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1-Bromo-2-Chloro-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
705270 |
| Chemical Formula | C7H3BrClF3 |
| Molecular Weight | 261.45 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 190 - 195 °C |
| Density | Data may vary, around 1.7 - 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Data may vary, potentially around 70 - 80 °C |
| Purity In Commercial Products | Typically available in high purity, e.g., 95%+ |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 1-Bromo-2-Chloro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 2 - chloro - 4 - (trifluoromethyl)benzene in sealed chemical - grade bottle. |
| Storage | 1 - bromo - 2 - chloro - 4 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be stored in a tightly sealed container, preferably made of corrosion - resistant materials like glass or specific plastics. Keep it segregated from oxidizing agents and incompatible substances to prevent potential reactions. |
| Shipping | 1 - bromo - 2 - chloro - 4 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transport to prevent leakage and environmental or safety risks. |
Competitive 1-Bromo-2-Chloro-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 1-Bromo-2-Chloro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-bromo-2-chloro-4- (trifluoromethyl) benzene
1 - bromo - 2 - chloro - 4 - (trifluoromethyl) benzene is an organic compound with unique chemical properties and is widely used in the field of organic synthesis.
Its chemical properties are the commonality of halogenated aromatics. Bromine and chlorine atoms are active substituents and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic reagents such as alkoxides and amines can attack the carbon atoms attached to the halogen atoms in the benzene ring, replace the halogen atoms, and form new carbon-heteroatomic bonds. This reaction condition often requires base catalysis to enhance the activity of nucleophiles, and the reaction rate is related to the nucleophilicity of nucleophiles and the ability of halogen atoms to leave. Bromine atoms have a slightly stronger ability to leave than chlorine atoms, so the location of bromine atoms is more prone to nucleophilic substitution.
Furthermore, the substituents on the benzene ring in this compound have a significant impact on the electron cloud density of the benzene ring. Trifluoromethyl is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, under specific electrophilic reagents and conditions, electrophilic substitution can still occur, and it mainly occurs at the position where the electron cloud density is relatively high, that is, the interposition of trifluoromethyl. Due to the electron-absorbing induction effect and conjugation effect of trifluoromethyl, the density of the interposition electron cloud is relatively high relative to the adjacent and para-position.
For example, under palladium catalysis, Suzuki coupling reaction can occur with organic boric acid to form new carbon-carbon bonds. This reaction has mild conditions and high selectivity, and is widely used in the construction of complex organic molecular skeletons.
1-bromo-2-chloro-4 - (trifluoromethyl) benzene is rich in chemical properties due to the presence of bromine, chlorine and trifluoromethyl. It can participate in a variety of organic reactions and provide an important intermediate for organic synthesis chemistry. It has potential application value in pharmaceutical chemistry, materials science and other fields.
Its chemical properties are the commonality of halogenated aromatics. Bromine and chlorine atoms are active substituents and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic reagents such as alkoxides and amines can attack the carbon atoms attached to the halogen atoms in the benzene ring, replace the halogen atoms, and form new carbon-heteroatomic bonds. This reaction condition often requires base catalysis to enhance the activity of nucleophiles, and the reaction rate is related to the nucleophilicity of nucleophiles and the ability of halogen atoms to leave. Bromine atoms have a slightly stronger ability to leave than chlorine atoms, so the location of bromine atoms is more prone to nucleophilic substitution.
Furthermore, the substituents on the benzene ring in this compound have a significant impact on the electron cloud density of the benzene ring. Trifluoromethyl is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, under specific electrophilic reagents and conditions, electrophilic substitution can still occur, and it mainly occurs at the position where the electron cloud density is relatively high, that is, the interposition of trifluoromethyl. Due to the electron-absorbing induction effect and conjugation effect of trifluoromethyl, the density of the interposition electron cloud is relatively high relative to the adjacent and para-position.
For example, under palladium catalysis, Suzuki coupling reaction can occur with organic boric acid to form new carbon-carbon bonds. This reaction has mild conditions and high selectivity, and is widely used in the construction of complex organic molecular skeletons.
1-bromo-2-chloro-4 - (trifluoromethyl) benzene is rich in chemical properties due to the presence of bromine, chlorine and trifluoromethyl. It can participate in a variety of organic reactions and provide an important intermediate for organic synthesis chemistry. It has potential application value in pharmaceutical chemistry, materials science and other fields.
What is the main use of 1-bromo-2-chloro-4- (trifluoromethyl) benzene?
1 - bromo - 2 - chloro - 4 - (trifluoromethyl) benzene is an organic compound with a wide range of main uses.
In the field of organic synthesis, this compound is a key intermediate. The unique presence of bromine, chlorine and trifluoromethyl in its molecular structure gives it rich reactivity. For example, bromine and chlorine atoms can be replaced by various nucleophilic reagents through nucleophilic substitution reactions. This property allows chemists to construct a variety of carbon-heteroatomic bonds, such as carbon-oxygen bonds, carbon-nitrogen bonds, etc. With careful selection of nucleophiles, a series of complex organic compounds, such as pharmaceutical molecules and pesticide active ingredients, can be skillfully synthesized.
In the field of drug development, 1-bromo-2-chloro-4 - (trifluoromethyl) benzene also plays an important role. The introduction of trifluoromethyl can often significantly change the physical and chemical properties of compounds, such as lipophilicity and metabolic stability. Medicinal chemists can use this compound as a starting material to build a molecular framework with specific biological activities through multi-step reactions, and then screen lead compounds with potential medicinal value.
In the field of materials science, this compound also has its uses. Because of its fluorine-containing structure, it can be used to prepare materials with special properties. For example, fluoropolymer materials often have excellent weather resistance, chemical corrosion resistance, etc. 1-bromo-2-chloro-4 - (trifluoromethyl) benzene can be used as a key monomer for the synthesis of such fluoropolymers, contributing to the development of materials science.
In the field of pesticides, 1-bromo-2-chloro-4 - (trifluoromethyl) benzene can be chemically modified and converted into pesticide components with high insecticidal, bactericidal or herbicidal activities. Its unique structure helps to enhance the effect of pesticides on target organisms, and the presence of trifluoromethyl may enhance the environmental adaptability and effectiveness of pesticides.
In the field of organic synthesis, this compound is a key intermediate. The unique presence of bromine, chlorine and trifluoromethyl in its molecular structure gives it rich reactivity. For example, bromine and chlorine atoms can be replaced by various nucleophilic reagents through nucleophilic substitution reactions. This property allows chemists to construct a variety of carbon-heteroatomic bonds, such as carbon-oxygen bonds, carbon-nitrogen bonds, etc. With careful selection of nucleophiles, a series of complex organic compounds, such as pharmaceutical molecules and pesticide active ingredients, can be skillfully synthesized.
In the field of drug development, 1-bromo-2-chloro-4 - (trifluoromethyl) benzene also plays an important role. The introduction of trifluoromethyl can often significantly change the physical and chemical properties of compounds, such as lipophilicity and metabolic stability. Medicinal chemists can use this compound as a starting material to build a molecular framework with specific biological activities through multi-step reactions, and then screen lead compounds with potential medicinal value.
In the field of materials science, this compound also has its uses. Because of its fluorine-containing structure, it can be used to prepare materials with special properties. For example, fluoropolymer materials often have excellent weather resistance, chemical corrosion resistance, etc. 1-bromo-2-chloro-4 - (trifluoromethyl) benzene can be used as a key monomer for the synthesis of such fluoropolymers, contributing to the development of materials science.
In the field of pesticides, 1-bromo-2-chloro-4 - (trifluoromethyl) benzene can be chemically modified and converted into pesticide components with high insecticidal, bactericidal or herbicidal activities. Its unique structure helps to enhance the effect of pesticides on target organisms, and the presence of trifluoromethyl may enhance the environmental adaptability and effectiveness of pesticides.
What are the synthesis methods of 1-bromo-2-chloro-4- (trifluoromethyl) benzene
There are several methods for synthesizing 1-bromo-2-chloro-4- (trifluoromethyl) benzene. The most common one is to use a benzene derivative containing trifluoromethyl as the starting material and undergo a halogenation reaction to prepare it. If p-trifluoromethyl benzene is taken first, under appropriate reaction conditions, a brominating agent and a chlorinating agent are used in sequence. When brominating, liquid bromine can be used, supplemented by a suitable catalyst, such as iron powder or iron tribromide, and heating or light is used to initiate the reaction, so that the bromine atom replaces the hydrogen atom at a specific position on the benzene ring to obtain a bromide. Then, a chlorination agent, such as chlorine, is used in the presence of a suitable catalyst such as aluminum trichloride to carry out a chlorination reaction, so that the chlorine atom is connected at a predetermined position, and the final target product is 1-bromo-2-chloro-4 - (trifluoromethyl) benzene.
The second method can start from halogenated benzene. First select a suitable halogenated benzene, such as p-chlorotrifluoromethylbenzene, and after bromination reaction, a bromine source and a catalyst are used to promote the bromine atom to be connected to the benzene ring. By controlling the reaction conditions, such as temperature, the proportion of reactants and the reaction time, the bromine atom Or it is obtained by chlorination with p-bromotrifluoromethylbenzene as raw material. When chlorinating, attention should be paid to controlling the selectivity of the reaction, so that the chlorine atoms can be precisely connected to the designated position.
Furthermore, aryl boric acid derivatives can also be used to participate in the reaction. In the presence of palladium catalyst and base, trifluoromethyl-containing aryl boric acid and halogenated aromatics are coupled to form carbon-carbon bonds. For example, with p-trifluoromethylphenylboronic acid and 1-bromo-2-chlorobenzene, under the action of suitable palladium catalysts such as tetra (triphenylphosphine) palladium and potassium carbonate, the reaction is heated in an organic solvent, and the synthesis of 1-bromo-2-chloro-4 - (trifluoromethyl) benzene is achieved through a series of complex reaction processes. However, in this process, the control of the reaction conditions is very critical, such as the amount of catalyst, the type and amount of base, and the choice of solvent, which all affect the yield and selectivity of the reaction.
The second method can start from halogenated benzene. First select a suitable halogenated benzene, such as p-chlorotrifluoromethylbenzene, and after bromination reaction, a bromine source and a catalyst are used to promote the bromine atom to be connected to the benzene ring. By controlling the reaction conditions, such as temperature, the proportion of reactants and the reaction time, the bromine atom Or it is obtained by chlorination with p-bromotrifluoromethylbenzene as raw material. When chlorinating, attention should be paid to controlling the selectivity of the reaction, so that the chlorine atoms can be precisely connected to the designated position.
Furthermore, aryl boric acid derivatives can also be used to participate in the reaction. In the presence of palladium catalyst and base, trifluoromethyl-containing aryl boric acid and halogenated aromatics are coupled to form carbon-carbon bonds. For example, with p-trifluoromethylphenylboronic acid and 1-bromo-2-chlorobenzene, under the action of suitable palladium catalysts such as tetra (triphenylphosphine) palladium and potassium carbonate, the reaction is heated in an organic solvent, and the synthesis of 1-bromo-2-chloro-4 - (trifluoromethyl) benzene is achieved through a series of complex reaction processes. However, in this process, the control of the reaction conditions is very critical, such as the amount of catalyst, the type and amount of base, and the choice of solvent, which all affect the yield and selectivity of the reaction.
What to pay attention to when storing and transporting 1-bromo-2-chloro-4- (trifluoromethyl) benzene
1 - bromo - 2 - chloro - 4 - (trifluoromethyl) benzene is an organic compound. When storing and transporting, many aspects need to be carefully paid attention to.
When storing, choose the first environment. It should be placed in a cool and well-ventilated place. This compound can easily cause a reaction when heated, and the temperature is too high or dangerous. A cool environment can maintain its stability. Good ventilation can disperse harmful gases that may evaporate in time to avoid the risk of poisoning or explosion caused by accumulation.
Furthermore, the choice of container is also critical. Use a container with good sealing performance to prevent it from evaporating or reacting with components in the air. If a glass or specific plastic material container is used, ensure that its chemical properties are stable and do not react with the compound.
When storing, it should also be stored separately from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with these substances is prone to violent chemical reactions, causing serious consequences such as fire and explosion.
When transporting, the packaging must be solid and stable. Packaging materials that meet relevant standards should be selected to ensure that the packaging is not damaged or leaked during transportation. There are also requirements for transporting vehicles, and corresponding fire-fighting equipment and leakage emergency treatment equipment should be equipped. During transportation, drivers and escorts must strictly abide by the operating procedures to avoid violent bumps and collisions in vehicles, so as to prevent compound leakage due to packaging damage.
In addition, during transportation and storage, relevant regulations and standards must be strictly followed, safety labels must be made, and personnel must be clearly aware of the danger, so as to take correct protection and handling measures. In this way, the storage and transportation of 1-bromo-2-chloro-4 - (trifluoromethyl) benzene can be guaranteed.
When storing, choose the first environment. It should be placed in a cool and well-ventilated place. This compound can easily cause a reaction when heated, and the temperature is too high or dangerous. A cool environment can maintain its stability. Good ventilation can disperse harmful gases that may evaporate in time to avoid the risk of poisoning or explosion caused by accumulation.
Furthermore, the choice of container is also critical. Use a container with good sealing performance to prevent it from evaporating or reacting with components in the air. If a glass or specific plastic material container is used, ensure that its chemical properties are stable and do not react with the compound.
When storing, it should also be stored separately from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with these substances is prone to violent chemical reactions, causing serious consequences such as fire and explosion.
When transporting, the packaging must be solid and stable. Packaging materials that meet relevant standards should be selected to ensure that the packaging is not damaged or leaked during transportation. There are also requirements for transporting vehicles, and corresponding fire-fighting equipment and leakage emergency treatment equipment should be equipped. During transportation, drivers and escorts must strictly abide by the operating procedures to avoid violent bumps and collisions in vehicles, so as to prevent compound leakage due to packaging damage.
In addition, during transportation and storage, relevant regulations and standards must be strictly followed, safety labels must be made, and personnel must be clearly aware of the danger, so as to take correct protection and handling measures. In this way, the storage and transportation of 1-bromo-2-chloro-4 - (trifluoromethyl) benzene can be guaranteed.
What are the effects of 1-bromo-2-chloro-4- (trifluoromethyl) benzene on the environment and human body?
1 - bromo - 2 - chloro - 4 - (trifluoromethyl) benzene is an organic compound that has an impact on both the environment and the human body.
First of all, its impact on the environment. If this compound is released into the environment, it has high stability due to its halogen atom and trifluoromethyl, and is not easy to decompose by natural processes or accumulate in the environment. It can migrate through air, water and other media, causing pollution diffusion. And it may be toxic to aquatic organisms. If the concentration in water reaches a certain level, it may harm the survival and reproduction of fish and plankton, and destroy the balance of aquatic ecology; if it is in the soil, it may affect the activity and function of soil microorganisms, and also have adverse effects on the growth and development of vegetation, or cause disturbance to plant physiological processes, growth retardation, and even death.
On its effects on the human body. If people are exposed to this compound through inhalation, ingestion or skin, it may be harmful to health. Inhalation of air containing this compound may irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. After ingestion, it may hurt the digestive system, causing nausea, vomiting, abdominal pain, etc. It may have potential carcinogenicity, teratogenicity and mutagenicity. Although there is no conclusive conclusion, its structure contains halogenated hydrocarbons and fluoroalkyl groups. According to the research experience of related chemicals, it should not be taken lightly. Long-term exposure to this compound environment may damage the human immune system, nervous system, etc., making the human body immune, prone to diseases, or cause abnormal nervous system function, such as headache, dizziness, insomnia, memory loss, etc.
In summary, 1-bromo-2-chloro-4 - (trifluoromethyl) benzene poses a potential threat to the environment and human body. When its production, use and disposal, appropriate measures should be taken to reduce its harm to the environment and human body.
First of all, its impact on the environment. If this compound is released into the environment, it has high stability due to its halogen atom and trifluoromethyl, and is not easy to decompose by natural processes or accumulate in the environment. It can migrate through air, water and other media, causing pollution diffusion. And it may be toxic to aquatic organisms. If the concentration in water reaches a certain level, it may harm the survival and reproduction of fish and plankton, and destroy the balance of aquatic ecology; if it is in the soil, it may affect the activity and function of soil microorganisms, and also have adverse effects on the growth and development of vegetation, or cause disturbance to plant physiological processes, growth retardation, and even death.
On its effects on the human body. If people are exposed to this compound through inhalation, ingestion or skin, it may be harmful to health. Inhalation of air containing this compound may irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. After ingestion, it may hurt the digestive system, causing nausea, vomiting, abdominal pain, etc. It may have potential carcinogenicity, teratogenicity and mutagenicity. Although there is no conclusive conclusion, its structure contains halogenated hydrocarbons and fluoroalkyl groups. According to the research experience of related chemicals, it should not be taken lightly. Long-term exposure to this compound environment may damage the human immune system, nervous system, etc., making the human body immune, prone to diseases, or cause abnormal nervous system function, such as headache, dizziness, insomnia, memory loss, etc.
In summary, 1-bromo-2-chloro-4 - (trifluoromethyl) benzene poses a potential threat to the environment and human body. When its production, use and disposal, appropriate measures should be taken to reduce its harm to the environment and human body.
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