Linshang Chemical
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1-Bromo-2-Chloro-3-Fluorobenzene
Linshang Chemical
|
HS Code |
576182 |
| Name | 1-Bromo-2-Chloro-3-Fluorobenzene |
| Molecular Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 190 - 195 °C |
| Density | Approx. 1.73 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, and dichloromethane |
As an accredited 1-Bromo-2-Chloro-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 2 - chloro - 3 - fluorobenzene packaged in a sealed glass bottle. |
| Storage | 1 - bromo - 2 - chloro - 3 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 1 - Bromo - 2 - chloro - 3 - fluorobenzene is shipped in sealed, corrosion - resistant containers. Adequate cushioning is used to prevent breakage. Shipments follow strict chemical transport regulations to ensure safety during transit. |
Competitive 1-Bromo-2-Chloro-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 1-Bromo-2-Chloro-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1 - bromo - 2 - chloro - 3 - fluorobenzene
1 + -Bromo-2-chloro-3-fluorobenzene is an organic compound. Its physical properties are quite important and it is useful in various fields of chemistry.
Looking at its properties, under normal circumstances, 1 + -bromo-2-chloro-3-fluorobenzene is a colorless to pale yellow liquid, which is convenient for the operation and application of many chemical reactions. It has a special smell, although it is difficult to describe it exactly, but chemical practitioners can distinguish one or two according to its taste.
When it comes to boiling points, it is about a certain range, because the exact value will vary slightly depending on the measurement environment. In general, its boiling point is sufficient to cause it to undergo a phase transition under appropriate heating conditions. This property is crucial in operations such as separation and purification. For example, in the distillation process, it can be separated from other substances with different boiling points according to its boiling point.
Melting point also has a specific value. The melting point determines the temperature at which it changes from solid to liquid, which is of great significance for the control of storage and transportation conditions. If the storage temperature is higher than the melting point, it will be in a liquid state, and attention should be paid to the sealing of the container; if it is lower than the melting point, attention should be paid to preventing it from freezing and causing the container to break.
In terms of solubility, 1 + -bromo-2-chloro-3-fluorobenzene often has good solubility in organic solvents, such as ethanol, ether, etc. This property enables it to participate in many organic synthesis reactions as a reactant or solvent. In water, its solubility is poor, which is due to the characteristics of its molecular structure. It is a non-polar or weakly polar molecule and interacts weakly with polar water molecules.
Density is also one of its important physical properties and has a certain value. By measuring the density, it can help to judge its purity. If the density deviates from the theoretical value, or it implies that it contains impurities.
In addition, the vapor pressure of 1 + -bromo-2-chloro-3-fluorobenzene cannot be ignored. The vapor pressure reflects the difficulty of volatilization at a certain temperature, and has a guiding role in the formulation of safety measures such as ventilation of the operating environment.
The physical properties of this compound are interrelated, which jointly affect its application in chemical research, industrial production, etc.
Looking at its properties, under normal circumstances, 1 + -bromo-2-chloro-3-fluorobenzene is a colorless to pale yellow liquid, which is convenient for the operation and application of many chemical reactions. It has a special smell, although it is difficult to describe it exactly, but chemical practitioners can distinguish one or two according to its taste.
When it comes to boiling points, it is about a certain range, because the exact value will vary slightly depending on the measurement environment. In general, its boiling point is sufficient to cause it to undergo a phase transition under appropriate heating conditions. This property is crucial in operations such as separation and purification. For example, in the distillation process, it can be separated from other substances with different boiling points according to its boiling point.
Melting point also has a specific value. The melting point determines the temperature at which it changes from solid to liquid, which is of great significance for the control of storage and transportation conditions. If the storage temperature is higher than the melting point, it will be in a liquid state, and attention should be paid to the sealing of the container; if it is lower than the melting point, attention should be paid to preventing it from freezing and causing the container to break.
In terms of solubility, 1 + -bromo-2-chloro-3-fluorobenzene often has good solubility in organic solvents, such as ethanol, ether, etc. This property enables it to participate in many organic synthesis reactions as a reactant or solvent. In water, its solubility is poor, which is due to the characteristics of its molecular structure. It is a non-polar or weakly polar molecule and interacts weakly with polar water molecules.
Density is also one of its important physical properties and has a certain value. By measuring the density, it can help to judge its purity. If the density deviates from the theoretical value, or it implies that it contains impurities.
In addition, the vapor pressure of 1 + -bromo-2-chloro-3-fluorobenzene cannot be ignored. The vapor pressure reflects the difficulty of volatilization at a certain temperature, and has a guiding role in the formulation of safety measures such as ventilation of the operating environment.
The physical properties of this compound are interrelated, which jointly affect its application in chemical research, industrial production, etc.
Chemical properties of 1 - bromo - 2 - chloro - 3 - fluorobenzene
1 + -Bromo-2-chloro-3-fluorobenzene is one of the organic compounds. Its chemical properties are unique and interesting.
First talk about the nucleophilic substitution reaction. Because there are halogen atoms attached to the benzene ring, bromine, chlorine and fluorine can all leave due to the attack of nucleophilic reagents. The difficulty of leaving is related to the properties of halogen atoms. Fluorine atoms are difficult to leave because of their small atomic radius and strong binding force with the benzene ring; while bromine atoms are relatively large and weakly bound to the benzene ring, making it easier to leave. Therefore, when nucleophiles such as hydroxyl anions (OH~) and amino anions (NH _ 2) attack, bromine atoms are more likely to be replaced to generate corresponding hydroxybenzene or aminobenzene derivatives.
The second discussion on the electrophilic substitution reaction. Benzene rings are electron-rich and can undergo electrophilic substitution. However, in this compound, the halogen atom is an electron-withdrawing group, which will reduce the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene itself. And the positioning effect of halogen atoms also plays a role. Bromine, chlorine, and fluorine are all ortho-para-sites. Although the reaction activity is reduced, they guide the electrophilic reagents to attack the ortho and para-sites of the benzene ring. For example, when reacting with the mixed acid of nitric acid and sulfuric acid, the electrophilic reagent nitro-positive ion (NO 2O 🥰) is more inclined to attack the neighbor and para-position of the halogen atom to form nitro-substituted products.
Re-discuss its reaction with metal-organic reagents. 1 + -Bromo-2-chloro-3-fluorobenzene can react with Grignard reagents (such as RMgX) or lithium reagents (such as RLi). Under appropriate conditions, halogen atoms can combine with hydrocarbon groups in metal reagents to form new carbon-carbon bonds, which is an important means in organic synthesis and can be used to synthesize organic compounds with more complex structures.
In conclusion, 1 + -bromo-2-chloro-3-fluorobenzene has rich and diverse chemical properties, and has great application potential in the field of organic synthesis. It can be synthesized by various reaction conditions and reagents.
First talk about the nucleophilic substitution reaction. Because there are halogen atoms attached to the benzene ring, bromine, chlorine and fluorine can all leave due to the attack of nucleophilic reagents. The difficulty of leaving is related to the properties of halogen atoms. Fluorine atoms are difficult to leave because of their small atomic radius and strong binding force with the benzene ring; while bromine atoms are relatively large and weakly bound to the benzene ring, making it easier to leave. Therefore, when nucleophiles such as hydroxyl anions (OH~) and amino anions (NH _ 2) attack, bromine atoms are more likely to be replaced to generate corresponding hydroxybenzene or aminobenzene derivatives.
The second discussion on the electrophilic substitution reaction. Benzene rings are electron-rich and can undergo electrophilic substitution. However, in this compound, the halogen atom is an electron-withdrawing group, which will reduce the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene itself. And the positioning effect of halogen atoms also plays a role. Bromine, chlorine, and fluorine are all ortho-para-sites. Although the reaction activity is reduced, they guide the electrophilic reagents to attack the ortho and para-sites of the benzene ring. For example, when reacting with the mixed acid of nitric acid and sulfuric acid, the electrophilic reagent nitro-positive ion (NO 2O 🥰) is more inclined to attack the neighbor and para-position of the halogen atom to form nitro-substituted products.
Re-discuss its reaction with metal-organic reagents. 1 + -Bromo-2-chloro-3-fluorobenzene can react with Grignard reagents (such as RMgX) or lithium reagents (such as RLi). Under appropriate conditions, halogen atoms can combine with hydrocarbon groups in metal reagents to form new carbon-carbon bonds, which is an important means in organic synthesis and can be used to synthesize organic compounds with more complex structures.
In conclusion, 1 + -bromo-2-chloro-3-fluorobenzene has rich and diverse chemical properties, and has great application potential in the field of organic synthesis. It can be synthesized by various reaction conditions and reagents.
Where is 1 - bromo - 2 - chloro - 3 - fluorobenzene used?
1 + -Bromo-2-chloro-3-fluorobenzene is useful in the field of organic synthesis, the field of medicinal chemistry, and the field of materials science.
In the field of organic synthesis, it is an important intermediate. Due to the different halogen atoms attached to the benzene ring, the activities of each halogen atom are different, and various functional groups can be introduced through many organic reactions, such as nucleophilic substitution reactions. For example, under appropriate conditions, halogen atoms can be replaced by hydroxyl groups, amino groups, etc., to construct complex organic compounds for the synthesis of other difficult-to-prepare organic molecules, which can expand the synthesis path for organic synthesis chemists.
In the field of medicinal chemistry, this compound is also of significance. Due to its special structure, it may exhibit unique biological activities. After modification, it may be developed into new drugs. For example, some halogenated aromatics with specific structures have affinity for specific biological targets and can be used for the treatment of diseases. 1 + -Bromo-2-chloro-3-fluorobenzene may also have this potential, providing a possible basic structure for the creation of new drugs and helping pharmaceutical developers find good drugs for treating difficult diseases.
In the realm of materials science, it may be used to prepare materials with special properties. The presence of halogen atoms can affect the electron cloud distribution and crystallization properties of materials. Therefore, materials with special optical and electrical properties can be prepared. For example, in the preparation of organic optoelectronic materials, it can be used as a structural unit to participate in the construction of materials, endow materials with unique photoelectric properties, and be used in Light Emitting Diodes, solar cells and other devices to promote the progress and development of materials science.
In the field of organic synthesis, it is an important intermediate. Due to the different halogen atoms attached to the benzene ring, the activities of each halogen atom are different, and various functional groups can be introduced through many organic reactions, such as nucleophilic substitution reactions. For example, under appropriate conditions, halogen atoms can be replaced by hydroxyl groups, amino groups, etc., to construct complex organic compounds for the synthesis of other difficult-to-prepare organic molecules, which can expand the synthesis path for organic synthesis chemists.
In the field of medicinal chemistry, this compound is also of significance. Due to its special structure, it may exhibit unique biological activities. After modification, it may be developed into new drugs. For example, some halogenated aromatics with specific structures have affinity for specific biological targets and can be used for the treatment of diseases. 1 + -Bromo-2-chloro-3-fluorobenzene may also have this potential, providing a possible basic structure for the creation of new drugs and helping pharmaceutical developers find good drugs for treating difficult diseases.
In the realm of materials science, it may be used to prepare materials with special properties. The presence of halogen atoms can affect the electron cloud distribution and crystallization properties of materials. Therefore, materials with special optical and electrical properties can be prepared. For example, in the preparation of organic optoelectronic materials, it can be used as a structural unit to participate in the construction of materials, endow materials with unique photoelectric properties, and be used in Light Emitting Diodes, solar cells and other devices to promote the progress and development of materials science.
What is the synthesis method of 1 - bromo - 2 - chloro - 3 - fluorobenzene
The method of preparing 1-bromo-2-chloro-3-fluorobenzene is an important problem in organic synthesis. To obtain this compound, the method of halogenation of aromatic hydrocarbons is often followed.
First, benzene is used as the starting material, which has aromatic properties and can undergo electrophilic substitution. The bromine group is first introduced, and bromobenzene can be reacted with benzene in the catalysis of iron (Fe) or iron tribromide (FeBr). This is a classic bromination reaction, and bromobenzene can be prepared. The reaction formula is: C H + Br <\ xrightarrow [] {FeBr} $C H Br + HBr.
times, the chlorine group is introduced on the basis of bromobenzene. In addition, chlorine (Cl ²) and bromobenzene are electrophilically substituted under the action of catalysts (such as ferric trichloride FeCl ²) to obtain a mixture of o-bromochlorobenzene or p-bromochlorobenzene. Because the bromo group is an o-para-locator, both are generated. Its reaction formula: C H Br + Cl ² $\ xrightarrow [] {FeCl 😉} $C H BrCl + HCl.
In addition, special methods are often required to introduce fluorine groups at specific locations. At this time, diazotization can be used. First, the amination of o-bromochlorobenzene is made, and the benzene ring is nitrified by mixing concentrated nitric acid with concentrated sulfuric acid to obtain a nitro compound. Then, the nitro group is reduced to an amino group by iron powder and hydrochloric acid to obtain o-bromochloroaniline. After that, the amino group is diazotized at low temperature with sodium nitrite (NaNO 2) and hydrochloric acid to form a diazonium salt. Finally, the diazonium salt is treated with fluoroboronic acid (HBF), which is decomposed by heating to obtain 1-bromo-2-chloro-3-fluorobenzene. Although this series of reactions is complicated, the target product can be precisely prepared.
In addition, there are other synthesis methods, such as cross-coupling reactions catalyzed by transition metals, but the conditions may be more severe, and the raw materials In short, to synthesize 1-bromo-2-chloro-3-fluorobenzene, it is necessary to make good use of the organic reaction mechanism and choose the optimal method according to the actual conditions.
First, benzene is used as the starting material, which has aromatic properties and can undergo electrophilic substitution. The bromine group is first introduced, and bromobenzene can be reacted with benzene in the catalysis of iron (Fe) or iron tribromide (FeBr). This is a classic bromination reaction, and bromobenzene can be prepared. The reaction formula is: C H + Br <\ xrightarrow [] {FeBr} $C H Br + HBr.
times, the chlorine group is introduced on the basis of bromobenzene. In addition, chlorine (Cl ²) and bromobenzene are electrophilically substituted under the action of catalysts (such as ferric trichloride FeCl ²) to obtain a mixture of o-bromochlorobenzene or p-bromochlorobenzene. Because the bromo group is an o-para-locator, both are generated. Its reaction formula: C H Br + Cl ² $\ xrightarrow [] {FeCl 😉} $C H BrCl + HCl.
In addition, special methods are often required to introduce fluorine groups at specific locations. At this time, diazotization can be used. First, the amination of o-bromochlorobenzene is made, and the benzene ring is nitrified by mixing concentrated nitric acid with concentrated sulfuric acid to obtain a nitro compound. Then, the nitro group is reduced to an amino group by iron powder and hydrochloric acid to obtain o-bromochloroaniline. After that, the amino group is diazotized at low temperature with sodium nitrite (NaNO 2) and hydrochloric acid to form a diazonium salt. Finally, the diazonium salt is treated with fluoroboronic acid (HBF), which is decomposed by heating to obtain 1-bromo-2-chloro-3-fluorobenzene. Although this series of reactions is complicated, the target product can be precisely prepared.
In addition, there are other synthesis methods, such as cross-coupling reactions catalyzed by transition metals, but the conditions may be more severe, and the raw materials In short, to synthesize 1-bromo-2-chloro-3-fluorobenzene, it is necessary to make good use of the organic reaction mechanism and choose the optimal method according to the actual conditions.
What are the environmental effects of 1 - bromo - 2 - chloro - 3 - fluorobenzene
The environmental impact of 1 + -bromo-2-chloro-3-fluorobenzene is particularly important. This compound contains halogen atoms. The characteristics of halogen atoms give this compound unique chemical properties, resulting in various effects on the environment.
First of all, its stability, 1 + -bromo-2-chloro-3-fluorobenzene contains bromine, chlorine and fluorine atoms, and its molecular structure is stable and difficult to decompose in the natural environment. This stability allows it to persist for a long time and accumulate in various parts of the environment, such as soil and water.
In the aquatic environment, it may dissolve into water and harm aquatic organisms. Because of its toxicity, or damage aquatic biological cells, hinder their growth and reproduction, and reduce the number of biological populations. Or pass through the food chain, enrich in high trophic organisms, endangering ecological balance.
In soil, 1 + -bromo-2-chloro-3-fluorobenzene or adsorbed on soil particles, affects the activity of soil microorganisms and disturbs the normal function of soil ecosystems. It may change the chemical properties of soil, affect the absorption of nutrients by plants, and cause poor plant growth.
In the atmosphere, this compound may evaporate, participate in photochemical reactions, and generate harmful secondary pollutants, such as ozone, which damage air quality and endanger human health. And it is a greenhouse gas, or cause global warming.
And because of its fat-soluble, it is easy to pass through the biofilm, enter the body of organisms, and accumulate in adipose tissue, posing a potential threat to biological health.
Therefore, 1 + -bromo-2-chloro-3-fluorobenzene has extensive and harmful effects on the environment, and it needs to be handled with caution to prevent its excessive discharge to ensure the safety of the ecological environment.
First of all, its stability, 1 + -bromo-2-chloro-3-fluorobenzene contains bromine, chlorine and fluorine atoms, and its molecular structure is stable and difficult to decompose in the natural environment. This stability allows it to persist for a long time and accumulate in various parts of the environment, such as soil and water.
In the aquatic environment, it may dissolve into water and harm aquatic organisms. Because of its toxicity, or damage aquatic biological cells, hinder their growth and reproduction, and reduce the number of biological populations. Or pass through the food chain, enrich in high trophic organisms, endangering ecological balance.
In soil, 1 + -bromo-2-chloro-3-fluorobenzene or adsorbed on soil particles, affects the activity of soil microorganisms and disturbs the normal function of soil ecosystems. It may change the chemical properties of soil, affect the absorption of nutrients by plants, and cause poor plant growth.
In the atmosphere, this compound may evaporate, participate in photochemical reactions, and generate harmful secondary pollutants, such as ozone, which damage air quality and endanger human health. And it is a greenhouse gas, or cause global warming.
And because of its fat-soluble, it is easy to pass through the biofilm, enter the body of organisms, and accumulate in adipose tissue, posing a potential threat to biological health.
Therefore, 1 + -bromo-2-chloro-3-fluorobenzene has extensive and harmful effects on the environment, and it needs to be handled with caution to prevent its excessive discharge to ensure the safety of the ecological environment.
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