Linshang Chemical
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1-Bromo-3-Chloro-2-Iodo-5-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
444243 |
| Chemical Formula | C7H3BrClF3I |
| Molecular Weight | 399.35 |
| Appearance | Solid (predicted) |
| Boiling Point | 246.4 - 246.6 °C at 760 mmHg (predicted) |
| Melting Point | 36 - 38 °C |
| Density | 2.243 g/cm³ (predicted) |
| Vapor Pressure | 0.0174 mmHg at 25 °C (predicted) |
| Logp | 4.86 (predicted) |
| Solubility | Insoluble in water (predicted) |
| Flash Point | 102.8 °C (predicted) |
As an accredited 1-Bromo-3-Chloro-2-Iodo-5-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl)benzene in a sealed glass bottle. |
| Storage | 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant material, to prevent leakage and evaporation. Label clearly to avoid misidentification. |
| Shipping | 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl)benzene is a chemical. Ship it in proper, sealed containers, following hazardous chemical regulations. Ensure secure packaging to prevent leakage during transit. |
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What is the Chinese name for 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
1-Bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene, this is the name of an organic compound. According to the general method of naming organic compounds, with the benzene ring as the parent body, the substituents attached to the benzene ring are sorted according to specific rules and their positions are identified.
Prospective substituents, bromine (-Br), chlorine (-Cl), iodine (-I), trifluoromethyl (-CF). Determine the order of substituents according to the order of order. Usually, the atomic number is higher, the iodine atomic number is greater than bromine, and bromine is greater than chlorine. In trifluoromethyl, the carbon has three fluorine, and the overall order also has its position due to the large atomic number of fluorine. When
is numbered, it is numbered along the benzene ring starting from the preferred substituent (here it can start from the carbon linked by iodine), so that the sum of the substituent positions is minimized. In this way, the name of 1-bromo-3-chloro-2-iodine-5 - (trifluoromethyl) benzene is obtained, which accurately describes the structure of the compound and is of great significance in chemical research, communication, synthesis and other links. With this name, chemists can clarify the specific composition of the compound and the way of atomic connection.
Prospective substituents, bromine (-Br), chlorine (-Cl), iodine (-I), trifluoromethyl (-CF). Determine the order of substituents according to the order of order. Usually, the atomic number is higher, the iodine atomic number is greater than bromine, and bromine is greater than chlorine. In trifluoromethyl, the carbon has three fluorine, and the overall order also has its position due to the large atomic number of fluorine. When
is numbered, it is numbered along the benzene ring starting from the preferred substituent (here it can start from the carbon linked by iodine), so that the sum of the substituent positions is minimized. In this way, the name of 1-bromo-3-chloro-2-iodine-5 - (trifluoromethyl) benzene is obtained, which accurately describes the structure of the compound and is of great significance in chemical research, communication, synthesis and other links. With this name, chemists can clarify the specific composition of the compound and the way of atomic connection.
What are the physical properties of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
1 + -Bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are very important and are related to the application and characteristics of this compound.
First of all, under normal temperature and pressure, 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene is in a liquid state. Looking at its color, it is often colorless to light yellow, clear and fluid. The color of this state is stable in the general environment, but it is slightly different under extreme conditions such as strong light and hot topic, or due to changes in molecular structure.
Second, its boiling point, the boiling point of this compound is quite high, about a certain temperature range. The higher boiling point is due to the intermolecular force. The presence of halogen atoms such as bromine, chlorine, and iodine in the molecule, as well as trifluoromethyl groups, enhances the intermolecular van der Waals force. To make it boil, more energy is required to break free from the intermolecular bondage.
Melting point is also an important physical property. The melting point of 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene also has a specific value. The melting point is related to the regularity of the molecular arrangement. The spatial arrangement of each atom and group in its molecular structure affects the compactness of the molecule in the solid state, which in turn determines the melting point.
Furthermore, its density is greater than that of water. This is due to the large relative atomic weight of the halogen atom and trifluoromethyl in the molecule, which increases the mass of the substance per unit volume. In practical applications, if this compound is mixed with water, it will sink to the bottom of the water, which is very critical in separation, extraction and other operations.
In terms of solubility, 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene is an organic compound, which is easily soluble in organic solvents, such as common ether, dichloromethane, carbon tetrachloride, etc. Due to the principle of "similarity and miscibility", its molecular structure is similar to that of organic solvents, and the intermolecular forces are appropriate, so it can be miscible. However, its solubility in water is poor, because its molecular polarity is quite different from that of water, and the polarity of water is strong. The polarity of this compound is relatively weak, and the intermolecular forces between the two are difficult to reach the degree of mutual solubility.
In summary, the physical properties of 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene, such as phase state, color, boiling point, melting point, density and solubility, are determined by its molecular structure, and have far-reaching influence in many fields such as organic synthesis and chemical production.
First of all, under normal temperature and pressure, 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene is in a liquid state. Looking at its color, it is often colorless to light yellow, clear and fluid. The color of this state is stable in the general environment, but it is slightly different under extreme conditions such as strong light and hot topic, or due to changes in molecular structure.
Second, its boiling point, the boiling point of this compound is quite high, about a certain temperature range. The higher boiling point is due to the intermolecular force. The presence of halogen atoms such as bromine, chlorine, and iodine in the molecule, as well as trifluoromethyl groups, enhances the intermolecular van der Waals force. To make it boil, more energy is required to break free from the intermolecular bondage.
Melting point is also an important physical property. The melting point of 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene also has a specific value. The melting point is related to the regularity of the molecular arrangement. The spatial arrangement of each atom and group in its molecular structure affects the compactness of the molecule in the solid state, which in turn determines the melting point.
Furthermore, its density is greater than that of water. This is due to the large relative atomic weight of the halogen atom and trifluoromethyl in the molecule, which increases the mass of the substance per unit volume. In practical applications, if this compound is mixed with water, it will sink to the bottom of the water, which is very critical in separation, extraction and other operations.
In terms of solubility, 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene is an organic compound, which is easily soluble in organic solvents, such as common ether, dichloromethane, carbon tetrachloride, etc. Due to the principle of "similarity and miscibility", its molecular structure is similar to that of organic solvents, and the intermolecular forces are appropriate, so it can be miscible. However, its solubility in water is poor, because its molecular polarity is quite different from that of water, and the polarity of water is strong. The polarity of this compound is relatively weak, and the intermolecular forces between the two are difficult to reach the degree of mutual solubility.
In summary, the physical properties of 1 + -bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene, such as phase state, color, boiling point, melting point, density and solubility, are determined by its molecular structure, and have far-reaching influence in many fields such as organic synthesis and chemical production.
What are the main uses of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
1 + -Bromo-3-chloro-2-iodine-5- (trifluoromethyl) benzene has a wide range of uses. In the field of organic synthesis, it is often a key intermediate, which can be derived through various chemical reactions. Organic compounds with complex structures and specific functions.
For example, when building a new drug molecular structure, this is used as a starting material, and the substitution reaction of halogenated hydrocarbons can precisely access specific active groups, laying the foundation for the creation of new drugs with unique pharmacological activities. In the field of materials science, its special structure can be used to prepare functional materials with special optical, electrical or thermal properties through polymerization or modification, such as luminescent materials for organic optoelectronics, or polymer materials with special electrical conductivity.
In the fine chemical industry, 1 + -bromo-3-chloro-2-iodine-5 - (trifluoromethyl) benzene can be used to synthesize high-end dyes, flavors and additives. Due to its halogen atom and trifluoromethyl, the product is endowed with special chemical stability and physical properties, and the dye may have better light resistance and washable fastness, while the fragrance may have unique volatilization and fragrance characteristics. Additives can also bring excellent properties such as UV resistance and enhanced lubrication to the product.
For example, when building a new drug molecular structure, this is used as a starting material, and the substitution reaction of halogenated hydrocarbons can precisely access specific active groups, laying the foundation for the creation of new drugs with unique pharmacological activities. In the field of materials science, its special structure can be used to prepare functional materials with special optical, electrical or thermal properties through polymerization or modification, such as luminescent materials for organic optoelectronics, or polymer materials with special electrical conductivity.
In the fine chemical industry, 1 + -bromo-3-chloro-2-iodine-5 - (trifluoromethyl) benzene can be used to synthesize high-end dyes, flavors and additives. Due to its halogen atom and trifluoromethyl, the product is endowed with special chemical stability and physical properties, and the dye may have better light resistance and washable fastness, while the fragrance may have unique volatilization and fragrance characteristics. Additives can also bring excellent properties such as UV resistance and enhanced lubrication to the product.
What are the synthesis methods of 1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene?
There are many synthetic methods of 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene, and several common ones are described in detail today.
One is the halogenation reaction method. First, benzene derivatives containing trifluoromethyl are taken as the starting material, and bromine atoms can be introduced by electrophilic substitution reaction. For example, concentrated sulfuric acid and concentrated nitric acid are mixed to form a mixed acid to nitrate the benzene ring, and then reduced to aniline compounds. After that, bromine atoms can be introduced by diazotization reaction and interaction with cuprous bromide. After that, chlorine atoms and iodine atoms are introduced in sequence using different reaction conditions. When introducing a chlorine atom, it can react with chlorine in the presence of an appropriate catalyst such as ferric trichloride; when introducing an iodine atom, it can react with an iodine elemental substance and an appropriate reducing agent such as sodium sulfite under basic conditions.
The second is a metal-catalyzed coupling reaction method. Benzene derivatives containing trifluoromethyl with suitable leaving groups (such as borate esters, etc.) can be prepared first, and the halogenated aromatics containing bromine, chlorine and iodine can be coupled with the presence of metal catalysts (such as palladium catalysts) and ligands. For example, the common Suzuki coupling reaction, Stille coupling reaction, etc. Taking Suzuki coupling as an example, under the action of alkali, halogenated aromatics react with phenylborate esters, which can effectively construct carbon-carbon bonds and gradually synthesize the target products.
The third is halogen atomic exchange method. First, benzene derivatives containing trifluoromethyl with partial halogen atoms are synthesized, and then the original halogen atoms are replaced with suitable halides under specific conditions through halogen atom exchange reaction, so as to obtain 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene. This method requires precise control of reaction conditions, such as temperature, solvent, catalyst, etc., to ensure the selectivity and yield of the exchange reaction.
When synthesizing this compound, it is necessary to weigh and select the appropriate synthesis method according to factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the cost. Different methods have their own advantages and disadvantages. The raw materials of the halogenation reaction method are common, but the steps are slightly complicated; the metal catalytic coupling reaction method has good selectivity, but the catalyst cost is higher; the halogen atom exchange method has harsh conditions, but it can achieve precise replacement of specific halogen atoms.
One is the halogenation reaction method. First, benzene derivatives containing trifluoromethyl are taken as the starting material, and bromine atoms can be introduced by electrophilic substitution reaction. For example, concentrated sulfuric acid and concentrated nitric acid are mixed to form a mixed acid to nitrate the benzene ring, and then reduced to aniline compounds. After that, bromine atoms can be introduced by diazotization reaction and interaction with cuprous bromide. After that, chlorine atoms and iodine atoms are introduced in sequence using different reaction conditions. When introducing a chlorine atom, it can react with chlorine in the presence of an appropriate catalyst such as ferric trichloride; when introducing an iodine atom, it can react with an iodine elemental substance and an appropriate reducing agent such as sodium sulfite under basic conditions.
The second is a metal-catalyzed coupling reaction method. Benzene derivatives containing trifluoromethyl with suitable leaving groups (such as borate esters, etc.) can be prepared first, and the halogenated aromatics containing bromine, chlorine and iodine can be coupled with the presence of metal catalysts (such as palladium catalysts) and ligands. For example, the common Suzuki coupling reaction, Stille coupling reaction, etc. Taking Suzuki coupling as an example, under the action of alkali, halogenated aromatics react with phenylborate esters, which can effectively construct carbon-carbon bonds and gradually synthesize the target products.
The third is halogen atomic exchange method. First, benzene derivatives containing trifluoromethyl with partial halogen atoms are synthesized, and then the original halogen atoms are replaced with suitable halides under specific conditions through halogen atom exchange reaction, so as to obtain 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene. This method requires precise control of reaction conditions, such as temperature, solvent, catalyst, etc., to ensure the selectivity and yield of the exchange reaction.
When synthesizing this compound, it is necessary to weigh and select the appropriate synthesis method according to factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the cost. Different methods have their own advantages and disadvantages. The raw materials of the halogenation reaction method are common, but the steps are slightly complicated; the metal catalytic coupling reaction method has good selectivity, but the catalyst cost is higher; the halogen atom exchange method has harsh conditions, but it can achieve precise replacement of specific halogen atoms.
1 - bromo - 3 - chloro - 2 - iodo - 5 - (trifluoromethyl) benzene, what are the precautions during storage and transportation?
1 + -Bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene is an organic compound. During storage and transportation, many matters need to be taken into account.
First words Storage, because of its certain chemical activity, should be stored in a cool, dry and well-ventilated place. If it is in a high temperature and humid environment, it may cause chemical reactions and cause quality damage. This compound is more sensitive to heat, the temperature is too high, or it may cause decomposition, polymerization and other reactions, so the warehouse temperature should be controlled within an appropriate range, generally not exceeding 30 ° C. And because it may be corrosive and toxic, it must be stored separately with oxidants, acids, bases and other substances to prevent interaction and risk of danger. And the storage place should be clearly marked to clearly indicate its characteristics and hazards, so that all contacts can be alert.
As for transportation, extreme caution is also required. Suitable packaging materials should be selected to ensure their sealing and impact resistance to prevent leakage during transportation. Transportation vehicles need to have perfect protective measures, such as fire protection, explosion protection and other equipment. And transport personnel should be professionally trained and familiar with the characteristics of this compound and emergency treatment methods. The planning of transportation routes should also avoid densely populated areas and water source protection areas to prevent accidental leakage, which will cause significant harm to the public and the environment. Check the integrity of the packaging regularly during the journey, and take immediate measures if there is any abnormality. In this way, the safety of 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene during storage and transportation is guaranteed.
First words Storage, because of its certain chemical activity, should be stored in a cool, dry and well-ventilated place. If it is in a high temperature and humid environment, it may cause chemical reactions and cause quality damage. This compound is more sensitive to heat, the temperature is too high, or it may cause decomposition, polymerization and other reactions, so the warehouse temperature should be controlled within an appropriate range, generally not exceeding 30 ° C. And because it may be corrosive and toxic, it must be stored separately with oxidants, acids, bases and other substances to prevent interaction and risk of danger. And the storage place should be clearly marked to clearly indicate its characteristics and hazards, so that all contacts can be alert.
As for transportation, extreme caution is also required. Suitable packaging materials should be selected to ensure their sealing and impact resistance to prevent leakage during transportation. Transportation vehicles need to have perfect protective measures, such as fire protection, explosion protection and other equipment. And transport personnel should be professionally trained and familiar with the characteristics of this compound and emergency treatment methods. The planning of transportation routes should also avoid densely populated areas and water source protection areas to prevent accidental leakage, which will cause significant harm to the public and the environment. Check the integrity of the packaging regularly during the journey, and take immediate measures if there is any abnormality. In this way, the safety of 1 + -bromo-3 + -chloro-2 + -iodine-5 + - (trifluoromethyl) benzene during storage and transportation is guaranteed.
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