Linshang Chemical
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1-Bromo-3-Chloro-6-Fluorobenzene
Linshang Chemical
|
HS Code |
471037 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 211.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 190 - 200 °C |
| Density | Around 1.7 - 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Pungent odor |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 1-Bromo-3-Chloro-6-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 3 - chloro - 6 - fluorobenzene packaged in a sealed glass bottle. |
| Storage | 1 - Bromo - 3 - chloro - 6 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. Use appropriate labeling for easy identification and safety. |
| Shipping | 1 - Bromo - 3 - chloro - 6 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring proper handling to prevent leakage and maintain safety during transit. |
Competitive 1-Bromo-3-Chloro-6-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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Where to Buy 1-Bromo-3-Chloro-6-Fluorobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-3-Chloro-6-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1 - bromo - 3 - chloro - 6 - fluorobenzene
1-Bromo-3-chloro-6-fluorobenzene is a kind of organic compound. Its physical properties are particularly important, related to its application and characteristics.
Looking at its properties, under normal temperature and pressure, 1-bromo-3-chloro-6-fluorobenzene is often colorless to light yellow liquid. This appearance feature is easy to identify and initially distinguish. It has a certain volatility and can be slowly emitted in the air.
When it comes to boiling point, it is about a specific temperature range. The value of this boiling point has a significant impact on its separation, purification and existence under different temperature conditions. In operations such as distillation, the characteristics of boiling point can help to achieve effective separation from other substances.
Melting point is also one of the important physical properties. The melting point of 1-bromo-3-chloro-6-fluorobenzene determines its state transition in a low temperature environment. When the temperature drops below the melting point, the compound will change from liquid to solid.
Its density is different from that of water, which is of great significance in processes such as liquid-liquid separation. If mixed with water, its position in the system can be determined according to the density difference, and then the corresponding separation means can be implemented.
In terms of solubility, 1-bromo-3-chloro-6-fluorobenzene exhibits different degrees of solubility in organic solvents. In some organic solvents, such as ethanol and ether, it may have good solubility, but its solubility in water is relatively limited. This solubility characteristic affects its application in the selection of chemical reaction media and product separation.
In addition, the vapor pressure of 1-bromo-3-chloro-6-fluorobenzene is also a physical property that cannot be ignored. The magnitude of the vapor pressure reflects the difficulty of volatilization at a certain temperature, and has a related impact on the safety of its storage and use environment.
In summary, the physical properties of 1-bromo-3-chloro-6-fluorobenzene, such as properties, boiling point, melting point, density, solubility, and vapor pressure, are interrelated and play an important role. They need to be carefully considered in the research and application of many fields such as organic synthesis and chemical production.
Looking at its properties, under normal temperature and pressure, 1-bromo-3-chloro-6-fluorobenzene is often colorless to light yellow liquid. This appearance feature is easy to identify and initially distinguish. It has a certain volatility and can be slowly emitted in the air.
When it comes to boiling point, it is about a specific temperature range. The value of this boiling point has a significant impact on its separation, purification and existence under different temperature conditions. In operations such as distillation, the characteristics of boiling point can help to achieve effective separation from other substances.
Melting point is also one of the important physical properties. The melting point of 1-bromo-3-chloro-6-fluorobenzene determines its state transition in a low temperature environment. When the temperature drops below the melting point, the compound will change from liquid to solid.
Its density is different from that of water, which is of great significance in processes such as liquid-liquid separation. If mixed with water, its position in the system can be determined according to the density difference, and then the corresponding separation means can be implemented.
In terms of solubility, 1-bromo-3-chloro-6-fluorobenzene exhibits different degrees of solubility in organic solvents. In some organic solvents, such as ethanol and ether, it may have good solubility, but its solubility in water is relatively limited. This solubility characteristic affects its application in the selection of chemical reaction media and product separation.
In addition, the vapor pressure of 1-bromo-3-chloro-6-fluorobenzene is also a physical property that cannot be ignored. The magnitude of the vapor pressure reflects the difficulty of volatilization at a certain temperature, and has a related impact on the safety of its storage and use environment.
In summary, the physical properties of 1-bromo-3-chloro-6-fluorobenzene, such as properties, boiling point, melting point, density, solubility, and vapor pressure, are interrelated and play an important role. They need to be carefully considered in the research and application of many fields such as organic synthesis and chemical production.
Chemical properties of 1 - bromo - 3 - chloro - 6 - fluorobenzene
1-Bromo-3-chloro-6-fluorobenzene is one of the organohalogenated aromatic hydrocarbons. Its chemical properties are unique, due to the existence of halogen atoms on the benzene ring, and it has diverse reaction characteristics.
The first word is nucleophilic substitution reaction. Because the halogen atom is affected by the electron cloud of the benzene ring, the density of the adjacent electron cloud of the halogen atom decreases, and the nucleophilic reagent is easy to attack. For example, when encountering hydroxyl negative ions, under appropriate conditions, the bromine atom can be replaced by hydroxyl groups to form corresponding phenolic compounds. In this reaction, the nucleophilic reagent hydroxyl negative ions attack the carbon atom connected to the bromine atom with their electron-rich properties, and the bromine ions leave and form new bonds.
Although there are already halogen atoms on the benzene ring, which are blunt groups, electrophilic substitution can still occur. Because the halogen atom has a lone pair of electrons, it can be conjugated with the benzene ring, so that the electron cloud density of the benzene ring is relatively concentrated in the ortho-para-position. Therefore, electrophilic reagents such as nitro positive ions are more likely to attack the ortho-para-position of the halogen atom, and nitrification reactions occur to form nitro substitutes.
There are differences in the activity of halogen atoms. Generally speaking, when fluorine atoms are connected to benzene rings, they are relatively difficult to be replaced because of their high electronegativity and high C-F bond energy; while bromine atoms and chlorine atoms, C-Br and C-Cl bond energy is lower than C-F bond energy, relatively active, and under appropriate conditions, it is easier to participate in the substitution reaction.
The chemical properties of 1-bromo-3-chloro-6-fluorobenzene are formed by the interaction of benzene rings and halogen atoms. Nucleophilic and electrophilic substitution reactions are the main types of reactions. The difference in the activity of halogen atoms is also an important characteristic, which is of great significance in organic synthesis and related fields.
The first word is nucleophilic substitution reaction. Because the halogen atom is affected by the electron cloud of the benzene ring, the density of the adjacent electron cloud of the halogen atom decreases, and the nucleophilic reagent is easy to attack. For example, when encountering hydroxyl negative ions, under appropriate conditions, the bromine atom can be replaced by hydroxyl groups to form corresponding phenolic compounds. In this reaction, the nucleophilic reagent hydroxyl negative ions attack the carbon atom connected to the bromine atom with their electron-rich properties, and the bromine ions leave and form new bonds.
Although there are already halogen atoms on the benzene ring, which are blunt groups, electrophilic substitution can still occur. Because the halogen atom has a lone pair of electrons, it can be conjugated with the benzene ring, so that the electron cloud density of the benzene ring is relatively concentrated in the ortho-para-position. Therefore, electrophilic reagents such as nitro positive ions are more likely to attack the ortho-para-position of the halogen atom, and nitrification reactions occur to form nitro substitutes.
There are differences in the activity of halogen atoms. Generally speaking, when fluorine atoms are connected to benzene rings, they are relatively difficult to be replaced because of their high electronegativity and high C-F bond energy; while bromine atoms and chlorine atoms, C-Br and C-Cl bond energy is lower than C-F bond energy, relatively active, and under appropriate conditions, it is easier to participate in the substitution reaction.
The chemical properties of 1-bromo-3-chloro-6-fluorobenzene are formed by the interaction of benzene rings and halogen atoms. Nucleophilic and electrophilic substitution reactions are the main types of reactions. The difference in the activity of halogen atoms is also an important characteristic, which is of great significance in organic synthesis and related fields.
Where is 1 - bromo - 3 - chloro - 6 - fluorobenzene used?
1 + -Bromo-3-chloro-6-fluorobenzene is useful in many fields.
In the field of pharmaceutical and chemical industry, it can be an important intermediate in organic synthesis. Due to its unique chemical structure, it can participate in a variety of chemical reactions, and can be converted into compounds with specific pharmacological activities through carefully designed synthesis paths. For example, when developing new antibacterial drugs, using this as a starting material, by modifying and transforming the substituents on its benzene ring, a unique molecular skeleton can be constructed, which is expected to obtain antibacterial ingredients with high inhibitory effect on specific pathogens.
In the field of materials science, this compound also has potential value. Based on it, polymer materials with special properties can be prepared by polymerization or combining with other functional monomers. For example, its halogen-containing properties can endow the material with certain flame retardant properties, or adjust the electrical and optical properties of the material, which can be used to make electronic materials or optical materials for special purposes.
Furthermore, in the field of pesticide research and development, 1 + -bromo-3-chloro-6-fluorobenzene can be used as a key intermediate for the synthesis of new pesticides. After reasonable structural modification and derivatization, high-efficiency and low-toxicity pesticide products for specific pests or weeds can be developed. Through its interaction with specific biological targets in pests or weeds, it precisely exerts its medicinal effect, is environmentally friendly, and reduces the impact on non-target organisms.
In summary, 1 + -bromo-3-chloro-6-fluorobenzene has shown important application potential in many fields such as medicine, materials, and pesticides. With the continuous development of science and technology, its application prospects may become broader.
In the field of pharmaceutical and chemical industry, it can be an important intermediate in organic synthesis. Due to its unique chemical structure, it can participate in a variety of chemical reactions, and can be converted into compounds with specific pharmacological activities through carefully designed synthesis paths. For example, when developing new antibacterial drugs, using this as a starting material, by modifying and transforming the substituents on its benzene ring, a unique molecular skeleton can be constructed, which is expected to obtain antibacterial ingredients with high inhibitory effect on specific pathogens.
In the field of materials science, this compound also has potential value. Based on it, polymer materials with special properties can be prepared by polymerization or combining with other functional monomers. For example, its halogen-containing properties can endow the material with certain flame retardant properties, or adjust the electrical and optical properties of the material, which can be used to make electronic materials or optical materials for special purposes.
Furthermore, in the field of pesticide research and development, 1 + -bromo-3-chloro-6-fluorobenzene can be used as a key intermediate for the synthesis of new pesticides. After reasonable structural modification and derivatization, high-efficiency and low-toxicity pesticide products for specific pests or weeds can be developed. Through its interaction with specific biological targets in pests or weeds, it precisely exerts its medicinal effect, is environmentally friendly, and reduces the impact on non-target organisms.
In summary, 1 + -bromo-3-chloro-6-fluorobenzene has shown important application potential in many fields such as medicine, materials, and pesticides. With the continuous development of science and technology, its application prospects may become broader.
What is the synthesis method of 1 - bromo - 3 - chloro - 6 - fluorobenzene
The synthesis of 1 + -bromo-3 -chloro-6 -fluorobenzene is an important topic in the field of organic synthesis. To synthesize this compound, you can follow the following steps.
The first step is to select a suitable starting material. Benzene is often used as the starting material, because of its stable aromatic ring structure, it is easy to carry out various substitution reactions.
The second step is to introduce bromine atoms. A bromination reaction can be used, and iron bromide or iron powder can be used as the catalyst to make benzene and bromine undergo an electrophilic substitution reaction to generate bromobenzene. In this reaction, the catalyst can promote the polarization of bromine molecules, making it easier to attack the benzene ring and generate bromobenzene.
The third step is to introduce chlorine atoms. On the basis of bromobenzene, it can be achieved by a similar chlorination reaction. Using ferric chloride as a catalyst, bromobenzene reacts with chlorine gas to obtain 1-bromo-3-chlorobenzene. This step requires attention to the control of reaction conditions, such as temperature, reactant ratio, etc., to ensure that chlorine atoms are precisely replaced to the target position.
Last step, fluorine atoms are introduced. Generally, nucleophilic substitution can be used. Use 1-bromo-3-chlorobenzene as a substrate and react with fluorinated reagents (such as potassium fluoride, etc.) in an appropriate organic solvent (such as dimethyl sulfoxide, etc.). This reaction needs to be carried out under heating conditions to promote the replacement of fluorine atoms with bromine atoms, and finally obtain 1 + -bromo-3-chloro-6-fluorobenzene.
During the synthesis process, the control of reaction conditions at each step, the proportion of reactants and the purification of intermediate products are all crucial, which are related to the purity and yield of the final product.
The first step is to select a suitable starting material. Benzene is often used as the starting material, because of its stable aromatic ring structure, it is easy to carry out various substitution reactions.
The second step is to introduce bromine atoms. A bromination reaction can be used, and iron bromide or iron powder can be used as the catalyst to make benzene and bromine undergo an electrophilic substitution reaction to generate bromobenzene. In this reaction, the catalyst can promote the polarization of bromine molecules, making it easier to attack the benzene ring and generate bromobenzene.
The third step is to introduce chlorine atoms. On the basis of bromobenzene, it can be achieved by a similar chlorination reaction. Using ferric chloride as a catalyst, bromobenzene reacts with chlorine gas to obtain 1-bromo-3-chlorobenzene. This step requires attention to the control of reaction conditions, such as temperature, reactant ratio, etc., to ensure that chlorine atoms are precisely replaced to the target position.
Last step, fluorine atoms are introduced. Generally, nucleophilic substitution can be used. Use 1-bromo-3-chlorobenzene as a substrate and react with fluorinated reagents (such as potassium fluoride, etc.) in an appropriate organic solvent (such as dimethyl sulfoxide, etc.). This reaction needs to be carried out under heating conditions to promote the replacement of fluorine atoms with bromine atoms, and finally obtain 1 + -bromo-3-chloro-6-fluorobenzene.
During the synthesis process, the control of reaction conditions at each step, the proportion of reactants and the purification of intermediate products are all crucial, which are related to the purity and yield of the final product.
What are the environmental effects of 1 - bromo - 3 - chloro - 6 - fluorobenzene
1 + -Bromo-3 + -chloro-6 + -fluorobenzene is one of the organic compounds. Its impact on the environment is quite complex and needs to be investigated in detail.
This compound has the characteristics of halogenated aromatics. The presence of bromine, chlorine and fluorine atoms makes its chemical properties different from ordinary benzene. First, due to the high electronegativity of halogen atoms, the electron cloud density of the benzene ring can be changed, resulting in different chemical reactivity. This may affect its tendency to participate in various chemical reactions in the environment.
In terms of environmental migration, 1 + -bromo-3 + -chloro-6 + -fluorobenzene has certain volatility and can be transported in the atmosphere. However, the presence of halogen atoms increases the probability of reaction with active substances in the atmosphere, such as hydroxyl radicals. Once reacted, new compounds may be formed, or degraded through a series of reactions.
In the water environment, due to its hydrophobicity, it is difficult to dissolve in water, and it tends to be adsorbed on suspended particles or sediments. If it enters the soil, it is also easily adsorbed by soil organic matter, slowing down its migration rate in the soil.
Its impact on organisms cannot be ignored. The enzyme system in organisms may be disturbed due to this. Halogen atoms can interact with the activity check point of enzymes, change the conformation and function of enzymes, and then affect the normal physiological metabolism of organisms. In the food chain, or due to bioaccumulation, the concentration gradually increases, posing a potential threat to high trophic organisms.
In short, the chemical behavior and ecological impact of 1 + -bromo-3 + -chloro-6 + -fluorobenzene in the environment depend on its special molecular structure and are interrelated with many factors in environmental media. Studying its impact is crucial for environmental safety.
This compound has the characteristics of halogenated aromatics. The presence of bromine, chlorine and fluorine atoms makes its chemical properties different from ordinary benzene. First, due to the high electronegativity of halogen atoms, the electron cloud density of the benzene ring can be changed, resulting in different chemical reactivity. This may affect its tendency to participate in various chemical reactions in the environment.
In terms of environmental migration, 1 + -bromo-3 + -chloro-6 + -fluorobenzene has certain volatility and can be transported in the atmosphere. However, the presence of halogen atoms increases the probability of reaction with active substances in the atmosphere, such as hydroxyl radicals. Once reacted, new compounds may be formed, or degraded through a series of reactions.
In the water environment, due to its hydrophobicity, it is difficult to dissolve in water, and it tends to be adsorbed on suspended particles or sediments. If it enters the soil, it is also easily adsorbed by soil organic matter, slowing down its migration rate in the soil.
Its impact on organisms cannot be ignored. The enzyme system in organisms may be disturbed due to this. Halogen atoms can interact with the activity check point of enzymes, change the conformation and function of enzymes, and then affect the normal physiological metabolism of organisms. In the food chain, or due to bioaccumulation, the concentration gradually increases, posing a potential threat to high trophic organisms.
In short, the chemical behavior and ecological impact of 1 + -bromo-3 + -chloro-6 + -fluorobenzene in the environment depend on its special molecular structure and are interrelated with many factors in environmental media. Studying its impact is crucial for environmental safety.
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