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1-Bromo-2-(Chloromethyl)-4-Fluorobenzene
Linshang Chemical
|
HS Code |
303028 |
| Chemical Formula | C7H5BrClF |
| Molar Mass | 225.47 g/mol |
| Appearance | Typically a colorless to pale yellow liquid |
| Boiling Point | Data may vary, around 220 - 230 °C under normal pressure |
| Density | Approximate density around 1.6 - 1.7 g/cm³ |
| Solubility | Soluble in common organic solvents like dichloromethane, chloroform, and toluene; insoluble in water |
| Flash Point | Relatively high, potentially around 90 - 100 °C |
| Odor | May have a pungent, characteristic organic odor |
| Reactivity | Reactive towards nucleophiles due to the presence of bromine and chloromethyl groups |
As an accredited 1-Bromo-2-(Chloromethyl)-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 2-(chloromethyl)-4 - fluorobenzene packaged in a sealed glass bottle. |
| Storage | 1 - bromo - 2 - (chloromethyl)-4 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials, as it may react with some substances. Store it separately from oxidizing agents and bases to prevent potentially hazardous reactions. |
| Shipping | 1 - bromo - 2 - (chloromethyl)-4 - fluorobenzene is a chemical. Ship it in sealed, corrosion - resistant containers. Follow all hazardous material shipping regulations, ensuring proper labeling and handling to prevent spills and ensure safety during transit. |
Competitive 1-Bromo-2-(Chloromethyl)-4-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Bromo-2-(Chloromethyl)-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-bromo-2- (chloromethyl) -4-fluorobenzene?
1 - bromo - 2 - (chloromethyl) - 4 - fluorobenzene is an organic compound with unique chemical properties, which is worth exploring.
When it comes to nucleophilic substitution, the bromine atom and chloromethyl in this compound are quite active. Bromine atoms, as good leaving groups, are vulnerable to nucleophilic reagents. For example, if you encounter nucleophilic reagents such as hydroxyl negative ions (OH), nucleophilic substitution will occur, and the bromine atom will leave, and the hydroxyl group will replace it to form the corresponding alcohol derivative. The chlorine atom in chloromethyl can also be attacked by nucleophilic reagents under suitable conditions to achieve a substitution reaction.
Let's talk about its reaction with metal reagents. 1 - bromo - 2 - (chloromethyl) - 4 - fluorobenzene can react with magnesium to form Grignard reagents. Grignard reagents are extremely active and can react with many carbonyl-containing compounds, such as aldides and ketones, to form new carbon-carbon bonds, which are widely used in organic synthesis.
Although the fluorine atoms in this compound are relatively stable, they have an impact on the electron cloud distribution of the molecule. Due to the extremely strong electronegativity of fluorine atoms, the electron cloud density on the benzene ring will decrease, and the activity of the electrophilic substitution reaction of the benzene ring will decrease. However, under certain conditions, it can still participate in some electrophilic substitution reactions, and due to the positioning effect of fluorine atoms, it will guide the reaction check point.
In terms of redox reactions, this compound may oxidize chloromethyl when it encounters suitable oxidants. For example, it can be oxidized to carboxyl groups, which can be converted into aromatic compounds containing carboxyl groups. In the case of reducing agents, bromine atoms or chlorine atoms may be reduced to form corresponding dehalogenation products.
1-bromo-2 - (chloromethyl) - 4 - fluorobenzene occupies an important position in the field of organic synthesis due to its diverse chemical properties, providing rich possibilities for the preparation of various functional organic compounds.
When it comes to nucleophilic substitution, the bromine atom and chloromethyl in this compound are quite active. Bromine atoms, as good leaving groups, are vulnerable to nucleophilic reagents. For example, if you encounter nucleophilic reagents such as hydroxyl negative ions (OH), nucleophilic substitution will occur, and the bromine atom will leave, and the hydroxyl group will replace it to form the corresponding alcohol derivative. The chlorine atom in chloromethyl can also be attacked by nucleophilic reagents under suitable conditions to achieve a substitution reaction.
Let's talk about its reaction with metal reagents. 1 - bromo - 2 - (chloromethyl) - 4 - fluorobenzene can react with magnesium to form Grignard reagents. Grignard reagents are extremely active and can react with many carbonyl-containing compounds, such as aldides and ketones, to form new carbon-carbon bonds, which are widely used in organic synthesis.
Although the fluorine atoms in this compound are relatively stable, they have an impact on the electron cloud distribution of the molecule. Due to the extremely strong electronegativity of fluorine atoms, the electron cloud density on the benzene ring will decrease, and the activity of the electrophilic substitution reaction of the benzene ring will decrease. However, under certain conditions, it can still participate in some electrophilic substitution reactions, and due to the positioning effect of fluorine atoms, it will guide the reaction check point.
In terms of redox reactions, this compound may oxidize chloromethyl when it encounters suitable oxidants. For example, it can be oxidized to carboxyl groups, which can be converted into aromatic compounds containing carboxyl groups. In the case of reducing agents, bromine atoms or chlorine atoms may be reduced to form corresponding dehalogenation products.
1-bromo-2 - (chloromethyl) - 4 - fluorobenzene occupies an important position in the field of organic synthesis due to its diverse chemical properties, providing rich possibilities for the preparation of various functional organic compounds.
What are the common uses of 1-bromo-2- (chloromethyl) -4-fluorobenzene
1 - bromo - 2 - (chloromethyl) - 4 - fluorobenzene is an organic compound with many common uses. In the field of organic synthesis, this compound is often used as a key intermediate. Because its molecular structure is rich in bromine, chloromethyl and fluorine atoms, these functional groups endow it with unique reactivity, and can be used to construct more complex organic molecular structures through various reactions, such as nucleophilic substitution reactions and coupling reactions.
In nucleophilic substitution reactions, both bromine atoms and chloromethyl groups can act as leaving groups and are replaced by various nucleophilic reagents. For example, when reacted with alcohols under alkaline conditions, bromine atoms can be replaced by alkoxy groups to form corresponding ether compounds; while chloromethyl can also react with nitrogen-containing nucleophiles, such as amines, to form nitrogen-containing derivatives. This property has made 1-bromo-2 - (chloromethyl) -4-fluorobenzene highly attractive in the field of medicinal chemistry. Drug developers often modify its structure by introducing specific functional groups to obtain compounds with biological activities, which can be used in the development of disease therapeutics.
In addition, in the field of materials science, 1-bromo-2 - (chloromethyl) -4-fluorobenzene is also useful. Through appropriate reactions, it can be connected to the main chain or side chain of the polymer to improve the properties of the polymer, such as improving the thermal stability and chemical stability of the material, or endowing the material with special optical and electrical properties. Due to its unique structure and reactivity, this compound has shown important application value in many fields such as organic synthesis, drug development and materials science, providing a rich material basis and reaction possibilities for the research and development of related fields.
In nucleophilic substitution reactions, both bromine atoms and chloromethyl groups can act as leaving groups and are replaced by various nucleophilic reagents. For example, when reacted with alcohols under alkaline conditions, bromine atoms can be replaced by alkoxy groups to form corresponding ether compounds; while chloromethyl can also react with nitrogen-containing nucleophiles, such as amines, to form nitrogen-containing derivatives. This property has made 1-bromo-2 - (chloromethyl) -4-fluorobenzene highly attractive in the field of medicinal chemistry. Drug developers often modify its structure by introducing specific functional groups to obtain compounds with biological activities, which can be used in the development of disease therapeutics.
In addition, in the field of materials science, 1-bromo-2 - (chloromethyl) -4-fluorobenzene is also useful. Through appropriate reactions, it can be connected to the main chain or side chain of the polymer to improve the properties of the polymer, such as improving the thermal stability and chemical stability of the material, or endowing the material with special optical and electrical properties. Due to its unique structure and reactivity, this compound has shown important application value in many fields such as organic synthesis, drug development and materials science, providing a rich material basis and reaction possibilities for the research and development of related fields.
What are the synthesis methods of 1-bromo-2- (chloromethyl) -4-fluorobenzene
The synthesis method of 1-bromo-2 - (chloromethyl) -4-fluorobenzene is often involved in the field of organic synthesis. To make this substance, various paths can be followed.
First, it can be started from benzene derivatives containing corresponding substituents. If p-fluorotoluene is used as a raw material, methyl chloride is first substituted to obtain p-fluorobenzyl chloride. This step can be caused by the reaction of chlorine gas in the presence of light or a free radical initiator. The mechanism is the substitution of free radicals, which grab methyl hydrogen and then generate p-fluorobenzyl chloride. Then, the bromination reaction is carried out, and bromine atoms are introduced into the ortho-position of the benzene ring under the action of suitable brominating reagents such as N-bromosuccinimide (NBS) and initiators, so the target product is 1-bromo-2- (chloromethyl) -4-fluorobenzene.
Second, 4-fluorobenzyl alcohol can also be used as the starting material. First, it is chlorinated and treated with chlorinated reagents such as thionyl chloride to obtain 4-fluorobenzyl chloride. Then, according to the above bromination method, bromine atoms are introduced into the ortho-position of the benzene ring with reagents such as NBS. This compound can also be obtained.
Furthermore, if 2-methyl-4-fluorobromobenzene is used as the raw material, the methyl group is first converted to chloromethyl. This can be achieved by a multi-step reaction, such as oxidizing the methyl group to the carboxyl group with potassium permanganate and other oxidants, and then through reduction, chlorination and other steps, the final product is 1-bromo-2- (chloromethyl) -4-fluorobenzene. All synthesis methods have their own advantages and disadvantages, and need to be weighed according to the availability of raw materials, the difficulty of reaction conditions and costs.
First, it can be started from benzene derivatives containing corresponding substituents. If p-fluorotoluene is used as a raw material, methyl chloride is first substituted to obtain p-fluorobenzyl chloride. This step can be caused by the reaction of chlorine gas in the presence of light or a free radical initiator. The mechanism is the substitution of free radicals, which grab methyl hydrogen and then generate p-fluorobenzyl chloride. Then, the bromination reaction is carried out, and bromine atoms are introduced into the ortho-position of the benzene ring under the action of suitable brominating reagents such as N-bromosuccinimide (NBS) and initiators, so the target product is 1-bromo-2- (chloromethyl) -4-fluorobenzene.
Second, 4-fluorobenzyl alcohol can also be used as the starting material. First, it is chlorinated and treated with chlorinated reagents such as thionyl chloride to obtain 4-fluorobenzyl chloride. Then, according to the above bromination method, bromine atoms are introduced into the ortho-position of the benzene ring with reagents such as NBS. This compound can also be obtained.
Furthermore, if 2-methyl-4-fluorobromobenzene is used as the raw material, the methyl group is first converted to chloromethyl. This can be achieved by a multi-step reaction, such as oxidizing the methyl group to the carboxyl group with potassium permanganate and other oxidants, and then through reduction, chlorination and other steps, the final product is 1-bromo-2- (chloromethyl) -4-fluorobenzene. All synthesis methods have their own advantages and disadvantages, and need to be weighed according to the availability of raw materials, the difficulty of reaction conditions and costs.
What are the precautions for 1-bromo-2- (chloromethyl) -4-fluorobenzene in storage and transportation?
1 - bromo - 2 - (chloromethyl) - 4 - fluorobenzene, Chinese name 1 - bromo - 2 - (chloromethyl) - 4 - fluorobenzene, many matters need to be paid attention to when storing and transporting this substance.
The first words of storage, because of its chemical activity, should be stored in a cool, dry and well ventilated place. Excessive temperature can easily cause chemical reactions, cause deterioration, or cause safety risks. Humidity must also be strictly controlled. High humidity environment or reactions such as hydrolysis can affect quality. Keep away from fire and heat sources because of their flammability, exposure to open flames, hot topics, or the risk of combustion and explosion. In addition, it should be stored separately from oxidizing agents, strong alkalis, etc., and these substances should come into contact with them or react violently. And the storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage from being dealt with in time.
As for transportation, there are also many precautions. Be sure to ensure that the packaging is complete and well sealed before transportation to prevent leakage during transportation. Transportation vehicles must be equipped with corresponding varieties and quantities of fire protection equipment and leakage emergency treatment equipment. When driving, it is necessary to prevent exposure to the sun, rain, and high temperature. When road transportation, it is necessary to follow the prescribed route and do not stop in residential areas and densely populated areas. During railway transportation, it is strictly forbidden to slip away. During handling, operators must strictly abide by the operating procedures, pack and unload lightly to prevent damage to packaging and containers.
In this way, the storage and transportation of 1-bromo-2- (chloromethyl) -4-fluorobenzene should be done with caution in all aspects to ensure safety and quality.
The first words of storage, because of its chemical activity, should be stored in a cool, dry and well ventilated place. Excessive temperature can easily cause chemical reactions, cause deterioration, or cause safety risks. Humidity must also be strictly controlled. High humidity environment or reactions such as hydrolysis can affect quality. Keep away from fire and heat sources because of their flammability, exposure to open flames, hot topics, or the risk of combustion and explosion. In addition, it should be stored separately from oxidizing agents, strong alkalis, etc., and these substances should come into contact with them or react violently. And the storage area should be equipped with suitable materials to contain leaks, so as to prevent accidental leakage from being dealt with in time.
As for transportation, there are also many precautions. Be sure to ensure that the packaging is complete and well sealed before transportation to prevent leakage during transportation. Transportation vehicles must be equipped with corresponding varieties and quantities of fire protection equipment and leakage emergency treatment equipment. When driving, it is necessary to prevent exposure to the sun, rain, and high temperature. When road transportation, it is necessary to follow the prescribed route and do not stop in residential areas and densely populated areas. During railway transportation, it is strictly forbidden to slip away. During handling, operators must strictly abide by the operating procedures, pack and unload lightly to prevent damage to packaging and containers.
In this way, the storage and transportation of 1-bromo-2- (chloromethyl) -4-fluorobenzene should be done with caution in all aspects to ensure safety and quality.
What are the effects of 1-bromo-2- (chloromethyl) -4-fluorobenzene on the environment and human body?
1 - bromo - 2 - (chloromethyl) - 4 - fluorobenzene is an organic compound. Its impact on the environment and the human body is unknown to the ancients. However, with today's scientific knowledge, it can be imitated by the ancient people.
In terms of the environment, if this compound is released in nature, it is difficult to degrade because it contains halogen atoms. Bromine, chlorine, and fluorine atoms stabilize the molecular structure, cause soil pollution, affect soil quality, and hinder plant growth. In water bodies, it may dissolve and endanger aquatic organisms. Because it has certain toxicity, or causes aberration and death of aquatic organisms, it destroys the ecological balance of water. And it persists in the environment for a long time, is transmitted and enriched through the food chain, and eventually involves high-end organisms.
In the human body, if people come into contact with this compound through breathing, diet or skin, it may have many hazards. It may irritate the respiratory tract, cause cough, asthma and other diseases, and damage the respiratory system. If it enters the digestive system, or hurts the gastrointestinal mucosa, it can cause nausea, vomiting, abdominal pain, etc. What's more, it may be potentially carcinogenic. Long-term exposure can cause cell abnormalities and increase the risk of cancer. It may also interfere with the human endocrine system, affect hormone balance, and have adverse effects on physiological processes such as reproduction and development. In short, this compound has potential harm to the environment and the human body, and needs to be treated with caution to prevent it from escaping into the environment and preventing people from being exposed to it.
In terms of the environment, if this compound is released in nature, it is difficult to degrade because it contains halogen atoms. Bromine, chlorine, and fluorine atoms stabilize the molecular structure, cause soil pollution, affect soil quality, and hinder plant growth. In water bodies, it may dissolve and endanger aquatic organisms. Because it has certain toxicity, or causes aberration and death of aquatic organisms, it destroys the ecological balance of water. And it persists in the environment for a long time, is transmitted and enriched through the food chain, and eventually involves high-end organisms.
In the human body, if people come into contact with this compound through breathing, diet or skin, it may have many hazards. It may irritate the respiratory tract, cause cough, asthma and other diseases, and damage the respiratory system. If it enters the digestive system, or hurts the gastrointestinal mucosa, it can cause nausea, vomiting, abdominal pain, etc. What's more, it may be potentially carcinogenic. Long-term exposure can cause cell abnormalities and increase the risk of cancer. It may also interfere with the human endocrine system, affect hormone balance, and have adverse effects on physiological processes such as reproduction and development. In short, this compound has potential harm to the environment and the human body, and needs to be treated with caution to prevent it from escaping into the environment and preventing people from being exposed to it.
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