Linshang Chemical
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1-Bromo-3-Chloro-2-Methylbenzene
Linshang Chemical
|
HS Code |
593029 |
| Chemical Formula | C7H6BrCl |
| Molecular Weight | 205.48 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 220 - 225 °C |
| Density | Around 1.5 - 1.6 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, etc. |
| Flash Point | Likely to be relatively high, around 90 - 100 °C (estimated) |
| Vapor Pressure | Low at room temperature |
As an accredited 1-Bromo-3-Chloro-2-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 3 - chloro - 2 - methylbenzene in a sealed, chemical - resistant bottle. |
| Storage | 1 - Bromo - 3 - chloro - 2 - methylbenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. |
| Shipping | 1 - bromo - 3 - chloro - 2 - methylbenzene is shipped in sealed, corrosion - resistant containers. These are carefully packed to prevent breakage. Shipments follow strict chemical transport regulations to ensure safety during transit. |
Competitive 1-Bromo-3-Chloro-2-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 1 - bromo - 3 - chloro - 2 - methylbenzene?
The chemical structure of 1 + -bromo-3-chloro-2-methylbenzene can be described as follows: The benzene ring is its fundamental structure, which is a planar hexagonal ring structure. The six carbon atoms on the ring are linked to each other by covalent bonds to form a stable conjugated system.
On the benzene ring, there are three places occupied by substituents. One is a bromine atom, which is at position 1 of the benzene ring, that is, a certain carbon atom is selected as the starting count, and the bromine atom is covalently connected to the carbon. The other is a chlorine atom, which is at position 3 of the benzene ring, and is bonded to the corresponding carbon atom. The third is methyl, which is a methyl group composed of one carbon atom and three hydrogen atoms at position 2, and is also related to the No. 2 carbon atom of the benzene ring by covalent bonds.
The existence of these substituents makes 1 + -bromo-3-chloro-2-methylbenzene exhibit unique chemical properties. Bromine and chlorine atoms are more electronegative than carbon, and in the conjugated system of the benzene ring, they will affect the distribution of electron clouds, causing the electron cloud density of the benzene ring to change. Methyl, because it is the power supply radical, also affects the electron cloud distribution of the benzene ring. The interaction of these substituents causes the compound to exhibit very different reactivity and selectivity from benzene in chemical reactions such as electrophilic substitution.
On the benzene ring, there are three places occupied by substituents. One is a bromine atom, which is at position 1 of the benzene ring, that is, a certain carbon atom is selected as the starting count, and the bromine atom is covalently connected to the carbon. The other is a chlorine atom, which is at position 3 of the benzene ring, and is bonded to the corresponding carbon atom. The third is methyl, which is a methyl group composed of one carbon atom and three hydrogen atoms at position 2, and is also related to the No. 2 carbon atom of the benzene ring by covalent bonds.
The existence of these substituents makes 1 + -bromo-3-chloro-2-methylbenzene exhibit unique chemical properties. Bromine and chlorine atoms are more electronegative than carbon, and in the conjugated system of the benzene ring, they will affect the distribution of electron clouds, causing the electron cloud density of the benzene ring to change. Methyl, because it is the power supply radical, also affects the electron cloud distribution of the benzene ring. The interaction of these substituents causes the compound to exhibit very different reactivity and selectivity from benzene in chemical reactions such as electrophilic substitution.
What are the physical properties of 1 - bromo - 3 - chloro - 2 - methylbenzene?
1 + -Bromo-3 + -chloro-2 + -methylbenzene is also an organic compound. It has various physical properties and can be described in detail.
First of all, under normal conditions, 1 + -bromo-3 + -chloro-2 + -methylbenzene is mostly colorless to pale yellow liquid. The formation of this state is determined by its intermolecular force. The attractive force between molecules is moderate, which makes it difficult to form a solid state at room temperature and pressure, and it is not easy to form a gaseous state, so it exists in a liquid state.
Times and its boiling point. The boiling point of 1 + -bromo-3 + -chloro-2 + -methylbenzene is quite high, about 200 degrees Celsius. Because the molecule contains bromine, chlorine and other halogen atoms, it increases the mass and polarizability of the molecule, resulting in enhanced van der Waals force between molecules. To make the molecule break free from the liquid phase and turn into the gas phase, more energy is required, so the boiling point is higher.
Furthermore, on its melting point. The melting point is relatively low, in the temperature range below zero. This is because although there is a certain force between molecules, it does not form a regular lattice structure. At lower temperatures, the molecules still have a certain space of activity and are not completely fixed, so the melting point is not high.
Its density is greater than that of water, and it often floats on water. This is determined by its molecular composition and structure. The relative atomic weight of bromine and chlorine atoms is large, which causes the molecular density to increase, so it sinks in water.
In terms of solubility, 1 + -bromo-3 + -chloro-2 + -methylbenzene is insoluble in water, but soluble in many organic solvents, such as ethanol, ether, benzene, etc. Water is a polar molecule, while 1 + -bromo-3 + -chloro-2 + -methylbenzene is a non-polar or weakly polar molecule. According to the principle of "similar miscibility", it is difficult to dissolve in polar water, but easy to dissolve in non-polar or weakly polar organic solvents.
1 + -bromo-3 + -chloro-2 + -methylbenzene has such physical properties and is widely used in chemical, pharmaceutical and other fields. It is also an important raw material and intermediate for organic synthesis.
First of all, under normal conditions, 1 + -bromo-3 + -chloro-2 + -methylbenzene is mostly colorless to pale yellow liquid. The formation of this state is determined by its intermolecular force. The attractive force between molecules is moderate, which makes it difficult to form a solid state at room temperature and pressure, and it is not easy to form a gaseous state, so it exists in a liquid state.
Times and its boiling point. The boiling point of 1 + -bromo-3 + -chloro-2 + -methylbenzene is quite high, about 200 degrees Celsius. Because the molecule contains bromine, chlorine and other halogen atoms, it increases the mass and polarizability of the molecule, resulting in enhanced van der Waals force between molecules. To make the molecule break free from the liquid phase and turn into the gas phase, more energy is required, so the boiling point is higher.
Furthermore, on its melting point. The melting point is relatively low, in the temperature range below zero. This is because although there is a certain force between molecules, it does not form a regular lattice structure. At lower temperatures, the molecules still have a certain space of activity and are not completely fixed, so the melting point is not high.
Its density is greater than that of water, and it often floats on water. This is determined by its molecular composition and structure. The relative atomic weight of bromine and chlorine atoms is large, which causes the molecular density to increase, so it sinks in water.
In terms of solubility, 1 + -bromo-3 + -chloro-2 + -methylbenzene is insoluble in water, but soluble in many organic solvents, such as ethanol, ether, benzene, etc. Water is a polar molecule, while 1 + -bromo-3 + -chloro-2 + -methylbenzene is a non-polar or weakly polar molecule. According to the principle of "similar miscibility", it is difficult to dissolve in polar water, but easy to dissolve in non-polar or weakly polar organic solvents.
1 + -bromo-3 + -chloro-2 + -methylbenzene has such physical properties and is widely used in chemical, pharmaceutical and other fields. It is also an important raw material and intermediate for organic synthesis.
What are the applications of 1 - bromo - 3 - chloro - 2 - methylbenzene in organic synthesis?
1 + -Bromo-3 + -chloro-2 + -methylbenzene, this substance is widely used in organic synthesis.
First, it is often used as a key starting material in the process of constructing complex aromatic compounds. Because of its benzene ring, bromine, chlorine and methyl are in specific positions, this unique substitution mode endows it with special reactivity and selectivity. For example, in nucleophilic substitution reactions, bromine and chlorine atoms can be replaced by various nucleophiles, thereby introducing different functional groups, thereby deriving a series of compounds with different structures.
Second, in the field of medicinal chemistry, its value cannot be underestimated. After rational chemical modification, drug molecules with specific biological activities can be created. In view of the fact that the structure and substituent properties of the benzene ring can significantly affect the interaction between molecules and biological targets, new therapeutic drugs may be created based on 1 + -bromo-3 + -chloro-2 + -methylbenzene.
Third, in the field of materials science, functional polymer materials can be synthesized on this basis. By polymerization, it can be cleverly embedded in the main chain or side chain of the polymer, which can endow the material with unique electrical, optical or thermal properties, such as the preparation of optoelectronic materials that respond to specific wavelengths of light.
Fourth, in organometallic catalytic reactions, 1 + -bromo-3 + -chloro-2 + -methylbenzene is often used as a substrate. Under the action of metal catalysts such as palladium and nickel, coupling reactions occur with various organometallic reagents to achieve efficient construction of carbon-carbon bonds or carbon-heteroatomic bonds, greatly expanding the pathways and product diversity of organic synthesis.
In short, 1 + -bromo-3 + -chloro-2 + -methylbenzene, with its unique structure, plays an indispensable role in many fields of organic synthesis, laying a solid foundation for the creation of novel compounds and materials.
First, it is often used as a key starting material in the process of constructing complex aromatic compounds. Because of its benzene ring, bromine, chlorine and methyl are in specific positions, this unique substitution mode endows it with special reactivity and selectivity. For example, in nucleophilic substitution reactions, bromine and chlorine atoms can be replaced by various nucleophiles, thereby introducing different functional groups, thereby deriving a series of compounds with different structures.
Second, in the field of medicinal chemistry, its value cannot be underestimated. After rational chemical modification, drug molecules with specific biological activities can be created. In view of the fact that the structure and substituent properties of the benzene ring can significantly affect the interaction between molecules and biological targets, new therapeutic drugs may be created based on 1 + -bromo-3 + -chloro-2 + -methylbenzene.
Third, in the field of materials science, functional polymer materials can be synthesized on this basis. By polymerization, it can be cleverly embedded in the main chain or side chain of the polymer, which can endow the material with unique electrical, optical or thermal properties, such as the preparation of optoelectronic materials that respond to specific wavelengths of light.
Fourth, in organometallic catalytic reactions, 1 + -bromo-3 + -chloro-2 + -methylbenzene is often used as a substrate. Under the action of metal catalysts such as palladium and nickel, coupling reactions occur with various organometallic reagents to achieve efficient construction of carbon-carbon bonds or carbon-heteroatomic bonds, greatly expanding the pathways and product diversity of organic synthesis.
In short, 1 + -bromo-3 + -chloro-2 + -methylbenzene, with its unique structure, plays an indispensable role in many fields of organic synthesis, laying a solid foundation for the creation of novel compounds and materials.
What are the preparation methods of 1 - bromo - 3 - chloro - 2 - methylbenzene?
The methods for preparing 1-bromo-3-chloro-2-methylbenzene are as follows.
First, use o-methyl chlorobenzene as the starting material. In a suitable reaction vessel, add o-methyl chlorobenzene and an appropriate amount of brominating reagent, such as bromine (Br ²), and add a suitable catalyst, such as iron powder (Fe) or iron tribromide (FeBr 😉). Under heating or lighting conditions, bromine atoms can replace hydrogen atoms on the benzene ring. Due to the localization effect of methyl and chlorine atoms, by controlling the reaction conditions, bromine atoms can mainly replace hydrogen in methyl ortho-sites or chlorine inter-sites to generate 1-bromo-3-chloro-2-methylbenzene. In this process, the reaction temperature, the proportion of reactants and the reaction time should be paid attention to to to improve the yield of the target product.
Second, take o-methyl bromobenzene as the starting material. Add a chlorination reagent to it, such as chlorine gas (Cl _ 2), and add a suitable catalyst, such as anhydrous aluminum trichloride (AlCl _ 3). Under certain reaction conditions, chlorine gas and o-methyl bromobenzene undergo a substitution reaction. Using the localization effect of the existing substituents on the benzene ring, the chlorine atoms mainly enter the methyl ortho-site and the bromine inter-site, so as to obtain 1-bromo-3-chloro-2-methylbenzene. During this period, the anhydrous conditions of the reaction environment are very critical to avoid the deactivation of the catalyst.
Third, 2-methylbenzoic acid can be prepared first. Using toluene as a raw material, through oxidation reaction, such as using an oxidant such as potassium permanganate (KMnO), the methyl is oxidized to a carboxyl group to obtain 2-methylbenzoic acid. After that, it is halogenated. Brominated first, then chlorinated, or vice versa. When brominating, use a suitable brominating agent, when chlorinating, use a suitable chlorinating agent, and choose the corresponding catalyst. After the reaction is completed, the carboxyl group is converted to methyl group. For example, through reduction reaction, using reducing agents such as lithium aluminum hydride (LiAlH), 1-bromo-3-chloro-2-methylbenzene can be obtained. However, this method has many steps and requires fine control of each step of the reaction.
First, use o-methyl chlorobenzene as the starting material. In a suitable reaction vessel, add o-methyl chlorobenzene and an appropriate amount of brominating reagent, such as bromine (Br ²), and add a suitable catalyst, such as iron powder (Fe) or iron tribromide (FeBr 😉). Under heating or lighting conditions, bromine atoms can replace hydrogen atoms on the benzene ring. Due to the localization effect of methyl and chlorine atoms, by controlling the reaction conditions, bromine atoms can mainly replace hydrogen in methyl ortho-sites or chlorine inter-sites to generate 1-bromo-3-chloro-2-methylbenzene. In this process, the reaction temperature, the proportion of reactants and the reaction time should be paid attention to to to improve the yield of the target product.
Second, take o-methyl bromobenzene as the starting material. Add a chlorination reagent to it, such as chlorine gas (Cl _ 2), and add a suitable catalyst, such as anhydrous aluminum trichloride (AlCl _ 3). Under certain reaction conditions, chlorine gas and o-methyl bromobenzene undergo a substitution reaction. Using the localization effect of the existing substituents on the benzene ring, the chlorine atoms mainly enter the methyl ortho-site and the bromine inter-site, so as to obtain 1-bromo-3-chloro-2-methylbenzene. During this period, the anhydrous conditions of the reaction environment are very critical to avoid the deactivation of the catalyst.
Third, 2-methylbenzoic acid can be prepared first. Using toluene as a raw material, through oxidation reaction, such as using an oxidant such as potassium permanganate (KMnO), the methyl is oxidized to a carboxyl group to obtain 2-methylbenzoic acid. After that, it is halogenated. Brominated first, then chlorinated, or vice versa. When brominating, use a suitable brominating agent, when chlorinating, use a suitable chlorinating agent, and choose the corresponding catalyst. After the reaction is completed, the carboxyl group is converted to methyl group. For example, through reduction reaction, using reducing agents such as lithium aluminum hydride (LiAlH), 1-bromo-3-chloro-2-methylbenzene can be obtained. However, this method has many steps and requires fine control of each step of the reaction.
What are the effects of 1 - bromo - 3 - chloro - 2 - methylbenzene on the environment and human health?
1 + -Bromo-3-chloro-2-methylbenzene, which has an impact on both the environment and human health.
In terms of the environment, it has a certain stability and is difficult to decompose rapidly on its own. If released into the atmosphere, it will slowly undergo photochemical reactions, which can generate secondary pollutants that harm the atmosphere, such as some components that can increase photochemical smog, which in turn affect air quality, damage regional and even global climate. If it enters the water body, it is easy to adsorb suspended particles due to its hydrophobicity, deposit in the bottom of the water, and persist for a long time, endangering the aquatic ecosystem. Once aquatic organisms are exposed to or ingested, it may cause abnormal physiological functions, interfere with their growth, reproduction and other key life processes, and in severe cases, it may cause a decrease in the number of species and damage to biodiversity. And through the food chain transmission, it can be enriched in advanced organisms and expand the scope of influence.
As for human health, it is toxic. Breathing and inhalation can irritate the respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, and long-term exposure or increased risk of respiratory diseases, such as chronic obstructive pulmonary disease, lung cancer, etc. Through skin contact, it can penetrate the skin, causing skin allergies, itching, redness, and even burns. If ingested carelessly, it will damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, and life-threatening in severe cases. In addition, due to its chemical structure characteristics, or potential teratogenicity, carcinogenicity, and mutagenicity, long-term exposure can interfere with the normal cell metabolism and genetic information transmission of the human body, threatening human health. Therefore, 1-bromo-3-chloro-2-methylbenzene must be properly controlled to reduce its adverse effects on the environment and human health.
In terms of the environment, it has a certain stability and is difficult to decompose rapidly on its own. If released into the atmosphere, it will slowly undergo photochemical reactions, which can generate secondary pollutants that harm the atmosphere, such as some components that can increase photochemical smog, which in turn affect air quality, damage regional and even global climate. If it enters the water body, it is easy to adsorb suspended particles due to its hydrophobicity, deposit in the bottom of the water, and persist for a long time, endangering the aquatic ecosystem. Once aquatic organisms are exposed to or ingested, it may cause abnormal physiological functions, interfere with their growth, reproduction and other key life processes, and in severe cases, it may cause a decrease in the number of species and damage to biodiversity. And through the food chain transmission, it can be enriched in advanced organisms and expand the scope of influence.
As for human health, it is toxic. Breathing and inhalation can irritate the respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, and long-term exposure or increased risk of respiratory diseases, such as chronic obstructive pulmonary disease, lung cancer, etc. Through skin contact, it can penetrate the skin, causing skin allergies, itching, redness, and even burns. If ingested carelessly, it will damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, and life-threatening in severe cases. In addition, due to its chemical structure characteristics, or potential teratogenicity, carcinogenicity, and mutagenicity, long-term exposure can interfere with the normal cell metabolism and genetic information transmission of the human body, threatening human health. Therefore, 1-bromo-3-chloro-2-methylbenzene must be properly controlled to reduce its adverse effects on the environment and human health.
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