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1-Bromo-2,3-Dichloro-5-Methylbenzene
|
HS Code |
369237 |
| Name | 1-Bromo-2,3-Dichloro-5-Methylbenzene |
| Molecular Formula | C7H5BrCl2 |
| Molar Mass | 239.92 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 220 - 230 °C |
| Density | Around 1.65 - 1.75 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low vapor pressure |
As an accredited 1-Bromo-2,3-Dichloro-5-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 2,3 - dichloro - 5 - methylbenzene in a sealed glass bottle. |
| Storage | 1 - Bromo - 2,3 - dichloro - 5 - methylbenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. Label the storage container clearly for easy identification. |
| Shipping | 1 - bromo - 2,3 - dichloro - 5 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. It's transported under strict safety protocols, ensuring separation from incompatible substances to prevent risks during transit. |
Competitive 1-Bromo-2,3-Dichloro-5-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Bromo-2,3-Dichloro-5-Methylbenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-2,3-Dichloro-5-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-bromo-2,3-dichloro-5-methylbenzene?
The physical properties of 1-% mercury-2,3-carbon dioxide-5-methylnaphthalene are as follows:
Mercury, a common water source, is the only gold source that exists in a liquid under normal conditions. Its outer surface is white and has a golden gloss. The density of mercury is high, 13.59 g/cm ³, so it is heavier than that of ordinary liquids. Melting temperature is -38.87 ° C, boiling temperature is 356.6 ° C. Mercury has good performance and is useful in polymers such as high temperature and blood pressure. However, mercury is toxic, and its toxicity should not be ignored. If it is accidentally leaked, its vapor can be easily inhaled by people, which is harmful to health.
Carbon dioxide, the taste of color and color. Its density is higher than that of air, 1.977g/L. Under normal conditions, 1% of carbon dioxide can be dissolved in 1% of water, and it can be dissolved in water to form carbonic acid. Carbon dioxide melts at -78.5 ° C (527kPa), fixing carbon dioxide. It is common to use ice, and dry ice is directly raised to form carbon dioxide at -78.5 ° C. This process absorbs water, so dry ice is often used for artificial rainfall, refrigeration, etc. Carbon dioxide is not flammable, generally does not support combustion, and is not flammable in itself. It is often used in fire.
Methylnaphthalene, there is α-methylnaphthalene β-methylnaphthalene. In the case of α-methylnaphthalene, its outer color oil is mixed with liquid, and it has a taste like naphthalene. Melting-30.5 ° C, boiling at 245.9 ° C, density 1.0259g/cm ³ (20/4 ° C). Insoluble in water, soluble in ethanol, ether, chloroform, etc. Its evaporation can form explosive mixtures, which can cause ignition and explosion in case of open fire and high temperature. β-methylnaphthalene is also a liquid solution with high color or micro-color oil, melting at 34.6 ° C, boiling at 241 ° C, density 1.0051g/cm ³ (20/4 ° C), insoluble in water, soluble in multi-soluble solution. Methylnaphthalene is commonly used in synthetic, and can be used in many refined chemical products.
Mercury, a common water source, is the only gold source that exists in a liquid under normal conditions. Its outer surface is white and has a golden gloss. The density of mercury is high, 13.59 g/cm ³, so it is heavier than that of ordinary liquids. Melting temperature is -38.87 ° C, boiling temperature is 356.6 ° C. Mercury has good performance and is useful in polymers such as high temperature and blood pressure. However, mercury is toxic, and its toxicity should not be ignored. If it is accidentally leaked, its vapor can be easily inhaled by people, which is harmful to health.
Carbon dioxide, the taste of color and color. Its density is higher than that of air, 1.977g/L. Under normal conditions, 1% of carbon dioxide can be dissolved in 1% of water, and it can be dissolved in water to form carbonic acid. Carbon dioxide melts at -78.5 ° C (527kPa), fixing carbon dioxide. It is common to use ice, and dry ice is directly raised to form carbon dioxide at -78.5 ° C. This process absorbs water, so dry ice is often used for artificial rainfall, refrigeration, etc. Carbon dioxide is not flammable, generally does not support combustion, and is not flammable in itself. It is often used in fire.
Methylnaphthalene, there is α-methylnaphthalene β-methylnaphthalene. In the case of α-methylnaphthalene, its outer color oil is mixed with liquid, and it has a taste like naphthalene. Melting-30.5 ° C, boiling at 245.9 ° C, density 1.0259g/cm ³ (20/4 ° C). Insoluble in water, soluble in ethanol, ether, chloroform, etc. Its evaporation can form explosive mixtures, which can cause ignition and explosion in case of open fire and high temperature. β-methylnaphthalene is also a liquid solution with high color or micro-color oil, melting at 34.6 ° C, boiling at 241 ° C, density 1.0051g/cm ³ (20/4 ° C), insoluble in water, soluble in multi-soluble solution. Methylnaphthalene is commonly used in synthetic, and can be used in many refined chemical products.
What are the chemical properties of 1-bromo-2,3-dichloro-5-methylbenzene?
1-% E6% BA% B4-2, 3-%E4%BA%8C%E6%B0%AF-5-%E7%94%B2%E5%9F%BA%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%85%B7%E6%9C%89%E5%A4%9A%E7%A7%8D%E7%89%B9%E6%80%A7.
In this compound, it has certain chemical activity. Under suitable conditions, it can participate in many chemical reactions. The different groups in its structure have their own unique chemical properties.
For the part of 1-% E6% BA% B4, the group may exhibit a specific electronic effect, which affects the charge distribution of the whole molecule, and then affects its chemical activity. In electrophilic or nucleophilic reactions, 1-% E6% BA% B4 may act as a check point to attract the corresponding reagents to react with it.
2, 3-%E4%BA%8C%E6%B0%AF part, the presence of the dihalogen atom gives the molecule the typical properties of halogenated hydrocarbons. The relatively large electronegativity of the halogen atom makes this part prone to substitution reactions. For example, under basic conditions, the halogen atom can be replaced by other nucleophiles, thereby realizing the transformation of molecular structure.
5-%E7%94%B2%E5%9F%BA%E8%8B%AF part, the conjugated structure of the benzene ring gives the molecule high stability. At the same time, methyl is attached to the benzene ring, which can affect the electron cloud density of the benzene ring through superconjugation effect. In the aromatic electrophilic substitution reaction, methyl is an ortho-and para-locator, which can guide the reaction towards a specific position of the benzene ring.
Overall, 1-% E6% BA% B4-2, 3-%E4%BA%8C%E6%B0%AF-5-%E7%94%B2%E5%9F%BA%E8%8B%AF shows rich and diverse chemical properties due to the interaction of various partial groups, and may have certain application potential in organic synthesis and other fields. Through the selective reaction of each group, more complex organic molecular structures can be constructed.
In this compound, it has certain chemical activity. Under suitable conditions, it can participate in many chemical reactions. The different groups in its structure have their own unique chemical properties.
For the part of 1-% E6% BA% B4, the group may exhibit a specific electronic effect, which affects the charge distribution of the whole molecule, and then affects its chemical activity. In electrophilic or nucleophilic reactions, 1-% E6% BA% B4 may act as a check point to attract the corresponding reagents to react with it.
2, 3-%E4%BA%8C%E6%B0%AF part, the presence of the dihalogen atom gives the molecule the typical properties of halogenated hydrocarbons. The relatively large electronegativity of the halogen atom makes this part prone to substitution reactions. For example, under basic conditions, the halogen atom can be replaced by other nucleophiles, thereby realizing the transformation of molecular structure.
5-%E7%94%B2%E5%9F%BA%E8%8B%AF part, the conjugated structure of the benzene ring gives the molecule high stability. At the same time, methyl is attached to the benzene ring, which can affect the electron cloud density of the benzene ring through superconjugation effect. In the aromatic electrophilic substitution reaction, methyl is an ortho-and para-locator, which can guide the reaction towards a specific position of the benzene ring.
Overall, 1-% E6% BA% B4-2, 3-%E4%BA%8C%E6%B0%AF-5-%E7%94%B2%E5%9F%BA%E8%8B%AF shows rich and diverse chemical properties due to the interaction of various partial groups, and may have certain application potential in organic synthesis and other fields. Through the selective reaction of each group, more complex organic molecular structures can be constructed.
What are the main uses of 1-bromo-2,3-dichloro-5-methylbenzene?
1-Bromo-2,3-difluoro-5-methylpyridine, this compound has important uses in many fields.
In the field of medicinal chemistry, it is a key intermediate for drug synthesis. With its unique chemical structure, it can participate in the construction of many types of complex drug molecules. For example, when developing new antibacterial drugs, 1-bromo-2,3-difluoro-5-methylpyridine can be used as a starting material. Through a series of chemical reactions, its bromine atom, fluorine atom and methyl functional groups are gradually converted, and other specific chemical fragments are connected to eventually synthesize drug molecules with specific antibacterial activities. This is because the fluorine atom in its structure can enhance the binding force between the drug and the target, improve the stability and bioavailability of the drug; the bromine atom provides a good activity check point for subsequent reactions, which is convenient for further modification.
In pesticide chemistry, this compound also plays an important role. It can be used to synthesize high-efficiency, low-toxicity and environmentally friendly new pesticides. Taking the synthesis of new pesticides as an example, 1-bromo-2,3-difluoro-5-methylpyridine can be used as a core structural unit to react with heterocyclic compounds containing nitrogen and sulfur to construct pesticide molecules with unique insecticidal mechanisms. Its fluorine atom gives pesticides better fat solubility, which helps the drug to penetrate the epidermis and cell membranes of insects and enhance the insecticidal effect; while the presence of methyl may affect the spatial configuration of pesticide molecules, making it easier to interact with specific targets in insects, so as to precisely inhibit the physiological activities of insects and achieve insecticidal purposes.
In addition, in the field of materials science, 1-bromo-2,3-difluoro-5-methyl pyridine also has potential applications. It can be used to prepare organic functional materials with special properties. For example, when synthesizing new photovoltaic materials, they are introduced into the polymer system as structural units, and the electron cloud distribution and energy level structure of the material are adjusted by their structural characteristics, thus endowing the material with unique photovoltaic properties, such as good fluorescence emission characteristics or high efficiency. The charge transfer ability is expected to be applied to the fabrication of photovoltaic devices such as organic light emitting diodes (OLEDs) and solar cells.
In the field of medicinal chemistry, it is a key intermediate for drug synthesis. With its unique chemical structure, it can participate in the construction of many types of complex drug molecules. For example, when developing new antibacterial drugs, 1-bromo-2,3-difluoro-5-methylpyridine can be used as a starting material. Through a series of chemical reactions, its bromine atom, fluorine atom and methyl functional groups are gradually converted, and other specific chemical fragments are connected to eventually synthesize drug molecules with specific antibacterial activities. This is because the fluorine atom in its structure can enhance the binding force between the drug and the target, improve the stability and bioavailability of the drug; the bromine atom provides a good activity check point for subsequent reactions, which is convenient for further modification.
In pesticide chemistry, this compound also plays an important role. It can be used to synthesize high-efficiency, low-toxicity and environmentally friendly new pesticides. Taking the synthesis of new pesticides as an example, 1-bromo-2,3-difluoro-5-methylpyridine can be used as a core structural unit to react with heterocyclic compounds containing nitrogen and sulfur to construct pesticide molecules with unique insecticidal mechanisms. Its fluorine atom gives pesticides better fat solubility, which helps the drug to penetrate the epidermis and cell membranes of insects and enhance the insecticidal effect; while the presence of methyl may affect the spatial configuration of pesticide molecules, making it easier to interact with specific targets in insects, so as to precisely inhibit the physiological activities of insects and achieve insecticidal purposes.
In addition, in the field of materials science, 1-bromo-2,3-difluoro-5-methyl pyridine also has potential applications. It can be used to prepare organic functional materials with special properties. For example, when synthesizing new photovoltaic materials, they are introduced into the polymer system as structural units, and the electron cloud distribution and energy level structure of the material are adjusted by their structural characteristics, thus endowing the material with unique photovoltaic properties, such as good fluorescence emission characteristics or high efficiency. The charge transfer ability is expected to be applied to the fabrication of photovoltaic devices such as organic light emitting diodes (OLEDs) and solar cells.
What are the synthesis methods of 1-bromo-2,3-dichloro-5-methylbenzene?
The synthesis of 1-bromo-2,3-dichloro-5-methylpyridine is a key research in the field of chemical synthesis. According to the text of "Tiangong Kaiwu", several common synthesis paths are described in ancient texts.
First, the corresponding pyridine derivative can be initiated. First, take a specific pyridine parent and introduce bromine atoms under suitable reaction conditions. This step requires the selection of suitable bromination reagents, such as liquid bromine and N-bromosuccinimide (NBS). If liquid bromine is used, the reaction temperature and dosage should be carefully controlled to prevent excessive bromination. After the bromine atom is successfully integrated into the pyridine ring, the dichloro substitution reaction is carried out. Chlorine, sulfoxide and other chlorinated reagents can be selected. Under the action of catalysts, chlorine atoms can precisely replace hydrogen atoms at specific positions on the pyridine ring. This process requires strict reaction conditions, and the temperature, catalyst type and dosage are all related to the selectivity and yield of the reaction. Finally, through the methylation reaction, methyl groups are introduced. Commonly used methylation reagents include iodomethane and dimethyl sulfate, etc., to achieve the construction of 5-methyl in an alkaline environment.
Second, the strategy of gradually constructing pyridine rings can also be adopted. Using small molecule compounds containing bromine and chlorine as starting materials, pyridine rings are constructed through multi-step reactions. Shilling compounds containing bromine and chlorine undergo condensation reactions to form the precursor structure of pyridine rings. This process requires the help of suitable organic bases and catalysts to promote the reaction. Subsequently, the precursor structure is modified and transformed, and the position and type of substituents are adjusted to eventually form the target product 1-bromo-2,3-dichloro-5-methylpyridine. Although this method has many steps, it has many advantages for the precise control of pyridine ring substituents.
Third, there is a strategy to use transition metal-catalyzed coupling reactions. First, pyridine derivatives containing bromine and chlorine with specific active groups are prepared, and then coupled with methyl-containing reagents under the action of transition metal catalysts such as palladium catalysts. The reaction conditions are relatively mild and highly selective, but the catalyst cost is high, and the reaction system needs to be strictly anhydrous and anaerobic. By carefully adjusting the reaction parameters, such as catalyst dosage, ligand type, reaction temperature and time, etc., the efficiency and product purity of the reaction can be effectively improved.
All these synthesis methods have advantages and disadvantages. It is necessary for chemists to carefully weigh and choose the best method according to actual needs and conditions to achieve the purpose of efficient synthesis of 1-bromo-2,3-dichloro-5-methylpyridine.
First, the corresponding pyridine derivative can be initiated. First, take a specific pyridine parent and introduce bromine atoms under suitable reaction conditions. This step requires the selection of suitable bromination reagents, such as liquid bromine and N-bromosuccinimide (NBS). If liquid bromine is used, the reaction temperature and dosage should be carefully controlled to prevent excessive bromination. After the bromine atom is successfully integrated into the pyridine ring, the dichloro substitution reaction is carried out. Chlorine, sulfoxide and other chlorinated reagents can be selected. Under the action of catalysts, chlorine atoms can precisely replace hydrogen atoms at specific positions on the pyridine ring. This process requires strict reaction conditions, and the temperature, catalyst type and dosage are all related to the selectivity and yield of the reaction. Finally, through the methylation reaction, methyl groups are introduced. Commonly used methylation reagents include iodomethane and dimethyl sulfate, etc., to achieve the construction of 5-methyl in an alkaline environment.
Second, the strategy of gradually constructing pyridine rings can also be adopted. Using small molecule compounds containing bromine and chlorine as starting materials, pyridine rings are constructed through multi-step reactions. Shilling compounds containing bromine and chlorine undergo condensation reactions to form the precursor structure of pyridine rings. This process requires the help of suitable organic bases and catalysts to promote the reaction. Subsequently, the precursor structure is modified and transformed, and the position and type of substituents are adjusted to eventually form the target product 1-bromo-2,3-dichloro-5-methylpyridine. Although this method has many steps, it has many advantages for the precise control of pyridine ring substituents.
Third, there is a strategy to use transition metal-catalyzed coupling reactions. First, pyridine derivatives containing bromine and chlorine with specific active groups are prepared, and then coupled with methyl-containing reagents under the action of transition metal catalysts such as palladium catalysts. The reaction conditions are relatively mild and highly selective, but the catalyst cost is high, and the reaction system needs to be strictly anhydrous and anaerobic. By carefully adjusting the reaction parameters, such as catalyst dosage, ligand type, reaction temperature and time, etc., the efficiency and product purity of the reaction can be effectively improved.
All these synthesis methods have advantages and disadvantages. It is necessary for chemists to carefully weigh and choose the best method according to actual needs and conditions to achieve the purpose of efficient synthesis of 1-bromo-2,3-dichloro-5-methylpyridine.
What are the precautions for storing and transporting 1-bromo-2,3-dichloro-5-methylbenzene?
1-% E6% BA% B4, 2, 3-%E4%BA%8C%E6%B0%AF, 5-%E7%94%B2%E5%9F%BA%E8%8B%AF and other substances need to be paid attention to during the storage process.
One is that they are not stored. This material is stored in the environment, through the environment. The environment can avoid the change of the material due to the high degree of resistance, such as 1-% E6% BA% B4 under high temperature or acceleration, or even lead to reaction; good communication can prevent harmful damage and ensure the safety of the environment. And the fire source and source, because of its flammability, in case of open flame, high flammable explosion, endangering the safety of people. At the same time, it is necessary to store the oxidizer, acid and other substances separately to prevent mutual reaction, such as 2, 3-%E4%BA%8C%E6%B0%AF may be strong reaction when oxidized.
Second, the safety aspect should not be minimized. Tools need to have good density to prevent the escape of 1-% E6% BA% B4, etc., pollute the environment, and avoid the contact of external objects. People must be trained, familiar with the dangerous characteristics and emergency management methods of the materials, if the 5-%E7%94%B2%E5%9F%BA%E8%8B%AF leakage on the way, can quickly and properly take measures. In addition, the road should be avoided in densely populated and environmentally sensitive areas to reduce accidental health hazards.
One is that they are not stored. This material is stored in the environment, through the environment. The environment can avoid the change of the material due to the high degree of resistance, such as 1-% E6% BA% B4 under high temperature or acceleration, or even lead to reaction; good communication can prevent harmful damage and ensure the safety of the environment. And the fire source and source, because of its flammability, in case of open flame, high flammable explosion, endangering the safety of people. At the same time, it is necessary to store the oxidizer, acid and other substances separately to prevent mutual reaction, such as 2, 3-%E4%BA%8C%E6%B0%AF may be strong reaction when oxidized.
Second, the safety aspect should not be minimized. Tools need to have good density to prevent the escape of 1-% E6% BA% B4, etc., pollute the environment, and avoid the contact of external objects. People must be trained, familiar with the dangerous characteristics and emergency management methods of the materials, if the 5-%E7%94%B2%E5%9F%BA%E8%8B%AF leakage on the way, can quickly and properly take measures. In addition, the road should be avoided in densely populated and environmentally sensitive areas to reduce accidental health hazards.
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