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1-Bromo-4-Chloro-2-Methoxybenzene
|
HS Code |
701544 |
| Chemical Formula | C7H6BrClO |
| Molecular Weight | 221.48 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Approximately 235 - 237 °C |
| Density | Data may vary, but around 1.6 g/cm³ |
| Solubility In Water | Insoluble in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, diethyl ether, and chloroform |
| Odor | May have a characteristic aromatic odor |
As an accredited 1-Bromo-4-Chloro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 4 - chloro - 2 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 1 - Bromo - 4 - chloro - 2 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Avoid storing it near oxidizing agents or reactive substances. Store it at a temperature below 30°C to prevent decomposition and potential hazards. |
| Shipping | 1 - bromo - 4 - chloro - 2 - methoxybenzene, a chemical, is shipped in well - sealed containers. Packaging adheres to safety regulations. Shipment may be via ground or air, depending on quantity and urgency, with proper hazard labels. |
Competitive 1-Bromo-4-Chloro-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to sales01@alchemist-chem.com.
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Where to Buy 1-Bromo-4-Chloro-2-Methoxybenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Bromo-4-Chloro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-bromo-4-chloro-2-methoxybenzene?
1+-+%E6%BA%B4+-+4+-+%E6%B0%AF+-+2+-+%E7%94%B2%E6%B0%A7%E5%9F%BA%E8%8B%AF, its chemical name is 1-bromo-4-chloro-2-methoxybenzene. This substance is an organic compound with specific physical properties.
Looking at its properties, it is mostly colorless to light yellow liquid under normal conditions, and can crystallize as a solid under specific conditions, depending on factors such as ambient temperature and pressure.
When it comes to the melting point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. Such melting boiling point characteristics make it possible to realize phase transition in chemical operations and in the corresponding temperature range, which is conducive to separation and purification processes.
Its density is larger than that of water, about [X] g/cm ³. In a liquid mixed system, it sinks more at the bottom. And it is insoluble in water. Because of its molecular structure, hydrophobic benzene rings and methoxy groups dominate, making it difficult to form an effective force with water molecules. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Due to the principle of "similar miscibility", its organic structure and organic solvent molecules can be miscible through interactions such as van der Waals force.
1-Bromo-4-chloro-2-methoxybenzene is also volatile to a certain extent. It will evaporate slowly in the air and emit a special odor. Pay attention to ventilation during operation to prevent inhalation. In addition, its chemical stability may change under light, heating and other conditions, triggering related chemical reactions.
Looking at its properties, it is mostly colorless to light yellow liquid under normal conditions, and can crystallize as a solid under specific conditions, depending on factors such as ambient temperature and pressure.
When it comes to the melting point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. Such melting boiling point characteristics make it possible to realize phase transition in chemical operations and in the corresponding temperature range, which is conducive to separation and purification processes.
Its density is larger than that of water, about [X] g/cm ³. In a liquid mixed system, it sinks more at the bottom. And it is insoluble in water. Because of its molecular structure, hydrophobic benzene rings and methoxy groups dominate, making it difficult to form an effective force with water molecules. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Due to the principle of "similar miscibility", its organic structure and organic solvent molecules can be miscible through interactions such as van der Waals force.
1-Bromo-4-chloro-2-methoxybenzene is also volatile to a certain extent. It will evaporate slowly in the air and emit a special odor. Pay attention to ventilation during operation to prevent inhalation. In addition, its chemical stability may change under light, heating and other conditions, triggering related chemical reactions.
What are the chemical properties of 1-bromo-4-chloro-2-methoxybenzene?
1+-+%E6%BA%B4+-+4+-+%E6%B0%AF+-+2+-+%E7%94%B2%E6%B0%A7%E5%9F%BA%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E6%9C%89%E5%93%AA%E4%BA%9B%EF%BC%9F
1+-+%E6%BA%B4+-+4+-+%E6%B0%AF+-+2+-+%E7%94%B2%E6%B0%A7%E5%9F%BA%E8%8B%AF%E7%9A%84%E5%88%86%E5%AD%90%E5%BC%8F%E4%B8%BA C H O ², which has the following chemical properties:
1. ** Acid and alkaline **: The hydroxyl group (-OH) contained in the molecule of this compound has a certain weak acidity. In an appropriate alkali solution, the hydrogen atom on the hydroxyl group can be replaced by alkali metal ions, and a reaction similar to acid-base neutralization occurs. For example, when reacting with sodium hydroxide solution, the corresponding sodium salt and water can be generated, showing its acidic side.
2. ** Oxidation reaction **: The carbon-carbon double bond and hydroxyl groups in this compound are more easily oxidized. For example, under the action of a suitable oxidant, such as potassium permanganate and other strong oxidants, the carbon-carbon double bond can be oxidized and broken to form an oxygenated compound, which may be a carboxylic acid or a ketone; the hydroxyl group can also be oxidized to a functional group in a higher oxidation state such as an aldehyde group or a carboxyl group. If a mild oxidant is used, such as manganese dioxide, the hydroxyl group can be selectively oxidized to an aldehyde group.
3. ** Addition reaction **: Due to the presence of carbon-carbon double bonds in its structure, an addition reaction can occur. For example, in the presence of a catalyst, an addition reaction can occur with hydrogen, one of the carbon-carbon double bonds is opened, and hydrogen atoms are added to the two unsaturated carbon atoms to generate saturated alkane derivatives; addition reactions can also occur with hydrogen halides, and halogen atoms and hydrogen atoms are added to the double-bonded carbon atoms to generate halogenated hydrocarbon derivatives.
4. ** Substitution reaction **: The hydroxyl group in the molecule can undergo a substitution reaction. When reacted with hydrogen halides, the hydroxyl group is replaced by a halogen atom to generate a halogenated hydrocarbon; esterification reaction occurs with carboxylic acids catalyzed by concentrated sulfuric acid, and the hydrogen atom in the hydroxyl group is replaced by the acyl group of the carboxylic acid to form an ester compound. At the same time, the hydrogen atom on the alkyl group in the molecule can also be replaced by the halogen atom under the conditions of light, and the free radical substitution reaction occurs.
1+-+%E6%BA%B4+-+4+-+%E6%B0%AF+-+2+-+%E7%94%B2%E6%B0%A7%E5%9F%BA%E8%8B%AF%E7%9A%84%E5%88%86%E5%AD%90%E5%BC%8F%E4%B8%BA C H O ², which has the following chemical properties:
1. ** Acid and alkaline **: The hydroxyl group (-OH) contained in the molecule of this compound has a certain weak acidity. In an appropriate alkali solution, the hydrogen atom on the hydroxyl group can be replaced by alkali metal ions, and a reaction similar to acid-base neutralization occurs. For example, when reacting with sodium hydroxide solution, the corresponding sodium salt and water can be generated, showing its acidic side.
2. ** Oxidation reaction **: The carbon-carbon double bond and hydroxyl groups in this compound are more easily oxidized. For example, under the action of a suitable oxidant, such as potassium permanganate and other strong oxidants, the carbon-carbon double bond can be oxidized and broken to form an oxygenated compound, which may be a carboxylic acid or a ketone; the hydroxyl group can also be oxidized to a functional group in a higher oxidation state such as an aldehyde group or a carboxyl group. If a mild oxidant is used, such as manganese dioxide, the hydroxyl group can be selectively oxidized to an aldehyde group.
3. ** Addition reaction **: Due to the presence of carbon-carbon double bonds in its structure, an addition reaction can occur. For example, in the presence of a catalyst, an addition reaction can occur with hydrogen, one of the carbon-carbon double bonds is opened, and hydrogen atoms are added to the two unsaturated carbon atoms to generate saturated alkane derivatives; addition reactions can also occur with hydrogen halides, and halogen atoms and hydrogen atoms are added to the double-bonded carbon atoms to generate halogenated hydrocarbon derivatives.
4. ** Substitution reaction **: The hydroxyl group in the molecule can undergo a substitution reaction. When reacted with hydrogen halides, the hydroxyl group is replaced by a halogen atom to generate a halogenated hydrocarbon; esterification reaction occurs with carboxylic acids catalyzed by concentrated sulfuric acid, and the hydrogen atom in the hydroxyl group is replaced by the acyl group of the carboxylic acid to form an ester compound. At the same time, the hydrogen atom on the alkyl group in the molecule can also be replaced by the halogen atom under the conditions of light, and the free radical substitution reaction occurs.
In what fields is 1-bromo-4-chloro-2-methoxybenzene used?
1+-+%E6%BA%B4+-+4+-+%E6%B0%AF+-+2+-+%E7%94%B2%E6%B0%A7%E5%9F%BA%E8%8B%AF%EF%BC%8C%E5%85%B6%E5%8F%82%E4%BB%B6%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%E5%AF%B9%E5%BA%94%E7%9A%84%E5%BA%94%E7%94%A8%E4%B8%96%E5%87%BB%E5%B9%B2%E5%91%BD%E3%80%82
1,4-dioxane-2-methylhydroxybenzene, which has special physical properties, has a wide range of uses in the field of pharmaceutical synthesis. Because of its unique chemical structure, it can add specific active groups to drug molecules, which helps to improve drug efficacy and improve pharmacokinetic properties. For example, when synthesizing cardiovascular drugs, it can be used to introduce key structural fragments to optimize the ability of drugs to bind to targets, improve efficacy, and reduce side effects.
In the context of materials science, 1,4-dioxane-2-methylhydroxybenzene can also be used. When preparing high-performance polymer materials, it can be used as a functional monomer to participate in the polymerization reaction, giving new properties to the materials. For example, synthesizing polymers with special optical and electrical properties can be used in the manufacture of optoelectronic devices, such as organic Light Emitting Diodes (OLEDs), solar cells, etc., or can improve device performance and improve photoelectric conversion efficiency.
Furthermore, in the field of fine chemicals, it is often used as an intermediate in organic synthesis. With its activity, it is converted into a variety of high-value-added fine chemicals, such as fragrances and dyes, through a series of chemical reactions. When synthesizing fragrances, with its structural characteristics, it adds a unique aroma structure to fragrance molecules, enriches fragrance categories, and improves product quality.
This substance has important applications in the fields of medicine, materials, and fine chemicals. With the development of science and technology, its potential uses may be further explored and expanded.
1,4-dioxane-2-methylhydroxybenzene, which has special physical properties, has a wide range of uses in the field of pharmaceutical synthesis. Because of its unique chemical structure, it can add specific active groups to drug molecules, which helps to improve drug efficacy and improve pharmacokinetic properties. For example, when synthesizing cardiovascular drugs, it can be used to introduce key structural fragments to optimize the ability of drugs to bind to targets, improve efficacy, and reduce side effects.
In the context of materials science, 1,4-dioxane-2-methylhydroxybenzene can also be used. When preparing high-performance polymer materials, it can be used as a functional monomer to participate in the polymerization reaction, giving new properties to the materials. For example, synthesizing polymers with special optical and electrical properties can be used in the manufacture of optoelectronic devices, such as organic Light Emitting Diodes (OLEDs), solar cells, etc., or can improve device performance and improve photoelectric conversion efficiency.
Furthermore, in the field of fine chemicals, it is often used as an intermediate in organic synthesis. With its activity, it is converted into a variety of high-value-added fine chemicals, such as fragrances and dyes, through a series of chemical reactions. When synthesizing fragrances, with its structural characteristics, it adds a unique aroma structure to fragrance molecules, enriches fragrance categories, and improves product quality.
This substance has important applications in the fields of medicine, materials, and fine chemicals. With the development of science and technology, its potential uses may be further explored and expanded.
What are the synthesis methods of 1-bromo-4-chloro-2-methoxybenzene?
The synthesis of 1 + -ether-4-alkane-2-methoxybenzene is related to the field of organic chemical synthesis. To synthesize this substance, the following methods can be followed:
First, phenolic compounds are used as starting materials. First, phenol is reacted with halomethane under basic conditions, and the hydroxyl group of phenol undergoes a nucleophilic substitution reaction with the halogen atom of halomethane to produce methoxyphenol. For example, using p-hydroxyphenyl ether as raw material, the hydroxyl oxide is nucleophilic, and the iodine atom of halomethane (such as iodomethane) is a good leaving group. Under the action of basic reagents such as potassium carbonate, the two react to form methoxylation products. Then, through a suitable reaction, such as the Fu-G reaction, the ether group and the alkyl group are introduced. In the Fu-G reaction, the halogenated ether and the halogenated alkane are used as reagents, and under the catalysis of Lewis acid such as aluminum trichloride, the halogen atom of the halogenated ether undergoes an electrophilic substitution reaction with the benzene ring to form an ether bond to connect to the benzene ring; the halogen atom of the halogenated alkane also undergoes an electrophilic substitution with the benzene ring to introduce an alkyl group. This process requires strict control of the reaction conditions, such as temperature, reagent dosage, reaction time, etc., to ensure that the reaction proceeds in the desired direction.
Second, halogenated benzene is used as the starting material. First, the halogenated benzene is reacted with metal magnesium to prepare Grignard's reagent. The halogen atom of the halogenated benzene reacts with magnesium to form magnesium halide and phenyl magnesium. This Grignard's reagent has strong nucleophilicity. After that, the Grignard's reagent reacts with methoxy halogenated alkanes. The carbon anion of the Grignard's reagent attacks the carbon atom connected to the halogen atom of the methoxy halogenated alkane. The halogen atom leaves to form a carbon-carbon bond, and the methoxy group is introduced at the same time. Subsequently, the ether group is introduced through a suitable reaction, such as the Williamson ether synthesis method. In the Williamson ether synthesis method, the halogenated alcohol reacts with the base to form alcohol anions, and the alcohol anions react with halogenated
Third, anisole derivatives are used as raw materials. The phenyl ring of anisole is substituted to introduce the required ether group and alkyl group. Electrophilic substitution reaction can be used, such as nitration reaction of anisole with mixed acid of concentrated sulfuric acid and concentrated nitric acid, nitro is introduced into the phenyl ring, and then the nitro group is reduced to amino group through reduction reaction. After that, the amino group is converted into diazonium salt by diazotization reaction. The diazonium salt can react with halogenated ether, halogenated alkane and other reagents to introduce ether group and alkyl group, and finally obtain the target product through a series of reactions. This method has many steps and requires high selectivity and yield of each step.
First, phenolic compounds are used as starting materials. First, phenol is reacted with halomethane under basic conditions, and the hydroxyl group of phenol undergoes a nucleophilic substitution reaction with the halogen atom of halomethane to produce methoxyphenol. For example, using p-hydroxyphenyl ether as raw material, the hydroxyl oxide is nucleophilic, and the iodine atom of halomethane (such as iodomethane) is a good leaving group. Under the action of basic reagents such as potassium carbonate, the two react to form methoxylation products. Then, through a suitable reaction, such as the Fu-G reaction, the ether group and the alkyl group are introduced. In the Fu-G reaction, the halogenated ether and the halogenated alkane are used as reagents, and under the catalysis of Lewis acid such as aluminum trichloride, the halogen atom of the halogenated ether undergoes an electrophilic substitution reaction with the benzene ring to form an ether bond to connect to the benzene ring; the halogen atom of the halogenated alkane also undergoes an electrophilic substitution with the benzene ring to introduce an alkyl group. This process requires strict control of the reaction conditions, such as temperature, reagent dosage, reaction time, etc., to ensure that the reaction proceeds in the desired direction.
Second, halogenated benzene is used as the starting material. First, the halogenated benzene is reacted with metal magnesium to prepare Grignard's reagent. The halogen atom of the halogenated benzene reacts with magnesium to form magnesium halide and phenyl magnesium. This Grignard's reagent has strong nucleophilicity. After that, the Grignard's reagent reacts with methoxy halogenated alkanes. The carbon anion of the Grignard's reagent attacks the carbon atom connected to the halogen atom of the methoxy halogenated alkane. The halogen atom leaves to form a carbon-carbon bond, and the methoxy group is introduced at the same time. Subsequently, the ether group is introduced through a suitable reaction, such as the Williamson ether synthesis method. In the Williamson ether synthesis method, the halogenated alcohol reacts with the base to form alcohol anions, and the alcohol anions react with halogenated
Third, anisole derivatives are used as raw materials. The phenyl ring of anisole is substituted to introduce the required ether group and alkyl group. Electrophilic substitution reaction can be used, such as nitration reaction of anisole with mixed acid of concentrated sulfuric acid and concentrated nitric acid, nitro is introduced into the phenyl ring, and then the nitro group is reduced to amino group through reduction reaction. After that, the amino group is converted into diazonium salt by diazotization reaction. The diazonium salt can react with halogenated ether, halogenated alkane and other reagents to introduce ether group and alkyl group, and finally obtain the target product through a series of reactions. This method has many steps and requires high selectivity and yield of each step.
What are the effects of 1-bromo-4-chloro-2-methoxybenzene on the environment and human health?
1 + -Mercury-4 + -arsenic-2 + -methoxyphenylmercury This substance has a great impact on the environment and human health.
Mercury is highly toxic. In the environment, it can be migrated and transformed in various ways. Once released into the atmosphere, mercury can be transported over long distances with air flow, and then settled in water bodies and soil. In water bodies, mercury can be converted into methylmercury by microbial action. It is highly fat-soluble and easily enriched in organisms, accumulating layer by layer along the food chain. After aquatic organisms such as fish and shrimp enrich mercury, if humans eat it, mercury will enter the human body. In the human body, mercury can damage the nervous system, cause cognitive impairment, memory loss, limb tremor and other diseases, and also affect the immune system and reproductive system. Exposure of pregnant women to mercury can cause abnormal fetal development and the risk of deformity.
Arsenic is also a toxic element. In the environment, high arsenic in soil can inhibit plant growth, reduce crop yield and deteriorate quality. In water, it can threaten the survival of aquatic organisms. For the human body, long-term intake of arsenic through drinking water and food can cause skin lesions, such as skin pigmentation, hyperkeratosis, etc., and also greatly increase the risk of cancer, such as lung cancer, skin cancer, bladder cancer, etc., and can also damage liver, kidney and other organ functions.
2 + -methoxyphenylmercury is an organic mercury compound with high stability in the environment and is difficult to degrade. It can enter the human body through the respiratory tract, skin, and digestive tract. In the human body, it can target the nervous system and endocrine system, interfere with the transmission of neurotransmitters, destroy the endocrine balance, cause symptoms related to endocrine disorders, and have an inhibitory effect on the immune system, so that the human body's ability to resist disease is reduced.
In short, these substances are extremely harmful to the environment and human health, and should be given high attention. Scientific methods should be used to monitor, prevent and control, reduce their harm, and protect the environment and human well-being.
Mercury is highly toxic. In the environment, it can be migrated and transformed in various ways. Once released into the atmosphere, mercury can be transported over long distances with air flow, and then settled in water bodies and soil. In water bodies, mercury can be converted into methylmercury by microbial action. It is highly fat-soluble and easily enriched in organisms, accumulating layer by layer along the food chain. After aquatic organisms such as fish and shrimp enrich mercury, if humans eat it, mercury will enter the human body. In the human body, mercury can damage the nervous system, cause cognitive impairment, memory loss, limb tremor and other diseases, and also affect the immune system and reproductive system. Exposure of pregnant women to mercury can cause abnormal fetal development and the risk of deformity.
Arsenic is also a toxic element. In the environment, high arsenic in soil can inhibit plant growth, reduce crop yield and deteriorate quality. In water, it can threaten the survival of aquatic organisms. For the human body, long-term intake of arsenic through drinking water and food can cause skin lesions, such as skin pigmentation, hyperkeratosis, etc., and also greatly increase the risk of cancer, such as lung cancer, skin cancer, bladder cancer, etc., and can also damage liver, kidney and other organ functions.
2 + -methoxyphenylmercury is an organic mercury compound with high stability in the environment and is difficult to degrade. It can enter the human body through the respiratory tract, skin, and digestive tract. In the human body, it can target the nervous system and endocrine system, interfere with the transmission of neurotransmitters, destroy the endocrine balance, cause symptoms related to endocrine disorders, and have an inhibitory effect on the immune system, so that the human body's ability to resist disease is reduced.
In short, these substances are extremely harmful to the environment and human health, and should be given high attention. Scientific methods should be used to monitor, prevent and control, reduce their harm, and protect the environment and human well-being.
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