Linshang Chemical
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1-Bromo-2-Chloro-3,4,5-Trifluorobenzene
Linshang Chemical
|
HS Code |
478052 |
| Chemical Formula | C6HBrClF3 |
| Molar Mass | 259.42 g/mol |
| Appearance | Liquid (usually) |
| Density | Data needed |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Solubility In Water | Low (organic compound) |
| Solubility In Organic Solvents | Good (in common organic solvents) |
| Flash Point | Data needed |
| Vapor Pressure | Data needed |
| Purity | Varies by source |
| Cas Number | Data needed |
As an accredited 1-Bromo-2-Chloro-3,4,5-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - bromo - 2 - chloro - 3,4,5 - trifluorobenzene packaged in 100 - mL glass bottles, 5 bottles per pack. |
| Storage | 1 - Bromo - 2 - chloro - 3,4,5 - trifluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential reactions. Label the storage clearly for easy identification and safety. |
| Shipping | 1 - bromo - 2 - chloro - 3,4,5 - trifluorobenzene is shipped in specialized, leak - proof containers. These are carefully packed to prevent breakage. Shipments follow strict hazardous chemical regulations for safe transportation. |
Competitive 1-Bromo-2-Chloro-3,4,5-Trifluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Bromo-2-Chloro-3,4,5-Trifluorobenzene in China?
As a trusted 1-Bromo-2-Chloro-3,4,5-Trifluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-2-Chloro-3,4,5-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-bromo-2-chloro-3,4,5-trifluorobenzene?
1 - bromo - 2 - chloro - 3,4,5 - trifluorobenzene is an organic compound, which has important uses in chemical engineering, medicine, materials and other fields.
In the chemical industry, it is often used as an intermediate in organic synthesis. Because of its active halogen atom in the molecule, it can introduce different functional groups through many chemical reactions, such as nucleophilic substitution reactions, and various nucleophilic reagents, and then synthesize organic compounds with complex structures. For example, by reacting with alkoxides, corresponding ether compounds can be formed; by reacting with amines, nitrogen-containing derivatives can be obtained. These reactions lay the foundation for the construction of diverse organic molecular structures and help to synthesize organic materials with specific properties and functions.
In the field of medicine, this compound also plays a key role. Some derivatives synthesized from it as a starting material through multi-step reactions may have potential biological activity. Researchers can develop new drugs by modifying their structures and adjusting the interaction between compounds and biological targets. For example, by rationally designing the reaction route, changing the substitution mode of halogen atoms or introducing specific pharmacokinetic groups, the pharmacological activity, selectivity and pharmacokinetic properties of compounds may be improved.
In the field of materials science, 1-bromo-2-chloro-3,4,5-trifluorobenzene can be used to prepare high-performance functional materials. Through the polymerization reaction it participates in, special structures can be introduced into the main chain or side chain of polymer materials, giving the material unique properties. For example, the preparation of fluoropolymers, due to the properties of fluorine atoms, can make the material have excellent chemical stability, low surface energy and good optical properties, and show broad application prospects in electronics, optics and protective materials.
In summary, 1-bromo-2-chloro-3,4,5-trifluorobenzene plays an important role in many fields due to its unique chemical structure and active reactivity, providing an important material basis for research and development in related fields.
In the chemical industry, it is often used as an intermediate in organic synthesis. Because of its active halogen atom in the molecule, it can introduce different functional groups through many chemical reactions, such as nucleophilic substitution reactions, and various nucleophilic reagents, and then synthesize organic compounds with complex structures. For example, by reacting with alkoxides, corresponding ether compounds can be formed; by reacting with amines, nitrogen-containing derivatives can be obtained. These reactions lay the foundation for the construction of diverse organic molecular structures and help to synthesize organic materials with specific properties and functions.
In the field of medicine, this compound also plays a key role. Some derivatives synthesized from it as a starting material through multi-step reactions may have potential biological activity. Researchers can develop new drugs by modifying their structures and adjusting the interaction between compounds and biological targets. For example, by rationally designing the reaction route, changing the substitution mode of halogen atoms or introducing specific pharmacokinetic groups, the pharmacological activity, selectivity and pharmacokinetic properties of compounds may be improved.
In the field of materials science, 1-bromo-2-chloro-3,4,5-trifluorobenzene can be used to prepare high-performance functional materials. Through the polymerization reaction it participates in, special structures can be introduced into the main chain or side chain of polymer materials, giving the material unique properties. For example, the preparation of fluoropolymers, due to the properties of fluorine atoms, can make the material have excellent chemical stability, low surface energy and good optical properties, and show broad application prospects in electronics, optics and protective materials.
In summary, 1-bromo-2-chloro-3,4,5-trifluorobenzene plays an important role in many fields due to its unique chemical structure and active reactivity, providing an important material basis for research and development in related fields.
What are the physical properties of 1-bromo-2-chloro-3,4,5-trifluorobenzene
1 - bromo - 2 - chloro - 3,4,5 - trifluorobenzene is an organic compound with unique physical properties. Its properties are mostly colorless to light yellow liquids, which are stable at room temperature and pressure, and may be dangerous in case of hot topics, open flames or strong oxidants.
This compound is volatile and can form vapors in air. Its boiling point is about 190 - 195 ° C, and its melting point is -30 - -25 ° C. Due to the presence of bromine, chlorine and fluorine atoms in the molecule, its density is greater than that of water, about 1.8 - 1.9 g/cm ³. It is insoluble in water, but miscible with common organic solvents such as ethanol, ether, acetone, etc.
The vapor pressure of 1-bromo-2-chloro-3,4,5-trifluorobenzene is relatively low, indicating that its volatilization rate is slow at room temperature. And because of its halogen atom, the molecule is polar, but the polarity is not strong. This polarity affects its solubility and intermolecular interactions. In the field of organic synthesis, it is often used as an intermediate because halogen atoms can participate in many chemical reactions, such as nucleophilic substitution reactions.
This compound is volatile and can form vapors in air. Its boiling point is about 190 - 195 ° C, and its melting point is -30 - -25 ° C. Due to the presence of bromine, chlorine and fluorine atoms in the molecule, its density is greater than that of water, about 1.8 - 1.9 g/cm ³. It is insoluble in water, but miscible with common organic solvents such as ethanol, ether, acetone, etc.
The vapor pressure of 1-bromo-2-chloro-3,4,5-trifluorobenzene is relatively low, indicating that its volatilization rate is slow at room temperature. And because of its halogen atom, the molecule is polar, but the polarity is not strong. This polarity affects its solubility and intermolecular interactions. In the field of organic synthesis, it is often used as an intermediate because halogen atoms can participate in many chemical reactions, such as nucleophilic substitution reactions.
What are the chemical properties of 1-bromo-2-chloro-3,4,5-trifluorobenzene
1-Bromo-2-chloro-3,4,5-trifluorobenzene is an organohalogenated aromatic hydrocarbon with unique chemical properties. This compound contains halogen atoms such as bromine, chlorine, and fluorine, and the electronic and spatial effects of halogen atoms have a great influence on its chemical behavior.
Due to the strong electronegativity of halogen atoms, the electron cloud density of aromatic rings in this compound decreases, and the electrophilic substitution reaction activity is lower than that of benzene. The localization effect of substituents on aromatic rings also changes. Halogen atoms are ortho and para-sites, but due to the electron-absorbing induction effect, the electron cloud density of ortho and para-sites decreases, and the electrophilic substitution reaction mainly occurs in the meso.
In the nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents. Different halogen atoms have different activities. Generally speaking, the activity of bromine atoms is higher than that of chlorine atoms and fluorine atoms, because its C-Br bond energy is relatively small and it is easier to break. When the nucleophilic reagent attacks, it can react according to the SN1 or SN2 mechanism, depending on the reaction conditions.
The fluorine atom of this compound gives it special properties. The fluorine atom has the largest electronegativity, the length of the C-F bond and the large bond energy, which enhances the molecular stability. Fluorine-containing compounds often have unique physical and chemical properties, such as high fat solubility and stability, and are widely used in the fields of medicine, pesticides and materials science.
In addition, 1-bromo-2-chloro-3,4,5-trifluorobenzene can participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc. Such reactions are important methods for constructing carbon-carbon bonds and are used in organic synthesis to prepare complex aromatic derivatives.
In summary, 1-bromo-2-chloro-3,4,5-trifluorobenzene has chemical properties such as electrophilic substitution, nucleophilic substitution and coupling reactions due to the presence of halogen atoms, and has important application value in organic synthesis and materials science.
Due to the strong electronegativity of halogen atoms, the electron cloud density of aromatic rings in this compound decreases, and the electrophilic substitution reaction activity is lower than that of benzene. The localization effect of substituents on aromatic rings also changes. Halogen atoms are ortho and para-sites, but due to the electron-absorbing induction effect, the electron cloud density of ortho and para-sites decreases, and the electrophilic substitution reaction mainly occurs in the meso.
In the nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents. Different halogen atoms have different activities. Generally speaking, the activity of bromine atoms is higher than that of chlorine atoms and fluorine atoms, because its C-Br bond energy is relatively small and it is easier to break. When the nucleophilic reagent attacks, it can react according to the SN1 or SN2 mechanism, depending on the reaction conditions.
The fluorine atom of this compound gives it special properties. The fluorine atom has the largest electronegativity, the length of the C-F bond and the large bond energy, which enhances the molecular stability. Fluorine-containing compounds often have unique physical and chemical properties, such as high fat solubility and stability, and are widely used in the fields of medicine, pesticides and materials science.
In addition, 1-bromo-2-chloro-3,4,5-trifluorobenzene can participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc. Such reactions are important methods for constructing carbon-carbon bonds and are used in organic synthesis to prepare complex aromatic derivatives.
In summary, 1-bromo-2-chloro-3,4,5-trifluorobenzene has chemical properties such as electrophilic substitution, nucleophilic substitution and coupling reactions due to the presence of halogen atoms, and has important application value in organic synthesis and materials science.
What are the synthesis methods of 1-bromo-2-chloro-3,4,5-trifluorobenzene?
The synthesis method of 1-bromo-2-chloro-3,4,5-trifluorobenzene can be obtained from many ways. First, benzene is used as the starting material and is prepared by multi-step reaction. First, benzene is halogenated, and bromine atoms are introduced under specific conditions and suitable halogenation reagents to obtain bromobenzene. On the basis of this bromobenzene, through chlorination reaction, a suitable chlorination agent and reaction environment are selected to introduce chlorine atoms at the ortho position to obtain 1-bromo-2-chlorobenzene. Afterwards, a trifluorobenzene substitution reaction is carried out, and fluorine-containing reagents, such as nucleophilic substitution method, are used to gradually replace the hydrogen atoms at the 3,4,5 positions with fluorine atoms under suitable conditions such as base and reaction temperature, and finally obtain the target product 1-bromo-2-chloro-3,4,5-trifluorobenzene.
Second, it can be started from other aromatic derivatives. If nitrobenzene is used as the starting material, bromine and chlorine atoms are introduced in turn through halogenation reaction, depending on the specific reaction conditions and halogenating agent. After that, through reduction reaction, the nitro group is converted into an amino group, and then through diazotization reaction and fluorination reaction, the trifluoride substitution is completed with specific reagents and conditions, and then the target compound is obtained.
Third, suitable halogenated aromatics can also be considered as starting materials and combined with fluorine-containing reagents through metal-catalyzed cross-coupling reactions. For example, a palladium-catalyzed system is used to introduce fluorine atoms under suitable ligand, base and solvent conditions, and 1-bromo-2-chloro-3,4,5-trifluorobenzene is synthesized through appropriate steps and conditions optimization. Each method needs to carefully control the reaction conditions, such as temperature, pressure, reagent dosage and reaction time, and should consider factors such as raw material availability, cost and yield to find the most suitable route.
Second, it can be started from other aromatic derivatives. If nitrobenzene is used as the starting material, bromine and chlorine atoms are introduced in turn through halogenation reaction, depending on the specific reaction conditions and halogenating agent. After that, through reduction reaction, the nitro group is converted into an amino group, and then through diazotization reaction and fluorination reaction, the trifluoride substitution is completed with specific reagents and conditions, and then the target compound is obtained.
Third, suitable halogenated aromatics can also be considered as starting materials and combined with fluorine-containing reagents through metal-catalyzed cross-coupling reactions. For example, a palladium-catalyzed system is used to introduce fluorine atoms under suitable ligand, base and solvent conditions, and 1-bromo-2-chloro-3,4,5-trifluorobenzene is synthesized through appropriate steps and conditions optimization. Each method needs to carefully control the reaction conditions, such as temperature, pressure, reagent dosage and reaction time, and should consider factors such as raw material availability, cost and yield to find the most suitable route.
What to pay attention to when storing and transporting 1-bromo-2-chloro-3,4,5-trifluorobenzene
1-Bromo-2-chloro-3,4,5-trifluorobenzene is an organic compound. When storing and transporting, many key matters must be paid attention to to to ensure its stability and safety.
First of all, this compound should be stored in a cool, dry and well-ventilated place. Because it is sensitive to heat, high temperature can easily decompose or cause other chemical reactions, so it should be kept away from heat and fire sources. If placed in direct sunlight, light may also cause photochemical reactions, so it needs to be stored in a container protected from light. In addition, the compound may be toxic and corrosive to a certain extent, and it must be stored separately from oxidants, acids, bases and other substances to prevent mutual reaction and cause danger. The storage place should be equipped with corresponding leakage emergency treatment equipment and suitable containment materials. In the event of leakage, it can be dealt with in time.
As for transportation, it is necessary to ensure that the packaging is complete and well sealed before transportation. Packaging materials need to be able to effectively prevent their leakage and volatilization, and have certain pressure and shock resistance properties to avoid danger caused by package damage during transportation. During transportation, relevant transportation regulations and operating procedures should be strictly observed to avoid mixed transportation with other incompatible goods. Transportation vehicles should also be equipped with necessary fire fighting equipment and leakage emergency treatment equipment. Transportation personnel need to undergo professional training and be familiar with the properties of the compound and emergency treatment methods. In the event of a leak during transportation, appropriate measures should be taken immediately to evacuate the surrounding personnel, prevent the expansion of pollution, and promptly report to the relevant departments for handling.
First of all, this compound should be stored in a cool, dry and well-ventilated place. Because it is sensitive to heat, high temperature can easily decompose or cause other chemical reactions, so it should be kept away from heat and fire sources. If placed in direct sunlight, light may also cause photochemical reactions, so it needs to be stored in a container protected from light. In addition, the compound may be toxic and corrosive to a certain extent, and it must be stored separately from oxidants, acids, bases and other substances to prevent mutual reaction and cause danger. The storage place should be equipped with corresponding leakage emergency treatment equipment and suitable containment materials. In the event of leakage, it can be dealt with in time.
As for transportation, it is necessary to ensure that the packaging is complete and well sealed before transportation. Packaging materials need to be able to effectively prevent their leakage and volatilization, and have certain pressure and shock resistance properties to avoid danger caused by package damage during transportation. During transportation, relevant transportation regulations and operating procedures should be strictly observed to avoid mixed transportation with other incompatible goods. Transportation vehicles should also be equipped with necessary fire fighting equipment and leakage emergency treatment equipment. Transportation personnel need to undergo professional training and be familiar with the properties of the compound and emergency treatment methods. In the event of a leak during transportation, appropriate measures should be taken immediately to evacuate the surrounding personnel, prevent the expansion of pollution, and promptly report to the relevant departments for handling.
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