Linshang Chemical
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1-Bromo-3-Chloro-2-Iodobenzene
Linshang Chemical
|
HS Code |
210013 |
| Name | 1-Bromo-3-Chloro-2-Iodobenzene |
| Molecular Formula | C6H3BrClI |
| Molar Mass | 328.35 g/mol |
| Appearance | Off - white to light yellow solid |
| Melting Point | 26 - 28 °C |
| Boiling Point | 265 - 267 °C |
| Density | 2.34 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | 114.3 °C |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Bromo-3-Chloro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 3 - chloro - 2 - iodobenzene in a sealed glass bottle. |
| Storage | 1 - Bromo - 3 - chloro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents and reactive substances. Label the container clearly to avoid misidentification. Follow proper safety regulations for handling and storing such halogen - substituted aromatic compounds. |
| Shipping | 1 - bromo - 3 - chloro - 2 - iodobenzene is a hazardous chemical. It should be shipped in accordance with strict regulations. Use appropriate, leak - proof containers, label clearly, and ensure compliance with shipping guidelines for hazardous substances. |
Competitive 1-Bromo-3-Chloro-2-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Bromo-3-Chloro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 1 - bromo - 3 - chloro - 2 - iodobenzene?
The chemical structure of 1-bromo-3-chloro-2-iodobenzene is quite interesting. The benzene ring is a stable six-membered cyclic structure composed of six carbon atoms connected to each other by conjugated double bonds, which is aromatic. In the structure of 1-bromo-3-chloro-2-iodobenzene, different halogen atoms are connected at specific positions above the benzene ring.
Among them, the bromine atom is connected to the No. 1 position of the benzene ring, the chlorine atom is in the No. 3 position, and the iodine atom is in the No. 2 position. These halogen atom substituents have different effects on the electron cloud density distribution of the benzene ring due to their own electronegativity. Bromine, chlorine, and iodine are all elements with strong electronegativity, which will absorb electrons, resulting in a decrease in the density of benzene ring electron clouds. However, due to the different atomic radii and electronegativity degrees, the effects of the three on the benzene ring electron cloud are also different.
Iodine has a larger atomic radius, although its electronegativity is weaker than that of bromine and chlorine, but its inductive effect and conjugation effect have a unique effect on the density of benzene ring electron clouds. Bromine and chlorine have relatively small atomic radii, stronger electronegativity, and more significant attraction to benzene ring electron clouds. This structural feature makes 1-bromo-3-chloro-2-iodobenzene exhibit unique chemical activity and selectivity in chemical reactions, and has specific applications in organic synthesis and other fields.
Among them, the bromine atom is connected to the No. 1 position of the benzene ring, the chlorine atom is in the No. 3 position, and the iodine atom is in the No. 2 position. These halogen atom substituents have different effects on the electron cloud density distribution of the benzene ring due to their own electronegativity. Bromine, chlorine, and iodine are all elements with strong electronegativity, which will absorb electrons, resulting in a decrease in the density of benzene ring electron clouds. However, due to the different atomic radii and electronegativity degrees, the effects of the three on the benzene ring electron cloud are also different.
Iodine has a larger atomic radius, although its electronegativity is weaker than that of bromine and chlorine, but its inductive effect and conjugation effect have a unique effect on the density of benzene ring electron clouds. Bromine and chlorine have relatively small atomic radii, stronger electronegativity, and more significant attraction to benzene ring electron clouds. This structural feature makes 1-bromo-3-chloro-2-iodobenzene exhibit unique chemical activity and selectivity in chemical reactions, and has specific applications in organic synthesis and other fields.
What are the physical properties of 1 - bromo - 3 - chloro - 2 - iodobenzene?
1 + -Bromo-3 + -chloro-2 + -iodobenzene is one of the organohalogenated aromatic hydrocarbons with special physical properties. This compound is mostly in liquid or solid state under normal conditions. Due to the existence of van der Waals forces between molecules, the melting boiling point is affected by the molecular weight and structure. When the molecular weight increases, the van der Waals force increases, and the melting boiling point also increases; in the molecular structure, if it has a symmetrical structure, the intermolecules are closely arranged, and the van der Waals force increases, the melting boiling point is also high. 1 + -bromo-3 + -chloro-2 + -iodobenzene has a higher density than water. Due to the presence of halogen atoms with large relative atomic mass such as bromine, chlorine, and iodine, the molecular
In terms of solubility, 1 + -bromo-3 + -chloro-2 + -iodobenzene is a non-polar or weakly polar molecule. According to the principle of "similar phase solubility", it is easily soluble in non-polar or weakly polar organic solvents, such as benzene, toluene, carbon tetrachloride, etc., and is difficult to dissolve in water with strong polarity. In organic solvents, similar intermolecular forces can be formed between molecules and solvent molecules, which is conducive to dissolution.
1 + -bromo-3 + -chloro-2 + -iodobenzene is volatile. Due to the non-extreme intermolecular forces, some molecules can obtain enough energy to overcome the intermolecular forces and enter the gas phase. Its volatility is affected by factors such as temperature and surface area, and the temperature increases, the surface area increases, and the volatility increases.
In addition, the compound has a special odor, halogenated aromatics often have a unique odor, 1 + -bromo-3 + -chloro-2 + -iodobenzene odor or due to the presence of bromine, chlorine, iodine atoms and benzene ring structure. This odor may be used as one of the characteristics to identify the compound, but due to its possible toxicity and irritation, caution should be used when smelling.
In terms of solubility, 1 + -bromo-3 + -chloro-2 + -iodobenzene is a non-polar or weakly polar molecule. According to the principle of "similar phase solubility", it is easily soluble in non-polar or weakly polar organic solvents, such as benzene, toluene, carbon tetrachloride, etc., and is difficult to dissolve in water with strong polarity. In organic solvents, similar intermolecular forces can be formed between molecules and solvent molecules, which is conducive to dissolution.
1 + -bromo-3 + -chloro-2 + -iodobenzene is volatile. Due to the non-extreme intermolecular forces, some molecules can obtain enough energy to overcome the intermolecular forces and enter the gas phase. Its volatility is affected by factors such as temperature and surface area, and the temperature increases, the surface area increases, and the volatility increases.
In addition, the compound has a special odor, halogenated aromatics often have a unique odor, 1 + -bromo-3 + -chloro-2 + -iodobenzene odor or due to the presence of bromine, chlorine, iodine atoms and benzene ring structure. This odor may be used as one of the characteristics to identify the compound, but due to its possible toxicity and irritation, caution should be used when smelling.
What is the common synthesis of 1 - bromo - 3 - chloro - 2 - iodobenzene?
There are several common synthesis methods for 1 + -bromo-3-chloro-2-iodobenzene. First, bromine, chlorine and iodine atoms can be gradually introduced from benzene through halogenation reaction. First, benzene and bromine under the action of appropriate catalysts, such as iron or iron tribromide, undergo an electrophilic substitution reaction to generate bromobenzene. Bromobenzene reacts with chlorine under specific conditions to introduce chlorine atoms into the benzene ring to obtain compounds containing bromine and chlorine. Then, using suitable reagents, such as iodide, under appropriate reaction conditions, iodine atoms are introduced into the benzene ring, and finally 1 + -bromo-3-chloro-2-iodobenzene is obtained.
Second, it can also start from benzene derivatives containing appropriate substituents. If some positioning groups already exist on the benzene ring, their positioning effect can be used to guide the halogen atoms into the desired position. For example, there is an ortho-para-position group on the benzene ring, which can be reacted with halogenated reagents first, so that the halogen atoms preferentially enter the ortho or para-position indicated by the positioning group, and then introduce the remaining halogen atoms through subsequent reactions to obtain the target product through multi-step conversion.
Furthermore, a coupling reaction catalyzed by transition metals can be used. The coupling reaction occurs under the action of transition metal catalysts such as palladium catalysts by using aryl halides and metal reagents such as organozinc and organoboron. First, aryl halides containing different halogen atoms were prepared, and each halogen atom was precisely connected to the benzene ring through suitable reaction sequence and conditions, so as to synthesize 1 + -bromo-3-chloro-2-iodobenzene. This method has relatively mild conditions and good selectivity, and is quite commonly used in complex organic synthesis.
Second, it can also start from benzene derivatives containing appropriate substituents. If some positioning groups already exist on the benzene ring, their positioning effect can be used to guide the halogen atoms into the desired position. For example, there is an ortho-para-position group on the benzene ring, which can be reacted with halogenated reagents first, so that the halogen atoms preferentially enter the ortho or para-position indicated by the positioning group, and then introduce the remaining halogen atoms through subsequent reactions to obtain the target product through multi-step conversion.
Furthermore, a coupling reaction catalyzed by transition metals can be used. The coupling reaction occurs under the action of transition metal catalysts such as palladium catalysts by using aryl halides and metal reagents such as organozinc and organoboron. First, aryl halides containing different halogen atoms were prepared, and each halogen atom was precisely connected to the benzene ring through suitable reaction sequence and conditions, so as to synthesize 1 + -bromo-3-chloro-2-iodobenzene. This method has relatively mild conditions and good selectivity, and is quite commonly used in complex organic synthesis.
What are the applications of 1 - bromo - 3 - chloro - 2 - iodobenzene in organic synthesis?
1 + -Bromo-3-chloro-2-iodobenzene is widely used in organic synthesis. It can be used as a key intermediate and participates in many organic reactions.
First, in the nucleophilic substitution reaction, the halogen atoms in the compound have different activities, and the bromine, chlorine and iodine atoms can be replaced by nucleophilic reagents. With this characteristic, various functional groups, such as hydroxyl, amino, alkyl, etc., can be introduced to construct organic molecules with diverse structures. For example, with sodium alcohol as the nucleophilic reagent, the halogen atoms can be replaced by alkoxy groups to form corresponding aromatic ether compounds, which is an important path for the synthesis of ethers with specific structures.
Second, in metal-catalyzed coupling reactions, 1 + -bromo-3-chloro-2-iodobenzene plays a key role. For example, palladium-catalyzed Suzuki coupling reaction can be coupled with aryl boronic acid to form carbon-carbon bonds and effectively construct biphenyl compounds. This reaction is widely used in drug synthesis and materials science, and can be used to prepare biologically active drug molecules or materials with special photoelectric properties.
Third, in the construction of complex cyclic compounds, 1 + -bromo-3-chloro-2-iodobenzene can be used as a starting material to achieve cyclization through a multi-step reaction. For example, through nucleophilic substitution or cyclization coupling reactions in molecules, a cyclic structure containing benzene rings can be constructed, providing an effective strategy for the synthesis of compounds with specific spatial structures, which is of great significance in the total synthesis of natural products and the development of new functional materials.
In addition, because it contains multiple halogen atoms, one of the halogen atoms can be selectively activated according to the difference in reaction conditions to achieve regioselectivity, which is extremely critical in the precise synthesis of complex organic molecules, which helps to improve the reaction efficiency and product purity. In conclusion, 1 + -bromo-3-chloro-2-iodobenzene occupies an important position in the field of organic synthesis due to its unique structure, providing a diverse and effective way for the synthesis of many organic compounds.
First, in the nucleophilic substitution reaction, the halogen atoms in the compound have different activities, and the bromine, chlorine and iodine atoms can be replaced by nucleophilic reagents. With this characteristic, various functional groups, such as hydroxyl, amino, alkyl, etc., can be introduced to construct organic molecules with diverse structures. For example, with sodium alcohol as the nucleophilic reagent, the halogen atoms can be replaced by alkoxy groups to form corresponding aromatic ether compounds, which is an important path for the synthesis of ethers with specific structures.
Second, in metal-catalyzed coupling reactions, 1 + -bromo-3-chloro-2-iodobenzene plays a key role. For example, palladium-catalyzed Suzuki coupling reaction can be coupled with aryl boronic acid to form carbon-carbon bonds and effectively construct biphenyl compounds. This reaction is widely used in drug synthesis and materials science, and can be used to prepare biologically active drug molecules or materials with special photoelectric properties.
Third, in the construction of complex cyclic compounds, 1 + -bromo-3-chloro-2-iodobenzene can be used as a starting material to achieve cyclization through a multi-step reaction. For example, through nucleophilic substitution or cyclization coupling reactions in molecules, a cyclic structure containing benzene rings can be constructed, providing an effective strategy for the synthesis of compounds with specific spatial structures, which is of great significance in the total synthesis of natural products and the development of new functional materials.
In addition, because it contains multiple halogen atoms, one of the halogen atoms can be selectively activated according to the difference in reaction conditions to achieve regioselectivity, which is extremely critical in the precise synthesis of complex organic molecules, which helps to improve the reaction efficiency and product purity. In conclusion, 1 + -bromo-3-chloro-2-iodobenzene occupies an important position in the field of organic synthesis due to its unique structure, providing a diverse and effective way for the synthesis of many organic compounds.
What are the safety and precautions for 1 - bromo - 3 - chloro - 2 - iodobenzene?
1 + -Bromo-3-chloro-2-iodobenzene is an organic compound, which is widely used in chemical, pharmaceutical and other fields. However, it has certain safety risks, and many matters must be paid attention to when using it.
When it comes to safety, this compound is flammable and dangerous to burn in case of open flames and hot topics. And it is irritating to the skin, eyes and respiratory props. If inadvertently exposed, it may cause discomfort or even damage. At the same time, it may be toxic. Inhalation, ingestion or skin absorption may endanger health, and long-term exposure may have chronic health effects such as sensitization.
When using 1 + -bromo-3-chloro-2-iodobenzene, many precautions must be kept in mind. Operators must wear appropriate protective equipment, such as protective clothing, gloves and protective glasses, to prevent skin and eye contact. The operation should be carried out in a well-ventilated place, or with the help of ventilation equipment, the volatile gas should be discharged in time to reduce the concentration in the air. During the use process, the action should be gentle to avoid spillage. If there is any spillage, it should be properly cleaned immediately in accordance with relevant procedures. Storage should not be ignored. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and stored separately from oxidants and food chemicals. Do not mix storage.
In conclusion, when using 1 + -bromo-3-chloro-2-iodobenzene, it is necessary to attach great importance to its safety, and operate and store it strictly according to regulations, so as to effectively prevent accidents and ensure that personnel safety and the environment are not endangered.
When it comes to safety, this compound is flammable and dangerous to burn in case of open flames and hot topics. And it is irritating to the skin, eyes and respiratory props. If inadvertently exposed, it may cause discomfort or even damage. At the same time, it may be toxic. Inhalation, ingestion or skin absorption may endanger health, and long-term exposure may have chronic health effects such as sensitization.
When using 1 + -bromo-3-chloro-2-iodobenzene, many precautions must be kept in mind. Operators must wear appropriate protective equipment, such as protective clothing, gloves and protective glasses, to prevent skin and eye contact. The operation should be carried out in a well-ventilated place, or with the help of ventilation equipment, the volatile gas should be discharged in time to reduce the concentration in the air. During the use process, the action should be gentle to avoid spillage. If there is any spillage, it should be properly cleaned immediately in accordance with relevant procedures. Storage should not be ignored. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and stored separately from oxidants and food chemicals. Do not mix storage.
In conclusion, when using 1 + -bromo-3-chloro-2-iodobenzene, it is necessary to attach great importance to its safety, and operate and store it strictly according to regulations, so as to effectively prevent accidents and ensure that personnel safety and the environment are not endangered.
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