Linshang Chemical
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1-Bromo-4-Chloro-3,5-Difluorobenzene
|
HS Code |
436274 |
| Chemical Formula | C6H2BrClF2 |
| Molecular Weight | 229.43 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 192 - 194 °C |
| Density | 1.806 g/mL at 25 °C |
| Flash Point | 79 °C |
| Solubility | Insoluble in water, soluble in organic solvents like ethanol, ether |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Bromo-4-Chloro-3,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - bromo - 4 - chloro - 3,5 - difluorobenzene packaged in 500g bottles. |
| Storage | 1 - Bromo - 4 - chloro - 3,5 - difluorobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and incompatible substances. Keep it in a tightly sealed container made of suitable materials, like glass or certain plastics resistant to its chemical action. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. |
| Shipping | 1 - bromo - 4 - chloro - 3,5 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transportation to prevent spills and environmental or safety risks. |
Competitive 1-Bromo-4-Chloro-3,5-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Bromo-4-Chloro-3,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1 - bromo - 4 - chloro - 3,5 - difluorobenzene
1-Bromo-4-chloro-3,5-difluorobenzene is a crucial intermediate in organic synthesis. It has a wide range of uses and has significant applications in many fields such as medicine, pesticides and materials science.
In the field of medicine, this compound is often used as a key intermediate to create new drugs. Due to the unique electronic and spatial effects of halogen and fluorine atoms, it can endow drug molecules with specific biological activities and pharmacokinetic properties. For example, through clever design and chemical reaction, it can be constructed into the molecular structure of drugs, enhancing the ability of drugs to bind to targets, improving drug efficacy, or improving the absorption, distribution, metabolism and excretion of drugs. With its unique structure, it is helpful to develop specific drugs for specific diseases, such as tumors and cardiovascular diseases.
In the field of pesticides, 1-bromo-4-chloro-3,5-difluorobenzene also plays a key role. The introduction of halogen atoms and fluorine atoms can enhance the biological activity, stability and environmental adaptability of pesticides. By using them as raw materials for synthesis reactions, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be created. Such pesticides are highly selective and lethal to pests and pathogens, and can effectively protect crops from pests and diseases, while reducing the harm to the environment and non-target organisms, meeting the needs of today's green agriculture development.
In the field of materials science, 1-bromo-4-chloro-3,5-difluorobenzene can be used to prepare high-performance functional materials. Due to its special chemical structure, it can participate in polymerization reactions or other material synthesis processes, endowing materials with unique electrical, optical and thermal properties. For example, it can be used to synthesize organic optoelectronic materials, which can be used in optoelectronic devices such as Light Emitting Diode (LED) and organic solar cells to improve the performance and efficiency of devices. It can also be used to prepare high-performance engineering plastics, enhance the mechanical properties, heat resistance and chemical stability of materials, and expand the application range of materials. With its unique structure and chemical properties, 1-bromo-4-chloro-3,5-difluorobenzene has shown great application potential in the fields of medicine, pesticides and materials science, and is of indispensable significance for promoting the development of related fields.
In the field of medicine, this compound is often used as a key intermediate to create new drugs. Due to the unique electronic and spatial effects of halogen and fluorine atoms, it can endow drug molecules with specific biological activities and pharmacokinetic properties. For example, through clever design and chemical reaction, it can be constructed into the molecular structure of drugs, enhancing the ability of drugs to bind to targets, improving drug efficacy, or improving the absorption, distribution, metabolism and excretion of drugs. With its unique structure, it is helpful to develop specific drugs for specific diseases, such as tumors and cardiovascular diseases.
In the field of pesticides, 1-bromo-4-chloro-3,5-difluorobenzene also plays a key role. The introduction of halogen atoms and fluorine atoms can enhance the biological activity, stability and environmental adaptability of pesticides. By using them as raw materials for synthesis reactions, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be created. Such pesticides are highly selective and lethal to pests and pathogens, and can effectively protect crops from pests and diseases, while reducing the harm to the environment and non-target organisms, meeting the needs of today's green agriculture development.
In the field of materials science, 1-bromo-4-chloro-3,5-difluorobenzene can be used to prepare high-performance functional materials. Due to its special chemical structure, it can participate in polymerization reactions or other material synthesis processes, endowing materials with unique electrical, optical and thermal properties. For example, it can be used to synthesize organic optoelectronic materials, which can be used in optoelectronic devices such as Light Emitting Diode (LED) and organic solar cells to improve the performance and efficiency of devices. It can also be used to prepare high-performance engineering plastics, enhance the mechanical properties, heat resistance and chemical stability of materials, and expand the application range of materials. With its unique structure and chemical properties, 1-bromo-4-chloro-3,5-difluorobenzene has shown great application potential in the fields of medicine, pesticides and materials science, and is of indispensable significance for promoting the development of related fields.
What are the physical properties of 1 - bromo - 4 - chloro - 3,5 - difluorobenzene
1 + -Bromo-4-chloro-3,5-difluorobenzene is also an organic compound. Its physical properties are particularly important, and it is related to the wide range of its applications.
First of all, discuss its physical state. At room temperature, 1 + -bromo-4-chloro-3,5-difluorobenzene is usually in a liquid state. When it is pure, it is clear and transparent, and it looks like a mirror. It has an orderly arrangement of molecules and a stable structure.
Times and boiling point. The boiling point of this substance is quite high, between about 180 ° C and 190 ° C. The high boiling point is caused by the intermolecular force. The halogen atoms such as bromine, chlorine, and fluorine in the molecule have strong electronegativity, and the intermolecular force formed is not weak. To make it change from liquid to gaseous state, more energy is required, so the boiling point is higher.
Melting point is also an important physical property. Its melting point is about -10 ° C - 0 ° C. The value of the melting point is related to the symmetry and close arrangement of the molecule. The molecular structure makes the interaction of each atom reach an equilibrium. At this temperature range, solid and liquid states can be converted into each other.
In terms of density, the density of 1 + -bromo-4-chloro-3,5-difluorobenzene is greater than that of water, which is about 1.8-1.9 g/cm ³. Because the bromine, chlorine, and fluorine atoms in the molecular weight are relatively large, they fill the molecular space and increase the weight per unit volume, so when they are put into water, they will sink to the bottom.
Solubility is another important item. It is difficult to dissolve in water, because water is a polar molecule, while 1 + -bromo-4-chlorine-3,5-difluorobenzene molecules contain halogen atoms, but the overall polarity is weak. According to the principle of "similar miscibility", the two are difficult to miscible. However, it is soluble in common organic solvents, such as ether, dichloromethane, carbon tetrachloride, etc. Because most organic solvents are non-polar or weakly polar, they are compatible with the molecular force of 1 + -bromo-4-chloro-3,5-difluorobenzene and are mutually soluble.
1 + -bromo-4-chloro-3,5-difluorobenzene also has a considerable color and smell. It is colorless, has no special irritating smell, and has a weak aromatic smell. This smell originates from the benzene ring structure. Although it is not strong and pungent, it can also be detected in specific environments.
The physical properties of this compound make it useful in the fields of organic synthesis, medicinal chemistry, and materials science. Researchers can make good use of its physical properties to achieve various innovative results.
First of all, discuss its physical state. At room temperature, 1 + -bromo-4-chloro-3,5-difluorobenzene is usually in a liquid state. When it is pure, it is clear and transparent, and it looks like a mirror. It has an orderly arrangement of molecules and a stable structure.
Times and boiling point. The boiling point of this substance is quite high, between about 180 ° C and 190 ° C. The high boiling point is caused by the intermolecular force. The halogen atoms such as bromine, chlorine, and fluorine in the molecule have strong electronegativity, and the intermolecular force formed is not weak. To make it change from liquid to gaseous state, more energy is required, so the boiling point is higher.
Melting point is also an important physical property. Its melting point is about -10 ° C - 0 ° C. The value of the melting point is related to the symmetry and close arrangement of the molecule. The molecular structure makes the interaction of each atom reach an equilibrium. At this temperature range, solid and liquid states can be converted into each other.
In terms of density, the density of 1 + -bromo-4-chloro-3,5-difluorobenzene is greater than that of water, which is about 1.8-1.9 g/cm ³. Because the bromine, chlorine, and fluorine atoms in the molecular weight are relatively large, they fill the molecular space and increase the weight per unit volume, so when they are put into water, they will sink to the bottom.
Solubility is another important item. It is difficult to dissolve in water, because water is a polar molecule, while 1 + -bromo-4-chlorine-3,5-difluorobenzene molecules contain halogen atoms, but the overall polarity is weak. According to the principle of "similar miscibility", the two are difficult to miscible. However, it is soluble in common organic solvents, such as ether, dichloromethane, carbon tetrachloride, etc. Because most organic solvents are non-polar or weakly polar, they are compatible with the molecular force of 1 + -bromo-4-chloro-3,5-difluorobenzene and are mutually soluble.
1 + -bromo-4-chloro-3,5-difluorobenzene also has a considerable color and smell. It is colorless, has no special irritating smell, and has a weak aromatic smell. This smell originates from the benzene ring structure. Although it is not strong and pungent, it can also be detected in specific environments.
The physical properties of this compound make it useful in the fields of organic synthesis, medicinal chemistry, and materials science. Researchers can make good use of its physical properties to achieve various innovative results.
What are the synthesis methods of 1 - bromo - 4 - chloro - 3,5 - difluorobenzene
There are several common methods for the synthesis of 1 + -bromo-4-chloro-3,5-difluorobenzene.
One is the halogenation reaction method. A suitable benzene derivative is used as the starting material, and bromine atoms are introduced first. Liquid bromine can be selected to react with benzene derivatives under the catalysis of Lewis acid such as iron tribromide. In this process, attention should be paid to the reaction temperature and catalyst dosage to ensure that the bromine atoms are precisely positioned in the desired position. Next, chlorine atoms are introduced. Chlorine gas can be used to carry out chlorination reaction under light or specific catalyst action. When introducing fluorine atoms, nucleophilic fluorination reagents, such as potassium fluoride, can be used to achieve fluorination reaction under suitable solvent and reaction conditions. The key to this method lies in the precise control of the reaction conditions at each step to improve the selectivity and yield of the target product.
The second is through functional group conversion. The benzene derivative containing the required part of the functional group is first prepared, and then a series of functional groups are converted to achieve the construction of the target molecule. For example, the benzene derivative containing bromine and chlorine is first synthesized, and then the specific group is converted into a fluorine atom through a suitable nucleophilic substitution reaction or other conversion reactions. This approach requires in-depth understanding of the reactivity and conversion conditions of various functional groups in order to skillfully design the reaction route, effectively avoid side reactions and improve the synthesis efficiency.
The third is the coupling reaction catalyzed by palladium. Using bromine and chlorine-containing benzene derivatives as substrates, the coupling reaction is carried out with fluorine-containing organometallic reagents or other suitable fluorinated substitutes under the action of palladium catalysts and ligands. This method can achieve the cleavage of carbon-halogen bonds and the formation of carbon-fluorine bonds under milder conditions, and has high selectivity for substrates. However, palladium catalysts are expensive, and the amount of catalyst and reaction conditions need to be carefully adjusted in the reaction to take into account the cost and reaction effect.
One is the halogenation reaction method. A suitable benzene derivative is used as the starting material, and bromine atoms are introduced first. Liquid bromine can be selected to react with benzene derivatives under the catalysis of Lewis acid such as iron tribromide. In this process, attention should be paid to the reaction temperature and catalyst dosage to ensure that the bromine atoms are precisely positioned in the desired position. Next, chlorine atoms are introduced. Chlorine gas can be used to carry out chlorination reaction under light or specific catalyst action. When introducing fluorine atoms, nucleophilic fluorination reagents, such as potassium fluoride, can be used to achieve fluorination reaction under suitable solvent and reaction conditions. The key to this method lies in the precise control of the reaction conditions at each step to improve the selectivity and yield of the target product.
The second is through functional group conversion. The benzene derivative containing the required part of the functional group is first prepared, and then a series of functional groups are converted to achieve the construction of the target molecule. For example, the benzene derivative containing bromine and chlorine is first synthesized, and then the specific group is converted into a fluorine atom through a suitable nucleophilic substitution reaction or other conversion reactions. This approach requires in-depth understanding of the reactivity and conversion conditions of various functional groups in order to skillfully design the reaction route, effectively avoid side reactions and improve the synthesis efficiency.
The third is the coupling reaction catalyzed by palladium. Using bromine and chlorine-containing benzene derivatives as substrates, the coupling reaction is carried out with fluorine-containing organometallic reagents or other suitable fluorinated substitutes under the action of palladium catalysts and ligands. This method can achieve the cleavage of carbon-halogen bonds and the formation of carbon-fluorine bonds under milder conditions, and has high selectivity for substrates. However, palladium catalysts are expensive, and the amount of catalyst and reaction conditions need to be carefully adjusted in the reaction to take into account the cost and reaction effect.
1 - bromo - 4 - chloro - 3,5 - difluorobenzene What are the precautions in storage and transportation
For 1 + -bromo-4-chloro-3,5-difluorobenzene, many matters need to be paid attention to during storage and transportation.
This compound is chemically active and has strict requirements on the temperature and humidity of the storage environment. If the temperature is high, it is easy to increase its reactivity, or cause reactions such as decomposition and polymerization, which will damage its quality; if it is wet, it is easy to get damp, or react with water vapor, causing the risk of deterioration. Therefore, it should be stored in a cool, dry and well-ventilated place. The temperature should be controlled within a specific range, and the humidity must also be strictly limited.
Furthermore, because of its active chemical properties, the packaging must be solid and well sealed. The packaging material should be resistant to the corrosion of this compound to prevent leakage. Commonly used glass bottles, plastic bottles or special metal containers must be strictly tested to ensure that there is no leakage. And the name, nature, danger warning and other information must be clearly marked on the outside of the package for identification and disposal.
When transporting, caution must also be taken. It is necessary to choose the appropriate mode of transportation according to its chemical characteristics. Do not mix with oxidizing, reducing or alkaline substances to prevent violent reactions and endanger transportation safety. Transportation tools should also be clean and dry without other chemical residues. During transportation, environmental parameters such as temperature and humidity must be closely monitored to ensure stable conditions. Escort personnel must undergo professional training and be familiar with the characteristics of this compound and emergency treatment methods. In case of emergencies, they can respond quickly and properly to ensure the safety of the entire transportation process.
This compound is chemically active and has strict requirements on the temperature and humidity of the storage environment. If the temperature is high, it is easy to increase its reactivity, or cause reactions such as decomposition and polymerization, which will damage its quality; if it is wet, it is easy to get damp, or react with water vapor, causing the risk of deterioration. Therefore, it should be stored in a cool, dry and well-ventilated place. The temperature should be controlled within a specific range, and the humidity must also be strictly limited.
Furthermore, because of its active chemical properties, the packaging must be solid and well sealed. The packaging material should be resistant to the corrosion of this compound to prevent leakage. Commonly used glass bottles, plastic bottles or special metal containers must be strictly tested to ensure that there is no leakage. And the name, nature, danger warning and other information must be clearly marked on the outside of the package for identification and disposal.
When transporting, caution must also be taken. It is necessary to choose the appropriate mode of transportation according to its chemical characteristics. Do not mix with oxidizing, reducing or alkaline substances to prevent violent reactions and endanger transportation safety. Transportation tools should also be clean and dry without other chemical residues. During transportation, environmental parameters such as temperature and humidity must be closely monitored to ensure stable conditions. Escort personnel must undergo professional training and be familiar with the characteristics of this compound and emergency treatment methods. In case of emergencies, they can respond quickly and properly to ensure the safety of the entire transportation process.
What are the effects of 1 - bromo - 4 - chloro - 3,5 - difluorobenzene on the environment and human health?
1 + -Bromo-4-chloro-3,5-difluorobenzene is a synthetic organic halide, which is widely used in the field of chemical production, but it has potential effects on the environment and human health.
At the environmental level, this substance is highly stable due to its halogen atoms, and it is not easy to be degraded by the natural environment, so it is easy to accumulate. If it flows into the soil through various channels, it will cause changes in the physical and chemical properties of the soil, hinder the normal activities of microorganisms in the soil and the absorption of nutrients by plant roots, thereby affecting the growth of vegetation and destroying the ecological balance. Inflow into water bodies, because of its hydrophobicity, or adsorption on suspended particulate matter, settles to the bottom sediment, and persists for a long time, posing a threat to aquatic organisms. Such as interfering with the endocrine system of aquatic organisms, causing their reproduction and development abnormalities, and reducing the population reproduction ability. And through the biomagnification of the food chain, it accumulates in high-trophic organisms, endangering the structure and function of the entire aquatic ecosystem.
As for human health, this substance can enter the human body through respiratory tract, skin contact or accidental ingestion. Its halogenated aromatic hydrocarbon structure easily reacts with biological macromolecules such as DNA and proteins in the body, or causes DNA damage and genetic mutations, increasing the risk of cancer. Long-term exposure, or damage to the nervous system, causing symptoms such as headache, dizziness, memory loss, etc., may also affect the immune system, weaken the body's resistance to diseases, and lead to immune dysfunction. Therefore, in the process of using and producing 1-bromo-4-chloro-3,5-difluorobenzene, proper protective measures and environmental management measures must be taken to reduce its harm to the environment and human health.
At the environmental level, this substance is highly stable due to its halogen atoms, and it is not easy to be degraded by the natural environment, so it is easy to accumulate. If it flows into the soil through various channels, it will cause changes in the physical and chemical properties of the soil, hinder the normal activities of microorganisms in the soil and the absorption of nutrients by plant roots, thereby affecting the growth of vegetation and destroying the ecological balance. Inflow into water bodies, because of its hydrophobicity, or adsorption on suspended particulate matter, settles to the bottom sediment, and persists for a long time, posing a threat to aquatic organisms. Such as interfering with the endocrine system of aquatic organisms, causing their reproduction and development abnormalities, and reducing the population reproduction ability. And through the biomagnification of the food chain, it accumulates in high-trophic organisms, endangering the structure and function of the entire aquatic ecosystem.
As for human health, this substance can enter the human body through respiratory tract, skin contact or accidental ingestion. Its halogenated aromatic hydrocarbon structure easily reacts with biological macromolecules such as DNA and proteins in the body, or causes DNA damage and genetic mutations, increasing the risk of cancer. Long-term exposure, or damage to the nervous system, causing symptoms such as headache, dizziness, memory loss, etc., may also affect the immune system, weaken the body's resistance to diseases, and lead to immune dysfunction. Therefore, in the process of using and producing 1-bromo-4-chloro-3,5-difluorobenzene, proper protective measures and environmental management measures must be taken to reduce its harm to the environment and human health.
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