Linshang Chemical
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1-Bromo-2,5-Dichlorobenzene
Linshang Chemical
|
HS Code |
848554 |
| Chemical Formula | C6H3BrCl2 |
| Molar Mass | 225.899 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 244 - 246 °C |
| Melting Point | 14 - 16 °C |
| Density | 1.756 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 109 °C |
| Vapor Pressure | Low at room temperature |
| Odor | Characteristic aromatic odor |
As an accredited 1-Bromo-2,5-Dichlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - bromo - 2,5 - dichlorobenzene in 100g sealed glass bottle for chemical packaging. |
| Storage | 1 - Bromo - 2,5 - dichlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container made of suitable materials like glass or high - density polyethylene to prevent leakage. Ensure proper labeling for easy identification and handling. |
| Shipping | 1 - bromo - 2,5 - dichlorobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under conditions compliant with chemical safety regulations to prevent leakage and ensure safe delivery. |
Competitive 1-Bromo-2,5-Dichlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-2,5-Dichlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1 - bromo - 2,5 - dichlorobenzene?
1-Bromo-2,5-dichlorobenzene is also an organic compound. Its chemical properties are unique and it has specific performance in many chemical reactions.
The halogen atoms of this compound, namely bromine and chlorine, are very active. Bromine atoms are highly active and can often participate in nucleophilic substitution reactions. Under appropriate conditions, nucleophilic reagents such as alkoxides and amines can attack the carbon atoms attached to bromine, causing bromine to leave and form new organic compounds. This is a common path for building carbon-heteroatomic bonds.
Furthermore, although the activity of chlorine atoms is slightly inferior to that of bromine atoms, it is not idle. In some specific reactions, such as at high temperatures and in the presence of catalysts, chlorine atoms can also participate in the reaction or be replaced by other groups. The structure of the benzene ring of this compound also has a significant impact on its chemical properties. The benzene ring has a conjugated system, and the electron cloud is uniformly distributed and stable.
Because of its conjugation effect, the localization effect of the substituent on the benzene ring on the electrophilic substitution reaction is obvious. Bromine and chlorine are both ortho and para-site locators, so when the electrophilic reagent attacks the benzene ring, it is easy to react in the adjacent and para-site where the steric resistance is small. In addition, the presence of 1-bromo-2,5-dichlorobenzene halogen atoms can participate in metal-catalyzed coupling reactions, such as Suzuki reaction, Stanley reaction, etc., which is of great significance in the field of organic synthesis to construct complex molecular structures. In short, 1-bromo-2,5-dichlorobenzene has rich and diverse chemical properties and has broad application prospects in the fields of organic synthesis and materials science.
The halogen atoms of this compound, namely bromine and chlorine, are very active. Bromine atoms are highly active and can often participate in nucleophilic substitution reactions. Under appropriate conditions, nucleophilic reagents such as alkoxides and amines can attack the carbon atoms attached to bromine, causing bromine to leave and form new organic compounds. This is a common path for building carbon-heteroatomic bonds.
Furthermore, although the activity of chlorine atoms is slightly inferior to that of bromine atoms, it is not idle. In some specific reactions, such as at high temperatures and in the presence of catalysts, chlorine atoms can also participate in the reaction or be replaced by other groups. The structure of the benzene ring of this compound also has a significant impact on its chemical properties. The benzene ring has a conjugated system, and the electron cloud is uniformly distributed and stable.
Because of its conjugation effect, the localization effect of the substituent on the benzene ring on the electrophilic substitution reaction is obvious. Bromine and chlorine are both ortho and para-site locators, so when the electrophilic reagent attacks the benzene ring, it is easy to react in the adjacent and para-site where the steric resistance is small. In addition, the presence of 1-bromo-2,5-dichlorobenzene halogen atoms can participate in metal-catalyzed coupling reactions, such as Suzuki reaction, Stanley reaction, etc., which is of great significance in the field of organic synthesis to construct complex molecular structures. In short, 1-bromo-2,5-dichlorobenzene has rich and diverse chemical properties and has broad application prospects in the fields of organic synthesis and materials science.
What are the main uses of 1 - bromo - 2,5 - dichlorobenzene?
1 + -Bromo-2,5-dichlorobenzene has a wide range of uses. It is often an important intermediate in the field of organic synthesis. The method of nucleophilic substitution can be used to replace the halogen atom with other functional groups, and then a variety of organic compounds can be built.
First, in the way of drug synthesis, 1 + -bromo-2,5-dichlorobenzene has its own uses. Based on it, molecules with specific pharmacological activities can be prepared. By modifying its structure, drugs that have curative effects on specific diseases can be obtained, such as the development and preparation of anti-cancer and anti-infection drugs, or the use of this substance as a starting material.
Second, in the process of pesticide synthesis, it is also indispensable. From it, pesticides such as insecticides and fungicides can be prepared. This kind of pesticide can effectively prevent pests and diseases of crops, maintain crop growth, and increase agricultural yield. Its structural characteristics make the prepared pesticide highly efficient, low toxic and environmentally friendly.
Furthermore, in the field of materials science, 1 + -bromo-2,5-dichlorobenzene can also play a role. Or it can be used to prepare special polymer materials, which can be introduced into the polymer skeleton by polymerization and other means to give the material unique properties, such as improving the heat resistance and chemical corrosion resistance of the material, so as to meet the special needs of different industrial fields for materials. From this perspective, 1 + -bromo-2,5-dichlorobenzene has important uses in various fields such as organic synthesis, pharmaceuticals, pesticides, and materials science, and is of critical significance for promoting the development of various industries.
First, in the way of drug synthesis, 1 + -bromo-2,5-dichlorobenzene has its own uses. Based on it, molecules with specific pharmacological activities can be prepared. By modifying its structure, drugs that have curative effects on specific diseases can be obtained, such as the development and preparation of anti-cancer and anti-infection drugs, or the use of this substance as a starting material.
Second, in the process of pesticide synthesis, it is also indispensable. From it, pesticides such as insecticides and fungicides can be prepared. This kind of pesticide can effectively prevent pests and diseases of crops, maintain crop growth, and increase agricultural yield. Its structural characteristics make the prepared pesticide highly efficient, low toxic and environmentally friendly.
Furthermore, in the field of materials science, 1 + -bromo-2,5-dichlorobenzene can also play a role. Or it can be used to prepare special polymer materials, which can be introduced into the polymer skeleton by polymerization and other means to give the material unique properties, such as improving the heat resistance and chemical corrosion resistance of the material, so as to meet the special needs of different industrial fields for materials. From this perspective, 1 + -bromo-2,5-dichlorobenzene has important uses in various fields such as organic synthesis, pharmaceuticals, pesticides, and materials science, and is of critical significance for promoting the development of various industries.
What is the synthesis of 1 - bromo - 2,5 - dichlorobenzene?
The method of preparing 1-bromo-2,5-dichlorobenzene is an important task in organic synthesis. It can be achieved by following several paths.
First, it can be started from 2,5-dichloroaniline. First, it reacts with sodium nitrite and hydrochloric acid. In a low temperature environment, sodium nitrite interacts with hydrochloric acid to produce nitrous acid, and nitrous acid quickly reacts with 2,5-dichloroaniline to form a diazonium salt. This diazonium salt is extremely unstable, and then a solution of cuprous bromide and hydrobromic acid is added. According to the Sandmeier reaction mechanism, the diazonium group is replaced by a bromine atom, and finally 1-bromo-2,5-dichlorobenzene is obtained. In this way, low temperature control is required in the diazotization reaction to prevent the decomposition of diazonium salts. And the quality and amount of cuprous bromide have a great impact on the reaction yield.
Second, 2,5-dichlorobenzene is used as the raw material. Shilling it to react with bromine in the catalyst. The commonly used catalyst is iron powder or iron tribromide. In this catalytic system, bromine molecules are polarized, and the electron cloud density on the benzene ring is relatively high. Because chlorine is an ortho-para-site, bromine atoms are mainly introduced into the ortho-site or para-site of chlorine atoms. After fine-tuning the reaction conditions, bromine can be mainly introduced into specific positions to prepare the target product. In this way, the amount of catalyst and the reaction temperature need to be well selected. If the temperature is too high, it is easy to cause the formation of polybrominates, which affects the purity of the product; if there is too little catalyst, the reaction rate will be slow.
Or there are other methods, but the above two are common paths. In the process of synthesis, it is necessary to abide by the experimental procedures, pay attention to safety and control conditions, and obtain satisfactory yield and purity.
First, it can be started from 2,5-dichloroaniline. First, it reacts with sodium nitrite and hydrochloric acid. In a low temperature environment, sodium nitrite interacts with hydrochloric acid to produce nitrous acid, and nitrous acid quickly reacts with 2,5-dichloroaniline to form a diazonium salt. This diazonium salt is extremely unstable, and then a solution of cuprous bromide and hydrobromic acid is added. According to the Sandmeier reaction mechanism, the diazonium group is replaced by a bromine atom, and finally 1-bromo-2,5-dichlorobenzene is obtained. In this way, low temperature control is required in the diazotization reaction to prevent the decomposition of diazonium salts. And the quality and amount of cuprous bromide have a great impact on the reaction yield.
Second, 2,5-dichlorobenzene is used as the raw material. Shilling it to react with bromine in the catalyst. The commonly used catalyst is iron powder or iron tribromide. In this catalytic system, bromine molecules are polarized, and the electron cloud density on the benzene ring is relatively high. Because chlorine is an ortho-para-site, bromine atoms are mainly introduced into the ortho-site or para-site of chlorine atoms. After fine-tuning the reaction conditions, bromine can be mainly introduced into specific positions to prepare the target product. In this way, the amount of catalyst and the reaction temperature need to be well selected. If the temperature is too high, it is easy to cause the formation of polybrominates, which affects the purity of the product; if there is too little catalyst, the reaction rate will be slow.
Or there are other methods, but the above two are common paths. In the process of synthesis, it is necessary to abide by the experimental procedures, pay attention to safety and control conditions, and obtain satisfactory yield and purity.
What are the precautions for 1 - bromo - 2,5 - dichlorobenzene during storage and transportation?
1 + -Bromo-2,5-dichlorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
When storing, the first choice of environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This compound may cause explosion due to heat or exposure to open flames. The temperature of the warehouse should be controlled within an appropriate range to prevent its chemical properties from changing due to excessive temperature.
Furthermore, it should be stored separately from oxidants, edible chemicals, etc., and should not be mixed. Due to its active chemical properties, contact with oxidants, etc., or severe chemical reactions may cause danger. At the same time, the warehouse should be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to avoid greater harm.
As for transportation, caution is also required. Before transportation, be sure to ensure that the packaging is complete and the loading is secure. Packaging materials must have good sealing and impact resistance to prevent material leakage caused by package damage during transportation. During transportation, the speed should be stable to avoid violent actions such as sudden braking and sharp turning to avoid damage to the packaging.
Transportation vehicles should also meet relevant safety standards and be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. And transportation personnel must be professionally trained and familiar with the dangerous characteristics of the compound and emergency treatment methods.
In conclusion, the storage and transportation of 1 + -bromo-2,5-dichlorobenzene is a matter of safety, and all aspects must be handled with caution in accordance with regulations to ensure safety.
When storing, the first choice of environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This compound may cause explosion due to heat or exposure to open flames. The temperature of the warehouse should be controlled within an appropriate range to prevent its chemical properties from changing due to excessive temperature.
Furthermore, it should be stored separately from oxidants, edible chemicals, etc., and should not be mixed. Due to its active chemical properties, contact with oxidants, etc., or severe chemical reactions may cause danger. At the same time, the warehouse should be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to avoid greater harm.
As for transportation, caution is also required. Before transportation, be sure to ensure that the packaging is complete and the loading is secure. Packaging materials must have good sealing and impact resistance to prevent material leakage caused by package damage during transportation. During transportation, the speed should be stable to avoid violent actions such as sudden braking and sharp turning to avoid damage to the packaging.
Transportation vehicles should also meet relevant safety standards and be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. And transportation personnel must be professionally trained and familiar with the dangerous characteristics of the compound and emergency treatment methods.
In conclusion, the storage and transportation of 1 + -bromo-2,5-dichlorobenzene is a matter of safety, and all aspects must be handled with caution in accordance with regulations to ensure safety.
What are the effects of 1 - bromo - 2,5 - dichlorobenzene on the environment and human health?
1 + -Bromo-2,5-dichlorobenzene has a significant impact on the environment and human health. This compound is toxic, difficult to degrade in the environment, and easy to cause pollution accumulation.
At the environmental level, it can remain in soil and water bodies. Entering the soil, or hindering the activities of microorganisms in the soil, disrupting the balance of soil ecology, causing soil fertility to decline, and affecting plant growth. Flowing into water bodies can poison aquatic organisms and damage aquatic ecosystems. If plankton are harmed by it, the foundation of the food chain will be shaken, which will endanger higher trophic organisms.
For human health, if people ingest it through breathing, diet or skin contact, it can be harmful to health. Or irritate the respiratory tract, causing cough, asthma and other diseases; it may also affect the nervous system, causing dizziness, fatigue, and memory loss. Long-term exposure may also increase the risk of cancer, because of its structural characteristics, or interfere with the normal metabolism and gene expression of human cells.
It can be seen that 1-bromo-2,5-dichlorobenzene has potential risks to the environment and human health, and it needs to be properly controlled to prevent its spread from causing greater harm.
At the environmental level, it can remain in soil and water bodies. Entering the soil, or hindering the activities of microorganisms in the soil, disrupting the balance of soil ecology, causing soil fertility to decline, and affecting plant growth. Flowing into water bodies can poison aquatic organisms and damage aquatic ecosystems. If plankton are harmed by it, the foundation of the food chain will be shaken, which will endanger higher trophic organisms.
For human health, if people ingest it through breathing, diet or skin contact, it can be harmful to health. Or irritate the respiratory tract, causing cough, asthma and other diseases; it may also affect the nervous system, causing dizziness, fatigue, and memory loss. Long-term exposure may also increase the risk of cancer, because of its structural characteristics, or interfere with the normal metabolism and gene expression of human cells.
It can be seen that 1-bromo-2,5-dichlorobenzene has potential risks to the environment and human health, and it needs to be properly controlled to prevent its spread from causing greater harm.
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