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1-Bromo-3-Chloro-5-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
572338 |
| Chemical Formula | C7H3BrClF3 |
| Molecular Weight | 275.45 |
| Appearance | Liquid (usually) |
| Boiling Point | Data varies, around 160 - 170 °C |
| Density | Data needed, expected to be >1 g/cm³ as halogenated compound |
| Solubility In Water | Low solubility, being non - polar |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low vapor pressure due to relatively high molecular weight |
| Flash Point | Data may vary, needs experimental determination |
As an accredited 1-Bromo-3-Chloro-5-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - bromo - 3 - chloro - 5 - (trifluoromethyl)benzene in sealed chemical - grade bottle. |
| Storage | 1 - Bromo - 3 - chloro - 5 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container made of materials resistant to corrosion, such as glass or certain plastics. Store separately from oxidizing agents and reactive substances to prevent potential chemical reactions. |
| Shipping | 1 - bromo - 3 - chloro - 5 - (trifluoromethyl)benzene is a chemical. Ship it in well - sealed, corrosion - resistant containers, following hazardous chemical shipping regulations. Ensure proper labeling for safe and compliant transport. |
Competitive 1-Bromo-3-Chloro-5-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1 - bromo - 3 - chloro - 5 - (trifluoromethyl) benzene?
1-Bromo-3-chloro-5- (trifluoromethyl) benzene is also an organic compound. Its chemical properties are particularly important, and it is often a key raw material in the field of organic synthesis.
In this compound, bromine, chlorine and trifluoromethyl are all important functional groups. Bromine atoms have considerable reactivity and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic testers can attack carbon atoms attached to bromine, causing bromine to leave, and then form new organic compounds. For example, ether or amine derivatives can be formed by interacting with nucleophilic reagents such as alkoxides and amines.
The chlorine atom is also reactive. Although its activity is slightly inferior to that of the bromine atom, it can also participate in the substitution reaction under certain conditions. Trifluoromethyl in this compound, due to its strong electronegativity of fluorine atoms, endows the molecule with unique electronic and spatial effects. Trifluoromethyl can reduce the electron cloud density of the benzene ring and affect the electrophilic substitution reaction on the benzene ring. Generally speaking, it will make the electrophilic substitution reaction difficult to occur, and the reaction check point will also be affected by it.
In addition, 1-bromo-3-chloro-5 - (trifluoromethyl) benzene is also used in some metal-catalyzed reactions. Such as palladium-catalyzed cross-coupling reaction, this compound can be coupled with other organic halides or alkenyl halides to build more complex organic molecular structures, which have important uses in drug synthesis, materials science and many other fields. The diversity of its chemical properties makes it an object of much attention in organic chemistry research and synthesis.
In this compound, bromine, chlorine and trifluoromethyl are all important functional groups. Bromine atoms have considerable reactivity and can participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic testers can attack carbon atoms attached to bromine, causing bromine to leave, and then form new organic compounds. For example, ether or amine derivatives can be formed by interacting with nucleophilic reagents such as alkoxides and amines.
The chlorine atom is also reactive. Although its activity is slightly inferior to that of the bromine atom, it can also participate in the substitution reaction under certain conditions. Trifluoromethyl in this compound, due to its strong electronegativity of fluorine atoms, endows the molecule with unique electronic and spatial effects. Trifluoromethyl can reduce the electron cloud density of the benzene ring and affect the electrophilic substitution reaction on the benzene ring. Generally speaking, it will make the electrophilic substitution reaction difficult to occur, and the reaction check point will also be affected by it.
In addition, 1-bromo-3-chloro-5 - (trifluoromethyl) benzene is also used in some metal-catalyzed reactions. Such as palladium-catalyzed cross-coupling reaction, this compound can be coupled with other organic halides or alkenyl halides to build more complex organic molecular structures, which have important uses in drug synthesis, materials science and many other fields. The diversity of its chemical properties makes it an object of much attention in organic chemistry research and synthesis.
What are the common uses of 1 - bromo - 3 - chloro - 5 - (trifluoromethyl) benzene?
1 + -Bromo-3-chloro-5- (trifluoromethyl) benzene, its common uses are as follows:
First, it is often a key intermediate in the synthesis of medicine. It can be converted into compounds with specific pharmacological activities through a series of reactions. For example, by chemical modification of halogen atoms and trifluoromethyl on the benzene ring, suitable functional groups are introduced to synthesize drug molecules that can act on specific targets, such as some inhibitors targeting specific protein targets in tumor cells, or drugs that have therapeutic effects on neurological diseases. The presence of benzene ring structure, halogen atoms and trifluoromethyl groups endows compounds with unique physical and chemical properties and biological activities, which can participate in the interaction between drugs and targets, affecting the efficacy and selectivity of drugs.
Second, in the field of pesticides, it also has important uses. Using it as a starting material, high-efficiency pesticides can be prepared by chemical transformation. The introduction of trifluoromethyl can enhance the lipophilicity and stability of the compound, making it easier for pesticides to penetrate the waxy layer on the surface of pests, and improve the efficacy and shelf life. For example, the synthesis of new insecticides, targeting the physiological characteristics of specific pests, precisely acts on the key check points of the nervous system or respiratory system of pests, achieving the purpose of efficient insecticide while reducing the impact on non-target organisms in the environment.
Third, in the field of materials science, 1 + -bromo-3-chloro-5- (trifluoromethyl) benzene can be used to synthesize special polymer materials. The halogen atoms on the benzene ring can participate in the polymerization reaction to build polymers with special structures and properties. For example, polymerization with specific monomers can prepare high temperature and chemical corrosion resistant polymer materials, which are used in aerospace, electronics industry and other fields. Due to its unique chemical structure, it can endow materials with good thermal stability, electrical and mechanical properties, meeting the needs of high-end fields for special properties of materials.
Fourth, in the study of organic synthetic chemistry, this compound is an important model substrate. Chemists use various chemical reactions to study it to explore new synthesis methods and reaction mechanisms. For example, studying the substitution reaction conditions, selectivity and influencing factors of its halogen atoms provides theoretical basis and practical guidance for the synthesis of other similar compounds, and promotes the development and innovation of organic synthetic chemistry.
First, it is often a key intermediate in the synthesis of medicine. It can be converted into compounds with specific pharmacological activities through a series of reactions. For example, by chemical modification of halogen atoms and trifluoromethyl on the benzene ring, suitable functional groups are introduced to synthesize drug molecules that can act on specific targets, such as some inhibitors targeting specific protein targets in tumor cells, or drugs that have therapeutic effects on neurological diseases. The presence of benzene ring structure, halogen atoms and trifluoromethyl groups endows compounds with unique physical and chemical properties and biological activities, which can participate in the interaction between drugs and targets, affecting the efficacy and selectivity of drugs.
Second, in the field of pesticides, it also has important uses. Using it as a starting material, high-efficiency pesticides can be prepared by chemical transformation. The introduction of trifluoromethyl can enhance the lipophilicity and stability of the compound, making it easier for pesticides to penetrate the waxy layer on the surface of pests, and improve the efficacy and shelf life. For example, the synthesis of new insecticides, targeting the physiological characteristics of specific pests, precisely acts on the key check points of the nervous system or respiratory system of pests, achieving the purpose of efficient insecticide while reducing the impact on non-target organisms in the environment.
Third, in the field of materials science, 1 + -bromo-3-chloro-5- (trifluoromethyl) benzene can be used to synthesize special polymer materials. The halogen atoms on the benzene ring can participate in the polymerization reaction to build polymers with special structures and properties. For example, polymerization with specific monomers can prepare high temperature and chemical corrosion resistant polymer materials, which are used in aerospace, electronics industry and other fields. Due to its unique chemical structure, it can endow materials with good thermal stability, electrical and mechanical properties, meeting the needs of high-end fields for special properties of materials.
Fourth, in the study of organic synthetic chemistry, this compound is an important model substrate. Chemists use various chemical reactions to study it to explore new synthesis methods and reaction mechanisms. For example, studying the substitution reaction conditions, selectivity and influencing factors of its halogen atoms provides theoretical basis and practical guidance for the synthesis of other similar compounds, and promotes the development and innovation of organic synthetic chemistry.
What are the synthesis methods of 1 - bromo - 3 - chloro - 5 - (trifluoromethyl) benzene?
The common methods for synthesizing 1 + -bromo-3-chloro-5- (trifluoromethyl) benzene are as follows.
First, the benzene derivative containing the appropriate substituent is used as the starting material. The benzene compound with the appropriate positioning group can be taken first, and bromine, chlorine and trifluoromethyl can be introduced by electrophilic substitution reaction. For example, if there is a positioning group on the starting benzene ring that can guide the electrophilic reagent to a specific position, under appropriate conditions, the interaction of a brominating reagent, such as bromine, with a suitable catalyst (such as iron filings or iron tribromide) can replace the bromine atom to the position guided by the positioning group to obtain a bromine-containing intermediate product. Subsequently, the conditions are changed, and the chlorination reaction is carried out using chlorine reagents (such as chlorine gas and appropriate catalysts), so that the desired halogen atom and trifluoromethyl are gradually introduced. This process requires fine control of the reaction conditions, because different substituents have different effects on the subsequent reaction check point. Temperature, reactant ratio, catalyst type, etc. all have a great influence on the reaction process and product selectivity.
Second, synthesized by halogen exchange reaction. First prepare benzene derivatives containing other halogens but in the right position, and then replace the halogen with the target bromine and chlorine atoms through halogen exchange reaction with suitable reagents. For example, using iodine or fluorine-containing benzene derivatives as starting materials, in the presence of specific solvents and catalysts, exchange reactions with bromide or chloride are carried out. The selection of suitable halogen exchange reagents and the control of reaction conditions are essential for the successful acquisition of the target product. A suitable solvent needs to have good solubility to the reactants and products without interfering with the reaction; the choice of catalyst depends on the specific type of halogen exchange reaction, which can speed up the reaction rate and increase the yield.
Third, use metal-organic chemistry methods. Using aryl halides as raw materials, react with metal reagents (such as organolithium reagents or Grignard reagents) to generate metal-organic intermediates. This intermediate can be further reacted with reagents containing bromine, chlorine and trifluoromethyl to construct the structure of the target product. For example, the aryl halide is first combined with an organolithium reagent to form an aryl lithium reagent, and then it is reacted with reagents such as halogenated hydrocarbons or acyl halides containing bromine, chlorine, and trifluoromethyl. The advantage of this method is that the reaction is highly selective, but the metal reagents have high activity, and the reaction conditions are demanding. It needs to be operated in an anhydrous and oxygen-free environment, and the reagents used for the reaction are relatively expensive and costly.
First, the benzene derivative containing the appropriate substituent is used as the starting material. The benzene compound with the appropriate positioning group can be taken first, and bromine, chlorine and trifluoromethyl can be introduced by electrophilic substitution reaction. For example, if there is a positioning group on the starting benzene ring that can guide the electrophilic reagent to a specific position, under appropriate conditions, the interaction of a brominating reagent, such as bromine, with a suitable catalyst (such as iron filings or iron tribromide) can replace the bromine atom to the position guided by the positioning group to obtain a bromine-containing intermediate product. Subsequently, the conditions are changed, and the chlorination reaction is carried out using chlorine reagents (such as chlorine gas and appropriate catalysts), so that the desired halogen atom and trifluoromethyl are gradually introduced. This process requires fine control of the reaction conditions, because different substituents have different effects on the subsequent reaction check point. Temperature, reactant ratio, catalyst type, etc. all have a great influence on the reaction process and product selectivity.
Second, synthesized by halogen exchange reaction. First prepare benzene derivatives containing other halogens but in the right position, and then replace the halogen with the target bromine and chlorine atoms through halogen exchange reaction with suitable reagents. For example, using iodine or fluorine-containing benzene derivatives as starting materials, in the presence of specific solvents and catalysts, exchange reactions with bromide or chloride are carried out. The selection of suitable halogen exchange reagents and the control of reaction conditions are essential for the successful acquisition of the target product. A suitable solvent needs to have good solubility to the reactants and products without interfering with the reaction; the choice of catalyst depends on the specific type of halogen exchange reaction, which can speed up the reaction rate and increase the yield.
Third, use metal-organic chemistry methods. Using aryl halides as raw materials, react with metal reagents (such as organolithium reagents or Grignard reagents) to generate metal-organic intermediates. This intermediate can be further reacted with reagents containing bromine, chlorine and trifluoromethyl to construct the structure of the target product. For example, the aryl halide is first combined with an organolithium reagent to form an aryl lithium reagent, and then it is reacted with reagents such as halogenated hydrocarbons or acyl halides containing bromine, chlorine, and trifluoromethyl. The advantage of this method is that the reaction is highly selective, but the metal reagents have high activity, and the reaction conditions are demanding. It needs to be operated in an anhydrous and oxygen-free environment, and the reagents used for the reaction are relatively expensive and costly.
1 - bromo - 3 - chloro - 5 - (trifluoromethyl) benzene what are the precautions in storage and transportation?
1 + -Bromo-3 + -chloro-5 + - (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
Its properties have certain chemical activity. When stored, the first environment is dry and cool. If it is in a humid place, water vapor may react with the compound and cause it to deteriorate. And the temperature is too high, or it may cause the acceleration of chemical reactions and damage its quality, so it should be controlled at a suitable low temperature.
Furthermore, this compound may be toxic and irritating, and the storage place should be away from people and food and beverages. There must be obvious warning labels so that people know its danger. When transporting, the packaging must be solid and reliable. In order to prevent the package from being damaged due to vibration and collision, and the compound from leaking.
Due to its chemical properties, it is not allowed to be stored and transported with reactive substances such as oxidizers and reducing agents. If mixed, or cause violent chemical reactions, endangering safety. Transportation vehicles should also have corresponding protective facilities and emergency treatment equipment for emergencies. During loading and unloading, operators must wear appropriate protective equipment, such as gloves, goggles, etc., to prevent contact with compounds and injure themselves. In this way, it is necessary to ensure the safety of 1 + -bromo-3 + -chloro-5 + - (trifluoromethyl) benzene in storage and transportation.
Its properties have certain chemical activity. When stored, the first environment is dry and cool. If it is in a humid place, water vapor may react with the compound and cause it to deteriorate. And the temperature is too high, or it may cause the acceleration of chemical reactions and damage its quality, so it should be controlled at a suitable low temperature.
Furthermore, this compound may be toxic and irritating, and the storage place should be away from people and food and beverages. There must be obvious warning labels so that people know its danger. When transporting, the packaging must be solid and reliable. In order to prevent the package from being damaged due to vibration and collision, and the compound from leaking.
Due to its chemical properties, it is not allowed to be stored and transported with reactive substances such as oxidizers and reducing agents. If mixed, or cause violent chemical reactions, endangering safety. Transportation vehicles should also have corresponding protective facilities and emergency treatment equipment for emergencies. During loading and unloading, operators must wear appropriate protective equipment, such as gloves, goggles, etc., to prevent contact with compounds and injure themselves. In this way, it is necessary to ensure the safety of 1 + -bromo-3 + -chloro-5 + - (trifluoromethyl) benzene in storage and transportation.
What are the effects of 1 - bromo - 3 - chloro - 5 - (trifluoromethyl) benzene on the environment and human health?
1 + -Bromo-3-chloro-5- (trifluoromethyl) benzene is also an organic compound. Its impact on the environment and human health cannot be ignored.
At the environmental end, this substance has high stability, is difficult to degrade naturally, or causes long-term residual accumulation in the environment. It enters the soil, or changes the properties of the soil, hindering plant growth. Enter water bodies or sewage sources, endangering aquatic organisms. After ingestion of aquatic organisms, it may cause abnormal physiological functions and affect population reproduction. And because of its volatility, after entering the atmosphere, it may participate in photochemical reactions, disturbing the atmospheric environment and reducing air quality.
As for human health, 1 + -bromo-3-chloro-5- (trifluoromethyl) benzene can enter the human body through respiration, diet, skin contact, etc. It may be a neurotoxin, which damages the nervous system and causes headaches, dizziness, fatigue, insomnia, etc. Long-term exposure may increase the risk of neurodegenerative diseases. In addition, it may be reproductive toxic, affecting the reproductive system, causing decreased reproductive capacity and abnormal fetal development. Animal experiments have shown that this substance may be potentially carcinogenic, and long-term exposure may increase the risk of cancer. Therefore, in the production, use, and disposal of 1 + -bromo-3 -chloro-5- (trifluoromethyl) benzene, careful measures should be taken to control its release into the environment and protect the ecological environment and human health.
At the environmental end, this substance has high stability, is difficult to degrade naturally, or causes long-term residual accumulation in the environment. It enters the soil, or changes the properties of the soil, hindering plant growth. Enter water bodies or sewage sources, endangering aquatic organisms. After ingestion of aquatic organisms, it may cause abnormal physiological functions and affect population reproduction. And because of its volatility, after entering the atmosphere, it may participate in photochemical reactions, disturbing the atmospheric environment and reducing air quality.
As for human health, 1 + -bromo-3-chloro-5- (trifluoromethyl) benzene can enter the human body through respiration, diet, skin contact, etc. It may be a neurotoxin, which damages the nervous system and causes headaches, dizziness, fatigue, insomnia, etc. Long-term exposure may increase the risk of neurodegenerative diseases. In addition, it may be reproductive toxic, affecting the reproductive system, causing decreased reproductive capacity and abnormal fetal development. Animal experiments have shown that this substance may be potentially carcinogenic, and long-term exposure may increase the risk of cancer. Therefore, in the production, use, and disposal of 1 + -bromo-3 -chloro-5- (trifluoromethyl) benzene, careful measures should be taken to control its release into the environment and protect the ecological environment and human health.
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