Linshang Chemical
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1-Bromo-4-Chloro-2-Fluoro-5-Methylbenzene
Linshang Chemical
|
HS Code |
336536 |
| Chemical Formula | C7H6BrClF |
| Molecular Weight | 211.48 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Approximately in the range of 180 - 200 °C |
| Density | Around 1.5 - 1.7 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Vapor Pressure | Low at room temperature |
| Flash Point | Moderate, around 70 - 90 °C |
As an accredited 1-Bromo-4-Chloro-2-Fluoro-5-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene in a sealed glass bottle. |
| Storage | 1 - Bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene should be stored in a cool, dry, well - ventilated area away from heat sources, ignition sources, and oxidizing agents. Keep it in a tightly - sealed container to prevent leakage. Store it in a dedicated chemical storage cabinet, separated from incompatible substances, in accordance with local safety regulations. |
| Shipping | 1 - bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene is shipped in properly sealed, corrosion - resistant containers. It adheres to strict hazardous material shipping regulations, ensuring secure transit to prevent any leakage or risk. |
Competitive 1-Bromo-4-Chloro-2-Fluoro-5-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 1-Bromo-4-Chloro-2-Fluoro-5-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1 - bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene
1 + -Bromo-4-chloro-2-fluoro-5-methylbenzene is also an organic compound. In its molecule, above the benzene ring, bromine, chlorine, fluorine, and methyl are in one place each.
This compound has the generality of aromatic compounds, and the conjugated π electronic system of the benzene ring makes it stable to a certain extent. Due to the existence of halogen atoms and methyl, it has unique chemical properties.
Bromine, chlorine, and fluorine atoms have large electronegativity and significant electron-withdrawing effect. This electron-withdrawing effect can affect the electron cloud density distribution of the benzene ring, and reduce the electron cloud density of the ortho and para-position of the benzene ring. Therefore, in the electrophilic substitution reaction, its reactivity is lower than that of benzene, and the newly introduced groups mostly enter the meta-site.
Methyl group is the donor group, which has the induction effect of pushing electrons and the super-conjugation effect, which can increase the electron cloud density of the benzene ring, especially the adjacent and para-sites. However, in this compound, methyl is checked and balanced by the electron-withdrawing effect of other halogen atoms, and its effect on the electron cloud density of the benzene ring is slightly changed.
This compound can participate in a variety of chemical reactions. In the nucleophilic substitution reaction, the halogen atom can be replaced by the nucleophilic reagent. In the case of strong nucleophilic reagents, bromine atoms are more likely to leave than chlorine and fluorine atoms, because the Under suitable reaction conditions, it can react with nucleophiles such as sodium alcohol and amines to form corresponding substitution products.
In addition, in the oxidation reaction, methyl can be oxidized. If a strong oxidant is used, methyl can be gradually oxidized to carboxyl groups. This process may involve a multi-step reaction, and the products vary depending on the reaction conditions.
And because it contains halogen atoms, under specific conditions, elimination reactions can occur. All of these are due to the interaction of atoms or groups in the molecule, resulting in rich and diverse chemical properties, which have important application potential in organic synthesis and other fields.
This compound has the generality of aromatic compounds, and the conjugated π electronic system of the benzene ring makes it stable to a certain extent. Due to the existence of halogen atoms and methyl, it has unique chemical properties.
Bromine, chlorine, and fluorine atoms have large electronegativity and significant electron-withdrawing effect. This electron-withdrawing effect can affect the electron cloud density distribution of the benzene ring, and reduce the electron cloud density of the ortho and para-position of the benzene ring. Therefore, in the electrophilic substitution reaction, its reactivity is lower than that of benzene, and the newly introduced groups mostly enter the meta-site.
Methyl group is the donor group, which has the induction effect of pushing electrons and the super-conjugation effect, which can increase the electron cloud density of the benzene ring, especially the adjacent and para-sites. However, in this compound, methyl is checked and balanced by the electron-withdrawing effect of other halogen atoms, and its effect on the electron cloud density of the benzene ring is slightly changed.
This compound can participate in a variety of chemical reactions. In the nucleophilic substitution reaction, the halogen atom can be replaced by the nucleophilic reagent. In the case of strong nucleophilic reagents, bromine atoms are more likely to leave than chlorine and fluorine atoms, because the Under suitable reaction conditions, it can react with nucleophiles such as sodium alcohol and amines to form corresponding substitution products.
In addition, in the oxidation reaction, methyl can be oxidized. If a strong oxidant is used, methyl can be gradually oxidized to carboxyl groups. This process may involve a multi-step reaction, and the products vary depending on the reaction conditions.
And because it contains halogen atoms, under specific conditions, elimination reactions can occur. All of these are due to the interaction of atoms or groups in the molecule, resulting in rich and diverse chemical properties, which have important application potential in organic synthesis and other fields.
What are the common uses of 1 - bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene
1-Bromo-4-chloro-2-fluoro-5-methylbenzene is an organic compound, and its preparation path is quite diverse. In the field of organic synthesis, there are several common methods as follows.
First, toluene is used as the initial raw material. The methyl group of toluene can be introduced into bromine atoms by halogenation reaction to obtain bromotoluene. In this process, liquid bromine is often used as the bromine source. Under the catalysis of appropriate catalysts, such as iron powder or iron tribromide, the hydrogen atom of the methyl ortho or para-position can be replaced by the bromine atom. Subsequently, in another reaction step, the resulting bromotoluene can be chlorinated. Select an appropriate chlorination agent, such as chlorine, and under the action of light or a specific catalyst, the hydrogen atom at a specific position on the benzene ring is replaced by a chlorine atom. Finally, through a fluorination reaction, a suitable fluorination reagent, such as potassium fluoride and a phase transfer catalyst system, fluorine atoms are introduced to obtain 1-bromo-4-chloro-2-fluoro-5-methylbenzene.
Second, p-chlorotoluene is used as the starting material. It is brominated first, and the bromine atom can be introduced into the appropriate position under specific conditions. After that, the fluorination reaction is carried out to gradually build the structure of the target compound.
Third, m-fluorotoluene is used as the raw material. First, the chlorine atom is connected to the specific check point of the benzene ring through chlorination reaction, and then the bromination reaction is carried out to finally synthesize 1-bromo-4-chloro-2-fluoro-5-methylbenzene.
When preparing this compound, it is necessary to pay attention to the control of the conditions of each step of the reaction, such as the reaction temperature, reaction time, the proportion of reactants and the choice of catalyst. This all has a significant impact on the yield and selectivity of the reaction. At the same time, due to the halogenation reaction, safety issues cannot be ignored, and appropriate protective measures need to be taken to ensure the safety and control of the reaction process.
First, toluene is used as the initial raw material. The methyl group of toluene can be introduced into bromine atoms by halogenation reaction to obtain bromotoluene. In this process, liquid bromine is often used as the bromine source. Under the catalysis of appropriate catalysts, such as iron powder or iron tribromide, the hydrogen atom of the methyl ortho or para-position can be replaced by the bromine atom. Subsequently, in another reaction step, the resulting bromotoluene can be chlorinated. Select an appropriate chlorination agent, such as chlorine, and under the action of light or a specific catalyst, the hydrogen atom at a specific position on the benzene ring is replaced by a chlorine atom. Finally, through a fluorination reaction, a suitable fluorination reagent, such as potassium fluoride and a phase transfer catalyst system, fluorine atoms are introduced to obtain 1-bromo-4-chloro-2-fluoro-5-methylbenzene.
Second, p-chlorotoluene is used as the starting material. It is brominated first, and the bromine atom can be introduced into the appropriate position under specific conditions. After that, the fluorination reaction is carried out to gradually build the structure of the target compound.
Third, m-fluorotoluene is used as the raw material. First, the chlorine atom is connected to the specific check point of the benzene ring through chlorination reaction, and then the bromination reaction is carried out to finally synthesize 1-bromo-4-chloro-2-fluoro-5-methylbenzene.
When preparing this compound, it is necessary to pay attention to the control of the conditions of each step of the reaction, such as the reaction temperature, reaction time, the proportion of reactants and the choice of catalyst. This all has a significant impact on the yield and selectivity of the reaction. At the same time, due to the halogenation reaction, safety issues cannot be ignored, and appropriate protective measures need to be taken to ensure the safety and control of the reaction process.
What is the preparation method of 1 - bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene
The preparation method of 1 + -bromo-4 + -chloro-2 + -fluoro-5 + -methylbenzene is the key to chemical synthesis. The method is often carried out according to the principles and techniques of organic synthesis.
The method of electrophilic substitution is first introduced. Using toluene as the starting material, because methyl is the ortho-para locator, the subsequent substituents can be mainly introduced into the ortho and para-sites. First, under appropriate conditions, such as catalyzed by iron or iron tribromide, and at room temperature or slightly higher temperature, the bromine molecule is polarized to attack the benzene ring, and o-bromotoluene can be obtained. In this process, iron or iron tribromide interacts with bromine to generate more active bromine positive ions, which promotes the smooth progress of the reaction.
After obtaining o-bromotoluene, chlorination is carried out. Under light or heating conditions, chlorine is used as a chlorination agent. Because light or heating can split chlorine molecules into chlorine radicals, chlorine radicals are active and can capture hydrogen atoms on o-bromotoluene methyl to form benzyl radicals, which then combine with chlorine radicals to form chlorine-containing intermediates.
Subsequently, the chlorine-containing intermediates are fluorinated. Fluorination reagents, such as potassium fluoride, are often used to achieve the replacement of chlorine atoms with fluorine atoms under appropriate solvent and temperature conditions. Among them, the choice of solvent is very important, which needs to be able to dissolve the reactants and not interfere with the reaction.
However, the preparation process needs to pay attention to the control of the conditions of each step of the reaction, such as temperature, catalyst dosage, reactant ratio, etc. If the temperature is too high or too low, the reaction rate and product selectivity may be affected; if the amount of catalyst is not used properly, the reaction efficiency will also change. And after each step of the reaction, appropriate separation and purification methods, such as distillation, recrystallization, column chromatography, etc., are required to obtain a pure product and provide qualified raw materials for the next reaction. In this way, through multi-step reaction and fine operation, the purpose of preparing 1 + -bromo-4 + -chloro-2 + -fluoro-5 + -methylbenzene can be achieved.
The method of electrophilic substitution is first introduced. Using toluene as the starting material, because methyl is the ortho-para locator, the subsequent substituents can be mainly introduced into the ortho and para-sites. First, under appropriate conditions, such as catalyzed by iron or iron tribromide, and at room temperature or slightly higher temperature, the bromine molecule is polarized to attack the benzene ring, and o-bromotoluene can be obtained. In this process, iron or iron tribromide interacts with bromine to generate more active bromine positive ions, which promotes the smooth progress of the reaction.
After obtaining o-bromotoluene, chlorination is carried out. Under light or heating conditions, chlorine is used as a chlorination agent. Because light or heating can split chlorine molecules into chlorine radicals, chlorine radicals are active and can capture hydrogen atoms on o-bromotoluene methyl to form benzyl radicals, which then combine with chlorine radicals to form chlorine-containing intermediates.
Subsequently, the chlorine-containing intermediates are fluorinated. Fluorination reagents, such as potassium fluoride, are often used to achieve the replacement of chlorine atoms with fluorine atoms under appropriate solvent and temperature conditions. Among them, the choice of solvent is very important, which needs to be able to dissolve the reactants and not interfere with the reaction.
However, the preparation process needs to pay attention to the control of the conditions of each step of the reaction, such as temperature, catalyst dosage, reactant ratio, etc. If the temperature is too high or too low, the reaction rate and product selectivity may be affected; if the amount of catalyst is not used properly, the reaction efficiency will also change. And after each step of the reaction, appropriate separation and purification methods, such as distillation, recrystallization, column chromatography, etc., are required to obtain a pure product and provide qualified raw materials for the next reaction. In this way, through multi-step reaction and fine operation, the purpose of preparing 1 + -bromo-4 + -chloro-2 + -fluoro-5 + -methylbenzene can be achieved.
1 - bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene What are the precautions in storage and transportation
1 + -Bromo-4 + -chloro-2 + -fluoro-5 + -methyl benzene is also an organic compound. During storage and transportation, many matters must not be ignored.
Safety first. This compound may be toxic, irritating, or even flammable and explosive. Therefore, the storage place should be selected as a cool, dry, well-ventilated place, away from fire and heat sources to prevent accidents. And it should be stored separately from oxidants, acids, bases, etc., and must not be mixed to avoid violent reactions and disasters.
Packaging must be tight. Suitable packaging materials, such as glass bottles, plastic bottles, etc., must be used, and sealed tightly to prevent leakage. During transportation, it is also necessary to ensure that the packaging is not damaged to prevent the material from escaping and endangering the environment and personal safety.
Furthermore, the marking is clear. On the storage container and the means of transportation, the name, hazard characteristics, emergency handling methods and other information should be clearly marked. In this way, in the event of an accident, the relevant personnel can quickly know its characteristics and take appropriate countermeasures.
Operating specifications are also key. Whether it is handling during storage or loading and unloading during transportation, operators should be professionally trained and familiar with the operating procedures. When working, it is necessary to wear protective equipment, such as gas masks, protective gloves, etc., to avoid direct contact.
Storage and transportation of 1 + -bromo-4 + -chloro-2 + -fluoro-5 + -methylbenzene requires caution at all times and strict adherence to various rules to ensure safety.
Safety first. This compound may be toxic, irritating, or even flammable and explosive. Therefore, the storage place should be selected as a cool, dry, well-ventilated place, away from fire and heat sources to prevent accidents. And it should be stored separately from oxidants, acids, bases, etc., and must not be mixed to avoid violent reactions and disasters.
Packaging must be tight. Suitable packaging materials, such as glass bottles, plastic bottles, etc., must be used, and sealed tightly to prevent leakage. During transportation, it is also necessary to ensure that the packaging is not damaged to prevent the material from escaping and endangering the environment and personal safety.
Furthermore, the marking is clear. On the storage container and the means of transportation, the name, hazard characteristics, emergency handling methods and other information should be clearly marked. In this way, in the event of an accident, the relevant personnel can quickly know its characteristics and take appropriate countermeasures.
Operating specifications are also key. Whether it is handling during storage or loading and unloading during transportation, operators should be professionally trained and familiar with the operating procedures. When working, it is necessary to wear protective equipment, such as gas masks, protective gloves, etc., to avoid direct contact.
Storage and transportation of 1 + -bromo-4 + -chloro-2 + -fluoro-5 + -methylbenzene requires caution at all times and strict adherence to various rules to ensure safety.
What are the environmental effects of 1 - bromo - 4 - chloro - 2 - fluoro - 5 - methylbenzene
1 + -Bromo-4-chloro-2-fluoro-5-methylbenzene, this is an organic compound. Its impact on the environment is quite complex, and it should be described from the end.
First of all, the influence of its physical and chemical properties. This compound has a specific vapor pressure and water solubility. If it escapes in the atmosphere, it participates in atmospheric photochemical reactions due to a certain vapor pressure or exists in the gas phase. The photochemical reactions in the atmosphere are complex, and many pollutants interact, or cause secondary pollutants such as smog and ozone to form. If its water solubility causes it to enter the water body, it will change the chemical composition of the water body, affect the water quality, or interfere with the living environment of aquatic organisms.
Secondary and bioaccumulation effects. Due to its hydrophobicity, it is easily ingested and accumulated by adipose tissue in organisms. Once it enters the ecosystem and is transmitted through the food chain, the concentration of enrichment in higher organisms may increase significantly. If small fish ingest plankton containing this compound, and large fish eat small fish, the compound will accumulate in the large fish, eventually causing greater harm to organisms at the top of the food chain, or causing damage to physiological functions, reproduction, etc.
Furthermore, it is related to toxic effects. Although the degree of toxicity varies depending on the species of organisms, it may be acute or chronic toxic to organisms. Acute toxicity or cause poisoning symptoms in organisms in a short period of time, such as abnormal behavior, physiological disorders, etc.; chronic toxicity acts for a long time, causing serious consequences such as biological gene mutation, carcinogenesis and teratogenicity, and destroying ecosystem balance and biodiversity.
In addition, its degradation products may also affect the environment. In the environment through chemical, biological and other degradation processes, the properties of the generated degradation products may be very different from the original compounds, or have stronger toxicity and migration, further expanding the scope and extent of environmental impact.
In conclusion, 1-bromo-4-chloro-2-fluoro-5-methylbenzene in the environment affects the ecological environment and biological health in many ways through physical, chemical and biological processes, from the atmosphere, water bodies to organisms, and requires careful treatment and in-depth study.
First of all, the influence of its physical and chemical properties. This compound has a specific vapor pressure and water solubility. If it escapes in the atmosphere, it participates in atmospheric photochemical reactions due to a certain vapor pressure or exists in the gas phase. The photochemical reactions in the atmosphere are complex, and many pollutants interact, or cause secondary pollutants such as smog and ozone to form. If its water solubility causes it to enter the water body, it will change the chemical composition of the water body, affect the water quality, or interfere with the living environment of aquatic organisms.
Secondary and bioaccumulation effects. Due to its hydrophobicity, it is easily ingested and accumulated by adipose tissue in organisms. Once it enters the ecosystem and is transmitted through the food chain, the concentration of enrichment in higher organisms may increase significantly. If small fish ingest plankton containing this compound, and large fish eat small fish, the compound will accumulate in the large fish, eventually causing greater harm to organisms at the top of the food chain, or causing damage to physiological functions, reproduction, etc.
Furthermore, it is related to toxic effects. Although the degree of toxicity varies depending on the species of organisms, it may be acute or chronic toxic to organisms. Acute toxicity or cause poisoning symptoms in organisms in a short period of time, such as abnormal behavior, physiological disorders, etc.; chronic toxicity acts for a long time, causing serious consequences such as biological gene mutation, carcinogenesis and teratogenicity, and destroying ecosystem balance and biodiversity.
In addition, its degradation products may also affect the environment. In the environment through chemical, biological and other degradation processes, the properties of the generated degradation products may be very different from the original compounds, or have stronger toxicity and migration, further expanding the scope and extent of environmental impact.
In conclusion, 1-bromo-4-chloro-2-fluoro-5-methylbenzene in the environment affects the ecological environment and biological health in many ways through physical, chemical and biological processes, from the atmosphere, water bodies to organisms, and requires careful treatment and in-depth study.
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