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1-Bromo-3-Chloro-4-Iodobenzene
Linshang Chemical
|
HS Code |
825849 |
| Chemical Formula | C6H3BrClI |
| Molar Mass | 336.35 g/mol |
| Appearance | Solid (likely colorless to off - white) |
| Physical State At Room Temperature | Solid |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low at room temperature |
| Reactivity | Reactive towards nucleophiles, can participate in substitution reactions |
| Stability | Stable under normal conditions, but may decompose on exposure to strong heat or light |
As an accredited 1-Bromo-3-Chloro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - bromo - 3 - chloro - 4 - iodobenzene packaged in 100 - gram bottles. |
| Storage | 1 - Bromo - 3 - chloro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. Ensure the storage location is out of reach of children and unauthorized personnel. |
| Shipping | 1 - bromo - 3 - chloro - 4 - iodobenzene is shipped in sealed, corrosion - resistant containers. These are carefully packed to prevent breakage. Shipments follow strict hazardous material regulations, ensuring safe transport. |
Competitive 1-Bromo-3-Chloro-4-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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1 - bromo - 3 - chloro - 4 - iodobenzene What is the Chinese name?
The Chinese name of 1-bromo-3-chloro-4-iodobenzene follows the rules for naming organic compounds. Looking at this compound, it is based on the benzene ring, and there are three halogen atoms of bromine, chlorine and iodine as substituents. When
is named, the benzene ring is first regarded as the parent, and then the position and name of the substituent are determined. In this compound, the sum of the substituent positions is minimized according to the principle of the lowest series. Therefore, the bromine atom is in the 1st position, the chlorine atom is in the 3rd position, and the iodine atom is in the 4th position.
According to the Chinese naming convention, the substituents are listed in order, first written bromine, followed by chlorine, and finally iodine, and then affixed with the name of parent benzene, thus obtaining the name "1-bromo-3-chloro-4-iodobenzene". This name is designed to accurately describe the structure of the compound, so that scholars can know its structure outline by name. It is of great significance in the study and communication of organic chemistry, and can help the academic community clearly identify and discuss this specific compound.
is named, the benzene ring is first regarded as the parent, and then the position and name of the substituent are determined. In this compound, the sum of the substituent positions is minimized according to the principle of the lowest series. Therefore, the bromine atom is in the 1st position, the chlorine atom is in the 3rd position, and the iodine atom is in the 4th position.
According to the Chinese naming convention, the substituents are listed in order, first written bromine, followed by chlorine, and finally iodine, and then affixed with the name of parent benzene, thus obtaining the name "1-bromo-3-chloro-4-iodobenzene". This name is designed to accurately describe the structure of the compound, so that scholars can know its structure outline by name. It is of great significance in the study and communication of organic chemistry, and can help the academic community clearly identify and discuss this specific compound.
What are the chemical properties of 1 - bromo - 3 - chloro - 4 - iodobenzene?
1-Bromo-3-chloro-4-iodobenzene is also an organic compound. Its chemical properties are unique and related to many reactions.
The first word is the electrophilic substitution reaction. The benzene ring has electron-rich properties and is easily attacked by electrophilic reagents. In this compound, the halogen atom is an ortho-para-site group. Because of its lone pair of electrons, it can be conjugated with the benzene ring, so that the electron cloud density of the ortho-para-site is relatively increased. The electrophilic substitution reaction mostly occurs in the ortho-para-site of the halogen atom. However, different halogen atoms have different activation capabilities. In bromine, chlorine, and iodine, although they are all ortho-para Therefore, the reactivity is slightly lower than that of benzene, and the substitution check point is affected by the comprehensive effect of each halogen atom, which often occurs where the steric resistance is small and the electronic effect is favorable.
On nucleophilic substitution reactions. Usually, the nucleophilic substitution reaction of aromatic halogenated hydrocarbons is difficult, due to the stable conjugation system of the benzene ring. However, in 1-bromo-3-chloro-4-iodobenzene, the carbon atom connected to the halogen atom is induced by the electron-absorbing effect of other halogen atoms, and the electron cloud density decreases. Under strong nucleophilic reagents and suitable conditions, nucleophil In case of strong bases or nucleophilic reagents, halogen atoms may be replaced, and different halogen atoms have different activities. Generally, iodine has the highest activity, followed by bromine, and chlorine is relatively difficult to be replaced.
and reduction reaction. Under the action of appropriate reducing agents, halogen atoms may be reduced and removed. For example, in the system of some metals (such as zinc, etc.) and acids, halogen atoms may be gradually reduced to form corresponding benzene derivatives. This process involves electron transfer and chemical bond breaking and formation.
There is a coupling reaction. Under the catalysis of transition metals, 1-bromo-3-chloro-4-iodobenzene can participate in a variety of coupling reactions, such as coupling with organometallic reagents (such as Grignard reagents, etc.) to form carbon-carbon bonds and construct more complex organic structures, which is of great significance in the field of organic synthesis.
In summary, the properties of 1-bromo-3-chloro-4-iodobenzene halogen atoms interact with benzene rings, presenting diverse chemical properties and potential application value in organic synthesis and other fields.
The first word is the electrophilic substitution reaction. The benzene ring has electron-rich properties and is easily attacked by electrophilic reagents. In this compound, the halogen atom is an ortho-para-site group. Because of its lone pair of electrons, it can be conjugated with the benzene ring, so that the electron cloud density of the ortho-para-site is relatively increased. The electrophilic substitution reaction mostly occurs in the ortho-para-site of the halogen atom. However, different halogen atoms have different activation capabilities. In bromine, chlorine, and iodine, although they are all ortho-para Therefore, the reactivity is slightly lower than that of benzene, and the substitution check point is affected by the comprehensive effect of each halogen atom, which often occurs where the steric resistance is small and the electronic effect is favorable.
On nucleophilic substitution reactions. Usually, the nucleophilic substitution reaction of aromatic halogenated hydrocarbons is difficult, due to the stable conjugation system of the benzene ring. However, in 1-bromo-3-chloro-4-iodobenzene, the carbon atom connected to the halogen atom is induced by the electron-absorbing effect of other halogen atoms, and the electron cloud density decreases. Under strong nucleophilic reagents and suitable conditions, nucleophil In case of strong bases or nucleophilic reagents, halogen atoms may be replaced, and different halogen atoms have different activities. Generally, iodine has the highest activity, followed by bromine, and chlorine is relatively difficult to be replaced.
and reduction reaction. Under the action of appropriate reducing agents, halogen atoms may be reduced and removed. For example, in the system of some metals (such as zinc, etc.) and acids, halogen atoms may be gradually reduced to form corresponding benzene derivatives. This process involves electron transfer and chemical bond breaking and formation.
There is a coupling reaction. Under the catalysis of transition metals, 1-bromo-3-chloro-4-iodobenzene can participate in a variety of coupling reactions, such as coupling with organometallic reagents (such as Grignard reagents, etc.) to form carbon-carbon bonds and construct more complex organic structures, which is of great significance in the field of organic synthesis.
In summary, the properties of 1-bromo-3-chloro-4-iodobenzene halogen atoms interact with benzene rings, presenting diverse chemical properties and potential application value in organic synthesis and other fields.
What are the common uses of 1 - bromo - 3 - chloro - 4 - iodobenzene?
1 + -Bromo-3-chloro-4-iodobenzene is also an organic compound. Its common preparation method is based on chemical synthesis.
First, benzene is used as the initial material. First, benzene and bromine are substituted under the action of an appropriate catalyst, such as iron tribromide, to obtain bromobenzene. This reaction is an electrophilic substitution, in which bromine atoms replace hydrogen atoms in the benzene ring. After bromobenzene is formed, chlorine atoms are introduced. Benzene derivatives containing bromine and chlorine can be formed by substitution at specific positions of bromobenzene with specific chlorination reagents, such as chlorine gas, under suitable reaction conditions. Then iodine atoms are introduced, often with iodization reagents, according to specific reaction steps, iodine atoms are substituted for hydrogen in the corresponding position, and finally 1 + -bromo-3-chloro-4-iodobenzene is obtained.
Second, benzene derivatives containing specific substituents can also be used as starters. If the starter has some of the desired substituents, the remaining bromine, chlorine, and iodine atoms can be gradually introduced by selecting suitable reaction reagents and conditions. For example, if there are chlorine-containing benzene derivatives, bromine and iodine atoms can be introduced sequentially through suitable bromination and iodization reactions to achieve the synthesis target.
When preparing this compound, the control of the reaction conditions is crucial. Such as reaction temperature, reaction time, dosage ratio of reagents, etc., will have a significant impact on the process of the reaction and the purity and yield of the product. Reaction parameters must be carefully adjusted to achieve the best synthesis effect.
First, benzene is used as the initial material. First, benzene and bromine are substituted under the action of an appropriate catalyst, such as iron tribromide, to obtain bromobenzene. This reaction is an electrophilic substitution, in which bromine atoms replace hydrogen atoms in the benzene ring. After bromobenzene is formed, chlorine atoms are introduced. Benzene derivatives containing bromine and chlorine can be formed by substitution at specific positions of bromobenzene with specific chlorination reagents, such as chlorine gas, under suitable reaction conditions. Then iodine atoms are introduced, often with iodization reagents, according to specific reaction steps, iodine atoms are substituted for hydrogen in the corresponding position, and finally 1 + -bromo-3-chloro-4-iodobenzene is obtained.
Second, benzene derivatives containing specific substituents can also be used as starters. If the starter has some of the desired substituents, the remaining bromine, chlorine, and iodine atoms can be gradually introduced by selecting suitable reaction reagents and conditions. For example, if there are chlorine-containing benzene derivatives, bromine and iodine atoms can be introduced sequentially through suitable bromination and iodization reactions to achieve the synthesis target.
When preparing this compound, the control of the reaction conditions is crucial. Such as reaction temperature, reaction time, dosage ratio of reagents, etc., will have a significant impact on the process of the reaction and the purity and yield of the product. Reaction parameters must be carefully adjusted to achieve the best synthesis effect.
What are the methods for preparing 1 - bromo - 3 - chloro - 4 - iodobenzene?
There are several methods for preparing 1 + -bromo-3 + -chloro-4 + -iodobenzene as follows.
One is the halogenation reaction method. Using benzene derivatives as starting materials, a suitable brominating reagent can be selected, such as bromine (Br ²). Under the catalysis of Lewis acid catalysts such as iron tribromide (FeBr ²), the benzene ring undergoes an electrophilic substitution reaction, and the bromine atom is connected to a specific position in the benzene ring. Then the chlorination reaction is carried out, and a suitable chlorination reagent, such as chlorine gas (Cl ²), is selected. Under similar catalytic conditions, the chlorine atom is connected to the benzene ring. Finally, the iodization reaction is carried out. Iodization reagents such as potassium iodide (KI) are usually used. With the help of oxidative iodization and other means, iodine atoms are introduced into the benzene ring to obtain 1 + -bromo-3 + -chloro-4 + -iodobenzene.
The second is the metal-organic reagent method. First, bromine-containing benzene derivatives are reacted with metal reagents to form organometallic intermediates, such as Grignard reagents or lithium reagents. For example, 1-bromobenzene is reacted with magnesium in a solvent such as anhydrous ether to form phenylmagnesium bromide. Subsequently, the intermediate undergoes a nucleophilic substitution reaction with chlorine-containing halogenated hydrocarbons to introduce Finally, it is reacted with iodine-containing halogenated hydrocarbons or iodine sources to achieve the integration of iodine atoms and achieve the purpose of preparation.
The third is the coupling reaction method. The cross-coupling reaction catalyzed by palladium can be used. For example, in the presence of bromine-containing benzene derivatives, chlorine-containing aromatic hydrocarbon halides and iodine-containing aromatic hydrocarbon halides as raw materials, in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium (Pd (PPh 🥰)), as well as suitable ligands and bases, bromine, chlorine, and iodine atoms are gradually integrated into the benzene ring in sequence to complete the preparation of 1 + -bromo-3 + -chloro-4 + This method has relatively mild conditions and good selectivity, and is widely used in the field of organic synthesis.
One is the halogenation reaction method. Using benzene derivatives as starting materials, a suitable brominating reagent can be selected, such as bromine (Br ²). Under the catalysis of Lewis acid catalysts such as iron tribromide (FeBr ²), the benzene ring undergoes an electrophilic substitution reaction, and the bromine atom is connected to a specific position in the benzene ring. Then the chlorination reaction is carried out, and a suitable chlorination reagent, such as chlorine gas (Cl ²), is selected. Under similar catalytic conditions, the chlorine atom is connected to the benzene ring. Finally, the iodization reaction is carried out. Iodization reagents such as potassium iodide (KI) are usually used. With the help of oxidative iodization and other means, iodine atoms are introduced into the benzene ring to obtain 1 + -bromo-3 + -chloro-4 + -iodobenzene.
The second is the metal-organic reagent method. First, bromine-containing benzene derivatives are reacted with metal reagents to form organometallic intermediates, such as Grignard reagents or lithium reagents. For example, 1-bromobenzene is reacted with magnesium in a solvent such as anhydrous ether to form phenylmagnesium bromide. Subsequently, the intermediate undergoes a nucleophilic substitution reaction with chlorine-containing halogenated hydrocarbons to introduce Finally, it is reacted with iodine-containing halogenated hydrocarbons or iodine sources to achieve the integration of iodine atoms and achieve the purpose of preparation.
The third is the coupling reaction method. The cross-coupling reaction catalyzed by palladium can be used. For example, in the presence of bromine-containing benzene derivatives, chlorine-containing aromatic hydrocarbon halides and iodine-containing aromatic hydrocarbon halides as raw materials, in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium (Pd (PPh 🥰)), as well as suitable ligands and bases, bromine, chlorine, and iodine atoms are gradually integrated into the benzene ring in sequence to complete the preparation of 1 + -bromo-3 + -chloro-4 + This method has relatively mild conditions and good selectivity, and is widely used in the field of organic synthesis.
What are the applications of 1 - bromo - 3 - chloro - 4 - iodobenzene in organic synthesis?
1 + -Bromo-3 + -chloro-4 + -iodobenzene is widely used in organic synthesis. This compound contains halogen atoms and can participate in many reactions.
First, in nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents. Because iodine atoms are highly active and easy to leave, nucleophilic reagents such as alkoxides and amines can react with them to generate corresponding substitution products. For example, sodium alcohol can be used as nucleophilic reagents to prepare ether compounds, which are important for constructing organic molecules containing ether bonds.
Second, metal catalytic coupling reactions are also commonly used. Under the action of metal catalysts such as palladium and nickel, 1 + -bromo-3 + -chloro-4 + -iodobenzene can be coupled with metal-containing reagents. For example, Suzuki coupling reaction with borate esters can construct carbon-carbon bonds and synthesize aromatic derivatives with complex structures, which are widely used in drug synthesis and materials science. In drug development, compounds with specific structures and biological activities can be prepared by this reaction.
Third, it can be used for halogen atom exchange reactions. By selecting suitable reagents and conditions, adjusting the types and positions of halogen atoms, optimizing the reactivity and properties of compounds to meet different synthesis needs.
Fourth, in the construction of polycyclic aromatic hydrocarbon systems, 1 + -bromo-3 + -chloro-4 + -iodobenzene can undergo multi-step reactions to participate in the cyclization process to form fused ring compounds, which have potential application value in the synthesis of materials with special photoelectric properties.
First, in nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents. Because iodine atoms are highly active and easy to leave, nucleophilic reagents such as alkoxides and amines can react with them to generate corresponding substitution products. For example, sodium alcohol can be used as nucleophilic reagents to prepare ether compounds, which are important for constructing organic molecules containing ether bonds.
Second, metal catalytic coupling reactions are also commonly used. Under the action of metal catalysts such as palladium and nickel, 1 + -bromo-3 + -chloro-4 + -iodobenzene can be coupled with metal-containing reagents. For example, Suzuki coupling reaction with borate esters can construct carbon-carbon bonds and synthesize aromatic derivatives with complex structures, which are widely used in drug synthesis and materials science. In drug development, compounds with specific structures and biological activities can be prepared by this reaction.
Third, it can be used for halogen atom exchange reactions. By selecting suitable reagents and conditions, adjusting the types and positions of halogen atoms, optimizing the reactivity and properties of compounds to meet different synthesis needs.
Fourth, in the construction of polycyclic aromatic hydrocarbon systems, 1 + -bromo-3 + -chloro-4 + -iodobenzene can undergo multi-step reactions to participate in the cyclization process to form fused ring compounds, which have potential application value in the synthesis of materials with special photoelectric properties.
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