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1-Bromo-2-Chloro-3,4-Difluorobenzene
|
HS Code |
986351 |
| Chemical Formula | C6H2BrClF2 |
| Molecular Weight | 229.43 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Around 190 - 200 °C (approximate, can vary with pressure) |
| Solubility In Water | Insoluble, as it's an organic halogen - containing compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Flash Point | No widely - reported value, but as an organic liquid, it has a flash point relevant for fire safety |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 1-Bromo-2-Chloro-3,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - bromo - 2 - chloro - 3,4 - difluorobenzene: Packed in 500 - gram bottles for chemical storage. |
| Storage | 1 - Bromo - 2 - chloro - 3,4 - difluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential chemical reactions. |
| Shipping | 1 - bromo - 2 - chloro - 3,4 - difluorobenzene is a chemical. Ship it in properly sealed, corrosion - resistant containers. Ensure compliance with hazardous material shipping regulations, and label containers clearly for safe transport. |
Competitive 1-Bromo-2-Chloro-3,4-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Bromo-2-Chloro-3,4-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-bromo-2-chloro-3,4-difluorobenzene?
1-Bromo-2-chloro-3,4-difluorobenzene is an organohalogenated aromatic hydrocarbon with unique chemical properties. Its chemical activity is caused by halogen atoms, which have different electronegativity, and have different effects on the electron cloud density of the benzene ring.
Bromine, chlorine and fluorine have different electronegativity, which causes uneven distribution of electron cloud density of the benzene ring. The fluorine electronegativity is large, which strongly attracts electrons, which decreases the density of the adjacent and para-potential electron clouds and decreases the activity of the electrophilic substitution reaction. However, it can undergo nucleophilic substitution reaction with nucleophilic reagents, and the halogen atoms can be replaced by nucleophilic groups. Because the halogen atoms absorb electrons, the benzene ring carbon atoms are partially positively charged, and the nucle
It can metallize and react with metal reagents such as magnesium and lithium to form active organometallic intermediates, which are used to construct carbon-carbon bonds, which are crucial in organic synthesis to construct complex molecular structures.
Good thermal stability, due to the conjugation system of benzene ring and the interaction of halogen atoms with benzene ring, the molecular structure is stable, and it can withstand high temperature under certain conditions. However, under specific conditions such as strong oxidizing agent, high temperature and high pressure and catalyst, the molecular structure will change, or cause halogen atoms to detach or benzene ring to open.
1 - bromo - 2 - chloro - 3,4 - difluorobenzene can participate in a variety of organic reactions due to the presence of halogen atoms and its active chemical properties. It is widely used in the field of organic synthesis and can synthesize functional compounds such as medicines, pesticides, and materials.
Bromine, chlorine and fluorine have different electronegativity, which causes uneven distribution of electron cloud density of the benzene ring. The fluorine electronegativity is large, which strongly attracts electrons, which decreases the density of the adjacent and para-potential electron clouds and decreases the activity of the electrophilic substitution reaction. However, it can undergo nucleophilic substitution reaction with nucleophilic reagents, and the halogen atoms can be replaced by nucleophilic groups. Because the halogen atoms absorb electrons, the benzene ring carbon atoms are partially positively charged, and the nucle
It can metallize and react with metal reagents such as magnesium and lithium to form active organometallic intermediates, which are used to construct carbon-carbon bonds, which are crucial in organic synthesis to construct complex molecular structures.
Good thermal stability, due to the conjugation system of benzene ring and the interaction of halogen atoms with benzene ring, the molecular structure is stable, and it can withstand high temperature under certain conditions. However, under specific conditions such as strong oxidizing agent, high temperature and high pressure and catalyst, the molecular structure will change, or cause halogen atoms to detach or benzene ring to open.
1 - bromo - 2 - chloro - 3,4 - difluorobenzene can participate in a variety of organic reactions due to the presence of halogen atoms and its active chemical properties. It is widely used in the field of organic synthesis and can synthesize functional compounds such as medicines, pesticides, and materials.
What are the common uses of 1-bromo-2-chloro-3,4-difluorobenzene?
1-Bromo-2-chloro-3,4-difluorobenzene is a compound commonly used in organic synthesis. Its common uses are quite extensive and are described in detail below.
In the field of medicinal chemistry, this compound plays an important role. Due to its unique chemical structure, it can be used as a key intermediate for the synthesis of many biologically active drug molecules. For example, by coupling with other compounds containing nitrogen, oxygen and other functional groups, specific chemical reactions can be used to construct drugs that are effective for specific diseases, such as potential therapeutic drugs for certain diseases such as inflammation and tumors. Due to the presence of halogen atoms in the structure, caps can affect the electron cloud distribution and spatial configuration of molecules, thereby changing the interaction mode and intensity between drugs and biological targets. Therefore, they are often regarded as promising starting materials in the process of drug development.
In the field of materials science, 1-bromo-2-chloro-3,4-difluorobenzene is also useful. It can participate in the synthesis of polymer materials and endow materials with special properties. For example, when preparing high-performance liquid crystal materials, the introduction of this compound structural unit can adjust the arrangement and orientation of liquid crystal molecules, improve the optical properties of liquid crystal materials, and make them suitable for high-resolution display technology. Furthermore, when synthesizing organic semiconductor materials, the compound can be used as a structural modifier to optimize the electrical properties of the material, improve its carrier mobility and other parameters, and provide assistance for the development of organic electronic devices.
In pesticide chemistry, this compound can be used as an important building block for the synthesis of new pesticides. Due to its structural characteristics, the synthesized pesticides may have the advantages of high efficiency, low toxicity and environmental friendliness. By combining with pesticide active groups containing phosphorus and sulfur, pesticide varieties with high selectivity to pests and low impact on the environment can be created, which is conducive to the sustainable development of agriculture and meets the needs of modern society for green and safe pesticides.
To sum up, 1-bromo-2-chloro-3,4-difluorobenzene has shown important uses in many fields such as medicine, materials, and pesticides due to its unique structure, which is of great significance to the development of related industries.
In the field of medicinal chemistry, this compound plays an important role. Due to its unique chemical structure, it can be used as a key intermediate for the synthesis of many biologically active drug molecules. For example, by coupling with other compounds containing nitrogen, oxygen and other functional groups, specific chemical reactions can be used to construct drugs that are effective for specific diseases, such as potential therapeutic drugs for certain diseases such as inflammation and tumors. Due to the presence of halogen atoms in the structure, caps can affect the electron cloud distribution and spatial configuration of molecules, thereby changing the interaction mode and intensity between drugs and biological targets. Therefore, they are often regarded as promising starting materials in the process of drug development.
In the field of materials science, 1-bromo-2-chloro-3,4-difluorobenzene is also useful. It can participate in the synthesis of polymer materials and endow materials with special properties. For example, when preparing high-performance liquid crystal materials, the introduction of this compound structural unit can adjust the arrangement and orientation of liquid crystal molecules, improve the optical properties of liquid crystal materials, and make them suitable for high-resolution display technology. Furthermore, when synthesizing organic semiconductor materials, the compound can be used as a structural modifier to optimize the electrical properties of the material, improve its carrier mobility and other parameters, and provide assistance for the development of organic electronic devices.
In pesticide chemistry, this compound can be used as an important building block for the synthesis of new pesticides. Due to its structural characteristics, the synthesized pesticides may have the advantages of high efficiency, low toxicity and environmental friendliness. By combining with pesticide active groups containing phosphorus and sulfur, pesticide varieties with high selectivity to pests and low impact on the environment can be created, which is conducive to the sustainable development of agriculture and meets the needs of modern society for green and safe pesticides.
To sum up, 1-bromo-2-chloro-3,4-difluorobenzene has shown important uses in many fields such as medicine, materials, and pesticides due to its unique structure, which is of great significance to the development of related industries.
What is the synthesis method of 1-bromo-2-chloro-3,4-difluorobenzene?
The synthesis of 1-bromo-2-chloro-3,4-difluorobenzene is an important topic in organic synthetic chemistry. The synthesis path often depends on the reaction efficiency and yield of the existing raw materials and the desired.
Common starting materials can be benzene or benzene derivatives with specific substituents. If benzene is used as the starting point, a multi-step reaction is required to introduce bromine, chlorine and fluorine atoms one after another.
The first step is to introduce bromine atoms by electrophilic substitution reaction. Using iron bromide ($FeBr_ {3} $) as a catalyst, benzene reacts with bromine elemental ($Br_ {2} $) to obtain bromobenzene. The reaction mechanism is that $FeBr_ {3} $interacts with $Br_ {2} $to form a more active $Br ^ {+} $ion, which attacks the benzene ring and forms a $\ sigma $complex, and then loses protons to obtain bromobenzene.
The second step is to introduce a chlorine atom on the basis of bromobenzene. Similarly, an electrophilic substitution reaction is used, using ferric chloride ($FeCl_ {3} $) as a catalyst and reacting with chlorine gas ($Cl_ {2} $) to obtain 1-bromo-2-chlorobenzene. In this process, because bromine is an ortho-para-site, chlorine atoms are mainly introduced into the ortho-site of bromine to form the target product.
The third step is to introduce fluorine atoms. A halogen exchange reaction can be used to react with potassium fluoride ($KF $) in a specific solvent (such as dimethyl sulfoxide, $DMSO $) using 1-bromo-2-chlorobenzene as raw material. The fluoride ion in $KF $nucleophilic substitutions of bromine or chlorine atoms. This reaction requires appropriate heating and phase transfer catalysts to promote the reaction. Due to the high activity of fluorine atoms and the steric resistance and other factors, it can selectively introduce specific positions to obtain 1-bromo-2-chloro-3,4-difluorobenzene.
There is another synthetic route. If the starting material is a benzene derivative with a suitable substituent, a simpler reaction route can be designed according to the localization effect of the substituent. But overall, each step requires precise control of the reaction conditions, including temperature, reactant ratio, catalyst dosage, etc., to obtain 1-bromo-2-chloro-3,4-difluorobenzene with high purity and yield.
Common starting materials can be benzene or benzene derivatives with specific substituents. If benzene is used as the starting point, a multi-step reaction is required to introduce bromine, chlorine and fluorine atoms one after another.
The first step is to introduce bromine atoms by electrophilic substitution reaction. Using iron bromide ($FeBr_ {3} $) as a catalyst, benzene reacts with bromine elemental ($Br_ {2} $) to obtain bromobenzene. The reaction mechanism is that $FeBr_ {3} $interacts with $Br_ {2} $to form a more active $Br ^ {+} $ion, which attacks the benzene ring and forms a $\ sigma $complex, and then loses protons to obtain bromobenzene.
The second step is to introduce a chlorine atom on the basis of bromobenzene. Similarly, an electrophilic substitution reaction is used, using ferric chloride ($FeCl_ {3} $) as a catalyst and reacting with chlorine gas ($Cl_ {2} $) to obtain 1-bromo-2-chlorobenzene. In this process, because bromine is an ortho-para-site, chlorine atoms are mainly introduced into the ortho-site of bromine to form the target product.
The third step is to introduce fluorine atoms. A halogen exchange reaction can be used to react with potassium fluoride ($KF $) in a specific solvent (such as dimethyl sulfoxide, $DMSO $) using 1-bromo-2-chlorobenzene as raw material. The fluoride ion in $KF $nucleophilic substitutions of bromine or chlorine atoms. This reaction requires appropriate heating and phase transfer catalysts to promote the reaction. Due to the high activity of fluorine atoms and the steric resistance and other factors, it can selectively introduce specific positions to obtain 1-bromo-2-chloro-3,4-difluorobenzene.
There is another synthetic route. If the starting material is a benzene derivative with a suitable substituent, a simpler reaction route can be designed according to the localization effect of the substituent. But overall, each step requires precise control of the reaction conditions, including temperature, reactant ratio, catalyst dosage, etc., to obtain 1-bromo-2-chloro-3,4-difluorobenzene with high purity and yield.
What are the physical properties of 1-bromo-2-chloro-3,4-difluorobenzene?
1-Bromo-2-chloro-3,4-difluorobenzene is one of the organic compounds. Its physical properties are particularly important, and it is related to the performance of this substance in different scenes.
First of all, its appearance is often colorless to light yellow liquid, clear and with a specific luster. This appearance characteristic can help to identify it initially. Its odor may have an aromatic smell, but such aromas may also be potentially harmful, so you need to smell it carefully.
As for the boiling point, it is about a certain temperature range, and this value is closely related to the intermolecular force. Due to the existence of bromine, chlorine, and fluorine atoms in the molecule, the intermolecular force is more complex, so that the boiling point is within the corresponding range. The exact value of the boiling point is crucial for its separation, purification and maintenance of the state under a specific temperature environment.
Melting point is also an important physical property. At a specific low temperature, 1-bromo-2-chloro-3,4-difluorobenzene will change from liquid to solid state. This transition temperature is related to the molecular arrangement and interaction. Knowing the melting point can control its physical state during storage and specific processing.
In terms of density, there is a specific value. Compared with water and other common solvents, its floating state in the mixed system can be clarified. It is of great significance in chemical experiments and phase separation operations in industrial production.
Solubility, in organic solvents such as ethanol and ether, or with some solubility, but in water or poor solubility. This property is derived from the ratio of polar to non-polar parts of its molecular structure, which has a profound impact on the selection of its chemical reaction environment and the way of product separation.
The physical properties of 1-bromo-2-chloro-3,4-difluorobenzene have their own uses, and are indispensable factors for chemical research and production practice.
First of all, its appearance is often colorless to light yellow liquid, clear and with a specific luster. This appearance characteristic can help to identify it initially. Its odor may have an aromatic smell, but such aromas may also be potentially harmful, so you need to smell it carefully.
As for the boiling point, it is about a certain temperature range, and this value is closely related to the intermolecular force. Due to the existence of bromine, chlorine, and fluorine atoms in the molecule, the intermolecular force is more complex, so that the boiling point is within the corresponding range. The exact value of the boiling point is crucial for its separation, purification and maintenance of the state under a specific temperature environment.
Melting point is also an important physical property. At a specific low temperature, 1-bromo-2-chloro-3,4-difluorobenzene will change from liquid to solid state. This transition temperature is related to the molecular arrangement and interaction. Knowing the melting point can control its physical state during storage and specific processing.
In terms of density, there is a specific value. Compared with water and other common solvents, its floating state in the mixed system can be clarified. It is of great significance in chemical experiments and phase separation operations in industrial production.
Solubility, in organic solvents such as ethanol and ether, or with some solubility, but in water or poor solubility. This property is derived from the ratio of polar to non-polar parts of its molecular structure, which has a profound impact on the selection of its chemical reaction environment and the way of product separation.
The physical properties of 1-bromo-2-chloro-3,4-difluorobenzene have their own uses, and are indispensable factors for chemical research and production practice.
What are the precautions for storing and transporting 1-bromo-2-chloro-3,4-difluorobenzene?
1-Bromo-2-chloro-3,4-difluorobenzene is an organic compound, and many things must be paid attention to during storage and transportation.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This compound may be dangerous when exposed to heat or open flames, so it is crucial to control the temperature and fire source. The temperature of the warehouse should be maintained within a specific range, and it should not be too high to prevent its properties from changing or triggering chemical reactions.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be stored together. Because of its active chemical properties, contact with other substances, or a violent reaction, endangering safety. The storage place should also be equipped with suitable materials to contain the leakage, in case of leakage, it can be dealt with in time to avoid greater harm.
When transporting, also need to be cautious. The transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During transportation, protect against sun exposure, rain, and high temperature. The road is bumpy, temperature changes, etc., may affect the stability of this material. When loading and unloading, it should be handled lightly to prevent damage to the packaging and containers. If the packaging is damaged, the compound leaks, which is easy to cause danger. Transport according to the specified route, do not stop in residential areas and densely populated areas, so as to avoid leakage and cause harm to the public. In short, the storage and transportation of 1-bromo-2-chloro-3,4-difluorobenzene should be strictly followed to ensure safety.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This compound may be dangerous when exposed to heat or open flames, so it is crucial to control the temperature and fire source. The temperature of the warehouse should be maintained within a specific range, and it should not be too high to prevent its properties from changing or triggering chemical reactions.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be stored together. Because of its active chemical properties, contact with other substances, or a violent reaction, endangering safety. The storage place should also be equipped with suitable materials to contain the leakage, in case of leakage, it can be dealt with in time to avoid greater harm.
When transporting, also need to be cautious. The transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During transportation, protect against sun exposure, rain, and high temperature. The road is bumpy, temperature changes, etc., may affect the stability of this material. When loading and unloading, it should be handled lightly to prevent damage to the packaging and containers. If the packaging is damaged, the compound leaks, which is easy to cause danger. Transport according to the specified route, do not stop in residential areas and densely populated areas, so as to avoid leakage and cause harm to the public. In short, the storage and transportation of 1-bromo-2-chloro-3,4-difluorobenzene should be strictly followed to ensure safety.
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