smell, but this smell is not pleasant, but a little irritating, so smell it carefully.
When it comes to boiling point, the boiling point of 1-benzyl-4-chlorobenzene is quite high, reaching about 275 ° C. This property allows it to exist in a liquid state in an ordinary high temperature environment, making it difficult to evaporate and dissipate. In industrial processes, if the system containing this substance needs to be heated, it can avoid premature gasification and escape due to its high boiling point, ensuring stable reaction.
As for the melting point, it is about -12 ° C. The lower melting point indicates that this substance is not easy to solidify at room temperature, and has good fluidity. It can flow smoothly in many chemical operations, such as pipeline transportation, mixing and stirring, which is conducive to the efficient operation of the production process.
Its density is also an important property. The relative density is about 1.10 g/cm ³, which is slightly higher than that of water. This density characteristic determines that when it is mixed with water, it will sink to the bottom of the water. When it involves operations such as liquid-liquid separation, this difference facilitates the use of gravity sedimentation to achieve separation from water.
In terms of solubility, 1-benzyl-4-chlorobenzene is insoluble in water. Due to the strong force of forming hydrogen bonds between water molecules, the compound is a non-polar or weakly polar molecule, and the force between water molecules is weak, so it is insoluble. However, in organic solvents, such as ethanol, ether, acetone, etc., its solubility is good, because it is similar to the force between organic solvent molecules, and follows the principle of "similar miscibility". This solubility makes it often used as a reactant or product in organic synthesis reactions, and can be dissolved, separated, and purified by organic solvents.
Looking at its appearance, under room temperature and pressure, 1-benzyl-4-chlorobenzene is mostly colorless to light yellow liquid, with a clear texture, which is easy to identify intuitively. Its smell has a specific aromatic smell, but this smell is not pleasant, but a little irritating, so smell it carefully.
When it comes to boiling point, the boiling point of 1-benzyl-4-chlorobenzene is quite high, reaching about 275 ° C. This property allows it to exist in a liquid state in an ordinary high temperature environment, making it difficult to evaporate and dissipate. In industrial processes, if the system containing this substance needs to be heated, it can avoid premature gasification and escape due to its high boiling point, ensuring stable reaction.
As for the melting point, it is about -12 ° C. The lower melting point indicates that this substance is not easy to solidify at room temperature, and has good fluidity. It can flow smoothly in many chemical operations, such as pipeline transportation, mixing and stirring, which is conducive to the efficient operation of the production process.
Its density is also an important property. The relative density is about 1.10 g/cm ³, which is slightly higher than that of water. This density characteristic determines that when it is mixed with water, it will sink to the bottom of the water. When it involves operations such as liquid-liquid separation, this difference facilitates the use of gravity sedimentation to achieve separation from water.
In terms of solubility, 1-benzyl-4-chlorobenzene is insoluble in water. Due to the strong force of forming hydrogen bonds between water molecules, the compound is a non-polar or weakly polar molecule, and the force between water molecules is weak, so it is insoluble. However, in organic solvents, such as ethanol, ether, acetone, etc., its solubility is good, because it is similar to the force between organic solvent molecules, and follows the principle of "similar miscibility". This solubility makes it often used as a reactant or product in organic synthesis reactions, and can be dissolved, separated, and purified by organic solvents.
What is the chemistry of 1-benzyl-4-chlorobenzene?
1-Benzyl-4-chlorobenzene, which is 1-benzyl-4-chlorobenzene, is one of the organic compounds. Its molecular structure contains a chlorine atom attached to the benzene ring, and the benzene ring has a benzyl group. This compound has unique chemical properties and has a wide range of uses in the field of organic synthesis.
1-benzyl-4-chlorobenzene contains a benzene ring structure. The benzene ring has aromatic properties, which makes the compound chemically stable and not prone to addition reactions, but is prone to electrophilic substitution reactions. For example, because both the chlorine atom and the benzyl group are blunt groups, the electron cloud density of the benzene ring is reduced. When the electrophilic reagent attacks, the substitution reaction mainly occurs in the benzene ring
Furthermore, the benzyl carbon-hydrogen bond in benzyl is relatively active, and under certain conditions, oxidation reactions can occur. For example, under the action of strong oxidants, benzyl can be oxidized to carboxyl groups. At the same time, chlorine atoms can also participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, chlorine atoms can be replaced to form new organic compounds. This property is particularly important in the construction of complex organic molecules.
The chemical properties of 1-benzyl-4-chlorobenzene are determined by their structure. These properties make them show important application value in many fields such as drug synthesis and materials science, and provide key raw materials and intermediates for the synthesis of various organic compounds.
1-benzyl-4-chlorobenzene contains a benzene ring structure. The benzene ring has aromatic properties, which makes the compound chemically stable and not prone to addition reactions, but is prone to electrophilic substitution reactions. For example, because both the chlorine atom and the benzyl group are blunt groups, the electron cloud density of the benzene ring is reduced. When the electrophilic reagent attacks, the substitution reaction mainly occurs in the benzene ring
Furthermore, the benzyl carbon-hydrogen bond in benzyl is relatively active, and under certain conditions, oxidation reactions can occur. For example, under the action of strong oxidants, benzyl can be oxidized to carboxyl groups. At the same time, chlorine atoms can also participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, chlorine atoms can be replaced to form new organic compounds. This property is particularly important in the construction of complex organic molecules.
The chemical properties of 1-benzyl-4-chlorobenzene are determined by their structure. These properties make them show important application value in many fields such as drug synthesis and materials science, and provide key raw materials and intermediates for the synthesis of various organic compounds.
What are 1-benzyl-4-chlorobenzene synthesis methods?
To prepare 1 - benzyl - 4 - chlorobenzene, there are two methods. First, 4 - chlorotoluene and benzyl chloride are used as materials and alkylated by Friedel - Crafts. Prepare a round bottom flask with a stirrer, a condenser and a thermometer. Place anhydrous aluminum trichloride in the flask, protect it with nitrogen, slowly inject dichloromethane as a solvent, and stir to form a homogeneous phase. Add the mixture of 4 - chlorotoluene and benzchloride at a second time, and control the temperature at a low temperature, usually 0 - 10 ° C. Due to the exothermic reaction, it is necessary to slowly add anti-flushing. After adding, heat up to room temperature and continue stirring for a few times. After the reaction is completed, pour in the ice hydrochloric acid solution, break the aluminum complex, divide the organic phase, wash it with water several times to remove impurities, dry it with anhydrous sodium sulfate, filter it and distillate under reduced pressure to obtain the product.
Second, use 4-chlorobenzyl chloride and benzene as materials, and also use Friedel-Crafts alkylation. Before the operation method, put anhydrous aluminum trichloride in the reaction bottle first, add carbon disulfide as a solvent, and stir to dissolve. Add a mixture of 4-chlorobenzyl chloride and benzene, control the temperature to a suitable range, such as 0-20 ° C, and add the temperature to complete the reaction. 1-Benzyl-4-chlorobenzene can be obtained by quenching, liquid separation, water washing, drying and distillation. Both methods rely on the principle of Friedel-Crafts alkylation, and each has its own advantages and disadvantages. The actual operation depends on the factors such as the availability of raw materials, cost and yield.
Second, use 4-chlorobenzyl chloride and benzene as materials, and also use Friedel-Crafts alkylation. Before the operation method, put anhydrous aluminum trichloride in the reaction bottle first, add carbon disulfide as a solvent, and stir to dissolve. Add a mixture of 4-chlorobenzyl chloride and benzene, control the temperature to a suitable range, such as 0-20 ° C, and add the temperature to complete the reaction. 1-Benzyl-4-chlorobenzene can be obtained by quenching, liquid separation, water washing, drying and distillation. Both methods rely on the principle of Friedel-Crafts alkylation, and each has its own advantages and disadvantages. The actual operation depends on the factors such as the availability of raw materials, cost and yield.
What are the precautions in storage and transportation of 1-benzyl-4-chlorobenzene?
1 - benzyl - 4 - chlorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. Cover it with heat and moisture, which can easily cause its properties to change. If it is in a high temperature environment, or causes chemical reactions, it will damage its quality; if it is in a humid atmosphere, it may cause reactions such as hydrolysis and affect its purity. It must be stored separately from oxidizing agents, acids, bases, etc. Because of contact with it, it is easy to react violently or cause danger. Storage containers must be firmly sealed to prevent leakage. The materials used should be selected according to their chemical properties, such as glass, specific plastics, etc., to ensure that they do not react with them.
As for transportation. Before transportation, make sure that the packaging is intact. Packaging materials must be well protected and can withstand external vibrations and collisions. During transportation, the vehicle should be selected to be stable, with a moderate speed, to avoid bumps and sudden braking, and to avoid leakage caused by package damage. The transportation environment also needs to be temperature controlled and moisture-proof. If conditions permit, temperature and humidity monitoring devices can be installed. And transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage and other accidents, they can respond quickly and effectively. If you accidentally leak, do not panic, quickly isolate the scene, evacuate people, and strictly prohibit fire from approaching. Small leaks can be absorbed by inert materials such as sand and vermiculite; for large leaks, embankments or pits need to be built for containment, and then handled according to professional methods. In this way, 1-benzyl-4-chlorobenzene can be safely stored and transported.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. Cover it with heat and moisture, which can easily cause its properties to change. If it is in a high temperature environment, or causes chemical reactions, it will damage its quality; if it is in a humid atmosphere, it may cause reactions such as hydrolysis and affect its purity. It must be stored separately from oxidizing agents, acids, bases, etc. Because of contact with it, it is easy to react violently or cause danger. Storage containers must be firmly sealed to prevent leakage. The materials used should be selected according to their chemical properties, such as glass, specific plastics, etc., to ensure that they do not react with them.
As for transportation. Before transportation, make sure that the packaging is intact. Packaging materials must be well protected and can withstand external vibrations and collisions. During transportation, the vehicle should be selected to be stable, with a moderate speed, to avoid bumps and sudden braking, and to avoid leakage caused by package damage. The transportation environment also needs to be temperature controlled and moisture-proof. If conditions permit, temperature and humidity monitoring devices can be installed. And transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. In case of leakage and other accidents, they can respond quickly and effectively. If you accidentally leak, do not panic, quickly isolate the scene, evacuate people, and strictly prohibit fire from approaching. Small leaks can be absorbed by inert materials such as sand and vermiculite; for large leaks, embankments or pits need to be built for containment, and then handled according to professional methods. In this way, 1-benzyl-4-chlorobenzene can be safely stored and transported.
What are the main uses of 1-benzyl-4-chlorobenzene?
1-Benzyl-4-chlorobenzene is 1-benzyl-4-chlorobenzene, which is widely used.
In the field of organic synthesis, it is an important intermediate. Using it as a starting material, through various chemical reactions, such as substitution reactions, addition reactions, etc., many organic compounds with specific structures and functions can be prepared. For example, by nucleophilic substitution, the chlorine atom on the benzene ring can be replaced by other functional groups, such as hydroxyl, amino, etc., and then compounds with potential biological activities in the fields of medicine and pesticides can be synthesized. In medicinal chemistry, the construction of many drug molecules relies on 1-benzyl-4-chlorobenzene as the basic framework. Through subsequent modifications, drugs can be endowed with better pharmacological properties, such as improving the affinity of drugs to specific targets and enhancing drug efficacy.
In materials science, 1-benzyl-4-chlorobenzene also plays a key role. It can be introduced into the synthesis of polymer materials, and it can be made into a part of the polymer structure by means of polymerization reactions, thereby giving polymer materials unique properties. For example, it can improve the thermal stability, mechanical properties or optical properties of materials. If it is used in the synthesis of special engineering plastics, it can improve the temperature resistance and chemical corrosion resistance of plastics, and broaden the application range of the plastic in extreme environments, such as aerospace, electronics industry and other high-demand fields.
In addition, in the fine chemical industry, 1-benzyl-4-chlorobenzene is often used to produce various fine chemicals, such as fragrances, dyes, etc. In the synthesis of fragrances, by chemically modifying it, a unique aroma of fragrance components can be prepared, adding the type and characteristics of fragrances. In the field of dye synthesis, dyes synthesized from it may have excellent dyeing properties and color stability, and are widely used in textile printing and dyeing and other industries to make fabrics look gorgeous and long-lasting.
In the field of organic synthesis, it is an important intermediate. Using it as a starting material, through various chemical reactions, such as substitution reactions, addition reactions, etc., many organic compounds with specific structures and functions can be prepared. For example, by nucleophilic substitution, the chlorine atom on the benzene ring can be replaced by other functional groups, such as hydroxyl, amino, etc., and then compounds with potential biological activities in the fields of medicine and pesticides can be synthesized. In medicinal chemistry, the construction of many drug molecules relies on 1-benzyl-4-chlorobenzene as the basic framework. Through subsequent modifications, drugs can be endowed with better pharmacological properties, such as improving the affinity of drugs to specific targets and enhancing drug efficacy.
In materials science, 1-benzyl-4-chlorobenzene also plays a key role. It can be introduced into the synthesis of polymer materials, and it can be made into a part of the polymer structure by means of polymerization reactions, thereby giving polymer materials unique properties. For example, it can improve the thermal stability, mechanical properties or optical properties of materials. If it is used in the synthesis of special engineering plastics, it can improve the temperature resistance and chemical corrosion resistance of plastics, and broaden the application range of the plastic in extreme environments, such as aerospace, electronics industry and other high-demand fields.
In addition, in the fine chemical industry, 1-benzyl-4-chlorobenzene is often used to produce various fine chemicals, such as fragrances, dyes, etc. In the synthesis of fragrances, by chemically modifying it, a unique aroma of fragrance components can be prepared, adding the type and characteristics of fragrances. In the field of dye synthesis, dyes synthesized from it may have excellent dyeing properties and color stability, and are widely used in textile printing and dyeing and other industries to make fabrics look gorgeous and long-lasting.
What are the physical properties of 1-benzyl-4-chlorobenzene?
1 - benzyl - 4 - chlorobenzene is also an organic compound. It has unique physical properties, let me tell them one by one.
Looking at its properties, it is mostly a colorless to light yellow liquid under normal conditions, which is determined by its molecular structure. In its molecule, the benzene ring is combined with benzyl and chlorine atoms, resulting in its appearance. And this compound has a special smell, which is not pungent and intolerable, but also has a unique smell, which can be identified by smell.
As for its melting point, it is in a relatively low range. Due to the intermolecular force, although there is a π-π interaction between the benzene rings, the presence of benzyl and chlorine atoms makes the overall molecular arrangement not close and the melting point is not high. Its boiling point is relatively high, because the molecular mass increases and the benzene ring structure is stable. To make it boil, more energy needs to be supplied to overcome the intermolecular force.
In terms of solubility, 1-benzyl-4-chlorobenzene exhibits good solubility in organic solvents, such as ethanol, ether, etc. This is due to the principle of "similarity and miscibility". The molecular structure of its organic and organic solvent molecules is similar, and the two can be miscible through interactions such as van der Waals forces. However, in water, its solubility is very small. Water is a polar molecule, while 1-benzyl-4-chlorobenzene has a weaker polarity, and the polarity difference between the two is large, so it is difficult to dissolve.
Above the density, 1-benzyl-4-chlorobenzene is heavier than water, so if it is mixed with water, it can be seen that it sinks to the bottom of the water. Due to the large relative atomic weight of chlorine atoms in the molecule, the overall density increases.
In addition, the volatility of 1-benzyl-4-chlorobenzene is relatively moderate. Although it is not highly volatile, some molecules will still escape the liquid surface and diffuse in the air under suitable temperatures and environments. This property is related to its boiling point and intermolecular forces.
Looking at its properties, it is mostly a colorless to light yellow liquid under normal conditions, which is determined by its molecular structure. In its molecule, the benzene ring is combined with benzyl and chlorine atoms, resulting in its appearance. And this compound has a special smell, which is not pungent and intolerable, but also has a unique smell, which can be identified by smell.
As for its melting point, it is in a relatively low range. Due to the intermolecular force, although there is a π-π interaction between the benzene rings, the presence of benzyl and chlorine atoms makes the overall molecular arrangement not close and the melting point is not high. Its boiling point is relatively high, because the molecular mass increases and the benzene ring structure is stable. To make it boil, more energy needs to be supplied to overcome the intermolecular force.
In terms of solubility, 1-benzyl-4-chlorobenzene exhibits good solubility in organic solvents, such as ethanol, ether, etc. This is due to the principle of "similarity and miscibility". The molecular structure of its organic and organic solvent molecules is similar, and the two can be miscible through interactions such as van der Waals forces. However, in water, its solubility is very small. Water is a polar molecule, while 1-benzyl-4-chlorobenzene has a weaker polarity, and the polarity difference between the two is large, so it is difficult to dissolve.
Above the density, 1-benzyl-4-chlorobenzene is heavier than water, so if it is mixed with water, it can be seen that it sinks to the bottom of the water. Due to the large relative atomic weight of chlorine atoms in the molecule, the overall density increases.
In addition, the volatility of 1-benzyl-4-chlorobenzene is relatively moderate. Although it is not highly volatile, some molecules will still escape the liquid surface and diffuse in the air under suitable temperatures and environments. This property is related to its boiling point and intermolecular forces.
What is the chemistry of 1-benzyl-4-chlorobenzene?
1-Benzyl-4-chlorobenzene is one of the organic compounds. Its chemical properties are unique and have the commonality of aromatics. Its molecular structure contains a benzene ring.
In this compound, the electron cloud of the benzyl ring has a conjugation effect, which makes its chemical activity different from that of ordinary alkanes. Benzyl group and chlorine atom are connected to the benzene ring, which has a significant impact on the electron cloud distribution of the benzene ring. Benzyl group is the power supply group, which can increase the density of the electron cloud of the ortho and para-position of the benzene ring. Although the chlorine atom has an electron-withdrawing induction effect, the conjugation of its lone pair electrons with the benzene ring also affects the activity check point of the benzene ring reaction.
As far as the electrophilic substitution reaction is concerned, 1-benzyl-4-chlorobenzene is more likely to occur than benzene. Because of its benzyl power supply, the electron cloud density of the benzene ring increases, and the electrophilic reagents are more likely to attack the benzene ring. And under the influence of benzyl, the reaction mainly occurs in the adjacent and para-position of benzyl. However, the presence of chlorine atoms also plays a role in the selectivity of the reaction area, or makes the selection of the reaction check point more complicated.
In the oxidation reaction, the α-hydrogen of benzyl group has a certain activity and can be oxidized. For example, under the action of appropriate oxidizing agents, benzyl can be oxidized At the same time, because the chlorine atom is connected to the benzene ring, under certain conditions, the nucleophilic substitution reaction may occur, and the chlorine atom is replaced by other nucleophilic reagents.
The chemical properties of 1-benzyl-4-chlorobenzene are determined by its molecular structure. The interaction between the benzyl ring and the benzyl group and the chlorine atom makes it have unique uses and reactivity in organic synthesis and other fields.
In this compound, the electron cloud of the benzyl ring has a conjugation effect, which makes its chemical activity different from that of ordinary alkanes. Benzyl group and chlorine atom are connected to the benzene ring, which has a significant impact on the electron cloud distribution of the benzene ring. Benzyl group is the power supply group, which can increase the density of the electron cloud of the ortho and para-position of the benzene ring. Although the chlorine atom has an electron-withdrawing induction effect, the conjugation of its lone pair electrons with the benzene ring also affects the activity check point of the benzene ring reaction.
As far as the electrophilic substitution reaction is concerned, 1-benzyl-4-chlorobenzene is more likely to occur than benzene. Because of its benzyl power supply, the electron cloud density of the benzene ring increases, and the electrophilic reagents are more likely to attack the benzene ring. And under the influence of benzyl, the reaction mainly occurs in the adjacent and para-position of benzyl. However, the presence of chlorine atoms also plays a role in the selectivity of the reaction area, or makes the selection of the reaction check point more complicated.
In the oxidation reaction, the α-hydrogen of benzyl group has a certain activity and can be oxidized. For example, under the action of appropriate oxidizing agents, benzyl can be oxidized At the same time, because the chlorine atom is connected to the benzene ring, under certain conditions, the nucleophilic substitution reaction may occur, and the chlorine atom is replaced by other nucleophilic reagents.
The chemical properties of 1-benzyl-4-chlorobenzene are determined by its molecular structure. The interaction between the benzyl ring and the benzyl group and the chlorine atom makes it have unique uses and reactivity in organic synthesis and other fields.
What are 1-benzyl-4-chlorobenzene synthesis methods?
The synthesis method of 1-benzyl-4-chlorobenzene has been explored by many talented people throughout the ages, and the method can be obtained for the use of the world.
First, p-chlorotoluene and benzyl chloride are used as raw materials. Before placing an appropriate amount of catalyst in the reactor, such as anhydrous aluminum trichloride, this is the key auxiliary agent of the reaction, which can promote the smooth progress of the reaction. Then pour p-chlorotoluene and benzyl chloride in an appropriate proportion. The ratio of the two must be precisely controlled to achieve efficient production. The reaction system is heated to a certain temperature, generally between 80 and 120 degrees Celsius. The temperature depends on the reaction rate and product purity. After a certain time, about 3-6 hours, the two occur Fu-gram alkylation reaction, the benzene ring of p-chlorotoluene is attacked by the electrophilic attack of benzyl in benzyl chloride, and then becomes 1-benzyl-4-chlorobenzene. After the reaction is completed, the impurities are removed through cooling, washing, liquid separation and other post-treatment processes to obtain a relatively pure product.
Second, 4-chlorophenylboronic acid and benzyl halide are used as raw materials. In the reactor, 4-chlorophenylboronic acid, benzyl halide (such as benzyl chloride or benzyl bromide), base (such as potassium carbonate) and appropriate ligand (such as bis (diphenylphosphine) ferrocene) are dissolved in a suitable solvent, such as N, N-dimethylformamide. This solvent can fully disperse the reactants and facilitate the reaction contact. Then the system is protected by nitrogen gas and drains the air, because some reactants are sensitive to oxygen. When heated to 60-100 ° C, the boron atom of 4-chlorophenylboronic acid is substituted with the halogen atom of benzyl halide by Suzuki reaction to form the target product 1-benzyl-4-chlorobenzene. At the end of the reaction, the purified product is obtained by extraction, column chromatography and other purification methods.
Third, 4-chlorobenzaldehyde is used as the starting material. First, 4-chlorobenzaldehyde is reduced by a reduction reaction, such as using sodium borohydride as the reducing agent, and in an alcohol solvent (such as methanol or ethanol), the aldehyde group is reduced to a hydroxyl group to obtain 4-chlorobenzyl alcohol. Then 4-chlorobenzyl alcohol is reacted with a chlorination reagent (such as thionyl chloride), and the hydroxyl group is replaced by a chlorine atom to obtain 4-chlorobenzyl chloride. Finally, 4-chlorobenzyl chloride and benzene underwent Fu-gram alkylation reaction under the action of catalyst to obtain 1-benzyl-4-chlorobenzene. After the reaction, the product was purified by distillation, recrystallization and other steps.
First, p-chlorotoluene and benzyl chloride are used as raw materials. Before placing an appropriate amount of catalyst in the reactor, such as anhydrous aluminum trichloride, this is the key auxiliary agent of the reaction, which can promote the smooth progress of the reaction. Then pour p-chlorotoluene and benzyl chloride in an appropriate proportion. The ratio of the two must be precisely controlled to achieve efficient production. The reaction system is heated to a certain temperature, generally between 80 and 120 degrees Celsius. The temperature depends on the reaction rate and product purity. After a certain time, about 3-6 hours, the two occur Fu-gram alkylation reaction, the benzene ring of p-chlorotoluene is attacked by the electrophilic attack of benzyl in benzyl chloride, and then becomes 1-benzyl-4-chlorobenzene. After the reaction is completed, the impurities are removed through cooling, washing, liquid separation and other post-treatment processes to obtain a relatively pure product.
Second, 4-chlorophenylboronic acid and benzyl halide are used as raw materials. In the reactor, 4-chlorophenylboronic acid, benzyl halide (such as benzyl chloride or benzyl bromide), base (such as potassium carbonate) and appropriate ligand (such as bis (diphenylphosphine) ferrocene) are dissolved in a suitable solvent, such as N, N-dimethylformamide. This solvent can fully disperse the reactants and facilitate the reaction contact. Then the system is protected by nitrogen gas and drains the air, because some reactants are sensitive to oxygen. When heated to 60-100 ° C, the boron atom of 4-chlorophenylboronic acid is substituted with the halogen atom of benzyl halide by Suzuki reaction to form the target product 1-benzyl-4-chlorobenzene. At the end of the reaction, the purified product is obtained by extraction, column chromatography and other purification methods.
Third, 4-chlorobenzaldehyde is used as the starting material. First, 4-chlorobenzaldehyde is reduced by a reduction reaction, such as using sodium borohydride as the reducing agent, and in an alcohol solvent (such as methanol or ethanol), the aldehyde group is reduced to a hydroxyl group to obtain 4-chlorobenzyl alcohol. Then 4-chlorobenzyl alcohol is reacted with a chlorination reagent (such as thionyl chloride), and the hydroxyl group is replaced by a chlorine atom to obtain 4-chlorobenzyl chloride. Finally, 4-chlorobenzyl chloride and benzene underwent Fu-gram alkylation reaction under the action of catalyst to obtain 1-benzyl-4-chlorobenzene. After the reaction, the product was purified by distillation, recrystallization and other steps.
1-benzyl-4-chlorobenzene what are the precautions during use
1 - benzyl - 4 - chlorobenzene, Chinese name 1 - benzyl - 4 - chlorobenzene, this substance has its use in chemical everything, but when using it, many matters need to be paid attention to.
Bear the brunt, safe to heavy. 1 - benzyl - 4 - chlorobenzene may have certain toxicity and irritation, and in contact with it, protective gear is indispensable. If you wear protective clothing, you can prevent it from sticking to your body; wear protective gloves to avoid skin contact; wear protective goggles to prevent it from splashing into your eyes. Where you operate, you must have good ventilation to avoid the risk of its vapor accumulating in the air and causing inhalation. If you accidentally touch it, quickly rinse it with a lot of water. If the situation is serious, seek medical treatment urgently.
Furthermore, the chemical properties should not be ignored. In chemical reactions, due to its unique structure, it exhibits specific activities. When using, the reaction conditions such as temperature, pH, catalyst, etc., need to be precisely controlled. If the temperature is too high or causes an overreaction, if it is too low, the reaction will be slow or difficult to occur. The pH affects the direction and rate of the reaction, and the catalyst is not selected properly, and it is difficult to achieve the expected results.
Storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Because of its flammability, it can be exposed to open flames, hot topics or cause fires. Mix with oxidants, or cause violent reactions, endangering safety.
When transporting, follow relevant regulations. According to its dangerous characteristics, choose suitable transportation methods and packaging materials to ensure that there is no risk of leakage during transportation, and ensure the safety of transporters and the environment.
In general, when using 1-benzyl-4-chlorobenzene, safety protection, chemical control, proper storage and compliance with transportation must be carefully considered, and no carelessness should be taken to ensure smooth operation and avoid accidents.
Bear the brunt, safe to heavy. 1 - benzyl - 4 - chlorobenzene may have certain toxicity and irritation, and in contact with it, protective gear is indispensable. If you wear protective clothing, you can prevent it from sticking to your body; wear protective gloves to avoid skin contact; wear protective goggles to prevent it from splashing into your eyes. Where you operate, you must have good ventilation to avoid the risk of its vapor accumulating in the air and causing inhalation. If you accidentally touch it, quickly rinse it with a lot of water. If the situation is serious, seek medical treatment urgently.
Furthermore, the chemical properties should not be ignored. In chemical reactions, due to its unique structure, it exhibits specific activities. When using, the reaction conditions such as temperature, pH, catalyst, etc., need to be precisely controlled. If the temperature is too high or causes an overreaction, if it is too low, the reaction will be slow or difficult to occur. The pH affects the direction and rate of the reaction, and the catalyst is not selected properly, and it is difficult to achieve the expected results.
Storage is also exquisite. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Because of its flammability, it can be exposed to open flames, hot topics or cause fires. Mix with oxidants, or cause violent reactions, endangering safety.
When transporting, follow relevant regulations. According to its dangerous characteristics, choose suitable transportation methods and packaging materials to ensure that there is no risk of leakage during transportation, and ensure the safety of transporters and the environment.
In general, when using 1-benzyl-4-chlorobenzene, safety protection, chemical control, proper storage and compliance with transportation must be carefully considered, and no carelessness should be taken to ensure smooth operation and avoid accidents.
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