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1-Bromo-3-(Chloromethyl)Benzene
Linshang Chemical
|
HS Code |
363397 |
| Chemical Formula | C7H6BrCl |
| Molar Mass | 205.48 g/mol |
| Appearance | Colorless to light - yellow liquid |
| Boiling Point | Around 220 - 222 °C |
| Density | Approx. 1.58 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ether, chloroform |
| Flash Point | Around 97 °C |
| Hazard Class | Irritant, potentially harmful if swallowed, inhaled or in contact with skin |
As an accredited 1-Bromo-3-(Chloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - bromo - 3 - (chloromethyl)benzene in 500 - mL glass bottle, tightly sealed. |
| Storage | 1 - Bromo - 3 - (chloromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is flammable. Keep it in a tightly sealed container to prevent vapors from escaping. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. |
| Shipping | 1 - bromo - 3 - (chloromethyl)benzene is a chemical. Shipping should comply with regulations for hazardous substances. It must be properly packaged in sealed containers, labeled clearly, and transported by approved carriers following safety protocols. |
Competitive 1-Bromo-3-(Chloromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 1-bromo-3- (chloromethyl) benzene?
The main use of 1 + - + ether + - + 3 + - + (hydroxymethyl) benzene is an extremely important reagent in organic synthesis. In the field of organic synthesis, it can be used to build a variety of organic molecular structures and help synthesize many compounds with special structures and properties.
This ether compound is often used as a key intermediate in chemical reactions. For example, when building a complex carbon chain structure, it can interact with many nucleophiles and electrophiles under specific reaction conditions to achieve the formation of carbon-carbon bonds and carbon-heteroatomic bonds, thereby expanding the complexity of molecules.
In the field of medicinal chemistry, (hydroxymethyl) phenyl ethers may exhibit specific biological activities. In the process of drug development, such structural units are introduced to improve the physicochemical properties of drugs, such as solubility and stability, or to affect the interaction between drugs and targets, enhance their pharmacological activities, and enhance their pharmacological effects.
In addition, in the field of materials science, it may also have applications. It can be used as a monomer or starting material to participate in the synthesis of polymer materials, giving materials specific properties, such as improving the mechanical properties, thermal stability, and optical properties of materials. Due to the reactive group of (hydroxymethyl) phenyl ether, it can play a key role in the polymerization reaction, promoting the material to have a unique microstructure and macroscopic properties.
Furthermore, in the preparation of fine chemicals, it can be used to synthesize fine chemicals such as fragrances and dyes. With its special chemical structure, specific functional groups can be introduced into the reaction, thus giving the fine chemicals unique color, aroma and other properties. In short, 1 + - + ether + - + 3 + - + (hydroxymethyl) benzene has important uses in many fields such as organic synthesis, medicinal chemistry, materials science and preparation of fine chemicals.
This ether compound is often used as a key intermediate in chemical reactions. For example, when building a complex carbon chain structure, it can interact with many nucleophiles and electrophiles under specific reaction conditions to achieve the formation of carbon-carbon bonds and carbon-heteroatomic bonds, thereby expanding the complexity of molecules.
In the field of medicinal chemistry, (hydroxymethyl) phenyl ethers may exhibit specific biological activities. In the process of drug development, such structural units are introduced to improve the physicochemical properties of drugs, such as solubility and stability, or to affect the interaction between drugs and targets, enhance their pharmacological activities, and enhance their pharmacological effects.
In addition, in the field of materials science, it may also have applications. It can be used as a monomer or starting material to participate in the synthesis of polymer materials, giving materials specific properties, such as improving the mechanical properties, thermal stability, and optical properties of materials. Due to the reactive group of (hydroxymethyl) phenyl ether, it can play a key role in the polymerization reaction, promoting the material to have a unique microstructure and macroscopic properties.
Furthermore, in the preparation of fine chemicals, it can be used to synthesize fine chemicals such as fragrances and dyes. With its special chemical structure, specific functional groups can be introduced into the reaction, thus giving the fine chemicals unique color, aroma and other properties. In short, 1 + - + ether + - + 3 + - + (hydroxymethyl) benzene has important uses in many fields such as organic synthesis, medicinal chemistry, materials science and preparation of fine chemicals.
What are the physical properties of 1-bromo-3- (chloromethyl) benzene?
The physical properties of 1 + - mercury-3- (cyanomethyl) naphthalene are as follows:
mercury, the only metal that is liquid at room temperature. Silver-white, metallic luster, density is quite high, about 13.6 g/cm3, which makes it heavy to the touch. Its melting point is extremely low, -38.87 ° C, so it is in a flowing state at room temperature; the boiling point is not high, 356.6 ° C. Mercury has good electrical conductivity, but its thermal conductivity is slightly inferior to other common metals. Its surface tension is very high, so mercury droplets are often spherical and easy to roll on smooth surfaces. And mercury is volatile, forming mercury vapor, which is toxic and needs to be handled with caution.
As for (cyanomethyl) naphthalene, it is an organic compound. It is usually in a solid state and has a specific crystal structure. Its melting point and boiling point vary depending on the specific structure. Generally speaking, (cyanomethyl) naphthalene has a relatively high melting point and requires a certain temperature to melt into a liquid state. Its density is greater than that of water. If placed in water, it will sink to the bottom of the water. (cyanomethyl) naphthalene is insoluble in water because it is an organic compound and has hydrophobicity. However, it can be soluble in some organic solvents, such as ethanol, ether, etc., based on the principle of similar compatibility. Its appearance may be white to light yellow crystalline powder, which has a certain odor, and under light, heat and other conditions, or chemical reactions occur, causing its physical properties to change.
mercury, the only metal that is liquid at room temperature. Silver-white, metallic luster, density is quite high, about 13.6 g/cm3, which makes it heavy to the touch. Its melting point is extremely low, -38.87 ° C, so it is in a flowing state at room temperature; the boiling point is not high, 356.6 ° C. Mercury has good electrical conductivity, but its thermal conductivity is slightly inferior to other common metals. Its surface tension is very high, so mercury droplets are often spherical and easy to roll on smooth surfaces. And mercury is volatile, forming mercury vapor, which is toxic and needs to be handled with caution.
As for (cyanomethyl) naphthalene, it is an organic compound. It is usually in a solid state and has a specific crystal structure. Its melting point and boiling point vary depending on the specific structure. Generally speaking, (cyanomethyl) naphthalene has a relatively high melting point and requires a certain temperature to melt into a liquid state. Its density is greater than that of water. If placed in water, it will sink to the bottom of the water. (cyanomethyl) naphthalene is insoluble in water because it is an organic compound and has hydrophobicity. However, it can be soluble in some organic solvents, such as ethanol, ether, etc., based on the principle of similar compatibility. Its appearance may be white to light yellow crystalline powder, which has a certain odor, and under light, heat and other conditions, or chemical reactions occur, causing its physical properties to change.
What are the chemical properties of 1-bromo-3- (chloromethyl) benzene
1 + -Shen-3- (cyanomethyl) naphthalene is an organic compound, and its chemical properties are as follows:
1. ** Electrophilic substitution reaction **: The naphthalene ring has electron-rich properties, as the ancient books say "where electrons are enriched, electrophilic reagents flock". On the benzene ring, the electron cloud density is uneven, and the electron cloud density at the α position is higher than that at the β position, so the electrophilic substitution reaction mostly occurs at the α position. Taking the bromide reaction as an example, under the catalysis of iron tribromide, 1- (cyanomethyl) naphthalene-3-bromide reacts with bromine elemental, and bromine atoms will preferentially replace hydrogen atoms at the α position This is because electrophilic reagents tend to attack the high-density check point of the electron cloud to achieve the redistribution of the electron cloud and the stability of the structure.
2. ** Reaction of cyano groups **: Cyanyl (-CN) is active in nature and can be analogous to "active nuclei, which cause many changes". It can undergo hydrolysis reactions. Under acid or base catalysis, cyanyl groups can be gradually converted into carboxyl groups (-COOH). Under acidic conditions, Mr. Amide intermediates are formed, which are then hydrolyzed to carboxylic acids; under alkaline conditions, carboxylic acids are hydrolyzed to form carboxylic salts, which can be obtained by acidification. In addition, the cyanyl group can also participate in nucleophilic addition reactions, such as reacting with Grignard reagents. The cyanyl carbon atom acts as an electrophilic center and accepts the attack of carbon negative ions in Grignard reagents to generate compounds containing nitrogen and growing carbon chains, which enriches the structure and function of the molecule.
3. ** Redox reaction **: The naphthalene ring part can be oxidized, and strong oxidants such as acidic solutions of potassium dichromate can make the naphthalene ring oxidize and open the ring to generate corresponding oxygen-containing compounds. At the same time, the cyanyl group can also be reduced. For example, under the action of strong reducing agents such as lithium aluminum hydride, the cyanyl group can be reduced to amino methyl (-CH ² NH ²), which realizes the transformation of functional groups and the change of compound properties, just like "Phoenix nirvana, property rebirth
4. ** Substituent Effect **: Cyanomethyl as a substituent affects the distribution of the electron cloud of the naphthalene ring, causing the density of the electron cloud of the adjacent and para-position to increase relatively, and the meta-position to decrease relatively, thereby affecting the regioselectivity of the electrophilic substitution reaction. This substituent effect is like "affecting the whole body", which changes the reactivity and check point preference of the whole molecule. In organic synthesis, the reaction route can be designed accordingly to prepare compounds with specific structures.
1. ** Electrophilic substitution reaction **: The naphthalene ring has electron-rich properties, as the ancient books say "where electrons are enriched, electrophilic reagents flock". On the benzene ring, the electron cloud density is uneven, and the electron cloud density at the α position is higher than that at the β position, so the electrophilic substitution reaction mostly occurs at the α position. Taking the bromide reaction as an example, under the catalysis of iron tribromide, 1- (cyanomethyl) naphthalene-3-bromide reacts with bromine elemental, and bromine atoms will preferentially replace hydrogen atoms at the α position This is because electrophilic reagents tend to attack the high-density check point of the electron cloud to achieve the redistribution of the electron cloud and the stability of the structure.
2. ** Reaction of cyano groups **: Cyanyl (-CN) is active in nature and can be analogous to "active nuclei, which cause many changes". It can undergo hydrolysis reactions. Under acid or base catalysis, cyanyl groups can be gradually converted into carboxyl groups (-COOH). Under acidic conditions, Mr. Amide intermediates are formed, which are then hydrolyzed to carboxylic acids; under alkaline conditions, carboxylic acids are hydrolyzed to form carboxylic salts, which can be obtained by acidification. In addition, the cyanyl group can also participate in nucleophilic addition reactions, such as reacting with Grignard reagents. The cyanyl carbon atom acts as an electrophilic center and accepts the attack of carbon negative ions in Grignard reagents to generate compounds containing nitrogen and growing carbon chains, which enriches the structure and function of the molecule.
3. ** Redox reaction **: The naphthalene ring part can be oxidized, and strong oxidants such as acidic solutions of potassium dichromate can make the naphthalene ring oxidize and open the ring to generate corresponding oxygen-containing compounds. At the same time, the cyanyl group can also be reduced. For example, under the action of strong reducing agents such as lithium aluminum hydride, the cyanyl group can be reduced to amino methyl (-CH ² NH ²), which realizes the transformation of functional groups and the change of compound properties, just like "Phoenix nirvana, property rebirth
4. ** Substituent Effect **: Cyanomethyl as a substituent affects the distribution of the electron cloud of the naphthalene ring, causing the density of the electron cloud of the adjacent and para-position to increase relatively, and the meta-position to decrease relatively, thereby affecting the regioselectivity of the electrophilic substitution reaction. This substituent effect is like "affecting the whole body", which changes the reactivity and check point preference of the whole molecule. In organic synthesis, the reaction route can be designed accordingly to prepare compounds with specific structures.
Why is 1-bromo-3- (chloromethyl) benzene often used as a raw material in the synthesis?
1 + -ether-3- (cyanomethyl) benzyl is often used as a raw material in synthesis because of its unique chemical properties. Ethers have stable structures, can be used as reaction mediators, and can also participate in specific reaction pathways, providing a basic framework for the construction of complex molecules. The lone pair electrons of their oxygen atoms can complex with metal ions, or play an important role in reactions such as nucleophilic substitution.
As for 3- (cyanomethyl) benzyl, cyanyl is a strong electron-absorbing group, which can significantly affect the electron cloud distribution of benzyl and enhance its reactivity. Cyanyl can be converted through various reactions, such as hydrolysis to form carboxyl groups and reduction to amino groups, etc., expanding the derivation direction of compounds. Benzyl itself provides an aromatic and relatively stable skeleton, which is conducive to electrophilic substitution and other reactions on the benzene ring, creating conditions for the introduction of diverse functional groups.
The combination of the two in 1 + -ether-3- (cyanomethyl) benzyl, which has both the characteristics of ether and the activity of cyanomethyl benzyl, makes this compound widely used in the field of organic synthesis. It can be used in the preparation of pharmaceutical intermediates, which can be used to construct complex molecular structures with biological activity through subsequent reactions. It can also play a role in material synthesis, and form polymer materials with unique properties through specific reactions. In short, its structural properties make it a key starting material for the synthesis of many important compounds, and it occupies an important position in the stage of organic synthesis chemistry.
As for 3- (cyanomethyl) benzyl, cyanyl is a strong electron-absorbing group, which can significantly affect the electron cloud distribution of benzyl and enhance its reactivity. Cyanyl can be converted through various reactions, such as hydrolysis to form carboxyl groups and reduction to amino groups, etc., expanding the derivation direction of compounds. Benzyl itself provides an aromatic and relatively stable skeleton, which is conducive to electrophilic substitution and other reactions on the benzene ring, creating conditions for the introduction of diverse functional groups.
The combination of the two in 1 + -ether-3- (cyanomethyl) benzyl, which has both the characteristics of ether and the activity of cyanomethyl benzyl, makes this compound widely used in the field of organic synthesis. It can be used in the preparation of pharmaceutical intermediates, which can be used to construct complex molecular structures with biological activity through subsequent reactions. It can also play a role in material synthesis, and form polymer materials with unique properties through specific reactions. In short, its structural properties make it a key starting material for the synthesis of many important compounds, and it occupies an important position in the stage of organic synthesis chemistry.
What are the production methods of 1-bromo-3- (chloromethyl) benzene?
1. ** The method of making mercury from alum **:
- This is a common method. "Baopuzi Neiban Jindan" states: "Dan sand is burned into mercury, and the accumulation changes to Dan sand." Dan sand is mercury sulfide, and mercury can be obtained by calcining and decomposing. For the specific operation, first take an appropriate amount of Dan sand and place it in a special cauldron to seal the cauldron mouth. Heat it slowly with charcoal fire, and the firepower should be uniform and moderate. Dan sand is thermally decomposed, and the mercury element escapes in a gaseous state and is collected by condensation to obtain pure mercury. This process needs to be controlled by the heat. If the fire is fierce, the mercury is easy to evaporate and dissipate, and if the fire is small, it decomposes slowly.
- There are also those who use aluminium stone to assist in mercury production. Alumite can provide a specific environment when heated, which is conducive to the separation of mercury from mercury-containing minerals. Mix alumite and mercury-containing ore in a certain proportion and put it in a closed alchemy furnace. Calcined alternately by civil and military fire, simmer slowly first, so that the drug can initially react, and then burn quickly, accelerating the precipitation of mercury. Through the condensation device on the top of the furnace, the mercury vapor is condensed into liquid mercury, and collected for later use.
2. ** Made of (3- (methoxy) benzyl) mercury from shiting fat and mercury **:
- Shiting fat is sulfur. First grind shiting fat into fine powder, put it in a crucible, and heat it on low heat to melt it. Take an appropriate amount of mercury, slowly add it to the molten stone pavilion fat, and stir while adding to make it fully react to form mercury sulfide. This mercury sulfide reacts with methoxylbenzyl related substances in subsequent steps.
- Preparation of (methoxy) benzyl related reactants, which can be prepared by reacting the corresponding alcohol with halogenated benzyl under basic conditions. The obtained (methoxy) benzyl and the above-mentioned mercury sulfide are placed in a reaction kettle, and an appropriate amount of organic solvent and catalyst are added. Under suitable temperature and pressure, the reaction is stirred. After the reaction is completed, through separation, purification and other processes, 3 - (methoxy) benzyl mercury can be obtained. During separation, distillation, extraction and other methods are commonly used, depending on the physical properties of the product and impurities. Purification can be achieved by means of recrystallization to enhance the purity of the product.
- This is a common method. "Baopuzi Neiban Jindan" states: "Dan sand is burned into mercury, and the accumulation changes to Dan sand." Dan sand is mercury sulfide, and mercury can be obtained by calcining and decomposing. For the specific operation, first take an appropriate amount of Dan sand and place it in a special cauldron to seal the cauldron mouth. Heat it slowly with charcoal fire, and the firepower should be uniform and moderate. Dan sand is thermally decomposed, and the mercury element escapes in a gaseous state and is collected by condensation to obtain pure mercury. This process needs to be controlled by the heat. If the fire is fierce, the mercury is easy to evaporate and dissipate, and if the fire is small, it decomposes slowly.
- There are also those who use aluminium stone to assist in mercury production. Alumite can provide a specific environment when heated, which is conducive to the separation of mercury from mercury-containing minerals. Mix alumite and mercury-containing ore in a certain proportion and put it in a closed alchemy furnace. Calcined alternately by civil and military fire, simmer slowly first, so that the drug can initially react, and then burn quickly, accelerating the precipitation of mercury. Through the condensation device on the top of the furnace, the mercury vapor is condensed into liquid mercury, and collected for later use.
2. ** Made of (3- (methoxy) benzyl) mercury from shiting fat and mercury **:
- Shiting fat is sulfur. First grind shiting fat into fine powder, put it in a crucible, and heat it on low heat to melt it. Take an appropriate amount of mercury, slowly add it to the molten stone pavilion fat, and stir while adding to make it fully react to form mercury sulfide. This mercury sulfide reacts with methoxylbenzyl related substances in subsequent steps.
- Preparation of (methoxy) benzyl related reactants, which can be prepared by reacting the corresponding alcohol with halogenated benzyl under basic conditions. The obtained (methoxy) benzyl and the above-mentioned mercury sulfide are placed in a reaction kettle, and an appropriate amount of organic solvent and catalyst are added. Under suitable temperature and pressure, the reaction is stirred. After the reaction is completed, through separation, purification and other processes, 3 - (methoxy) benzyl mercury can be obtained. During separation, distillation, extraction and other methods are commonly used, depending on the physical properties of the product and impurities. Purification can be achieved by means of recrystallization to enhance the purity of the product.
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