Linshang Chemical
PRODUCTS
1-Bromo-3-Chloro-2-Methoxybenzene
Linshang Chemical
|
HS Code |
876824 |
| Name | 1-Bromo-3-Chloro-2-Methoxybenzene |
| Molecular Formula | C7H6BrClO |
| Molar Mass | 221.48 g/mol |
| Appearance | Liquid (expected, typical for many such aromatic halides with alkoxy group) |
| Boiling Point | Approx. 230 - 240 °C (estimated based on similar aromatic compounds) |
| Density | Around 1.5 - 1.7 g/cm³ (estimated) |
| Solubility In Water | Insoluble (aromatic halide with alkoxy group, non - polar nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, chloroform |
| Flash Point | Estimated around 90 - 110 °C (flammability related property estimate for such organic compound) |
As an accredited 1-Bromo-3-Chloro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - bromo - 3 - chloro - 2 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 1 - bromo - 3 - chloro - 2 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources, open flames, and oxidizing agents. Keep it in a tightly sealed container to prevent evaporation and potential leakage. Store it separately from incompatible substances like strong acids and bases to avoid chemical reactions. Use proper labeling for easy identification. |
| Shipping | 1 - bromo - 3 - chloro - 2 - methoxybenzene is shipped in sealed, corrosion - resistant containers. It's transported via approved chemical - shipping methods, following safety regulations to prevent leakage and ensure safe transit. |
Competitive 1-Bromo-3-Chloro-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Bromo-3-Chloro-2-Methoxybenzene in China?
As a trusted 1-Bromo-3-Chloro-2-Methoxybenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-3-Chloro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1 - bromo - 3 - chloro - 2 - methoxybenzene
1-Bromo-3-chloro-2-methoxybenzene is widely used in various fields of chemical industry.
One of them is a key intermediary in the field of organic synthesis. Organic synthesis aims to build complex organic molecules, and 1-bromo-3-chloro-2-methoxybenzene can participate in a variety of chemical reactions due to its specific chemical structure. For example, nucleophilic substitution reactions, whose bromine atoms and chlorine atoms are highly active, can be replaced by many nucleophiles, introducing different functional groups, and then deriving more complex organic compounds, laying the foundation for the creation of new drugs, pesticides and materials.
Second, it is of great significance in the field of medicinal chemistry. Drug development requires the precise design and synthesis of molecules with specific biological activities. The structure of 1-bromo-3-chloro-2-methoxybenzene can be modified and modified to meet the needs of specific drug targets. By introducing different groups on its benzene ring, or adjusting functional groups such as methoxy, bromine, and chlorine, the physicochemical properties and biological activities of molecules can be adjusted, helping to develop innovative drugs with better curative effects and fewer side effects.
Third, it is also applied in the field of materials science. With the rapid development of materials science, the demand for materials with special properties is increasing day by day. 1-Bromo-3-chloro-2-methoxybenzene can be used as a raw material for the synthesis of materials with special optical, electrical or thermal properties. For example, through specific polymerization reactions or organometallic chemical reactions, it is integrated into polymer materials or metal-organic framework materials, giving the material unique functions to meet the specific needs of electronic devices, optical sensors and other fields.
One of them is a key intermediary in the field of organic synthesis. Organic synthesis aims to build complex organic molecules, and 1-bromo-3-chloro-2-methoxybenzene can participate in a variety of chemical reactions due to its specific chemical structure. For example, nucleophilic substitution reactions, whose bromine atoms and chlorine atoms are highly active, can be replaced by many nucleophiles, introducing different functional groups, and then deriving more complex organic compounds, laying the foundation for the creation of new drugs, pesticides and materials.
Second, it is of great significance in the field of medicinal chemistry. Drug development requires the precise design and synthesis of molecules with specific biological activities. The structure of 1-bromo-3-chloro-2-methoxybenzene can be modified and modified to meet the needs of specific drug targets. By introducing different groups on its benzene ring, or adjusting functional groups such as methoxy, bromine, and chlorine, the physicochemical properties and biological activities of molecules can be adjusted, helping to develop innovative drugs with better curative effects and fewer side effects.
Third, it is also applied in the field of materials science. With the rapid development of materials science, the demand for materials with special properties is increasing day by day. 1-Bromo-3-chloro-2-methoxybenzene can be used as a raw material for the synthesis of materials with special optical, electrical or thermal properties. For example, through specific polymerization reactions or organometallic chemical reactions, it is integrated into polymer materials or metal-organic framework materials, giving the material unique functions to meet the specific needs of electronic devices, optical sensors and other fields.
What are the physical properties of 1 - bromo - 3 - chloro - 2 - methoxybenzene
1 + -Bromo-3 + -chloro-2 + -methoxybenzene, this is an organic compound. Its physical properties are very interesting, let me elaborate.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, clear and with a certain fluidity. The smell of this compound is quite unique, with a slightly irritating aromatic smell. Although it is not rich and pungent, it can still be perceived by people.
The melting point is about -30 ° C, and the lower melting point makes it a liquid at room temperature. The boiling point is in the range of 220-230 ° C, and the relatively high boiling point indicates that the intermolecular force is strong. This boiling point characteristic can be separated by distillation according to the difference between its boiling point and other substances during the separation and purification process.
Furthermore, the density of 1 + -bromo-3 + -chloro-2 + -methoxybenzene is slightly higher than that of water, about 1.5 g/cm ³. When mixed with water, it can be seen that it sinks to the bottom of water, which is quite useful in liquid-liquid separation operations.
In terms of solubility, the compound is insoluble in water because its molecular structure contains a large proportion of hydrophobic groups. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. In addition, 1 + -bromo-3 + -chloro-2 + -methoxybenzene contains halogen atoms such as bromine and chlorine and methoxy groups, and its molecular polarity is reflected to a certain extent. Under the action of an electric field, it will have a specific orientation. This polarity characteristic affects its physical properties and chemical reactivity.
All these physical properties have important reference value in the fields of organic synthesis, drug development and chemical production, and can provide a key basis for related operations and research.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, clear and with a certain fluidity. The smell of this compound is quite unique, with a slightly irritating aromatic smell. Although it is not rich and pungent, it can still be perceived by people.
The melting point is about -30 ° C, and the lower melting point makes it a liquid at room temperature. The boiling point is in the range of 220-230 ° C, and the relatively high boiling point indicates that the intermolecular force is strong. This boiling point characteristic can be separated by distillation according to the difference between its boiling point and other substances during the separation and purification process.
Furthermore, the density of 1 + -bromo-3 + -chloro-2 + -methoxybenzene is slightly higher than that of water, about 1.5 g/cm ³. When mixed with water, it can be seen that it sinks to the bottom of water, which is quite useful in liquid-liquid separation operations.
In terms of solubility, the compound is insoluble in water because its molecular structure contains a large proportion of hydrophobic groups. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. In addition, 1 + -bromo-3 + -chloro-2 + -methoxybenzene contains halogen atoms such as bromine and chlorine and methoxy groups, and its molecular polarity is reflected to a certain extent. Under the action of an electric field, it will have a specific orientation. This polarity characteristic affects its physical properties and chemical reactivity.
All these physical properties have important reference value in the fields of organic synthesis, drug development and chemical production, and can provide a key basis for related operations and research.
What are the chemical properties of 1 - bromo - 3 - chloro - 2 - methoxybenzene
The chemical properties of 1 + -bromo-3 + -chloro-2 + -methoxylbenzene are particularly important. In this compound, bromine, chlorine, and methoxy groups each have their own properties and interact with each other, resulting in their unique properties.
First, bromine groups, whose halogen properties make molecular nucleophilic substitution easy. In case of nucleophiles, bromine atoms are often leaving groups, which are replaced by nucleophiles. This is because bromine atoms have high electronegativity and carbon-bromine bonds are easily broken. Nucleophilic reagents such as alkoxides and amines can react with systems containing this compound to form new carbon-heteroatom bonds.
Chloro and halogen elements, although their electronegativity is slightly different from that of bromine, also change the electron cloud density of the benzene ring. In the electrophilic substitution reaction, the localization effects of chlorine and bromine digroups coexist. Both are ortho and para-localization groups, which make the electrophilic reagents tend to attack the ortho and para-localization of the benzene ring. However, due to the combination of steric resistance and electronic effects, the substitution check point is not absolute.
As for the methoxy group, it has the effect of electron conjugation, which can increase the electron cloud density of the benzene ring, especially the ortho and para-localization. This not only affects the activity and check point of the electrophilic substitution reaction, but also interacts with the electron-absorbing induction effects of bromine In some reactions, the action of methoxy groups can promote the attack of nucleophiles on the benzene ring, and can also affect the charge distribution and reactivity of the molecule as a whole.
In addition, the physical properties of 1 + -bromo-3 + -chloro-2 + -methoxybenzene, such as melting point, boiling point, solubility, etc., are also related to the structure. Because of its halogen atom and methoxy group, it has good solubility in organic solvents, while the melting point and boiling point are affected by intermolecular forces, such as van der Waals force, dipole-dipole interaction, etc. In short, the chemical properties of this compound are complex, and it has potential applications in organic synthesis, medicinal chemistry and other fields, which need to be further explored.
First, bromine groups, whose halogen properties make molecular nucleophilic substitution easy. In case of nucleophiles, bromine atoms are often leaving groups, which are replaced by nucleophiles. This is because bromine atoms have high electronegativity and carbon-bromine bonds are easily broken. Nucleophilic reagents such as alkoxides and amines can react with systems containing this compound to form new carbon-heteroatom bonds.
Chloro and halogen elements, although their electronegativity is slightly different from that of bromine, also change the electron cloud density of the benzene ring. In the electrophilic substitution reaction, the localization effects of chlorine and bromine digroups coexist. Both are ortho and para-localization groups, which make the electrophilic reagents tend to attack the ortho and para-localization of the benzene ring. However, due to the combination of steric resistance and electronic effects, the substitution check point is not absolute.
As for the methoxy group, it has the effect of electron conjugation, which can increase the electron cloud density of the benzene ring, especially the ortho and para-localization. This not only affects the activity and check point of the electrophilic substitution reaction, but also interacts with the electron-absorbing induction effects of bromine In some reactions, the action of methoxy groups can promote the attack of nucleophiles on the benzene ring, and can also affect the charge distribution and reactivity of the molecule as a whole.
In addition, the physical properties of 1 + -bromo-3 + -chloro-2 + -methoxybenzene, such as melting point, boiling point, solubility, etc., are also related to the structure. Because of its halogen atom and methoxy group, it has good solubility in organic solvents, while the melting point and boiling point are affected by intermolecular forces, such as van der Waals force, dipole-dipole interaction, etc. In short, the chemical properties of this compound are complex, and it has potential applications in organic synthesis, medicinal chemistry and other fields, which need to be further explored.
What are the synthesis methods of 1 - bromo - 3 - chloro - 2 - methoxybenzene
The synthesis method of 1 + -bromo-3 + -chloro-2 + -methoxybenzene, allow me to come to you.
First, it can be started from phenols. First, take the corresponding phenol and make it react with halomethane under basic conditions to form methoxylation products. Commonly used bases, such as potassium carbonate, are heated and stirred in suitable organic solvents, such as acetone, etc., to obtain methoxybenzene derivatives by nucleophilic substitution of the hydroxyl group of phenol and halomethane.
Then, this derivative is halogenated. If bromine and chlorine atoms are to be introduced, they can be carried out in steps. First, bromine atoms can be introduced at suitable positions in the benzene ring by using a brominating reagent, such as N-bromosuccinimide (NBS), in the presence of an initiator such as benzoyl peroxide, in a suitable solvent such as carbon tetrachloride under light or heating. Then, chlorination reagents, such as chlorine gas or thionyl chloride, react in solvents such as dichloromethane under the catalysis of Lewis acids such as aluminum trichloride, and chlorine atoms can be introduced. By controlling the reaction conditions and the amount of reagents, it is expected that bromine and chlorine atoms can be replaced at the target position.
Second, halobenzene can also be started from halobenzene. First, halobenzene containing chlorine is prepared, and the chlorine atom is used as the positioning group, and the methoxylation reaction Then, the bromination reaction is carried out, and the bromine atom is replaced at a specific position by controlling the conditions to achieve the purpose of synthesizing 1 + -bromo-3 + -chloro-2 + -methoxybenzene.
When synthesizing, it is necessary to pay attention to the precise control of the reaction conditions, such as temperature, reaction time, reagent ratio, etc., which are all related to the purity and yield of the product. After each step of the reaction, the product should be purified by appropriate separation and purification methods, such as column chromatography, recrystallization, etc., to provide pure raw materials for the next reaction, and finally obtain the target product 1 + -bromo-3 + -chloro-2 + -methoxybenzene.
First, it can be started from phenols. First, take the corresponding phenol and make it react with halomethane under basic conditions to form methoxylation products. Commonly used bases, such as potassium carbonate, are heated and stirred in suitable organic solvents, such as acetone, etc., to obtain methoxybenzene derivatives by nucleophilic substitution of the hydroxyl group of phenol and halomethane.
Then, this derivative is halogenated. If bromine and chlorine atoms are to be introduced, they can be carried out in steps. First, bromine atoms can be introduced at suitable positions in the benzene ring by using a brominating reagent, such as N-bromosuccinimide (NBS), in the presence of an initiator such as benzoyl peroxide, in a suitable solvent such as carbon tetrachloride under light or heating. Then, chlorination reagents, such as chlorine gas or thionyl chloride, react in solvents such as dichloromethane under the catalysis of Lewis acids such as aluminum trichloride, and chlorine atoms can be introduced. By controlling the reaction conditions and the amount of reagents, it is expected that bromine and chlorine atoms can be replaced at the target position.
Second, halobenzene can also be started from halobenzene. First, halobenzene containing chlorine is prepared, and the chlorine atom is used as the positioning group, and the methoxylation reaction Then, the bromination reaction is carried out, and the bromine atom is replaced at a specific position by controlling the conditions to achieve the purpose of synthesizing 1 + -bromo-3 + -chloro-2 + -methoxybenzene.
When synthesizing, it is necessary to pay attention to the precise control of the reaction conditions, such as temperature, reaction time, reagent ratio, etc., which are all related to the purity and yield of the product. After each step of the reaction, the product should be purified by appropriate separation and purification methods, such as column chromatography, recrystallization, etc., to provide pure raw materials for the next reaction, and finally obtain the target product 1 + -bromo-3 + -chloro-2 + -methoxybenzene.
Precautions for 1 - bromo - 3 - chloro - 2 - methoxybenzene during storage and transportation
1 + -Bromo-3 + -chloro-2 + -methoxybenzene is an organic compound. When storing and transporting, many things need to be paid attention to.
The first thing to pay attention to is its chemical properties. This compound contains bromine, chlorine and other halogen atoms and methoxy groups, which are active in nature. When storing, be sure to keep away from fire and heat sources, because it may cause combustion or even explosion in case of open flame, hot topic. The warehouse must be cool and well ventilated, and the temperature and humidity should be properly controlled. If the temperature is too high, it may cause the compound to evaporate faster, increasing the risk of leakage; if the humidity is too high, it may cause the compound to undergo reactions such as hydrolysis, which will affect its quality.
The transportation process should It is necessary to ensure that the packaging is intact, and it is appropriate to hold it in metal drums or special plastic containers to prevent the packaging from cracking due to collision and friction. When handling, the operator should handle it with care to avoid violent vibration.
Because of its certain toxicity and irritation, it may be harmful to human health. Storage and transportation sites should be equipped with complete protective equipment, such as gas masks, protective gloves, protective glasses, etc., for operators to use. In the event of a leak, personnel should be evacuated to a safe area quickly, and according to the leakage situation, corresponding emergency treatment measures should be taken. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; if a large amount of leakage, it needs to be built into a dike or dug for containment and then dealt with.
In addition, storage and transportation must also follow relevant regulations and standards. The necessary permits and formalities should be carried out, the transport vehicles should be clearly marked with dangerous goods, and the transport personnel should also be professionally trained to be familiar with the characteristics of the compound and emergency disposal methods. In this way, the safety of 1 + -bromo-3 + -chloro-2 + -methoxybenzene during storage and transportation can be ensured.
The first thing to pay attention to is its chemical properties. This compound contains bromine, chlorine and other halogen atoms and methoxy groups, which are active in nature. When storing, be sure to keep away from fire and heat sources, because it may cause combustion or even explosion in case of open flame, hot topic. The warehouse must be cool and well ventilated, and the temperature and humidity should be properly controlled. If the temperature is too high, it may cause the compound to evaporate faster, increasing the risk of leakage; if the humidity is too high, it may cause the compound to undergo reactions such as hydrolysis, which will affect its quality.
The transportation process should It is necessary to ensure that the packaging is intact, and it is appropriate to hold it in metal drums or special plastic containers to prevent the packaging from cracking due to collision and friction. When handling, the operator should handle it with care to avoid violent vibration.
Because of its certain toxicity and irritation, it may be harmful to human health. Storage and transportation sites should be equipped with complete protective equipment, such as gas masks, protective gloves, protective glasses, etc., for operators to use. In the event of a leak, personnel should be evacuated to a safe area quickly, and according to the leakage situation, corresponding emergency treatment measures should be taken. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; if a large amount of leakage, it needs to be built into a dike or dug for containment and then dealt with.
In addition, storage and transportation must also follow relevant regulations and standards. The necessary permits and formalities should be carried out, the transport vehicles should be clearly marked with dangerous goods, and the transport personnel should also be professionally trained to be familiar with the characteristics of the compound and emergency disposal methods. In this way, the safety of 1 + -bromo-3 + -chloro-2 + -methoxybenzene during storage and transportation can be ensured.
Scan to WhatsApp
