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1-Bromo-3-Chloro-2,4-Difluorobenzene
|
HS Code |
526910 |
| Chemical Formula | C6H2BrClF2 |
| Molecular Weight | 229.434 |
| Appearance | Liquid (Typical) |
| Boiling Point | Around 190 - 200 °C (Estimated) |
| Solubility In Water | Low, as it is an organic halogenated compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low, due to its relatively high molecular weight |
As an accredited 1-Bromo-3-Chloro-2,4-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 1 - bromo - 3 - chloro - 2,4 - difluorobenzene, well - sealed. |
| Storage | 1 - Bromo - 3 - chloro - 2,4 - difluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent vapor leakage. Since it is a potentially hazardous chemical, ensure storage in a location inaccessible to unauthorized personnel and in accordance with local safety regulations. |
| Shipping | 1 - bromo - 3 - chloro - 2,4 - difluorobenzene is a chemical. Shipping requires proper packaging in accordance with hazardous materials regulations, ensuring leak - proof containers and appropriate labeling for safe transportation. |
Competitive 1-Bromo-3-Chloro-2,4-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-3-Chloro-2,4-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1 - bromo - 3 - chloro - 2,4 - difluorobenzene
1-Bromo-3-chloro-2,4-difluorobenzene is also an organic compound. Its main uses are quite wide, in the field of medicinal chemistry, and it is often a key intermediate for the synthesis of specific drugs. Drug developers use its unique chemical structure, add various functional groups through subtle reactions, and then obtain compounds with specific biological activities, providing the possibility to overcome difficult diseases.
In the field of materials science, 1-bromo-3-chloro-2,4-difluorobenzene also plays an important role. It can be used to create new polymer materials. After polymerization, it can be integrated into the polymer backbone, endowing the material with unique properties, such as enhanced heat resistance and chemical corrosion resistance, so that the material can remain stable under extreme conditions. It can be used in aerospace, electronic devices and other fields that require strict material properties.
Furthermore, in the field of pesticide chemistry, this compound is also an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design, it can be converted into pesticide components with strong targeted killing or inhibitory effects on harmful organisms, while reducing the adverse effects on the environment and non-target organisms, meeting the needs of modern green agriculture development.
In conclusion, the unique chemical structure and reactivity of 1-bromo-3-chloro-2,4-difluorobenzene play a key role in many fields such as medicine, materials, and pesticides, and promote innovation and progress in related industries.
In the field of materials science, 1-bromo-3-chloro-2,4-difluorobenzene also plays an important role. It can be used to create new polymer materials. After polymerization, it can be integrated into the polymer backbone, endowing the material with unique properties, such as enhanced heat resistance and chemical corrosion resistance, so that the material can remain stable under extreme conditions. It can be used in aerospace, electronic devices and other fields that require strict material properties.
Furthermore, in the field of pesticide chemistry, this compound is also an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design, it can be converted into pesticide components with strong targeted killing or inhibitory effects on harmful organisms, while reducing the adverse effects on the environment and non-target organisms, meeting the needs of modern green agriculture development.
In conclusion, the unique chemical structure and reactivity of 1-bromo-3-chloro-2,4-difluorobenzene play a key role in many fields such as medicine, materials, and pesticides, and promote innovation and progress in related industries.
What are the physical properties of 1 - bromo - 3 - chloro - 2,4 - difluorobenzene
1 + -Bromo-3-chloro-2,4-difluorobenzene is a kind of organic compound. Its physical properties are particularly important, which is related to the application and characteristics of this compound.
First of all, its appearance is usually colorless to light yellow liquid, clear and transparent, and it can be seen that it flows freely and has a liquid state. This color state is determined by its molecular structure and electron transition characteristics. The atomic bonding and electron distribution in the molecule cause it to absorb and reflect visible light in this way.
As for the boiling point, it is in a specific temperature range. There are interactions such as van der Waals forces between the cover molecules. To make the molecule break free from the liquid phase and transform into the gas phase, it needs to reach the corresponding energy, that is, the boiling point temperature. This boiling point value is related to the size, shape and polarity of the molecule. In the molecular structure of 1 + -bromo-3-chloro-2,4-difluorobenzene, the presence of halogen atoms changes the polarity of the molecule and increases the intermolecular force, so the boiling point has a specific value.
Melting point is also an important physical property. When the temperature drops to the melting point, the compound gradually changes from the liquid state to the solid state. When the molecules are in the solid state, the arrangement is more orderly, and the lattice structure is formed. The level of melting point is also determined by the intermolecular force and the lattice energy. The electronegativity difference of the halogen atoms in this compound results in a strong dipole-dipole interaction between molecules, which affects the melting point.
In terms of density, its value is greater than that of water. Due to the large relative atomic weight of the halogen atoms such as bromine, chlorine, and fluorine in the molecule, and the compact molecular structure, the mass per unit volume increases, so the density is high. This property has its significance in operations such as separation and extraction.
In terms of solubility, it is slightly soluble in water. Due to the fact that its molecules are organic structures and water is a solvent with extremely strong polarity, the forces between the two molecules are greatly different, making it difficult to form effective interactions. However, the solubility in organic solvents such as ethanol and ether is quite good, because organic solvents and 1 + -bromo-3-chloro-2,4-difluorobenzene molecules can form similar van der Waals forces or other interactions, such as dispersion forces, inducing forces, etc., so they are mutually soluble. This solubility characteristic is crucial in organic synthesis, purification and other processes, according to which suitable solvents can be selected for related operations.
First of all, its appearance is usually colorless to light yellow liquid, clear and transparent, and it can be seen that it flows freely and has a liquid state. This color state is determined by its molecular structure and electron transition characteristics. The atomic bonding and electron distribution in the molecule cause it to absorb and reflect visible light in this way.
As for the boiling point, it is in a specific temperature range. There are interactions such as van der Waals forces between the cover molecules. To make the molecule break free from the liquid phase and transform into the gas phase, it needs to reach the corresponding energy, that is, the boiling point temperature. This boiling point value is related to the size, shape and polarity of the molecule. In the molecular structure of 1 + -bromo-3-chloro-2,4-difluorobenzene, the presence of halogen atoms changes the polarity of the molecule and increases the intermolecular force, so the boiling point has a specific value.
Melting point is also an important physical property. When the temperature drops to the melting point, the compound gradually changes from the liquid state to the solid state. When the molecules are in the solid state, the arrangement is more orderly, and the lattice structure is formed. The level of melting point is also determined by the intermolecular force and the lattice energy. The electronegativity difference of the halogen atoms in this compound results in a strong dipole-dipole interaction between molecules, which affects the melting point.
In terms of density, its value is greater than that of water. Due to the large relative atomic weight of the halogen atoms such as bromine, chlorine, and fluorine in the molecule, and the compact molecular structure, the mass per unit volume increases, so the density is high. This property has its significance in operations such as separation and extraction.
In terms of solubility, it is slightly soluble in water. Due to the fact that its molecules are organic structures and water is a solvent with extremely strong polarity, the forces between the two molecules are greatly different, making it difficult to form effective interactions. However, the solubility in organic solvents such as ethanol and ether is quite good, because organic solvents and 1 + -bromo-3-chloro-2,4-difluorobenzene molecules can form similar van der Waals forces or other interactions, such as dispersion forces, inducing forces, etc., so they are mutually soluble. This solubility characteristic is crucial in organic synthesis, purification and other processes, according to which suitable solvents can be selected for related operations.
What are the chemical properties of 1 - bromo - 3 - chloro - 2,4 - difluorobenzene
1 + -Bromo-3-chloro-2,4-difluorobenzene is also an organic compound. Its molecule contains bromine, chlorine, and fluorine halogen atoms, and this structure is endowed with unique chemical properties.
In terms of reactivity, the presence of halogen atoms changes the electron cloud density of the benzene ring. Bromine, chlorine, and fluorine are all electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene. However, under certain conditions, electrophilic substitution can still occur. Its substitution position is dominated by the localization effect of halogen atoms. Halogen atoms belong to adjacent and para-localization groups, so electrophilic reagents attack their adjacent and para-positions more often.
In addition, halogen atoms in this compound can Under appropriate nucleophilic reagents and reaction conditions, bromine, chlorine, and fluorine atoms can be replaced by other groups. In case of strong nucleophilic reagents, bromine atoms can be replaced first, because its C-Br bond energy is relatively low and it is easier to break.
Because it contains multiple halogen atoms, it can participate in many organic synthesis reactions and is an important intermediate for the construction of complex organic molecules. It can be converted into halogen atoms and introduce different functional groups to expand the structure and function of compounds.
The chemical properties of 1 + -bromo-3-chloro-2,4-difluorobenzene are determined by the halogen atoms in its molecular structure. It has important value in the field of organic synthesis. With its unique reactive properties, various organic compounds can be prepared.
In terms of reactivity, the presence of halogen atoms changes the electron cloud density of the benzene ring. Bromine, chlorine, and fluorine are all electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene. However, under certain conditions, electrophilic substitution can still occur. Its substitution position is dominated by the localization effect of halogen atoms. Halogen atoms belong to adjacent and para-localization groups, so electrophilic reagents attack their adjacent and para-positions more often.
In addition, halogen atoms in this compound can Under appropriate nucleophilic reagents and reaction conditions, bromine, chlorine, and fluorine atoms can be replaced by other groups. In case of strong nucleophilic reagents, bromine atoms can be replaced first, because its C-Br bond energy is relatively low and it is easier to break.
Because it contains multiple halogen atoms, it can participate in many organic synthesis reactions and is an important intermediate for the construction of complex organic molecules. It can be converted into halogen atoms and introduce different functional groups to expand the structure and function of compounds.
The chemical properties of 1 + -bromo-3-chloro-2,4-difluorobenzene are determined by the halogen atoms in its molecular structure. It has important value in the field of organic synthesis. With its unique reactive properties, various organic compounds can be prepared.
What are the synthesis methods of 1 - bromo - 3 - chloro - 2,4 - difluorobenzene
There are many ways to synthesize 1 + -bromo-3-chloro-2,4-difluorobenzene. The following are described in detail:
First, halogenated aromatic hydrocarbons are used as starting materials. Appropriate halogenated benzene can be taken first, and the halogen atoms on it need to be gradually replaced in subsequent steps according to the reaction plan. If a chlorobenzene derivative is selected, the chlorine atom at a specific position can be replaced by a bromine atom through a nucleophilic substitution reaction. This reaction needs to be carried out in a suitable solvent, such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), to improve the solubility and reactivity of the reactants. During the reaction, metal reagents, such as copper salts, can be added to catalyze the reaction process and improve the reaction rate and selectivity. After the bromine atom is successfully introduced, fluorine atoms are introduced under suitable conditions by a nucleophilic substitution method similar to another position. This process requires fine regulation of the reaction temperature, the proportion of reactants and the reaction time to obtain the target product with higher yield and purity.
Second, start with the strategy of benzene ring construction. A benzene ring containing the target substituent can be gradually constructed from a simple raw material through a multi-step reaction. For example, with m-chlorobenzoic acid as the starting material, the carboxyl group is converted into an ester group through an esterification reaction to enhance its chemical stability. Then, bromine atoms are introduced at a specific position through a halogenation reaction. This halogenation reaction can use a brominating agent, such as N-bromosuccinimide (NBS), and select an appropriate initiator, light or free radical initiator, so that the reaction orientation occurs at the desired position. After decarboxylation and fluorination, suitable fluorination reagents, such as Selectfluor, are used to remove carboxyl groups and introduce fluorine atoms, and finally construct 1-bromo-3-chloro-2,4-difluorobenzene. Although there are many steps in this path, the precise control of the reaction conditions in each step can effectively improve the purity and yield of the product.
Third, cross-coupling reaction catalyzed by transition metals. The cross-coupling reaction of benzene derivatives containing chlorine and fluorine with bromine-containing organometallic reagents such as organolithium or organozinc reagents is carried out under the action of transition metal catalysts such as palladium catalysts. The reaction needs to be carried out in an inert gas protective atmosphere at a suitable temperature. The ligand selection of palladium catalysts is crucial, and different ligands can significantly affect the selectivity and activity of the reaction. By rationally adjusting the reaction conditions and the proportion of reactants, bromine atoms can be precisely connected to the specific position of the benzene ring, and the structure of the target product can be formed with the original chlorine and fluorine atoms. Due to the high efficiency and selectivity of transition metal catalysis, this method provides a promising way for the synthesis of 1-bromo-3-chloro-2,4-difluorobenzene.
The above synthetic methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively weigh factors such as raw material availability, cost considerations, and purity requirements of target products to choose the optimal solution.
First, halogenated aromatic hydrocarbons are used as starting materials. Appropriate halogenated benzene can be taken first, and the halogen atoms on it need to be gradually replaced in subsequent steps according to the reaction plan. If a chlorobenzene derivative is selected, the chlorine atom at a specific position can be replaced by a bromine atom through a nucleophilic substitution reaction. This reaction needs to be carried out in a suitable solvent, such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), to improve the solubility and reactivity of the reactants. During the reaction, metal reagents, such as copper salts, can be added to catalyze the reaction process and improve the reaction rate and selectivity. After the bromine atom is successfully introduced, fluorine atoms are introduced under suitable conditions by a nucleophilic substitution method similar to another position. This process requires fine regulation of the reaction temperature, the proportion of reactants and the reaction time to obtain the target product with higher yield and purity.
Second, start with the strategy of benzene ring construction. A benzene ring containing the target substituent can be gradually constructed from a simple raw material through a multi-step reaction. For example, with m-chlorobenzoic acid as the starting material, the carboxyl group is converted into an ester group through an esterification reaction to enhance its chemical stability. Then, bromine atoms are introduced at a specific position through a halogenation reaction. This halogenation reaction can use a brominating agent, such as N-bromosuccinimide (NBS), and select an appropriate initiator, light or free radical initiator, so that the reaction orientation occurs at the desired position. After decarboxylation and fluorination, suitable fluorination reagents, such as Selectfluor, are used to remove carboxyl groups and introduce fluorine atoms, and finally construct 1-bromo-3-chloro-2,4-difluorobenzene. Although there are many steps in this path, the precise control of the reaction conditions in each step can effectively improve the purity and yield of the product.
Third, cross-coupling reaction catalyzed by transition metals. The cross-coupling reaction of benzene derivatives containing chlorine and fluorine with bromine-containing organometallic reagents such as organolithium or organozinc reagents is carried out under the action of transition metal catalysts such as palladium catalysts. The reaction needs to be carried out in an inert gas protective atmosphere at a suitable temperature. The ligand selection of palladium catalysts is crucial, and different ligands can significantly affect the selectivity and activity of the reaction. By rationally adjusting the reaction conditions and the proportion of reactants, bromine atoms can be precisely connected to the specific position of the benzene ring, and the structure of the target product can be formed with the original chlorine and fluorine atoms. Due to the high efficiency and selectivity of transition metal catalysis, this method provides a promising way for the synthesis of 1-bromo-3-chloro-2,4-difluorobenzene.
The above synthetic methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively weigh factors such as raw material availability, cost considerations, and purity requirements of target products to choose the optimal solution.
1 - bromo - 3 - chloro - 2,4 - difluorobenzene in the storage and transport of what precautions
1 + -Bromo-3-chloro-2,4-difluorobenzene is an organic compound. When storing and transporting, there are several things to pay attention to, as detailed below:
First, when storing, it should be placed in a cool and ventilated warehouse. This compound is prone to change when heated, and high temperature can cause it to decompose or cause other chemical reactions, so a cool place can ensure the stability of its chemical properties. Well ventilated can avoid the accumulation of volatile gases, reducing the risk of fire and explosion.
Second, it should be stored separately from oxidants and alkalis, and should not be mixed. Due to its active chemical properties, it is easy to react violently with oxidants, and may also react chemically with alkalis, causing the compound to deteriorate and may be dangerous.
Third, the storage area should be equipped with suitable materials to contain leaks. If there is a leak, it can be collected in time to prevent its spread and pollute the environment, and to avoid safety accidents caused by leaks.
Fourth, when transporting, make sure that the container does not leak, collapse, fall or damage. Because of its certain toxicity and corrosiveness, if the container is damaged and the material leaks, it will endanger the safety of transporters and pollute the surrounding environment.
Fifth, the transportation process should be kept away from fire and heat sources. This compound may burn or even explode in case of open fire and hot topic, so the fire source and temperature must be strictly controlled during transportation.
Sixth, the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. In the event of a fire or spill, it can be responded to quickly to reduce the degree of harm.
In short, the storage and transportation of 1 + -bromo-3-chloro-2,4-difluorobenzene requires caution and strict compliance with relevant regulations and operating procedures to ensure the safety of personnel and the environment from pollution.
First, when storing, it should be placed in a cool and ventilated warehouse. This compound is prone to change when heated, and high temperature can cause it to decompose or cause other chemical reactions, so a cool place can ensure the stability of its chemical properties. Well ventilated can avoid the accumulation of volatile gases, reducing the risk of fire and explosion.
Second, it should be stored separately from oxidants and alkalis, and should not be mixed. Due to its active chemical properties, it is easy to react violently with oxidants, and may also react chemically with alkalis, causing the compound to deteriorate and may be dangerous.
Third, the storage area should be equipped with suitable materials to contain leaks. If there is a leak, it can be collected in time to prevent its spread and pollute the environment, and to avoid safety accidents caused by leaks.
Fourth, when transporting, make sure that the container does not leak, collapse, fall or damage. Because of its certain toxicity and corrosiveness, if the container is damaged and the material leaks, it will endanger the safety of transporters and pollute the surrounding environment.
Fifth, the transportation process should be kept away from fire and heat sources. This compound may burn or even explode in case of open fire and hot topic, so the fire source and temperature must be strictly controlled during transportation.
Sixth, the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. In the event of a fire or spill, it can be responded to quickly to reduce the degree of harm.
In short, the storage and transportation of 1 + -bromo-3-chloro-2,4-difluorobenzene requires caution and strict compliance with relevant regulations and operating procedures to ensure the safety of personnel and the environment from pollution.
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