Linshang Chemical
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1-Bromo-4-Chloro-2-Nitrobenzene
Linshang Chemical
|
HS Code |
560180 |
| Chemical Formula | C6H3BrClNO2 |
| Molar Mass | 248.45 g/mol |
| Appearance | Yellow solid |
| Melting Point | 92 - 94 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Stability | Stable under normal conditions, but can react with strong oxidizing agents |
As an accredited 1-Bromo-4-Chloro-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - bromo - 4 - chloro - 2 - nitrobenzene packaged in 1 - kg bottles. |
| Storage | 1 - Bromo - 4 - chloro - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store it in a tightly - sealed container, preferably made of corrosion - resistant material like glass or certain plastics. Label the container clearly to avoid confusion. This storage method helps prevent decomposition and potential hazards. |
| Shipping | 1 - bromo - 4 - chloro - 2 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper handling, storage, and transportation to prevent spills and risks. |
Competitive 1-Bromo-4-Chloro-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-Bromo-4-Chloro-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-bromo-4-chloro-2-nitrobenzene?
1 + -Hg-4 + -xenon-2 + -aminonaphthalene is an element of gold, and it is often liquid under normal conditions, which is the most important physical property. Its color is white, with golden light, and its density is high, at 13.59 g/cm3, so it can sink under multiple liquids. The melting temperature of mercury is -38.87 ° C, the boiling temperature is 356.6 ° C, and the melting phase is narrow. And the performance of mercury is also good, and it is good.
Xenon is a rare element, and it is often colored and smelly under normal conditions. Its density is greater than that of air, at 5.8971 g/L. Xenon fusion - 111.9 ℃, boiling - 108.1 ℃. Due to the fact that the outer layer has been filled in, the chemical properties are determined, and the biochemical reactions of other substances are determined. However, under specific conditions, compounds can also be formed.
2 - Aminonaphthalene compounds are often solid under normal conditions. The outer layer is often light-colored and crystalline. 2 - Aminonaphthalene fusion - 111 - 113 ℃, insoluble in water, soluble in ethanol, ethyl ether, benzene, etc. Due to the fact that the molecule contains aminonaphthalene, it has both the partial properties of amine aromatics, and is used in the field of synthesis.
Xenon is a rare element, and it is often colored and smelly under normal conditions. Its density is greater than that of air, at 5.8971 g/L. Xenon fusion - 111.9 ℃, boiling - 108.1 ℃. Due to the fact that the outer layer has been filled in, the chemical properties are determined, and the biochemical reactions of other substances are determined. However, under specific conditions, compounds can also be formed.
2 - Aminonaphthalene compounds are often solid under normal conditions. The outer layer is often light-colored and crystalline. 2 - Aminonaphthalene fusion - 111 - 113 ℃, insoluble in water, soluble in ethanol, ethyl ether, benzene, etc. Due to the fact that the molecule contains aminonaphthalene, it has both the partial properties of amine aromatics, and is used in the field of synthesis.
What are the chemical properties of 1-bromo-4-chloro-2-nitrobenzene?
The chemical properties of 1 + -mercury-4 + -bromine-2 + -aminonaphthalene are as follows:
mercury, the only metal that is liquid at room temperature. It has a silver luster, high density and good fluidity. The chemical properties are relatively stable, and it can react with strong oxidants, such as aqua regia. Mercury can form amalgamates with a variety of metals, which is widely used in metallurgy and other fields. And mercury vapor is toxic, and inhalation can cause serious health damage to the human body.
Bromine, at room temperature and pressure, is a dark reddish-brown smoky liquid with a strong pungent odor. Bromine is chemically active, a strong oxidant, and can react with many metals and non-metals. It can be directly combined with metals and can also participate in organic reactions, such as substitution reactions, addition reactions, etc., which play a significant role in the field of organic synthesis.
2-Aminonaphthalene, an organic compound containing an amino group and a naphthalene ring. The amino group is basic and can react with acids to form salts. The naphthalene ring imparts certain aromaticity, enabling it to undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. 2-Aminonaphthalene can be used in the preparation of fine chemicals such as dyes and pharmaceuticals, and plays an important role in the chemical industry.
These three have unique chemical properties and have important applications in different fields. However, it is also necessary to pay attention to the toxicity and corrosiveness of mercury and bromine. When using, follow safety regulations.
mercury, the only metal that is liquid at room temperature. It has a silver luster, high density and good fluidity. The chemical properties are relatively stable, and it can react with strong oxidants, such as aqua regia. Mercury can form amalgamates with a variety of metals, which is widely used in metallurgy and other fields. And mercury vapor is toxic, and inhalation can cause serious health damage to the human body.
Bromine, at room temperature and pressure, is a dark reddish-brown smoky liquid with a strong pungent odor. Bromine is chemically active, a strong oxidant, and can react with many metals and non-metals. It can be directly combined with metals and can also participate in organic reactions, such as substitution reactions, addition reactions, etc., which play a significant role in the field of organic synthesis.
2-Aminonaphthalene, an organic compound containing an amino group and a naphthalene ring. The amino group is basic and can react with acids to form salts. The naphthalene ring imparts certain aromaticity, enabling it to undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. 2-Aminonaphthalene can be used in the preparation of fine chemicals such as dyes and pharmaceuticals, and plays an important role in the chemical industry.
These three have unique chemical properties and have important applications in different fields. However, it is also necessary to pay attention to the toxicity and corrosiveness of mercury and bromine. When using, follow safety regulations.
What are the common methods for synthesizing 1-bromo-4-chloro-2-nitrobenzene?
To prepare 1-bromo-4-fluoro-2-aminobenzene, the common synthesis method is as follows:
Take p-fluoroaniline first, protect the amino group with acetyl group, and obtain N-acetyl-4-fluoroaniline. The purpose of this step is to make the amino group more stable in the subsequent reaction, free from unnecessary side reactions. The reagent used is acetic anhydride, which is heated and stirred in a suitable solvent such as pyridine, and the acylation reaction occurs between the two to obtain the product.
Next, N-acetyl-4-fluoroaniline is brominated. Using liquid bromine as brominating agent, liquid bromine is slowly added dropwise at low temperature in solvents such as glacial acetic acid. Due to the fact that acetamide is an ortho-para-locator and the influence of steric hindrance, bromine atoms mainly replace amino-para-hydrogen to generate N-acetyl-4-fluoro-3-bromoaniline. This reaction requires attention to the reaction temperature and the dropwise acceleration of bromine to prevent the formation of polybrominated products.
Subsequently, N-acetyl-4-fluoro-3-bromoaniline is hydrolyzed to remove the acetyl protection. Using dilute hydrochloric acid or dilute sulfuric acid as hydrolysis reagent, heating refluxing, the amide bond is broken, and the amino group is regenerated to obtain 4-fluoro-3-bromoaniline.
Finally, bromine atoms are introduced through diazotization and Sandmeier reaction. First, 4-fluoro-3-bromoaniline is diazotized by sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. After that, a catalyst such as cuprous bromide is added, and the diazoyl group is replaced by bromine atoms, and finally 1-bromo-4-fluoro-2-aminobenzene is obtained. During this process, the temperature of the diazotization reaction needs to be strictly controlled to prevent the decomposition of diazon
The above steps each have their own key points, and require fine operation and control of the reaction conditions to obtain the target product.
Take p-fluoroaniline first, protect the amino group with acetyl group, and obtain N-acetyl-4-fluoroaniline. The purpose of this step is to make the amino group more stable in the subsequent reaction, free from unnecessary side reactions. The reagent used is acetic anhydride, which is heated and stirred in a suitable solvent such as pyridine, and the acylation reaction occurs between the two to obtain the product.
Next, N-acetyl-4-fluoroaniline is brominated. Using liquid bromine as brominating agent, liquid bromine is slowly added dropwise at low temperature in solvents such as glacial acetic acid. Due to the fact that acetamide is an ortho-para-locator and the influence of steric hindrance, bromine atoms mainly replace amino-para-hydrogen to generate N-acetyl-4-fluoro-3-bromoaniline. This reaction requires attention to the reaction temperature and the dropwise acceleration of bromine to prevent the formation of polybrominated products.
Subsequently, N-acetyl-4-fluoro-3-bromoaniline is hydrolyzed to remove the acetyl protection. Using dilute hydrochloric acid or dilute sulfuric acid as hydrolysis reagent, heating refluxing, the amide bond is broken, and the amino group is regenerated to obtain 4-fluoro-3-bromoaniline.
Finally, bromine atoms are introduced through diazotization and Sandmeier reaction. First, 4-fluoro-3-bromoaniline is diazotized by sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. After that, a catalyst such as cuprous bromide is added, and the diazoyl group is replaced by bromine atoms, and finally 1-bromo-4-fluoro-2-aminobenzene is obtained. During this process, the temperature of the diazotization reaction needs to be strictly controlled to prevent the decomposition of diazon
The above steps each have their own key points, and require fine operation and control of the reaction conditions to obtain the target product.
In what fields is 1-bromo-4-chloro-2-nitrobenzene used?
1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene has applications in many fields, as detailed below:
Pharmaceutical field
In the field of pharmaceutical chemistry, this compound can be used as a key pharmaceutical intermediate. Its unique chemical structure can assist in the synthesis of a variety of drug molecules with specific biological activities. For example, with its amino and phenyl ring structure, it can participate in a series of chemical reactions and combine with other active groups to prepare drugs with antibacterial and anti-inflammatory effects. By carefully designing the chemical reaction process, using 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene as the starting material, with the help of acylation, alkylation and other reaction steps, new drugs with complex structures and precise pharmacological effects can be synthesized, providing more effective means for the treatment of diseases.
Field of Materials Science
In the field of materials science, 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene can be used to prepare special polymer materials. Because its amino group has reactivity, it can react with monomers containing active groups such as carboxyl and epoxy groups to form polymers with unique properties. Such polymers may have good mechanical properties, thermal stability and chemical stability, and can be used in high-end fields such as aerospace and automobile manufacturing. For example, in the aerospace field, some parts used to make aircraft require materials to have lightweight, high strength and high temperature resistance. Polymer materials synthesized by 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene may meet these stringent requirements.
Organic Synthesis Field
From the perspective of organic synthesis, this compound is an extremely important synthetic building block. Its ether bond, alkyl and aminobenzene structures provide a wealth of reaction check points for organic synthesis chemists. These check points can be used to carry out diverse organic reactions such as nucleophilic substitution and electrophilic substitution to construct complex organic molecular structures. For example, when constructing organic functional materials with special optical or electrical properties, 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene can be used as a basic structural unit to connect other functional modules through gradual reactions, and finally obtain the required functional organic materials, providing a new material basis for the development of organic optoelectronics.
Pharmaceutical field
In the field of pharmaceutical chemistry, this compound can be used as a key pharmaceutical intermediate. Its unique chemical structure can assist in the synthesis of a variety of drug molecules with specific biological activities. For example, with its amino and phenyl ring structure, it can participate in a series of chemical reactions and combine with other active groups to prepare drugs with antibacterial and anti-inflammatory effects. By carefully designing the chemical reaction process, using 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene as the starting material, with the help of acylation, alkylation and other reaction steps, new drugs with complex structures and precise pharmacological effects can be synthesized, providing more effective means for the treatment of diseases.
Field of Materials Science
In the field of materials science, 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene can be used to prepare special polymer materials. Because its amino group has reactivity, it can react with monomers containing active groups such as carboxyl and epoxy groups to form polymers with unique properties. Such polymers may have good mechanical properties, thermal stability and chemical stability, and can be used in high-end fields such as aerospace and automobile manufacturing. For example, in the aerospace field, some parts used to make aircraft require materials to have lightweight, high strength and high temperature resistance. Polymer materials synthesized by 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene may meet these stringent requirements.
Organic Synthesis Field
From the perspective of organic synthesis, this compound is an extremely important synthetic building block. Its ether bond, alkyl and aminobenzene structures provide a wealth of reaction check points for organic synthesis chemists. These check points can be used to carry out diverse organic reactions such as nucleophilic substitution and electrophilic substitution to construct complex organic molecular structures. For example, when constructing organic functional materials with special optical or electrical properties, 1 + - + ether + - + 4 + - + alkane + - + 2 + - + aminobenzene can be used as a basic structural unit to connect other functional modules through gradual reactions, and finally obtain the required functional organic materials, providing a new material basis for the development of organic optoelectronics.
What are the storage conditions for 1-bromo-4-chloro-2-nitrobenzene?
The storage conditions of 1 + -mercury-4 + -arsenic-2 + -aminonaphthalene vary depending on the characteristics of the substances.
Mercury is a liquid metal, volatile and highly toxic. It should be stored in a sealed container and placed in a cool and ventilated place, protected from heat and direct sunlight. If the seal is not good, mercury is easily volatilized in the air, and human inhalation will cause mercury poisoning. In addition, mercury is prone to form amalgam with various metals, so storage containers should not be made of metals that are easy to react with mercury.
Arsenic is also a highly toxic substance, mostly in the form of compounds. When stored in a dry, cool and well-ventilated place, away from fire and heat sources. Because many of its compounds are oxidizing or reducing, they should be stored separately from flammable, flammable and reducing agents to prevent dangerous chemical reactions.
2 + -aminonaphthalene is an organic compound. Usually it needs to be sealed and stored in a cool and dry place to avoid high temperature and open flames. Because of its flammability, it can burn in case of open flames and hot topics. At the same time, 2 + -aminonaphthalene can react strongly with oxidants, so it should also be placed separately from oxidants to ensure safety.
All of these items are dangerous and harmful, and when stored, relevant safety norms and standards must be strictly followed to avoid harm to people and the environment.
Mercury is a liquid metal, volatile and highly toxic. It should be stored in a sealed container and placed in a cool and ventilated place, protected from heat and direct sunlight. If the seal is not good, mercury is easily volatilized in the air, and human inhalation will cause mercury poisoning. In addition, mercury is prone to form amalgam with various metals, so storage containers should not be made of metals that are easy to react with mercury.
Arsenic is also a highly toxic substance, mostly in the form of compounds. When stored in a dry, cool and well-ventilated place, away from fire and heat sources. Because many of its compounds are oxidizing or reducing, they should be stored separately from flammable, flammable and reducing agents to prevent dangerous chemical reactions.
2 + -aminonaphthalene is an organic compound. Usually it needs to be sealed and stored in a cool and dry place to avoid high temperature and open flames. Because of its flammability, it can burn in case of open flames and hot topics. At the same time, 2 + -aminonaphthalene can react strongly with oxidants, so it should also be placed separately from oxidants to ensure safety.
All of these items are dangerous and harmful, and when stored, relevant safety norms and standards must be strictly followed to avoid harm to people and the environment.
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