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1-Bromo-2-Chloro-4-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
354841 |
| Chemical Formula | C7H3BrClF3O |
| Molecular Weight | 289.45 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Data may vary, around a certain temperature range depending on purity |
| Melting Point | Specific value based on pure substance data |
| Density | A specific density value in g/cm³ |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, etc. |
| Vapor Pressure | A particular vapor pressure value at a given temperature |
| Flash Point | A certain flash point value indicating flammability risk |
As an accredited 1-Bromo-2-Chloro-4-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 2 - chloro - 4 - (trifluoromethoxy)benzene in a sealed glass bottle. |
| Storage | 1 - bromo - 2 - chloro - 4 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area, away from direct sunlight. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential reactions. Adhere to local safety regulations for proper storage. |
| Shipping | 1 - bromo - 2 - chloro - 4 - (trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper handling, storage, and transportation to prevent any leaks or risks. |
Competitive 1-Bromo-2-Chloro-4-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Where to Buy 1-Bromo-2-Chloro-4-(Trifluoromethoxy)Benzene in China?
As a trusted 1-Bromo-2-Chloro-4-(Trifluoromethoxy)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-2-Chloro-4-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
1 - bromo - 2 - chloro - 4 - (trifluoromethoxy) benzene
1 + -Bromo-2-chloro-4- (trifluoromethoxy) benzene is one of the organic compounds. Its chemical properties are well-researched.
In this compound, the functional groups such as bromine, chlorine and trifluoromethoxy show their own properties. Bromine atoms have certain nucleophilic substitution activities, and can be replaced by many nucleophilic reagents under suitable reaction conditions. In case of strong nucleophiles, such as alkoxides, amines, etc., bromine atoms can undergo nucleophilic substitution reactions with them to generate novel organic compounds. This reaction path may be an effective means to construct carbon-heteroatomic bonds.
Chlorine atoms also have considerable chemical activity. Although its activity may be slightly inferior to that of bromine atoms, it can also participate in nucleophilic substitution reactions under certain circumstances. And because of the electronegativity of chlorine atoms, it can affect the electron cloud density distribution of the benzene ring, thereby affecting the reactivity of other positions on the benzene ring. The existence of
trifluoromethoxy gives this compound unique properties. Trifluoromethoxy has strong electron-withdrawing properties, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution reactions on the benzene ring. At the same time, its electron-withdrawing effect can make the electron cloud density of carbon atoms in the ortho-position and the para-position different, and have a guiding effect on the attack check point of nucleophilic reagents.
In addition, the compound contains fluorine atoms, which gives the molecule high stability and unique physical and chemical properties. Fluorinated compounds often have good fat solubility and hydrophobicity, and may have potential applications in the fields of medicine, pesticides, etc.
In the field of organic synthesis, 1 + -bromo-2 -chloro-4- (trifluoromethoxy) benzene can be used as a key intermediate. By selectively transforming its functional groups, it can construct complex and diverse organic molecules, which may play an important role in the creation of new drugs, high-performance materials, etc.
In this compound, the functional groups such as bromine, chlorine and trifluoromethoxy show their own properties. Bromine atoms have certain nucleophilic substitution activities, and can be replaced by many nucleophilic reagents under suitable reaction conditions. In case of strong nucleophiles, such as alkoxides, amines, etc., bromine atoms can undergo nucleophilic substitution reactions with them to generate novel organic compounds. This reaction path may be an effective means to construct carbon-heteroatomic bonds.
Chlorine atoms also have considerable chemical activity. Although its activity may be slightly inferior to that of bromine atoms, it can also participate in nucleophilic substitution reactions under certain circumstances. And because of the electronegativity of chlorine atoms, it can affect the electron cloud density distribution of the benzene ring, thereby affecting the reactivity of other positions on the benzene ring. The existence of
trifluoromethoxy gives this compound unique properties. Trifluoromethoxy has strong electron-withdrawing properties, which can reduce the electron cloud density of the benzene ring and increase the difficulty of electrophilic substitution reactions on the benzene ring. At the same time, its electron-withdrawing effect can make the electron cloud density of carbon atoms in the ortho-position and the para-position different, and have a guiding effect on the attack check point of nucleophilic reagents.
In addition, the compound contains fluorine atoms, which gives the molecule high stability and unique physical and chemical properties. Fluorinated compounds often have good fat solubility and hydrophobicity, and may have potential applications in the fields of medicine, pesticides, etc.
In the field of organic synthesis, 1 + -bromo-2 -chloro-4- (trifluoromethoxy) benzene can be used as a key intermediate. By selectively transforming its functional groups, it can construct complex and diverse organic molecules, which may play an important role in the creation of new drugs, high-performance materials, etc.
What is the main use of 1 - bromo - 2 - chloro - 4 - (trifluoromethoxy) benzene
1-Bromo-2-chloro-4- (trifluoromethoxy) benzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the creation of medicine, this compound can be used as a starting material, through a series of chemical reactions to construct structural units with specific physiological activities, and then synthesize new drugs. The introduction of trifluoromethoxy can significantly change the physical, chemical and biological properties of molecules, such as lipophilicity and stability, which have a profound impact on the activity and pharmacokinetic properties of drugs.
Second, it also plays an important role in the field of pesticide research and development. With its unique structure, pesticide products with high insecticidal, bactericidal or herbicidal effects can be derived. The presence of trifluoromethoxy may enhance the interaction between pesticides and specific receptors in target organisms, enhance drug efficacy and reduce environmental impact.
Third, in the field of materials science, 1-bromo-2-chloro-4 - (trifluoromethoxy) benzene can be used to prepare special functional materials. If it participates in polymerization reactions to form fluoropolymers, such polymers often have excellent thermal stability, chemical stability and electrical properties, and have broad application prospects in high-end fields such as aerospace and electronics.
Furthermore, it is also a commonly used raw material in the synthesis of fine chemicals. It can synthesize a variety of fine chemicals with special functions through selective transformation of its bromine, chlorine and other functional groups to meet different industrial and scientific research needs.
First, in the creation of medicine, this compound can be used as a starting material, through a series of chemical reactions to construct structural units with specific physiological activities, and then synthesize new drugs. The introduction of trifluoromethoxy can significantly change the physical, chemical and biological properties of molecules, such as lipophilicity and stability, which have a profound impact on the activity and pharmacokinetic properties of drugs.
Second, it also plays an important role in the field of pesticide research and development. With its unique structure, pesticide products with high insecticidal, bactericidal or herbicidal effects can be derived. The presence of trifluoromethoxy may enhance the interaction between pesticides and specific receptors in target organisms, enhance drug efficacy and reduce environmental impact.
Third, in the field of materials science, 1-bromo-2-chloro-4 - (trifluoromethoxy) benzene can be used to prepare special functional materials. If it participates in polymerization reactions to form fluoropolymers, such polymers often have excellent thermal stability, chemical stability and electrical properties, and have broad application prospects in high-end fields such as aerospace and electronics.
Furthermore, it is also a commonly used raw material in the synthesis of fine chemicals. It can synthesize a variety of fine chemicals with special functions through selective transformation of its bromine, chlorine and other functional groups to meet different industrial and scientific research needs.
1 - bromo - 2 - chloro - 4 - (trifluoromethoxy) benzene
The synthesis method of 1 + -bromo-2-chloro-4- (trifluoromethoxy) benzene, let me tell you.
First, the phenolic compound containing the corresponding substituent can be started. First, the phenolic compound and suitable halogenating reagents, such as hydrobromic acid, hydrochloric acid, etc., are halogenated under suitable reaction conditions to introduce bromine and chlorine atoms. Then, through nucleophilic substitution, the phenolic hydroxyl group is converted into trifluoromethoxy. Among them, suitable bases, such as potassium carbonate, sodium carbonate, etc. are selected to promote the reaction. Polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) should be selected for the reaction solvent, which will help to improve the reaction efficiency.
Second, halogenated aromatics can also be used. Using aromatic hydrocarbons containing bromine and chlorine as raw materials, the purpose of introducing trifluoromethoxy is achieved by reacting with trifluoromethoxylation reagents. This reaction usually needs to be carried out under the action of catalysts, such as copper catalysts. Common trifluoromethoxylation reagents include potassium trifluoromethoxy. During the reaction, the reaction temperature, time and reagent dosage need to be precisely controlled to ensure the selectivity and yield of the reaction.
Third, the benzene ring can also be considered as the starting material to gradually introduce the required substituents. First, benzene is halogenated, and bromine and chlorine atoms are selectively introduced, and then the amino-containing intermediates are obtained through nitration and reduction. Then, through the diazotization reaction, the amino group is converted to a hydroxyl group, and then through the above nucleophilic substitution reaction, the trifluoromethoxy group is introduced.
There are many methods for synthesizing 1 + -bromo-2-chloro-4- (trifluoromethoxy) benzene, and each method has its own advantages and disadvantages. The appropriate synthesis path should be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the product.
First, the phenolic compound containing the corresponding substituent can be started. First, the phenolic compound and suitable halogenating reagents, such as hydrobromic acid, hydrochloric acid, etc., are halogenated under suitable reaction conditions to introduce bromine and chlorine atoms. Then, through nucleophilic substitution, the phenolic hydroxyl group is converted into trifluoromethoxy. Among them, suitable bases, such as potassium carbonate, sodium carbonate, etc. are selected to promote the reaction. Polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) should be selected for the reaction solvent, which will help to improve the reaction efficiency.
Second, halogenated aromatics can also be used. Using aromatic hydrocarbons containing bromine and chlorine as raw materials, the purpose of introducing trifluoromethoxy is achieved by reacting with trifluoromethoxylation reagents. This reaction usually needs to be carried out under the action of catalysts, such as copper catalysts. Common trifluoromethoxylation reagents include potassium trifluoromethoxy. During the reaction, the reaction temperature, time and reagent dosage need to be precisely controlled to ensure the selectivity and yield of the reaction.
Third, the benzene ring can also be considered as the starting material to gradually introduce the required substituents. First, benzene is halogenated, and bromine and chlorine atoms are selectively introduced, and then the amino-containing intermediates are obtained through nitration and reduction. Then, through the diazotization reaction, the amino group is converted to a hydroxyl group, and then through the above nucleophilic substitution reaction, the trifluoromethoxy group is introduced.
There are many methods for synthesizing 1 + -bromo-2-chloro-4- (trifluoromethoxy) benzene, and each method has its own advantages and disadvantages. The appropriate synthesis path should be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the product.
1 - bromo - 2 - chloro - 4 - (trifluoromethoxy) benzene in storage and transport
For 1 + -bromo-2-chloro-4- (trifluoromethoxy) benzene, there are many things to pay attention to during storage and transportation, which should not be ignored.
First words storage, this substance should be placed in a cool and dry place. Cover because of its chemical properties, if it is placed in a high temperature or humid place, it may cause chemical reactions and cause it to deteriorate. High temperature can easily enhance molecular activity or cause decomposition; humid environment may cause it to react with water vapor and damage its purity. Therefore, the temperature of the warehouse should be controlled within a specific range, and the humidity should also be strictly supervised, and there should be equipment for temperature and humidity monitoring, so as to detect environmental changes at any time and adjust in time.
Furthermore, this substance should be stored in isolation from oxidants and alkalis. 1 + -Bromo-2-chloro-4 - (trifluoromethoxy) benzene meets the oxidant, or has a violent oxidation reaction, there is a risk of fire and explosion; contact with alkalis, or chemical reaction, resulting in impure products, and the reaction process or heat generation, which also increases danger. Therefore, when storing, different types of chemicals must be placed in separate storage areas, and clear signs should be set to prevent mismixing.
As for transportation, extreme caution is also required. When handling, be sure to pack lightly and handle it lightly, and do not operate brutally. Because it is a fine chemical, it is easy to cause package damage and material leakage due to violent vibration or collision. Leaks not only pollute the environment, but also contact the human body or cause harm. Transport vehicles should also be properly selected and equipped with good protection and ventilation devices to prevent the evaporation and accumulation of leaked materials and cause danger.
During transportation, it is also necessary to strictly abide by relevant regulations and transportation routes. Drive according to the prescribed route, avoid densely populated areas and environmentally sensitive areas, and have appropriate emergency measures in case of emergencies, so as to ensure the safety of 1 + -bromo-2-chloro-4- (trifluoromethoxy) benzene during storage and transportation.
First words storage, this substance should be placed in a cool and dry place. Cover because of its chemical properties, if it is placed in a high temperature or humid place, it may cause chemical reactions and cause it to deteriorate. High temperature can easily enhance molecular activity or cause decomposition; humid environment may cause it to react with water vapor and damage its purity. Therefore, the temperature of the warehouse should be controlled within a specific range, and the humidity should also be strictly supervised, and there should be equipment for temperature and humidity monitoring, so as to detect environmental changes at any time and adjust in time.
Furthermore, this substance should be stored in isolation from oxidants and alkalis. 1 + -Bromo-2-chloro-4 - (trifluoromethoxy) benzene meets the oxidant, or has a violent oxidation reaction, there is a risk of fire and explosion; contact with alkalis, or chemical reaction, resulting in impure products, and the reaction process or heat generation, which also increases danger. Therefore, when storing, different types of chemicals must be placed in separate storage areas, and clear signs should be set to prevent mismixing.
As for transportation, extreme caution is also required. When handling, be sure to pack lightly and handle it lightly, and do not operate brutally. Because it is a fine chemical, it is easy to cause package damage and material leakage due to violent vibration or collision. Leaks not only pollute the environment, but also contact the human body or cause harm. Transport vehicles should also be properly selected and equipped with good protection and ventilation devices to prevent the evaporation and accumulation of leaked materials and cause danger.
During transportation, it is also necessary to strictly abide by relevant regulations and transportation routes. Drive according to the prescribed route, avoid densely populated areas and environmentally sensitive areas, and have appropriate emergency measures in case of emergencies, so as to ensure the safety of 1 + -bromo-2-chloro-4- (trifluoromethoxy) benzene during storage and transportation.
What are the environmental effects of 1 - bromo - 2 - chloro - 4 - (trifluoromethoxy) benzene
1-Bromo-2-chloro-4- (trifluoromethoxy) benzene, this substance has a significant impact on the environment. Its chemical properties are active, difficult to degrade in the natural environment, or long-term residual accumulation in the environment.
When it enters the water body, it poses a threat to the aquatic ecosystem due to its hydrophobicity, or adsorption on suspended particles, and settles to the bottom sediment. After aquatic organisms are exposed, they may cause abnormal physiological functions, growth and development, and even death. If some organisms enrich it and pass it through the food chain, it will cause harm to higher organisms.
In soil, it will affect soil microbial activity and community structure, interfere with normal soil ecological functions, affect plant nutrient absorption, hinder plant growth, and change soil physicochemical properties.
Its volatilization to the atmosphere will participate in photochemical reactions, affect atmospheric chemical processes, or generate secondary pollutants, endanger air quality, and cause damage to the human respiratory system.
In addition, if the production and use process of 1-bromo-2-chloro-4- (trifluoromethoxy) benzene is not properly managed and leaks occur, it will cause sudden pollution events to the surrounding environment, and have a serious impact on the ecological environment and human health in a short period of time. Therefore, its production, use, and emissions need to be strictly regulated to reduce the harm to the environment.
When it enters the water body, it poses a threat to the aquatic ecosystem due to its hydrophobicity, or adsorption on suspended particles, and settles to the bottom sediment. After aquatic organisms are exposed, they may cause abnormal physiological functions, growth and development, and even death. If some organisms enrich it and pass it through the food chain, it will cause harm to higher organisms.
In soil, it will affect soil microbial activity and community structure, interfere with normal soil ecological functions, affect plant nutrient absorption, hinder plant growth, and change soil physicochemical properties.
Its volatilization to the atmosphere will participate in photochemical reactions, affect atmospheric chemical processes, or generate secondary pollutants, endanger air quality, and cause damage to the human respiratory system.
In addition, if the production and use process of 1-bromo-2-chloro-4- (trifluoromethoxy) benzene is not properly managed and leaks occur, it will cause sudden pollution events to the surrounding environment, and have a serious impact on the ecological environment and human health in a short period of time. Therefore, its production, use, and emissions need to be strictly regulated to reduce the harm to the environment.
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