Linshang Chemical
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1-(Benzyloxy)-4-(Chloromethyl)Benzene
Linshang Chemical
|
HS Code |
332169 |
| Chemical Formula | C14H13ClO |
| Molecular Weight | 232.705 g/mol |
| Appearance | Solid (Typically) |
| Boiling Point | Approx. 323 - 325 °C |
| Melting Point | 52 - 56 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Approx. 137.8 °C |
| Odor | Typically has an aromatic odor |
As an accredited 1-(Benzyloxy)-4-(Chloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(benzyloxy)-4-(chloromethyl)benzene packaged in a sealed glass bottle. |
| Storage | 1-(Benzyloxy)-4-(chloromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents as it may pose a fire risk. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or reaction. |
| Shipping | 1-(Benzyloxy)-4-(chloromethyl)benzene, a chemical, should be shipped in accordance with strict hazardous materials regulations. Pack it in a well - sealed, corrosion - resistant container, clearly labeled, and transported by carriers licensed for such chemicals. |
Competitive 1-(Benzyloxy)-4-(Chloromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 1- (benzyloxy) -4- (chloromethyl) benzene?
1 - (hydroxy) -4- (chloromethyl) benzene, also known as p-chloromethylphenol, is widely used.
In the field of medicine, it can be used as a preservative. With its own characteristics of coagulation and denaturation of microbial proteins, it can effectively inhibit the growth of bacteria and fungi, ensure the quality and stability of drugs, and prolong the shelf life of drugs. It can often be found in some external disinfectants, contributing to wound infection prevention.
In the chemical industry, it is an important raw material for organic synthesis. With it as a starting material, through a series of chemical reactions, many fine chemicals with specific functions can be synthesized. For example, it reacts with certain reagents to generate surfactants containing chlorine methyl structures. Such active agents play a role in reducing surface tension, enhancing emulsification and dispersion properties in detergents, emulsifiers and other products.
In agriculture, it can participate in the synthesis of pesticides. The chlorine methyl and hydroxyl groups in its structure endow the synthesized pesticides with specific biological activities and have a good control effect on crop pests. It can precisely act on specific physiological links of pests, or interfere with the normal growth and development of pests, or damage the nervous system of pests, so as to achieve pest prevention and control, ensure the healthy growth of crops, and improve crop yield and quality.
In the field of materials science, 1- (hydroxyl) -4- (chloromethyl) benzene also shows unique value. It can be used to prepare special polymer materials, introducing them into polymer segments through chemical reactions, endowing polymer materials with new properties, such as improving the antibacterial properties of materials, enhancing the stability of materials, etc., expanding the application range of polymer materials in medical and health care, food packaging, and other special fields.
In the field of medicine, it can be used as a preservative. With its own characteristics of coagulation and denaturation of microbial proteins, it can effectively inhibit the growth of bacteria and fungi, ensure the quality and stability of drugs, and prolong the shelf life of drugs. It can often be found in some external disinfectants, contributing to wound infection prevention.
In the chemical industry, it is an important raw material for organic synthesis. With it as a starting material, through a series of chemical reactions, many fine chemicals with specific functions can be synthesized. For example, it reacts with certain reagents to generate surfactants containing chlorine methyl structures. Such active agents play a role in reducing surface tension, enhancing emulsification and dispersion properties in detergents, emulsifiers and other products.
In agriculture, it can participate in the synthesis of pesticides. The chlorine methyl and hydroxyl groups in its structure endow the synthesized pesticides with specific biological activities and have a good control effect on crop pests. It can precisely act on specific physiological links of pests, or interfere with the normal growth and development of pests, or damage the nervous system of pests, so as to achieve pest prevention and control, ensure the healthy growth of crops, and improve crop yield and quality.
In the field of materials science, 1- (hydroxyl) -4- (chloromethyl) benzene also shows unique value. It can be used to prepare special polymer materials, introducing them into polymer segments through chemical reactions, endowing polymer materials with new properties, such as improving the antibacterial properties of materials, enhancing the stability of materials, etc., expanding the application range of polymer materials in medical and health care, food packaging, and other special fields.
What are the physical properties of 1- (benzyloxy) -4- (chloromethyl) benzene?
(1) The name of this substance is 1- (hydroxyethyl) -4- (chloromethyl) benzene, and its physical properties are unique and worthy of detailed investigation.
(2) Looking at its shape, under normal conditions, 1- (hydroxyethyl) -4- (chloromethyl) benzene is a colorless to slightly yellow liquid, with a clear texture, like autumn water, shining in the light, and its flowing state is smooth and natural, as smooth as silk.
(3) Smell its smell. The smell emitted by this substance is neither rich fragrance nor pungent odor. It is a special smell. It is slightly pungent, but it is not enough to cover the nose, but it is alarming, as if it is declaring its unique chemical identity.
(4) When it comes to the melting point, its melting point is relatively low. When it encounters a slightly higher temperature, it is easy to turn from solid to liquid, just like ice and snow melting in spring. As for the boiling point, under specific pressure conditions, it needs to reach a certain temperature to boil and transform into a gaseous state. After the temperature value is accurately determined, it can be used as an important indicator to identify the substance.
(Wu) When it comes to solubility, 1- (hydroxyethyl) -4- (chloromethyl) benzene exhibits good solubility in organic solvents, such as ethanol, ether, etc., and can be mutually soluble with it. It is like water and water are emulsified, and it is difficult to distinguish each other. However, in water, its solubility is not good, and the two meet, such as oil floating in water, with a clear boundary.
(Lu) Its density is also different compared to water, and its exact value can be obtained by accurate measurement with specific instruments. In many fields such as chemical applications, this density characteristic is related to the separation and mixing of substances. In addition, 1- (hydroxyethyl) -4- (chloromethyl) benzene also has a certain refractive index. When light passes through, it will be refracted at a specific angle. This property is also an important characteristic of its physical properties. It plays an indispensable role in the analysis and identification of the substance.
(2) Looking at its shape, under normal conditions, 1- (hydroxyethyl) -4- (chloromethyl) benzene is a colorless to slightly yellow liquid, with a clear texture, like autumn water, shining in the light, and its flowing state is smooth and natural, as smooth as silk.
(3) Smell its smell. The smell emitted by this substance is neither rich fragrance nor pungent odor. It is a special smell. It is slightly pungent, but it is not enough to cover the nose, but it is alarming, as if it is declaring its unique chemical identity.
(4) When it comes to the melting point, its melting point is relatively low. When it encounters a slightly higher temperature, it is easy to turn from solid to liquid, just like ice and snow melting in spring. As for the boiling point, under specific pressure conditions, it needs to reach a certain temperature to boil and transform into a gaseous state. After the temperature value is accurately determined, it can be used as an important indicator to identify the substance.
(Wu) When it comes to solubility, 1- (hydroxyethyl) -4- (chloromethyl) benzene exhibits good solubility in organic solvents, such as ethanol, ether, etc., and can be mutually soluble with it. It is like water and water are emulsified, and it is difficult to distinguish each other. However, in water, its solubility is not good, and the two meet, such as oil floating in water, with a clear boundary.
(Lu) Its density is also different compared to water, and its exact value can be obtained by accurate measurement with specific instruments. In many fields such as chemical applications, this density characteristic is related to the separation and mixing of substances. In addition, 1- (hydroxyethyl) -4- (chloromethyl) benzene also has a certain refractive index. When light passes through, it will be refracted at a specific angle. This property is also an important characteristic of its physical properties. It plays an indispensable role in the analysis and identification of the substance.
What are the chemical properties of 1- (benzyloxy) -4- (chloromethyl) benzene?
1 - (hydroxyethyl) - 4 - (chloromethyl) benzene, this is an organic compound. Its chemical properties are unique and contain many characteristics.
Looking at its structure, the benzene ring is the core skeleton, giving it a certain stability. Hydroxyethyl at position 1 has significant hydrophilicity due to the presence of hydroxyl groups. Hydroxyl has high electronegativity of oxygen atoms, which makes it easy to form hydrogen bonds with water, which improves the solubility of the substance in water; and hydroxyl can participate in a variety of chemical reactions, such as esterification reactions. Under acid catalysis, it can react with carboxylic acids to form ester compounds. This reaction is often used in organic synthesis to prepare ester products with specific functions.
And chloromethyl at position 4 is active. On the one hand, chlorine atoms have strong electron-absorbing ability, which changes the electron cloud density of the benzene ring, which affects the electrophilic substitution reaction activity and check point on the benzene ring; on the other hand, chloromethyl can undergo nucleophilic substitution reactions, such as reacting with nucleophilic reagents such as sodium alcohol and amines to generate ether or amine derivatives, which are widely used in the field of drug synthesis and material preparation. Complex organic molecular structures can be constructed through such reactions.
In addition, the compound has a relatively regular spatial structure due to the two substituents in the para-position, which has a certain impact on its physical properties such as melting point and boiling point. Intermolecular forces vary due to the polarity and spatial arrangement of substituents, resulting in different melting boiling points compared with benzene. In chemical reactions, the steric hindrance effect cannot be ignored. Although the two substituents are in the para-position, the steric hindrance is relatively small, but in some reactions involving larger groups, it will still affect the reaction rate and product selectivity.
Looking at its structure, the benzene ring is the core skeleton, giving it a certain stability. Hydroxyethyl at position 1 has significant hydrophilicity due to the presence of hydroxyl groups. Hydroxyl has high electronegativity of oxygen atoms, which makes it easy to form hydrogen bonds with water, which improves the solubility of the substance in water; and hydroxyl can participate in a variety of chemical reactions, such as esterification reactions. Under acid catalysis, it can react with carboxylic acids to form ester compounds. This reaction is often used in organic synthesis to prepare ester products with specific functions.
And chloromethyl at position 4 is active. On the one hand, chlorine atoms have strong electron-absorbing ability, which changes the electron cloud density of the benzene ring, which affects the electrophilic substitution reaction activity and check point on the benzene ring; on the other hand, chloromethyl can undergo nucleophilic substitution reactions, such as reacting with nucleophilic reagents such as sodium alcohol and amines to generate ether or amine derivatives, which are widely used in the field of drug synthesis and material preparation. Complex organic molecular structures can be constructed through such reactions.
In addition, the compound has a relatively regular spatial structure due to the two substituents in the para-position, which has a certain impact on its physical properties such as melting point and boiling point. Intermolecular forces vary due to the polarity and spatial arrangement of substituents, resulting in different melting boiling points compared with benzene. In chemical reactions, the steric hindrance effect cannot be ignored. Although the two substituents are in the para-position, the steric hindrance is relatively small, but in some reactions involving larger groups, it will still affect the reaction rate and product selectivity.
What are the synthesis methods of 1- (benzyloxy) -4- (chloromethyl) benzene?
To prepare 1 - (hydroxyethyl) -4 - (chloromethyl) benzene, there are various ways to synthesize it.
First, it can be started from the corresponding halogenated aromatic hydrocarbons. Halogenated benzene derivatives are selected to be combined with reagents containing hydroxyethyl and chloromethyl groups according to the method of nucleophilic substitution. In suitable solvents, such as aprotic polar solvents, such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), under the catalysis of bases, the halogen atoms of halogenated benzene undergo nucleophilic substitution reactions with the activity check points of reagents containing corresponding groups. Bases such as potassium carbonate and sodium carbonate can capture the active hydrogen of the reagent, enhance its nucleophilicity, and promote the reaction.
Second, the Fu-gram reaction of aromatic hydrocarbons can be used. Using benzene as a substrate, the hydroxyethylation reagent, such as hydroxyethyl halide or its equivalent, is first alkylated by Fu-gram under the action of Lewis acid catalyst, such as anhydrous aluminum trichloride, to obtain hydroxyethylbenzene. Then, the obtained product is chloromethylated with a combination of chloromethyl methyl ether and anhydrous zinc chloride, and chloromethyl is introduced into the para-position of the benzene ring. This is because hydroxyethyl is an ortho-para-position group, so that the reaction mainly occurs in the para-position.
Third, the method of functional group transformation can be started from the benzene ring with suitable substituents. If there are groups on the benzene ring that can be converted into hydroxyethyl and chloromethyl, such as a substituent containing hydroxyl and halomethyl precursors, it can be gradually converted into the target 1- (hydroxyethyl) -4- (chloromethyl) benzene by oxidation, reduction, and substitution in an appropriate order. For example, if there is a hydroxyl-protected substituent on the benzene ring, it can be deprotected first, then oxidized to an aldehyde group, and then reduced to hydroxyethyl group; for another suitable substituent, chloromethyl is introduced by substitution reaction.
All these synthesis methods have their own advantages and disadvantages. It is necessary to choose carefully according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the high or low yield, in order to achieve the purpose of efficient synthesis of the target product.
First, it can be started from the corresponding halogenated aromatic hydrocarbons. Halogenated benzene derivatives are selected to be combined with reagents containing hydroxyethyl and chloromethyl groups according to the method of nucleophilic substitution. In suitable solvents, such as aprotic polar solvents, such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), under the catalysis of bases, the halogen atoms of halogenated benzene undergo nucleophilic substitution reactions with the activity check points of reagents containing corresponding groups. Bases such as potassium carbonate and sodium carbonate can capture the active hydrogen of the reagent, enhance its nucleophilicity, and promote the reaction.
Second, the Fu-gram reaction of aromatic hydrocarbons can be used. Using benzene as a substrate, the hydroxyethylation reagent, such as hydroxyethyl halide or its equivalent, is first alkylated by Fu-gram under the action of Lewis acid catalyst, such as anhydrous aluminum trichloride, to obtain hydroxyethylbenzene. Then, the obtained product is chloromethylated with a combination of chloromethyl methyl ether and anhydrous zinc chloride, and chloromethyl is introduced into the para-position of the benzene ring. This is because hydroxyethyl is an ortho-para-position group, so that the reaction mainly occurs in the para-position.
Third, the method of functional group transformation can be started from the benzene ring with suitable substituents. If there are groups on the benzene ring that can be converted into hydroxyethyl and chloromethyl, such as a substituent containing hydroxyl and halomethyl precursors, it can be gradually converted into the target 1- (hydroxyethyl) -4- (chloromethyl) benzene by oxidation, reduction, and substitution in an appropriate order. For example, if there is a hydroxyl-protected substituent on the benzene ring, it can be deprotected first, then oxidized to an aldehyde group, and then reduced to hydroxyethyl group; for another suitable substituent, chloromethyl is introduced by substitution reaction.
All these synthesis methods have their own advantages and disadvantages. It is necessary to choose carefully according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the high or low yield, in order to achieve the purpose of efficient synthesis of the target product.
What are the precautions for using 1- (benzyloxy) -4- (chloromethyl) benzene?
1 - (hydroxyethyl) -4 - (chloromethyl) benzene requires attention to many matters during use.
One of them is related to its chemical properties. This substance contains chloromethyl and hydroxyethyl, and has high chemical activity. Chloromethyl has strong electrophilicity and is easy to react with nucleophiles. When storing and using, it is necessary to avoid contact with nucleophiles such as amines and alcohols, otherwise it is easy to cause substitution reactions, resulting in impure products or accidental reactions. The hydroxyl groups in hydroxyethyl can participate in esterification, dehydration and other reactions. When using, attention should be paid to the pH and temperature of the reaction system to prevent the unprovoked reaction of hydroxyl groups and interfere with the expected reaction process.
Second, the safety aspect cannot be ignored. Chloromethyl chloride has certain toxicity and irritation, and protective measures must be taken when operating. Protective clothing, gloves and goggles should be worn to prevent it from contacting the skin and eyes. If it comes into contact accidentally, rinse with plenty of water immediately and seek medical attention in time. And this substance may evaporate, the operation should be carried out in a well-ventilated place, preferably in a fume hood to prevent inhalation of volatile gases, endangering respiratory tract and physical health.
Third, storage conditions are very critical. Store in a cool, dry and ventilated place, away from fire and heat sources. Due to its active chemical properties, light and high temperature may promote its reaction or decomposition, so it needs to be stored away from light, and it should be stored separately from oxidants, acids, bases, etc., and should not be mixed with storage to avoid dangerous reactions.
Fourth, the measurement accuracy during use is important. In view of its high reactivity, the amount of dosage has a significant impact on the reaction result. It is necessary to use accurate measurement tools to weigh according to the specific reaction needs to ensure that the reaction proceeds as expected and obtain the ideal product yield and purity.
One of them is related to its chemical properties. This substance contains chloromethyl and hydroxyethyl, and has high chemical activity. Chloromethyl has strong electrophilicity and is easy to react with nucleophiles. When storing and using, it is necessary to avoid contact with nucleophiles such as amines and alcohols, otherwise it is easy to cause substitution reactions, resulting in impure products or accidental reactions. The hydroxyl groups in hydroxyethyl can participate in esterification, dehydration and other reactions. When using, attention should be paid to the pH and temperature of the reaction system to prevent the unprovoked reaction of hydroxyl groups and interfere with the expected reaction process.
Second, the safety aspect cannot be ignored. Chloromethyl chloride has certain toxicity and irritation, and protective measures must be taken when operating. Protective clothing, gloves and goggles should be worn to prevent it from contacting the skin and eyes. If it comes into contact accidentally, rinse with plenty of water immediately and seek medical attention in time. And this substance may evaporate, the operation should be carried out in a well-ventilated place, preferably in a fume hood to prevent inhalation of volatile gases, endangering respiratory tract and physical health.
Third, storage conditions are very critical. Store in a cool, dry and ventilated place, away from fire and heat sources. Due to its active chemical properties, light and high temperature may promote its reaction or decomposition, so it needs to be stored away from light, and it should be stored separately from oxidants, acids, bases, etc., and should not be mixed with storage to avoid dangerous reactions.
Fourth, the measurement accuracy during use is important. In view of its high reactivity, the amount of dosage has a significant impact on the reaction result. It is necessary to use accurate measurement tools to weigh according to the specific reaction needs to ensure that the reaction proceeds as expected and obtain the ideal product yield and purity.
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