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1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
386902 |
| Chemical Formula | C7H3BrClF3O |
| Molecular Weight | 277.45 |
| Appearance | Liquid (usually, actual may vary) |
| Solubility In Water | Poor (organic halide, likely low solubility) |
| Solubility In Organic Solvents | Good (common for organic halides in solvents like dichloromethane, etc.) |
| Odor | Characteristic (organic halide - like, pungent) |
| Stability | Stable under normal conditions (but may react with strong bases, oxidizers) |
As an accredited 1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy)benzene in sealed chemical - grade vial. |
| Storage | 1 - Bromo - 2 - chloro - 5 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent evaporation and exposure to air and moisture. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy)benzene is shipped in accordance with chemical transportation regulations. Packed securely in appropriate containers, it's transported by methods ensuring safety, handling its hazardous nature with care. |
Competitive 1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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Where to Buy 1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene in China?
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As a leading 1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene?
1 - bromo - 2 - chloro - 5 - (trifluoromethoxy) benzene is an organic compound with the following chemical properties:
1. ** Nucleophilic Substitution Reaction **: The bromine and chlorine atoms in this compound are quite active, and because it is connected to the benzene ring, the electron cloud density of the halogen atom is reduced and it is easier to leave. When encountering nucleophilic reagents, such as sodium alcohols and amines, the halogen atom can be replaced by a nucleophilic group. For example, when reacting with sodium alcohols, bromine or chlorine atoms will be replaced by alkoxy groups to form corresponding ether compounds. This reaction follows the mechanism of nucleophilic substitution and is often used as a means to construct carbon-heteroatom bonds in organic synthesis.
2. ** Aromatic electrophilic substitution reaction **: The electron cloud density distribution of the benzene ring is changed due to the influence of halogen atoms and trifluoromethoxy groups. The trifluoromethoxy group has a strong electron-absorbing induction effect, which causes the electron cloud density of the benzene ring to decrease and the reactivity to decrease. However, under suitable conditions, aromatic electrophilic substitution reactions, such as nitrification and sulfonation, can still occur. The reaction mainly occurs in the position of relatively high electron cloud density, that is, in the position of interposition with the trifluoromethoxy group, because the halogen atom and the trifluoromethoxy group are both interposition positioning groups.
3. ** Reduction reaction **: The halogen atom in the molecule can be reduced and removed under the action of a specific reducing agent. For example, using a system composed of metal zinc and acid, bromine atoms and chlorine atoms can be gradually reduced to form halogen-free benzene compounds. This reduction reaction is very important in adjusting the molecular structure and preparing specific benzene derivatives.
4. ** Reaction with metal reagents **: It can react with metal reagents, such as magnesium, to form Grignard reagents. Grignard reagents are highly active and can react with a variety of electrophilic reagents, such as aldodes, ketones, esters, etc., to achieve carbon chain growth and functional group transformation, which is a key step in the construction of complex organic molecules in organic synthesis. The diverse chemical properties of 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy) benzene make it widely used in the field of organic synthesis, and various functional organic compounds can be prepared through different reaction pathways.
1. ** Nucleophilic Substitution Reaction **: The bromine and chlorine atoms in this compound are quite active, and because it is connected to the benzene ring, the electron cloud density of the halogen atom is reduced and it is easier to leave. When encountering nucleophilic reagents, such as sodium alcohols and amines, the halogen atom can be replaced by a nucleophilic group. For example, when reacting with sodium alcohols, bromine or chlorine atoms will be replaced by alkoxy groups to form corresponding ether compounds. This reaction follows the mechanism of nucleophilic substitution and is often used as a means to construct carbon-heteroatom bonds in organic synthesis.
2. ** Aromatic electrophilic substitution reaction **: The electron cloud density distribution of the benzene ring is changed due to the influence of halogen atoms and trifluoromethoxy groups. The trifluoromethoxy group has a strong electron-absorbing induction effect, which causes the electron cloud density of the benzene ring to decrease and the reactivity to decrease. However, under suitable conditions, aromatic electrophilic substitution reactions, such as nitrification and sulfonation, can still occur. The reaction mainly occurs in the position of relatively high electron cloud density, that is, in the position of interposition with the trifluoromethoxy group, because the halogen atom and the trifluoromethoxy group are both interposition positioning groups.
3. ** Reduction reaction **: The halogen atom in the molecule can be reduced and removed under the action of a specific reducing agent. For example, using a system composed of metal zinc and acid, bromine atoms and chlorine atoms can be gradually reduced to form halogen-free benzene compounds. This reduction reaction is very important in adjusting the molecular structure and preparing specific benzene derivatives.
4. ** Reaction with metal reagents **: It can react with metal reagents, such as magnesium, to form Grignard reagents. Grignard reagents are highly active and can react with a variety of electrophilic reagents, such as aldodes, ketones, esters, etc., to achieve carbon chain growth and functional group transformation, which is a key step in the construction of complex organic molecules in organic synthesis. The diverse chemical properties of 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy) benzene make it widely used in the field of organic synthesis, and various functional organic compounds can be prepared through different reaction pathways.
What are the common synthesis methods of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene?
1 - bromo - 2 - chloro - 5 - (trifluoromethoxy) benzene is an important compound in the field of organic synthesis. Its common synthesis methods include the following.
First, the hydroxyl-containing benzene derivative is used as the starting material. First, the hydroxyl group is converted into the corresponding halide. This step can be achieved by suitable halogenation reagents, such as thionyl chloride, phosphorus tribromide, etc., and then halogenated benzene derivatives are obtained. Then, under specific reaction conditions, a trifluoromethoxy reagent is used to react with it. Common trifluoromethoxy reagents include trifluoromethoxy silver, etc. After nucleophilic substitution, the target product 1-bromo-2-chloro-5 - (trifluoromethoxy) benzene can be obtained. The key to this route lies in the precise control of the halogenation reaction conditions to ensure the selective introduction of halogen atoms; and during the trifluoromethoxylation reaction, the suitability of the reagent activity and the reaction solvent needs to be considered, so as to improve the reaction yield and selectivity.
Second, starting from halogenated benzene. Introduce the trifluoromethoxy group first, which can be achieved by means of palladium-catalyzed or copper-catalyzed coupling reactions. In the presence of suitable ligands, bases and solvents, halogenated benzene is coupled with a trifluoromethoxy source to form trifluoromethoxy-containing benzene derivatives. Subsequently, bromine and chlorine atoms are introduced at specific locations according to requirements. When introducing bromine atoms, brominating reagents such as N-bromosuccinimide (NBS) can be used, and chlorine or other chlorine reagents can be used for chlorine atomic introduction. In this path, factors such as the choice and amount of catalyst for the catalytic coupling reaction, the reaction temperature and time have a great influence on the success or failure of the reaction; and the subsequent halogen atomic introduction steps also need to pay attention to the selectivity of the reaction check point to avoid unnecessary side reactions.
Third, the benzene ring is used as the starting material to gradually construct the substituent. First, the halogen-containing atomic substituent is introduced into the benzene ring by means of Fourier-Gram reaction to form the halogenated benzene intermediate. Then, the nucleophilic substitution or other suitable reactions are used to introduce the trifluoromethoxy group. In this process, the ratio of reactants, the type and amount of catalysts in the Fourier-Gram reaction, and the optimization of the conditions of the subsequent reaction steps are all key to obtaining high-purity 1-bromo-2-chloro-5 - (trifluoromethoxy) benzene.
All synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be selected based on factors such as the availability of raw materials, reaction cost, and purity requirements of target products.
First, the hydroxyl-containing benzene derivative is used as the starting material. First, the hydroxyl group is converted into the corresponding halide. This step can be achieved by suitable halogenation reagents, such as thionyl chloride, phosphorus tribromide, etc., and then halogenated benzene derivatives are obtained. Then, under specific reaction conditions, a trifluoromethoxy reagent is used to react with it. Common trifluoromethoxy reagents include trifluoromethoxy silver, etc. After nucleophilic substitution, the target product 1-bromo-2-chloro-5 - (trifluoromethoxy) benzene can be obtained. The key to this route lies in the precise control of the halogenation reaction conditions to ensure the selective introduction of halogen atoms; and during the trifluoromethoxylation reaction, the suitability of the reagent activity and the reaction solvent needs to be considered, so as to improve the reaction yield and selectivity.
Second, starting from halogenated benzene. Introduce the trifluoromethoxy group first, which can be achieved by means of palladium-catalyzed or copper-catalyzed coupling reactions. In the presence of suitable ligands, bases and solvents, halogenated benzene is coupled with a trifluoromethoxy source to form trifluoromethoxy-containing benzene derivatives. Subsequently, bromine and chlorine atoms are introduced at specific locations according to requirements. When introducing bromine atoms, brominating reagents such as N-bromosuccinimide (NBS) can be used, and chlorine or other chlorine reagents can be used for chlorine atomic introduction. In this path, factors such as the choice and amount of catalyst for the catalytic coupling reaction, the reaction temperature and time have a great influence on the success or failure of the reaction; and the subsequent halogen atomic introduction steps also need to pay attention to the selectivity of the reaction check point to avoid unnecessary side reactions.
Third, the benzene ring is used as the starting material to gradually construct the substituent. First, the halogen-containing atomic substituent is introduced into the benzene ring by means of Fourier-Gram reaction to form the halogenated benzene intermediate. Then, the nucleophilic substitution or other suitable reactions are used to introduce the trifluoromethoxy group. In this process, the ratio of reactants, the type and amount of catalysts in the Fourier-Gram reaction, and the optimization of the conditions of the subsequent reaction steps are all key to obtaining high-purity 1-bromo-2-chloro-5 - (trifluoromethoxy) benzene.
All synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be selected based on factors such as the availability of raw materials, reaction cost, and purity requirements of target products.
Where is 1-bromo-2-chloro-5- (trifluoromethoxy) benzene used?
1 - bromo - 2 - chloro - 5 - (trifluoromethoxy) benzene is an organic compound that has applications in many fields.
In the field of pharmaceutical chemistry, such benzene compounds containing halides and special substituents are often key intermediates for the creation of new drugs. Due to their unique chemical structure, different functional groups can be introduced through chemical reactions to build molecular structures with specific biological activities. For example, by modifying the structure of this compound, inhibitors targeting specific disease targets can be developed, opening up new directions for pharmaceutical research and development.
In the field of materials science, this compound can participate in the synthesis of polymer materials with special properties. Due to the characteristics of fluorine-containing groups, it can endow materials with excellent properties such as chemical resistance and low surface energy. Or it can be used to prepare high-performance coatings to improve the protective performance and durability of coatings; or it can be used to make plastics with special functions to meet the needs of special properties of materials in aerospace, electronics and other fields.
In the field of pesticide chemistry, such structural compounds may have certain biological activities. It can be optimized as a lead compound to develop new pesticides with high efficiency, low toxicity and environmental friendliness. By adjusting the substituent, it can change its action mode and effect on pests and pathogens, providing new means for agricultural pest control.
This compound has shown potential application value in many fields such as medicine, materials, and pesticides, and is of great significance to promoting technological progress and innovation in various fields.
In the field of pharmaceutical chemistry, such benzene compounds containing halides and special substituents are often key intermediates for the creation of new drugs. Due to their unique chemical structure, different functional groups can be introduced through chemical reactions to build molecular structures with specific biological activities. For example, by modifying the structure of this compound, inhibitors targeting specific disease targets can be developed, opening up new directions for pharmaceutical research and development.
In the field of materials science, this compound can participate in the synthesis of polymer materials with special properties. Due to the characteristics of fluorine-containing groups, it can endow materials with excellent properties such as chemical resistance and low surface energy. Or it can be used to prepare high-performance coatings to improve the protective performance and durability of coatings; or it can be used to make plastics with special functions to meet the needs of special properties of materials in aerospace, electronics and other fields.
In the field of pesticide chemistry, such structural compounds may have certain biological activities. It can be optimized as a lead compound to develop new pesticides with high efficiency, low toxicity and environmental friendliness. By adjusting the substituent, it can change its action mode and effect on pests and pathogens, providing new means for agricultural pest control.
This compound has shown potential application value in many fields such as medicine, materials, and pesticides, and is of great significance to promoting technological progress and innovation in various fields.
What are the physical properties of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene?
1 - bromo - 2 - chloro - 5 - (trifluoromethoxy) benzene, Chinese name for 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy) benzene. This substance is a chemical compound, and its physical properties are not well described.
< br The spatial arrangement of molecules and the interaction of atoms determine their melting level. In terms of solubility, because of its solubility, it has a certain solubility in commonly soluble molecules such as ethanol and ether. This is due to the principle of similar phase dissolution, and its molecules are similar to each other, so they can miscible with each other.
And the density is one, and the molecules form a close phase. The amount of atoms and trifluoromethoxy groups does not exist, so that its density is lower than that of normal substances such as water. Generally speaking, its density is higher than that of water, and this characteristic is significant in operations such as liquid-liquid separation.
In addition, its stability is also worth mentioning. Because the molecular force is not stable, under a certain degree of stability and environment, there is a certain degree of stability, which affects the survival and use of benzene, and needs to be paid attention to. Therefore, the rationality of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene is determined by the depth of its molecules, and the various properties are interdependent, which affects the use of this substance in various combinations.
< br The spatial arrangement of molecules and the interaction of atoms determine their melting level. In terms of solubility, because of its solubility, it has a certain solubility in commonly soluble molecules such as ethanol and ether. This is due to the principle of similar phase dissolution, and its molecules are similar to each other, so they can miscible with each other.
And the density is one, and the molecules form a close phase. The amount of atoms and trifluoromethoxy groups does not exist, so that its density is lower than that of normal substances such as water. Generally speaking, its density is higher than that of water, and this characteristic is significant in operations such as liquid-liquid separation.
In addition, its stability is also worth mentioning. Because the molecular force is not stable, under a certain degree of stability and environment, there is a certain degree of stability, which affects the survival and use of benzene, and needs to be paid attention to. Therefore, the rationality of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene is determined by the depth of its molecules, and the various properties are interdependent, which affects the use of this substance in various combinations.
What is the market price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene?
1-Bromo-2-chloro-5- (trifluoromethoxy) benzene, this product is in the market, its price is variable, due to a variety of reasons.
First, the supply and demand situation is the primary reason for pricing. If there are many seekers in the market, but there are few producers, the price will rise; conversely, if the supply exceeds the demand, the price may decline. At some point, many pharmaceutical companies are eager to use it for drug research, and the demand has increased greatly, but the producer has not caught it, and its price has risen; if the producer expands production, the supply is abundant, and the demand has not changed, the price may drop.
Second, the price of raw materials also affects the market. When synthesizing this substance, if the price of the raw materials used increases, the production cost increases, and the merchant must raise the price in order to ensure profitability. For example, raw materials such as bromine and chlorine, etc., are disturbed by the amount of resources, origin situation, mining costs, etc., and the price fluctuates, all of which lead to changes in the price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene.
Third, the process is difficult and easy, which is related to cost and price. If the synthesis of this benzene is complicated, it requires multiple steps of reaction, high requirements for equipment and technology, high energy consumption, and high labor costs, the cost is high and the price is not cheap; if the process is improved, the operation is simplified, the cost is reduced, and the price may be adjusted.
Fourth, the state of market competition has a deep impact. Many competitors in the city compete for customers, or reduce profits to promote sales, resulting in low prices; if you operate exclusively, there is no worry about competition, and the price may be high.
Fifth, the system of policies and regulations also plays a role. Strict environmental protection regulations, manufacturers need to invest in environmental protection, costs rise, and prices are affected; import and export policies change, tariff adjustments, and price changes.
In summary, the market price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene is often subject to dynamic changes due to supply and demand, raw materials, processes, competition, policies, etc., and it is difficult to determine a constant value.
First, the supply and demand situation is the primary reason for pricing. If there are many seekers in the market, but there are few producers, the price will rise; conversely, if the supply exceeds the demand, the price may decline. At some point, many pharmaceutical companies are eager to use it for drug research, and the demand has increased greatly, but the producer has not caught it, and its price has risen; if the producer expands production, the supply is abundant, and the demand has not changed, the price may drop.
Second, the price of raw materials also affects the market. When synthesizing this substance, if the price of the raw materials used increases, the production cost increases, and the merchant must raise the price in order to ensure profitability. For example, raw materials such as bromine and chlorine, etc., are disturbed by the amount of resources, origin situation, mining costs, etc., and the price fluctuates, all of which lead to changes in the price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene.
Third, the process is difficult and easy, which is related to cost and price. If the synthesis of this benzene is complicated, it requires multiple steps of reaction, high requirements for equipment and technology, high energy consumption, and high labor costs, the cost is high and the price is not cheap; if the process is improved, the operation is simplified, the cost is reduced, and the price may be adjusted.
Fourth, the state of market competition has a deep impact. Many competitors in the city compete for customers, or reduce profits to promote sales, resulting in low prices; if you operate exclusively, there is no worry about competition, and the price may be high.
Fifth, the system of policies and regulations also plays a role. Strict environmental protection regulations, manufacturers need to invest in environmental protection, costs rise, and prices are affected; import and export policies change, tariff adjustments, and price changes.
In summary, the market price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene is often subject to dynamic changes due to supply and demand, raw materials, processes, competition, policies, etc., and it is difficult to determine a constant value.
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