Linshang Chemical
PRODUCTS
1-Bromo-2-Chloro-4-(Tert-Butyl)Benzene
Linshang Chemical
|
HS Code |
805112 |
| Chemical Formula | C10H12BrCl |
| Molecular Weight | 249.56 |
| Appearance | Solid (Typical) |
| Boiling Point | Approximately 260 - 270 °C |
| Density | Approx. 1.3 - 1.4 g/cm³ (estimated based on similar compounds) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Relatively high due to large molecular structure, estimate around 100 - 120 °C |
| Odor | Typical aromatic - halogen - like odor |
As an accredited 1-Bromo-2-Chloro-4-(Tert-Butyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - bromo - 2 - chloro - 4 - (tert - butyl)benzene in a sealed glass bottle. |
| Storage | 1 - Bromo - 2 - chloro - 4 - (tert - butyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics, to prevent leakage and exposure to air and moisture, which could potentially cause degradation. |
| Shipping | 1 - bromo - 2 - chloro - 4 - (tert - butyl)benzene is shipped in properly sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transport to prevent any spills or environmental risks. |
Competitive 1-Bromo-2-Chloro-4-(Tert-Butyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Bromo-2-Chloro-4-(Tert-Butyl)Benzene in China?
As a trusted 1-Bromo-2-Chloro-4-(Tert-Butyl)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-2-Chloro-4-(Tert-Butyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the Chinese name for 1-bromo-2-chloro-4- (tert-butyl) benzene?
1-Bromo-2-chloro-4- (tert-butyl) benzene, this is the name of an organic compound. According to the naming rules of organic chemistry, the benzene ring is used as the parent body, and the substituent position, type and name are clarified.
Prospective substituents, bromo, chloro and tert-butyl. According to the rules of priority, the preferred groups are listed later. When naming, write small groups first, then large groups, with the benzene ring as the parent. Each substituent position is marked with a number before its name, and the number and the name are connected with "-".
In the name of this compound, "1-bromine" means that the bromine atom is attached to the benzene ring at position 1; "2-chlorine" means that the chlorine atom is attached to the benzene ring at position 2; "4 - (tert-butyl) " means that the tert-butyl is attached to the benzene ring at position 4. In this way, by means of systematic nomenclature, the structure of the compound can be accurately determined, which is a key basis for communication and research in the field of chemistry.
Prospective substituents, bromo, chloro and tert-butyl. According to the rules of priority, the preferred groups are listed later. When naming, write small groups first, then large groups, with the benzene ring as the parent. Each substituent position is marked with a number before its name, and the number and the name are connected with "-".
In the name of this compound, "1-bromine" means that the bromine atom is attached to the benzene ring at position 1; "2-chlorine" means that the chlorine atom is attached to the benzene ring at position 2; "4 - (tert-butyl) " means that the tert-butyl is attached to the benzene ring at position 4. In this way, by means of systematic nomenclature, the structure of the compound can be accurately determined, which is a key basis for communication and research in the field of chemistry.
What are the physical properties of 1-bromo-2-chloro-4- (tert-butyl) benzene?
1 - bromo - 2 - chloro - 4 - (tert - butyl) benzene is an organic compound, and its physical properties are particularly important, which is related to many applications of this compound.
First of all, under normal temperature, 1 - bromo - 2 - chloro - 4 - (tert - butyl) benzene is mostly colorless to light yellow liquid, with a clear and transparent appearance. This color and shape are easy to intuitively identify. In experimental and production scenarios, its purity and state can be preliminarily judged by its appearance.
times and boiling point. According to experimental measurements and theoretical calculations, the boiling point of this substance is quite high, about 230-240 ° C. The high boiling point is due to intermolecular forces, including van der Waals forces and possible weak interactions. A high boiling point allows the compound to remain liquid at higher temperatures, and its stability is demonstrated during reactions or separations that require high temperatures.
Furthermore, the melting point is also an important physical property. 1 - bromo - 2 - chloro - 4 - (tert - butyl) benzene has a relatively low melting point, around -20 ° C. Low melting points indicate that the molecular arrangement is low and the intermolecular forces are weak. This allows the compound to melt at lower temperatures, making it easy to manipulate its state during specific low-temperature processes or preparations.
In terms of solubility, this compound is insoluble in water, but easily soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic is closely related to its molecular structure. The phenyl ring and alkyl group in the molecule are hydrophobic groups, resulting in weak interaction with water molecules and strong interaction with organic solvent molecules. This property is helpful in organic synthesis to select suitable solvents for reaction and separation operations.
Density is also one of the key physical properties. The density of 1-bromo-2-chloro-4 - (tert-butyl) benzene is greater than that of water, about 1.3-1.4 g/cm ³. Density differences can be exploited in the liquid-liquid separation process to achieve separation from water or other low-density liquids through stratification.
In addition, 1-bromo-2-chloro-4 - (tert-butyl) benzene is volatile to a certain extent. Although the volatility is not strong, long-term exposure in a poorly ventilated environment may still cause it to accumulate in the air. Understanding this property requires appropriate ventilation measures during storage and use to ensure the safety of the operating environment.
In summary, the physical properties of 1-bromo-2-chloro-4 - (tert-butyl) benzene, such as properties, boiling point, melting point, solubility, density, and volatility, are of great significance in organic synthesis, chemical production, and related scientific research fields. Only by deeply understanding and making good use of these properties can we effectively carry out related work.
First of all, under normal temperature, 1 - bromo - 2 - chloro - 4 - (tert - butyl) benzene is mostly colorless to light yellow liquid, with a clear and transparent appearance. This color and shape are easy to intuitively identify. In experimental and production scenarios, its purity and state can be preliminarily judged by its appearance.
times and boiling point. According to experimental measurements and theoretical calculations, the boiling point of this substance is quite high, about 230-240 ° C. The high boiling point is due to intermolecular forces, including van der Waals forces and possible weak interactions. A high boiling point allows the compound to remain liquid at higher temperatures, and its stability is demonstrated during reactions or separations that require high temperatures.
Furthermore, the melting point is also an important physical property. 1 - bromo - 2 - chloro - 4 - (tert - butyl) benzene has a relatively low melting point, around -20 ° C. Low melting points indicate that the molecular arrangement is low and the intermolecular forces are weak. This allows the compound to melt at lower temperatures, making it easy to manipulate its state during specific low-temperature processes or preparations.
In terms of solubility, this compound is insoluble in water, but easily soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic is closely related to its molecular structure. The phenyl ring and alkyl group in the molecule are hydrophobic groups, resulting in weak interaction with water molecules and strong interaction with organic solvent molecules. This property is helpful in organic synthesis to select suitable solvents for reaction and separation operations.
Density is also one of the key physical properties. The density of 1-bromo-2-chloro-4 - (tert-butyl) benzene is greater than that of water, about 1.3-1.4 g/cm ³. Density differences can be exploited in the liquid-liquid separation process to achieve separation from water or other low-density liquids through stratification.
In addition, 1-bromo-2-chloro-4 - (tert-butyl) benzene is volatile to a certain extent. Although the volatility is not strong, long-term exposure in a poorly ventilated environment may still cause it to accumulate in the air. Understanding this property requires appropriate ventilation measures during storage and use to ensure the safety of the operating environment.
In summary, the physical properties of 1-bromo-2-chloro-4 - (tert-butyl) benzene, such as properties, boiling point, melting point, solubility, density, and volatility, are of great significance in organic synthesis, chemical production, and related scientific research fields. Only by deeply understanding and making good use of these properties can we effectively carry out related work.
What are the main uses of 1-bromo-2-chloro-4- (tert-butyl) benzene?
1-Bromo-2-chloro-4- (tert-butyl) benzene, Chinese name 1-bromo-2-chloro-4-tert-butylbenzene, is widely used.
In the field of organic synthesis, it can be used as a key intermediate. Taking the preparation of aromatic compounds with specific structures as an example, by virtue of the characteristics of bromine, chlorine and tert-butyl on the benzene ring, by the nucleophilic substitution reaction of halogenated hydrocarbons, bromine and chlorine atoms can be replaced by various nucleophiles, and then new carbon-carbon bonds and carbon-heteroatomic bonds can be constructed. For example, by reacting with nucleophiles containing nitrogen, oxygen, sulfur, etc., a series of compounds with different functional groups can be synthesized, and these products have potential application value in the fields of medicinal chemistry and materials science.
In the field of materials science, functionalized polymer materials can be prepared by chemically modifying them. Due to the large steric resistance of tert-butyl, it can affect the molecular arrangement and aggregate structure of materials, thus endowing materials with unique physical and chemical properties, such as improving the solubility and thermal stability of materials, and may have extraordinary performance in coatings, plastics and other industries.
In pharmaceutical chemistry, as a structural fragment of drug molecules, it can be used to participate in the construction of drug molecules. The benzene ring and its substituents can interact specifically with biological targets, such as by hydrophobic interaction, hydrogen bonding, etc. to bind to receptors, laying a structural foundation for the development of new drugs, which is of great significance for the creation of drugs with specific pharmacological activities.
In addition, in the preparation of fine chemical products, 1-bromo-2-chloro-4-tert-butylbenzene may also serve as a starting material or intermediate for the synthesis of flavors, additives and other products, adding to the fine chemical industry.
In the field of organic synthesis, it can be used as a key intermediate. Taking the preparation of aromatic compounds with specific structures as an example, by virtue of the characteristics of bromine, chlorine and tert-butyl on the benzene ring, by the nucleophilic substitution reaction of halogenated hydrocarbons, bromine and chlorine atoms can be replaced by various nucleophiles, and then new carbon-carbon bonds and carbon-heteroatomic bonds can be constructed. For example, by reacting with nucleophiles containing nitrogen, oxygen, sulfur, etc., a series of compounds with different functional groups can be synthesized, and these products have potential application value in the fields of medicinal chemistry and materials science.
In the field of materials science, functionalized polymer materials can be prepared by chemically modifying them. Due to the large steric resistance of tert-butyl, it can affect the molecular arrangement and aggregate structure of materials, thus endowing materials with unique physical and chemical properties, such as improving the solubility and thermal stability of materials, and may have extraordinary performance in coatings, plastics and other industries.
In pharmaceutical chemistry, as a structural fragment of drug molecules, it can be used to participate in the construction of drug molecules. The benzene ring and its substituents can interact specifically with biological targets, such as by hydrophobic interaction, hydrogen bonding, etc. to bind to receptors, laying a structural foundation for the development of new drugs, which is of great significance for the creation of drugs with specific pharmacological activities.
In addition, in the preparation of fine chemical products, 1-bromo-2-chloro-4-tert-butylbenzene may also serve as a starting material or intermediate for the synthesis of flavors, additives and other products, adding to the fine chemical industry.
What are the synthesis methods of 1-bromo-2-chloro-4- (tert-butyl) benzene?
There are three ways to synthesize 1-bromo-2-chloro-4- (tert-butyl) benzene.
One is the electrophilic substitution of aromatic hydrocarbons. Tert-butyl benzene is used as the starting material, because tert-butyl is an ortho-para-localization group. Shilling it reacts with bromine under heating conditions catalyzed by iron powder or iron tribromide. Bromine electrophilic attacks the benzene ring, mainly forming ortho-and para-substitution products, and 4-tert-butyl-1-bromobenzene can be obtained by separation. Then the product is reacted with chlorine under similar catalytic conditions. Due to the fact that bromine is an ortho-para-locator and the influence of tert-butyl, chlorine atoms can mainly enter the ortho-site of bromine to obtain 1-bromo-2-chloro-4- (tert-butyl) benzene. This process requires fine control of the reaction conditions and separation steps to improve the yield and purity of the target product.
The second is the halogenated hydrocarbon substitution method. It can be started from 4-tert-butyl phenol, which is first reacted with thionyl chloride, and the phenolic hydroxyl group is replaced by the chlorine atom to obtain 4-tert-butyl chlorobenzene. After that, the Grignard reagent is used to react magnesium with 4-tert-butyl chlorobenzene in anhydrous ether to make Grignard reagent. The Grignard reagent is then reacted with bromoethane, introduced into ethyl, and then converted into 1-bromo-2-chloro-4- (tert-butyl) benzene through oxidation, elimination and other steps. There are many steps in this path, and the reaction conditions of each step need to be precisely controlled to ensure the smooth progress of the reaction.
The third is a cross-coupling reaction catalyzed by palladium. Using 1-bromo-2-chlorobenzene and tert-butyl boric acid or tert-butyl halide as raw materials, catalyzed by palladium catalysts such as tetra (triphenylphosphine) palladium, and adding bases such as potassium carbonate, the reaction is highly selective and can efficiently synthesize 1-bromo-2-chloro-4- (tert-butyl) benzene. However, palladium catalysts are expensive and the reaction cost is high, and the practical application needs to weigh the cost and benefit.
One is the electrophilic substitution of aromatic hydrocarbons. Tert-butyl benzene is used as the starting material, because tert-butyl is an ortho-para-localization group. Shilling it reacts with bromine under heating conditions catalyzed by iron powder or iron tribromide. Bromine electrophilic attacks the benzene ring, mainly forming ortho-and para-substitution products, and 4-tert-butyl-1-bromobenzene can be obtained by separation. Then the product is reacted with chlorine under similar catalytic conditions. Due to the fact that bromine is an ortho-para-locator and the influence of tert-butyl, chlorine atoms can mainly enter the ortho-site of bromine to obtain 1-bromo-2-chloro-4- (tert-butyl) benzene. This process requires fine control of the reaction conditions and separation steps to improve the yield and purity of the target product.
The second is the halogenated hydrocarbon substitution method. It can be started from 4-tert-butyl phenol, which is first reacted with thionyl chloride, and the phenolic hydroxyl group is replaced by the chlorine atom to obtain 4-tert-butyl chlorobenzene. After that, the Grignard reagent is used to react magnesium with 4-tert-butyl chlorobenzene in anhydrous ether to make Grignard reagent. The Grignard reagent is then reacted with bromoethane, introduced into ethyl, and then converted into 1-bromo-2-chloro-4- (tert-butyl) benzene through oxidation, elimination and other steps. There are many steps in this path, and the reaction conditions of each step need to be precisely controlled to ensure the smooth progress of the reaction.
The third is a cross-coupling reaction catalyzed by palladium. Using 1-bromo-2-chlorobenzene and tert-butyl boric acid or tert-butyl halide as raw materials, catalyzed by palladium catalysts such as tetra (triphenylphosphine) palladium, and adding bases such as potassium carbonate, the reaction is highly selective and can efficiently synthesize 1-bromo-2-chloro-4- (tert-butyl) benzene. However, palladium catalysts are expensive and the reaction cost is high, and the practical application needs to weigh the cost and benefit.
What should I pay attention to when storing and transporting 1-bromo-2-chloro-4- (tert-butyl) benzene?
1 - bromo - 2 - chloro - 4 - (tert - butyl) benzene is an organic compound. When storing and transporting, many aspects need to be carefully paid attention to.
When storing, the first priority is to choose the environment. A cool, dry and well-ventilated place should be found. This is because the compound may be sensitive to heat and humidity, high temperature and humid environment, or cause it to deteriorate or cause dangerous reactions. If it is in a high temperature environment, the chemical bond activity in the molecule may be enhanced, causing it to decompose or react with substances in the environment; in a humid environment, moisture may participate in the reaction, affecting its stability.
In addition, storage containers are also critical. Containers with good sealing performance must be used to prevent them from evaporating or coming into contact with air components. Due to its volatility, if the container is not well sealed, the steam will escape or pollute the environment, and the vapor concentration reaches a certain level, or there may be a risk of explosion. Oxygen, carbon dioxide and other components in the air may also react with the compound.
When transporting, the packaging must be solid and reliable. Wrap with suitable buffer materials to avoid damage to the container due to collision and vibration during transportation. Because the compound has a certain chemical activity, once it leaks or reacts with external substances, it will cause a safety accident.
The choice of transportation means also needs to be cautious. Those that meet the transportation specifications of chemical substances should be selected, and the appropriate temperature and humidity conditions should be maintained during transportation. At the same time, transportation personnel must undergo professional training and be familiar with the characteristics of the compound and emergency treatment methods, so that in the event of an accident, they can respond quickly and effectively to reduce the harm.
When storing, the first priority is to choose the environment. A cool, dry and well-ventilated place should be found. This is because the compound may be sensitive to heat and humidity, high temperature and humid environment, or cause it to deteriorate or cause dangerous reactions. If it is in a high temperature environment, the chemical bond activity in the molecule may be enhanced, causing it to decompose or react with substances in the environment; in a humid environment, moisture may participate in the reaction, affecting its stability.
In addition, storage containers are also critical. Containers with good sealing performance must be used to prevent them from evaporating or coming into contact with air components. Due to its volatility, if the container is not well sealed, the steam will escape or pollute the environment, and the vapor concentration reaches a certain level, or there may be a risk of explosion. Oxygen, carbon dioxide and other components in the air may also react with the compound.
When transporting, the packaging must be solid and reliable. Wrap with suitable buffer materials to avoid damage to the container due to collision and vibration during transportation. Because the compound has a certain chemical activity, once it leaks or reacts with external substances, it will cause a safety accident.
The choice of transportation means also needs to be cautious. Those that meet the transportation specifications of chemical substances should be selected, and the appropriate temperature and humidity conditions should be maintained during transportation. At the same time, transportation personnel must undergo professional training and be familiar with the characteristics of the compound and emergency treatment methods, so that in the event of an accident, they can respond quickly and effectively to reduce the harm.
Scan to WhatsApp
