Linshang Chemical
PRODUCTS
1-Bromo-4-Chloro-2,3-Difluorobenzene
|
HS Code |
240584 |
| Chemical Formula | C6H2BrClF2 |
| Molar Mass | 227.43 g/mol |
| Appearance | Liquid (likely, based on similar compounds) |
| Solubility In Water | Low solubility (aromatic halides generally have low water solubility) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ether |
As an accredited 1-Bromo-4-Chloro-2,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 4 - chloro - 2,3 - difluorobenzene packaged in a sealed glass bottle. |
| Storage | 1 - Bromo - 4 - chloro - 2,3 - difluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Avoid storing it near oxidizing agents, as this chemical may react. Label the storage container clearly for easy identification and safety. |
| Shipping | 1 - Bromo - 4 - chloro - 2,3 - difluorobenzene is a chemical. Shipping requires proper packaging in sealed, corrosion - resistant containers. It must comply with hazardous materials regulations, with clear labeling for safe transportation. |
Competitive 1-Bromo-4-Chloro-2,3-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Bromo-4-Chloro-2,3-Difluorobenzene in China?
As a trusted 1-Bromo-4-Chloro-2,3-Difluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-4-Chloro-2,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1-bromo-4-chloro-2,3-difluorobenzene?
1-Bromo-4-chloro-2,3-difluorobenzene is an organic compound with a wide range of main uses. In the field of organic synthesis, this compound is often used as a key intermediate. Due to its molecular structure containing many halogen atoms, it has high reactivity and can be converted to other more complex organic compounds through many chemical reactions, such as nucleophilic substitution reactions and metal catalytic coupling reactions.
In the field of medicinal chemistry, this compound also has important applications. Its halogen atoms can participate in the interaction between drug molecules and targets, which affects the activity and selectivity of drugs. Researchers can create new drug molecules with specific pharmacological activities by using 1-bromo-4-chloro-2,3-difluorobenzene as a starting material and through a series of chemical modification and synthesis steps.
In the field of materials science, this compound also shows potential value. Through the polymerization reaction or other chemical processes it participates in, functional materials with specific properties can be prepared, such as optoelectronic materials. Its halogen atom gives the material unique electronic and structural characteristics, which in turn affects the optical and electrical properties of the material. With its unique structure and reactivity, 1-bromo-4-chloro-2,3-difluorobenzene plays an indispensable role in many fields such as organic synthesis, drug development and material preparation, providing an important material basis and research starting point for many scientific research and industrial applications.
In the field of medicinal chemistry, this compound also has important applications. Its halogen atoms can participate in the interaction between drug molecules and targets, which affects the activity and selectivity of drugs. Researchers can create new drug molecules with specific pharmacological activities by using 1-bromo-4-chloro-2,3-difluorobenzene as a starting material and through a series of chemical modification and synthesis steps.
In the field of materials science, this compound also shows potential value. Through the polymerization reaction or other chemical processes it participates in, functional materials with specific properties can be prepared, such as optoelectronic materials. Its halogen atom gives the material unique electronic and structural characteristics, which in turn affects the optical and electrical properties of the material. With its unique structure and reactivity, 1-bromo-4-chloro-2,3-difluorobenzene plays an indispensable role in many fields such as organic synthesis, drug development and material preparation, providing an important material basis and research starting point for many scientific research and industrial applications.
What are the physical properties of 1-bromo-4-chloro-2,3-difluorobenzene?
1-Bromo-4-chloro-2,3-difluorobenzene is an organic compound, its physical properties are very critical, and it has a great impact in the fields of chemical industry and materials.
Looking at its properties, under room temperature and pressure, this compound is mostly colorless to light yellow liquid, with a clear texture and a very clear view. Its odor is specific, although it is difficult to describe accurately, it is often irritating. When using and operating, it is necessary to pay attention to protection.
Boiling point is an important indicator to measure its volatility. The boiling point of 1-bromo-4-chloro-2,3-difluorobenzene is moderate, and the specific value varies slightly according to the experimental conditions, which is roughly within a certain temperature range. This boiling point characteristic determines its performance in distillation, separation and other operations, and is of great significance to the design of industrial production processes.
Melting point is also one of the important physical properties. The low melting point of the compound indicates that it can change from solid to liquid at a lower temperature. This characteristic is helpful for the control of material form in the process of material processing and preparation.
In terms of density, the density of 1-bromo-4-chloro-2,3-difluorobenzene is greater than that of water, so it will sink to the bottom in water. This characteristic can provide a basis for the choice of separation method in liquid-liquid separation, extraction and other operations.
In terms of solubility, it has good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., but it is difficult to dissolve in water. This difference in solubility lays the foundation for the selection of solvents in its synthesis, purification and application. For example, in organic synthesis reactions, suitable solvents can be selected according to the solubility of reactants and products to promote the smooth progress of the reaction.
In addition, the vapor pressure of 1-bromo-4-chloro-2,3-difluorobenzene has a certain value at a specific temperature, reflecting its volatilization tendency. The magnitude of the vapor pressure affects its diffusion and concentration in the air, which is related to the safety of the operating environment. When storing and using, corresponding ventilation and sealing measures should be taken according to the characteristics of the vapor pressure.
Looking at its properties, under room temperature and pressure, this compound is mostly colorless to light yellow liquid, with a clear texture and a very clear view. Its odor is specific, although it is difficult to describe accurately, it is often irritating. When using and operating, it is necessary to pay attention to protection.
Boiling point is an important indicator to measure its volatility. The boiling point of 1-bromo-4-chloro-2,3-difluorobenzene is moderate, and the specific value varies slightly according to the experimental conditions, which is roughly within a certain temperature range. This boiling point characteristic determines its performance in distillation, separation and other operations, and is of great significance to the design of industrial production processes.
Melting point is also one of the important physical properties. The low melting point of the compound indicates that it can change from solid to liquid at a lower temperature. This characteristic is helpful for the control of material form in the process of material processing and preparation.
In terms of density, the density of 1-bromo-4-chloro-2,3-difluorobenzene is greater than that of water, so it will sink to the bottom in water. This characteristic can provide a basis for the choice of separation method in liquid-liquid separation, extraction and other operations.
In terms of solubility, it has good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., but it is difficult to dissolve in water. This difference in solubility lays the foundation for the selection of solvents in its synthesis, purification and application. For example, in organic synthesis reactions, suitable solvents can be selected according to the solubility of reactants and products to promote the smooth progress of the reaction.
In addition, the vapor pressure of 1-bromo-4-chloro-2,3-difluorobenzene has a certain value at a specific temperature, reflecting its volatilization tendency. The magnitude of the vapor pressure affects its diffusion and concentration in the air, which is related to the safety of the operating environment. When storing and using, corresponding ventilation and sealing measures should be taken according to the characteristics of the vapor pressure.
Is 1-bromo-4-chloro-2,3-difluorobenzene chemically stable?
1-Bromo-4-chloro-2,3-difluorobenzene is an organohalogenated aromatic hydrocarbon. The stability of its chemical properties needs to be viewed from the molecular structure. In this molecule, the benzene ring has a conjugated large π bond, which gives it a certain stability. However, the halogen atoms such as bromine, chlorine and fluorine attached to it also have a significant impact on its properties.
First of all, the electronegativity of the halogen atom. The electronegativity of bromine, chlorine and fluorine is greater than that of carbon. When connected to the benzene ring, it will absorb electrons and cause the electron cloud density of the benzene ring to decrease. This decreases the electrophilic substitution activity of the benzene ring, which is more difficult to occur than benzene. For example, benzene can be easily brominated with bromine catalyzed by iron bromide, while similar reactions in this compound require more severe conditions.
From the perspective of the reactivity of halogen atoms, different halogen atoms have different reactivity due to differences in atomic radius and bond energy. Usually, the order of carbon-halogen bond energy is C-F > C-Cl > C-Br. The higher the bond energy, the higher the energy required for fracture, and the lower the reactivity. Therefore, in this compound, bromine atoms are relatively more prone to substitution reactions. For example, in nucleophilic substitution reactions, bromine atoms can be replaced by nucleophiles, while fluorine atoms are more difficult to be replaced due to high C-F bond energy.
In addition, from the perspective of steric hindrance, multiple halogen atoms on the benzene ring are replaced, resulting in a certain steric hindrance. Spatial hindrance will affect the proximity of the reagent to the benzene ring and halogen atoms, thus affecting the reaction rate and selectivity. For example, when nucleophiles attack halogen atoms, it is more difficult to carry out reactions with large steric hindrance.
Overall, 1-bromo-4-chloro-2,3-difluorobenzene has certain chemical stability due to the conjugation system of benzene rings and the electron-absorbing effect of halogen atoms. However, the existence of halogen atoms makes it possible to undergo many chemical reactions, and the stability is not absolute. Under suitable conditions, it can participate in a variety of reactions. Its chemical properties are the result of
First of all, the electronegativity of the halogen atom. The electronegativity of bromine, chlorine and fluorine is greater than that of carbon. When connected to the benzene ring, it will absorb electrons and cause the electron cloud density of the benzene ring to decrease. This decreases the electrophilic substitution activity of the benzene ring, which is more difficult to occur than benzene. For example, benzene can be easily brominated with bromine catalyzed by iron bromide, while similar reactions in this compound require more severe conditions.
From the perspective of the reactivity of halogen atoms, different halogen atoms have different reactivity due to differences in atomic radius and bond energy. Usually, the order of carbon-halogen bond energy is C-F > C-Cl > C-Br. The higher the bond energy, the higher the energy required for fracture, and the lower the reactivity. Therefore, in this compound, bromine atoms are relatively more prone to substitution reactions. For example, in nucleophilic substitution reactions, bromine atoms can be replaced by nucleophiles, while fluorine atoms are more difficult to be replaced due to high C-F bond energy.
In addition, from the perspective of steric hindrance, multiple halogen atoms on the benzene ring are replaced, resulting in a certain steric hindrance. Spatial hindrance will affect the proximity of the reagent to the benzene ring and halogen atoms, thus affecting the reaction rate and selectivity. For example, when nucleophiles attack halogen atoms, it is more difficult to carry out reactions with large steric hindrance.
Overall, 1-bromo-4-chloro-2,3-difluorobenzene has certain chemical stability due to the conjugation system of benzene rings and the electron-absorbing effect of halogen atoms. However, the existence of halogen atoms makes it possible to undergo many chemical reactions, and the stability is not absolute. Under suitable conditions, it can participate in a variety of reactions. Its chemical properties are the result of
What are the synthesis methods of 1-bromo-4-chloro-2,3-difluorobenzene?
The synthesis of 1-bromo-4-chloro-2,3-difluorobenzene follows the path of organic synthesis. There are three methods, and let me tell you one by one.
First, halogenated aromatics are used as starting materials. First, take aromatic hydrocarbons containing appropriate substituents, such as p-chlorobromobenzene as a group. After a specific halogenation reaction of p-chlorobromobenzene, fluorine atoms can be attracted to the benzene ring. To perform this step, it is often necessary to choose a suitable fluorination reagent, such as anhydrous potassium fluoride, and heat it in a suitable solvent, such as dimethyl sulfoxide (DMSO), to promote the reaction. In this process, the amount of fluorination reagent, reaction temperature and time are all key factors. Fine regulation is required to introduce fluorine atoms into the 2,3-position accurately, and finally obtain 1-bromo-4-chloro-2,3-difluorobenzene.
Second, benzene is used as the starting material to construct the target product through a multi-step reaction. Benzene is first halogenated, and bromine and chlorine atoms are introduced in turn to obtain 1-bromo-4-chlorobenzene. In this step of halogenation, different halogenating reagents can be selected, such as bromine atoms are introduced by the reaction with bromine catalyzed by iron bromide, and then chlorine atoms are introduced in a similar manner. Then, the fluorination reaction is carried out again. The fluorination conditions in this step are different from the former. Milder conditions or specific fluorination catalysts can be used to successfully introduce fluorine atoms into the 2,3-position. After multiple steps and careful operation, the target product can be synthesized.
Third, fluorine-containing aromatics are used as starting materials. If you find aromatics containing fluorine with appropriate substitution check points, you can follow the halogenation reaction path and introduce bromine and chlorine atoms in sequence. In this process, the activity of the halogenating reagent, the reaction sequence, and the control of the reaction conditions are all related to the success or failure of the reaction. If a halogenating agent with moderate activity is selected to avoid excessive halogenation or halogenation position deviation, and the reaction steps are cleverly designed, the synthesis of 1-bromo-4-chloro-2,3-difluorobenzene is finally achieved.
Synthesis of 1-bromo-4-chloro-2,3-difluorobenzene, each method has its own advantages and disadvantages, and needs to be weighed according to the actual situation, such as the availability of raw materials, cost, and controllability of reaction conditions, in order to achieve the best synthetic effect.
First, halogenated aromatics are used as starting materials. First, take aromatic hydrocarbons containing appropriate substituents, such as p-chlorobromobenzene as a group. After a specific halogenation reaction of p-chlorobromobenzene, fluorine atoms can be attracted to the benzene ring. To perform this step, it is often necessary to choose a suitable fluorination reagent, such as anhydrous potassium fluoride, and heat it in a suitable solvent, such as dimethyl sulfoxide (DMSO), to promote the reaction. In this process, the amount of fluorination reagent, reaction temperature and time are all key factors. Fine regulation is required to introduce fluorine atoms into the 2,3-position accurately, and finally obtain 1-bromo-4-chloro-2,3-difluorobenzene.
Second, benzene is used as the starting material to construct the target product through a multi-step reaction. Benzene is first halogenated, and bromine and chlorine atoms are introduced in turn to obtain 1-bromo-4-chlorobenzene. In this step of halogenation, different halogenating reagents can be selected, such as bromine atoms are introduced by the reaction with bromine catalyzed by iron bromide, and then chlorine atoms are introduced in a similar manner. Then, the fluorination reaction is carried out again. The fluorination conditions in this step are different from the former. Milder conditions or specific fluorination catalysts can be used to successfully introduce fluorine atoms into the 2,3-position. After multiple steps and careful operation, the target product can be synthesized.
Third, fluorine-containing aromatics are used as starting materials. If you find aromatics containing fluorine with appropriate substitution check points, you can follow the halogenation reaction path and introduce bromine and chlorine atoms in sequence. In this process, the activity of the halogenating reagent, the reaction sequence, and the control of the reaction conditions are all related to the success or failure of the reaction. If a halogenating agent with moderate activity is selected to avoid excessive halogenation or halogenation position deviation, and the reaction steps are cleverly designed, the synthesis of 1-bromo-4-chloro-2,3-difluorobenzene is finally achieved.
Synthesis of 1-bromo-4-chloro-2,3-difluorobenzene, each method has its own advantages and disadvantages, and needs to be weighed according to the actual situation, such as the availability of raw materials, cost, and controllability of reaction conditions, in order to achieve the best synthetic effect.
What is the price range of 1-bromo-4-chloro-2,3-difluorobenzene in the market?
1 - bromo - 4 - chloro - 2,3 - difluorobenzene is an organic compound, and its price range in the market varies due to a variety of factors.
First, purity has a great impact on price. If the purity is extremely high and almost perfect, it is suitable for high-end scientific research, pharmaceuticals and other precision fields. Because the preparation process requires fine technology and high investment costs, the price is also high. On the contrary, the purity is slightly lower, which is suitable for general industrial use, and the price is relatively close to the people.
Second, the market supply and demand relationship determines the price. If the demand for this compound is strong, just like in the wave of emerging drug research and development, many pharmaceutical companies urgently need this as a raw material, and the supply is limited, the price will rise. On the contrary, if the demand is weak and the supply is sufficient, the price will naturally fall.
Third, the production scale is closely related to the cost. In large-scale production, due to the scale effect, the unit production cost is reduced, and the price may be reduced. Small-scale production is more expensive and the price is also high.
Fourth, different sales channels will also cause price differences. Buy directly from the manufacturer, without intermediaries, the price may be more favorable. And buy through dealers, through layers of price increases, the price will increase.
Comprehensive market common situation, those with high purity, the price per gram may be hundreds of yuan or even higher; those with slightly lower purity, for industrial use, the price per gram may be around tens of yuan to hundreds of yuan. However, the market is constantly changing, and prices can change at any time in response to these factors.
First, purity has a great impact on price. If the purity is extremely high and almost perfect, it is suitable for high-end scientific research, pharmaceuticals and other precision fields. Because the preparation process requires fine technology and high investment costs, the price is also high. On the contrary, the purity is slightly lower, which is suitable for general industrial use, and the price is relatively close to the people.
Second, the market supply and demand relationship determines the price. If the demand for this compound is strong, just like in the wave of emerging drug research and development, many pharmaceutical companies urgently need this as a raw material, and the supply is limited, the price will rise. On the contrary, if the demand is weak and the supply is sufficient, the price will naturally fall.
Third, the production scale is closely related to the cost. In large-scale production, due to the scale effect, the unit production cost is reduced, and the price may be reduced. Small-scale production is more expensive and the price is also high.
Fourth, different sales channels will also cause price differences. Buy directly from the manufacturer, without intermediaries, the price may be more favorable. And buy through dealers, through layers of price increases, the price will increase.
Comprehensive market common situation, those with high purity, the price per gram may be hundreds of yuan or even higher; those with slightly lower purity, for industrial use, the price per gram may be around tens of yuan to hundreds of yuan. However, the market is constantly changing, and prices can change at any time in response to these factors.
Scan to WhatsApp
