Linshang Chemical
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1-Bromo-3-Chloro-2-Fluorobenzene
Linshang Chemical
|
HS Code |
181581 |
| Chemical Formula | C6H3BrClF |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 188 - 190 °C |
| Density | 1.725 g/mL at 25 °C |
| Flash Point | 76 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Stability | Stable under normal conditions |
| Hazard Class | Irritant |
As an accredited 1-Bromo-3-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 3 - chloro - 2 - fluorobenzene in a sealed, chemical - resistant bottle. |
| Storage | 1 - Bromo - 3 - chloro - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential hazardous reactions. Label the storage clearly for easy identification. |
| Shipping | 1 - bromo - 3 - chloro - 2 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper handling, storage, and transport to prevent spills and exposure. |
Competitive 1-Bromo-3-Chloro-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the chemical properties of 1 - bromo - 3 - chloro - 2 - fluorobenzene?
1 + -Bromo-3 + -chloro-2 + -fluorobenzene is also a halogenated aromatic hydrocarbon. Its chemical properties are particularly interesting, and the halogen atom is on the benzene ring, which makes it have unique reactivity.
First of all, the electrophilic substitution reaction is an important property of benzene. The benzene ring is rich in electrons. Although the halogen atom is an ortho-para-site, its electron-absorbing induction effect cannot be ignored. Because the electronegativity of fluorine, chlorine and bromine is greater than that of carbon, the electron cloud density of the benzene ring is reduced, so the electrophilic substitution reaction activity is slightly lower than that of benzene. In this compound, due to the synthesis of the localization effects of each halogen atom, the electrophilic reagents mostly attack the position where the electron cloud density However, due to factors such as steric hindrance, the substitution position is also affected.
Furthermore, halogen atoms can participate in nucleophilic substitution reactions. Although the nucleophilic substitution of aromatic halogenated hydrocarbons is more difficult than that of alkyl halogenated hydrocarbons, halogen atoms can be replaced by nucleophilic reagents under specific conditions, such as high temperature, strong bases or catalysts. Fluorine atoms are relatively difficult to be replaced due to high carbon-fluorine bond energy; while bromine atoms are more active, under suitable conditions, they may be replaced by nucleophilic reagents first.
In addition, 1 + -bromo-3 + -chloro-2 + -fluorobenzene can also participate in metal-catalyzed reactions. For example, under palladium catalysis, it can be coupled with carbon-containing nucleophiles, which is widely used in the construction of carbon-carbon bonds and can provide an effective path for the synthesis of complex organic compounds.
And because it contains a variety of halogen atoms, in organic synthesis, different derivatives can be synthesized according to the needs by selective dehalogenation and other reactions, providing a variety of strategies and possibilities for the study of organic synthetic chemistry.
First of all, the electrophilic substitution reaction is an important property of benzene. The benzene ring is rich in electrons. Although the halogen atom is an ortho-para-site, its electron-absorbing induction effect cannot be ignored. Because the electronegativity of fluorine, chlorine and bromine is greater than that of carbon, the electron cloud density of the benzene ring is reduced, so the electrophilic substitution reaction activity is slightly lower than that of benzene. In this compound, due to the synthesis of the localization effects of each halogen atom, the electrophilic reagents mostly attack the position where the electron cloud density However, due to factors such as steric hindrance, the substitution position is also affected.
Furthermore, halogen atoms can participate in nucleophilic substitution reactions. Although the nucleophilic substitution of aromatic halogenated hydrocarbons is more difficult than that of alkyl halogenated hydrocarbons, halogen atoms can be replaced by nucleophilic reagents under specific conditions, such as high temperature, strong bases or catalysts. Fluorine atoms are relatively difficult to be replaced due to high carbon-fluorine bond energy; while bromine atoms are more active, under suitable conditions, they may be replaced by nucleophilic reagents first.
In addition, 1 + -bromo-3 + -chloro-2 + -fluorobenzene can also participate in metal-catalyzed reactions. For example, under palladium catalysis, it can be coupled with carbon-containing nucleophiles, which is widely used in the construction of carbon-carbon bonds and can provide an effective path for the synthesis of complex organic compounds.
And because it contains a variety of halogen atoms, in organic synthesis, different derivatives can be synthesized according to the needs by selective dehalogenation and other reactions, providing a variety of strategies and possibilities for the study of organic synthetic chemistry.
What is the common synthesis of 1 - bromo - 3 - chloro - 2 - fluorobenzene?
1 + -Bromo-3-chloro-2-fluorobenzene is also an organic compound. Its common synthesis method follows the conventional path of organic synthesis.
First, benzene can be used as the beginning, and the halogenation reaction can be carried out first. To obtain this specific substituted product, it can be delicately regulated according to different halogenating reagents and reaction conditions. For example, with a brominating reagent, under a suitable catalyst and temperature, bromine atoms can be selected to replace the hydrogen of the benzene ring to obtain bromobenzene derivatives. Thereafter, chlorine atoms and fluorine atoms are introduced. When introducing chlorine atoms, chlorination reagents can be selected, and chlorine atoms can be connected at suitable positions according to the rules of reaction activity and positioning. As for the introduction of fluorine atoms, special fluorination reagents and conditions are often required, which vary depending on the reactivity of fluorine.
Second, benzene derivatives with specific substituents can also be used as starting materials. For example, those with suitable substituents occupying a specific position can be converted into functional groups. In an appropriate reaction, existing functional groups can be converted into bromine, chlorine, and fluorine atoms. This process requires a good understanding of the mechanisms and conditions of various reactions in order to precisely control and obtain the target product 1 + -bromo-3-chloro-2-fluorobenzene.
Or the electrophilic substitution reaction sequence on the aromatic ring can be used. First, a halogen atom is used for electrophilic substitution, and the electron cloud density distribution and positioning effect of the benzene ring are used to guide the subsequent substitution position of the halogen atom. Then the reaction conditions, such as temperature, solvent, catalyst type and dosage, are finely adjusted, so that each halogen atom is connected to the benzene ring in sequence according to the desired position, and finally 1 + -bromo-3-chloro-2-fluorobenzene is obtained. During the synthesis, the raw materials need to be carefully selected and the conditions carefully controlled to achieve the purpose of efficient and highly selective synthesis.
First, benzene can be used as the beginning, and the halogenation reaction can be carried out first. To obtain this specific substituted product, it can be delicately regulated according to different halogenating reagents and reaction conditions. For example, with a brominating reagent, under a suitable catalyst and temperature, bromine atoms can be selected to replace the hydrogen of the benzene ring to obtain bromobenzene derivatives. Thereafter, chlorine atoms and fluorine atoms are introduced. When introducing chlorine atoms, chlorination reagents can be selected, and chlorine atoms can be connected at suitable positions according to the rules of reaction activity and positioning. As for the introduction of fluorine atoms, special fluorination reagents and conditions are often required, which vary depending on the reactivity of fluorine.
Second, benzene derivatives with specific substituents can also be used as starting materials. For example, those with suitable substituents occupying a specific position can be converted into functional groups. In an appropriate reaction, existing functional groups can be converted into bromine, chlorine, and fluorine atoms. This process requires a good understanding of the mechanisms and conditions of various reactions in order to precisely control and obtain the target product 1 + -bromo-3-chloro-2-fluorobenzene.
Or the electrophilic substitution reaction sequence on the aromatic ring can be used. First, a halogen atom is used for electrophilic substitution, and the electron cloud density distribution and positioning effect of the benzene ring are used to guide the subsequent substitution position of the halogen atom. Then the reaction conditions, such as temperature, solvent, catalyst type and dosage, are finely adjusted, so that each halogen atom is connected to the benzene ring in sequence according to the desired position, and finally 1 + -bromo-3-chloro-2-fluorobenzene is obtained. During the synthesis, the raw materials need to be carefully selected and the conditions carefully controlled to achieve the purpose of efficient and highly selective synthesis.
What are the applications of 1 - bromo - 3 - chloro - 2 - fluorobenzene in organic synthesis?
1-Bromo-3-chloro-2-fluorobenzene is widely used in organic synthesis.
First, it can be used as a key intermediate for the preparation of various drugs. The halogen atom on the benzene ring has different activities, and it can borrow nucleophilic substitution reactions to introduce multiple active groups to synthesize drug molecules with specific physiological activities. For example, it reacts with nitrogen-containing heterocyclic compounds under the action of appropriate bases and catalysts to generate nitrogen-containing heterocyclic-substituted benzene derivatives, which often have antibacterial, anti-inflammatory and other pharmacological activities.
Second, in the field of materials science, this compound can be used to prepare functional materials. After a specific reaction, it is connected to the polymer skeleton to give the material special properties. For example, by copolymerizing with ethylene monomers, polymers containing halobenzene structures can be prepared, which can improve the thermal stability and flame retardancy of materials.
In addition, it also has important applications in pesticide synthesis. Pesticide active ingredients containing 1-bromo-3-chloro-2-fluorobenzene structures can be constructed through multi-step reactions. Such ingredients have specific mechanisms of action on pests, or interfere with the nervous system of pests, or affect their growth and development, thereby exerting insecticidal and deworming effects.
In addition, in the field of dye synthesis, this is used as a starting material to synthesize characteristic dyes by introducing chromophore and chromophore. Due to the presence of benzene cyclohalogen atoms, the electron cloud distribution of dye molecules can be adjusted, affecting its color and dyeing properties.
In short, 1-bromo-3-chloro-2-fluorobenzene plays an important role in many fields of organic synthesis, and is an important cornerstone for the preparation of many functional compounds.
First, it can be used as a key intermediate for the preparation of various drugs. The halogen atom on the benzene ring has different activities, and it can borrow nucleophilic substitution reactions to introduce multiple active groups to synthesize drug molecules with specific physiological activities. For example, it reacts with nitrogen-containing heterocyclic compounds under the action of appropriate bases and catalysts to generate nitrogen-containing heterocyclic-substituted benzene derivatives, which often have antibacterial, anti-inflammatory and other pharmacological activities.
Second, in the field of materials science, this compound can be used to prepare functional materials. After a specific reaction, it is connected to the polymer skeleton to give the material special properties. For example, by copolymerizing with ethylene monomers, polymers containing halobenzene structures can be prepared, which can improve the thermal stability and flame retardancy of materials.
In addition, it also has important applications in pesticide synthesis. Pesticide active ingredients containing 1-bromo-3-chloro-2-fluorobenzene structures can be constructed through multi-step reactions. Such ingredients have specific mechanisms of action on pests, or interfere with the nervous system of pests, or affect their growth and development, thereby exerting insecticidal and deworming effects.
In addition, in the field of dye synthesis, this is used as a starting material to synthesize characteristic dyes by introducing chromophore and chromophore. Due to the presence of benzene cyclohalogen atoms, the electron cloud distribution of dye molecules can be adjusted, affecting its color and dyeing properties.
In short, 1-bromo-3-chloro-2-fluorobenzene plays an important role in many fields of organic synthesis, and is an important cornerstone for the preparation of many functional compounds.
What are the physical properties of 1 - bromo - 3 - chloro - 2 - fluorobenzene?
1 + -Bromo-3-chloro-2-fluorobenzene is an organic compound. Its physical properties are unique and may be used in various fields such as chemical industry and materials.
Looking at its properties, at room temperature, 1 + -bromo-3-chloro-2-fluorobenzene is a colorless to light yellow liquid. Due to the influence of halogen atoms in the molecular structure, the electron cloud distribution is specific, so this color state appears. It has a certain volatility, smell, and has a special smell. This smell originates from the specific structure composed of benzene ring and halogen atoms, and its smell can be used as one of the identification aids.
When it comes to density, the density of 1 + -bromo-3-chloro-2-fluorobenzene is greater than that of water due to the large relative atomic mass of the halogen atom. This property is crucial in operations such as mixture separation. For example, by separating the liquid, it can be separated from the water phase by the difference in density.
Furthermore, the boiling point is also an important physical property. Due to the presence of van der Waals forces between molecules, and the electronegativity of the halogen atom makes the molecule polar, resulting in increased intermolecular forces, the boiling point of 1 + -bromo-3-chloro-2-fluorobenzene is higher. This property is indispensable in distillation and purification processes, and can be accurately controlled according to its boiling point to achieve separation from other substances with different boiling points.
In terms of solubility, 1 + -bromo-3-chloro-2-fluorobenzene is a non-polar or weakly polar molecule, so it is easily soluble in organic solvents, such as ethanol, ether, etc., but difficult to dissolve in water. This follows the principle of "similarity and compatibility". The molecular structure of organic solvents is similar to that of 1 + -bromo-3-chloro-2-fluorobenzene, and the two are miscible with each other. This property is of great significance in the selection of solvents for organic synthesis reactions.
Looking at its properties, at room temperature, 1 + -bromo-3-chloro-2-fluorobenzene is a colorless to light yellow liquid. Due to the influence of halogen atoms in the molecular structure, the electron cloud distribution is specific, so this color state appears. It has a certain volatility, smell, and has a special smell. This smell originates from the specific structure composed of benzene ring and halogen atoms, and its smell can be used as one of the identification aids.
When it comes to density, the density of 1 + -bromo-3-chloro-2-fluorobenzene is greater than that of water due to the large relative atomic mass of the halogen atom. This property is crucial in operations such as mixture separation. For example, by separating the liquid, it can be separated from the water phase by the difference in density.
Furthermore, the boiling point is also an important physical property. Due to the presence of van der Waals forces between molecules, and the electronegativity of the halogen atom makes the molecule polar, resulting in increased intermolecular forces, the boiling point of 1 + -bromo-3-chloro-2-fluorobenzene is higher. This property is indispensable in distillation and purification processes, and can be accurately controlled according to its boiling point to achieve separation from other substances with different boiling points.
In terms of solubility, 1 + -bromo-3-chloro-2-fluorobenzene is a non-polar or weakly polar molecule, so it is easily soluble in organic solvents, such as ethanol, ether, etc., but difficult to dissolve in water. This follows the principle of "similarity and compatibility". The molecular structure of organic solvents is similar to that of 1 + -bromo-3-chloro-2-fluorobenzene, and the two are miscible with each other. This property is of great significance in the selection of solvents for organic synthesis reactions.
What are the storage conditions for 1 - bromo - 3 - chloro - 2 - fluorobenzene?
1 + -Bromo-3-chloro-2-fluorobenzene is also an organic compound. The key to its preservation is to avoid heat. Although this compound is still stable, it is easy to cause molecular activities to intensify when heated, or to decompose and polymerize, which will damage its quality. Therefore, it should be placed in a cool place, usually at a temperature not exceeding 25 ° C.
It is necessary to keep out moisture. Water is often the medium for many chemical reactions. 1 + -bromo-3-chloro-2-fluorobenzene encounters moisture, or due to the catalysis of water, hydrolysis and other reactions occur, causing the composition to change. Therefore, when stored in a dry place, it can be supplemented with a desiccant to absorb the surrounding moisture.
In addition, it is also necessary to avoid light. Light contains energy, which can stimulate the formation of active free radicals and initiate photochemical reactions. 1 + -Bromo-3-chloro-2-fluorobenzene under light, or cause the activity of bromine, chlorine, fluorine and other atoms to change, and cause reactions such as substitution and elimination. It should be stored in a brown bottle or a light-shielding material, and kept in the dark.
In addition, 1 + -bromo-3-chloro-2-fluorobenzene is a chemical, which has certain toxicity and corrosiveness. Keep the place away from fire and heat sources, and store it separately from oxidants, acids, bases, etc. Because it coexists with oxidants, or produces a violent oxidation reaction; encounters with acids and alkalis, or causes a chemical reaction, causing danger. When taking it, you must follow safety procedures and wear protective equipment, such as gloves, goggles, etc., to prevent it from coming into contact with the body, skin, eyes, etc., to avoid damage. In this way, the purity and stability of 1 + -bromo-3-chloro-2-fluorobenzene can be guaranteed for scientific research, industry, etc.
It is necessary to keep out moisture. Water is often the medium for many chemical reactions. 1 + -bromo-3-chloro-2-fluorobenzene encounters moisture, or due to the catalysis of water, hydrolysis and other reactions occur, causing the composition to change. Therefore, when stored in a dry place, it can be supplemented with a desiccant to absorb the surrounding moisture.
In addition, it is also necessary to avoid light. Light contains energy, which can stimulate the formation of active free radicals and initiate photochemical reactions. 1 + -Bromo-3-chloro-2-fluorobenzene under light, or cause the activity of bromine, chlorine, fluorine and other atoms to change, and cause reactions such as substitution and elimination. It should be stored in a brown bottle or a light-shielding material, and kept in the dark.
In addition, 1 + -bromo-3-chloro-2-fluorobenzene is a chemical, which has certain toxicity and corrosiveness. Keep the place away from fire and heat sources, and store it separately from oxidants, acids, bases, etc. Because it coexists with oxidants, or produces a violent oxidation reaction; encounters with acids and alkalis, or causes a chemical reaction, causing danger. When taking it, you must follow safety procedures and wear protective equipment, such as gloves, goggles, etc., to prevent it from coming into contact with the body, skin, eyes, etc., to avoid damage. In this way, the purity and stability of 1 + -bromo-3-chloro-2-fluorobenzene can be guaranteed for scientific research, industry, etc.
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