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1-Bromo-4-(Chloromethyl)-2-Methoxybenzene
Linshang Chemical
|
HS Code |
475848 |
| Chemical Formula | C8H8BrClO |
| Molar Mass | 235.505 g/mol |
| Appearance | Typically a colorless to light - colored liquid or solid |
| Boiling Point | Estimated around 270 - 280 °C under normal pressure (approximate, needs experimental verification) |
| Density | Approximate density around 1.5 - 1.7 g/cm³ (estimated) |
| Solubility In Water | Low solubility in water due to its non - polar aromatic and halogenated nature |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Flash Point | Should be handled with care, flash point may be in the range relevant to organic halogen - containing compounds, estimated around 100 - 120 °C |
| Purity | Purity can vary depending on synthesis and purification methods, can be achieved up to high purity levels like 95% or more in well - controlled processes |
As an accredited 1-Bromo-4-(Chloromethyl)-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 4 - (chloromethyl) - 2 - methoxybenzene in a sealed chemical - grade bottle. |
| Storage | 1 - bromo - 4 - (chloromethyl)-2 - methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air or moisture, which could potentially cause decomposition or unwanted reactions. Label the storage container clearly for easy identification. |
| Shipping | 1 - bromo - 4 - (chloromethyl)-2 - methoxybenzene is a chemical. It should be shipped in properly labeled, sealed containers, compliant with hazardous materials regulations, ensuring safe transport to prevent spills and exposure. |
Competitive 1-Bromo-4-(Chloromethyl)-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1 - bromo - 4 - (chloromethyl) -2 - methoxybenzene
1-Bromo-4- (chloromethyl) -2-methoxybenzene, this is an organic compound. Its chemical properties are unique and contain many key properties.
In this compound, bromine atoms, chloromethyl groups and methoxy groups are all chemically active. As a halogen atom, bromine atoms are easy to participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic reagents can attack the carbon atoms connected to bromine, causing bromine ions to leave, and then generate new compounds. This reaction has a wide range of uses in organic synthesis and can be used to construct carbon-carbon bonds, carbon-heteroatomic bonds, etc. The chlorine atoms in chloromethyl are also active and can undergo nucleophilic substitution reactions similar to those in chloromethyl. Due to its halogenated hydrocarbon structure, chlorine atoms are easily replaced by other nucleophilic groups under basic conditions, thus achieving diverse modification of molecular structures.
Methoxy group as the power supply subgroup will affect the electron cloud density distribution of the benzene ring. It increases the electron cloud density of the ortho and para-sites of the benzene ring, makes the benzene ring more prone to electrophilic substitution reaction, and the localization effect makes the electrophilic reagents more inclined to attack the ortho and para-sites of the methoxy group.
In addition, the benzene ring in this compound is aromatic and relatively stable, but under certain conditions, such as the action of strong oxidants or high temperature and high pressure with catalysts, the structure of the benzene ring may also change, participating in oxidation, addition and other reactions.
Due to the simultaneous presence of bromine atoms and chloromethyl groups in the molecule, the reaction conditions and reagents need to be carefully selected in the reaction to achieve selective reaction of specific groups, so as to achieve the synthesis of target compounds. In short, 1-bromo-4- (chloromethyl) -2-methoxybenzene has rich and diverse chemical properties and has broad application prospects in the field of organic synthetic chemistry.
In this compound, bromine atoms, chloromethyl groups and methoxy groups are all chemically active. As a halogen atom, bromine atoms are easy to participate in nucleophilic substitution reactions. Under suitable conditions, nucleophilic reagents can attack the carbon atoms connected to bromine, causing bromine ions to leave, and then generate new compounds. This reaction has a wide range of uses in organic synthesis and can be used to construct carbon-carbon bonds, carbon-heteroatomic bonds, etc. The chlorine atoms in chloromethyl are also active and can undergo nucleophilic substitution reactions similar to those in chloromethyl. Due to its halogenated hydrocarbon structure, chlorine atoms are easily replaced by other nucleophilic groups under basic conditions, thus achieving diverse modification of molecular structures.
Methoxy group as the power supply subgroup will affect the electron cloud density distribution of the benzene ring. It increases the electron cloud density of the ortho and para-sites of the benzene ring, makes the benzene ring more prone to electrophilic substitution reaction, and the localization effect makes the electrophilic reagents more inclined to attack the ortho and para-sites of the methoxy group.
In addition, the benzene ring in this compound is aromatic and relatively stable, but under certain conditions, such as the action of strong oxidants or high temperature and high pressure with catalysts, the structure of the benzene ring may also change, participating in oxidation, addition and other reactions.
Due to the simultaneous presence of bromine atoms and chloromethyl groups in the molecule, the reaction conditions and reagents need to be carefully selected in the reaction to achieve selective reaction of specific groups, so as to achieve the synthesis of target compounds. In short, 1-bromo-4- (chloromethyl) -2-methoxybenzene has rich and diverse chemical properties and has broad application prospects in the field of organic synthetic chemistry.
What are the main uses of 1 - bromo - 4 - (chloromethyl) -2 - methoxybenzene
1-Bromo-4- (chloromethyl) -2-methoxybenzene is an important raw material for organic synthesis. It has a wide range of uses and is often a key intermediate for the creation of new drugs in the field of medicinal chemistry. If a compound with specific pharmacological activity is synthesized, the introduction of this structure through a delicate reaction path can endow the drug with unique efficacy, or increase its affinity to specific targets, or modify its pharmacokinetic properties.
In the field of materials science, it also has its uses. It can participate in the preparation of polymer materials with special properties. Through its active halogenated hydrocarbon groups, it can react with other monomers to create materials with unique electrical, optical or mechanical properties, such as for organic optoelectronic materials, or to improve the solubility and stability of materials.
Furthermore, in the synthesis of fine chemicals, this compound is also indispensable. It can be used as a starting material through multiple steps to prepare fine chemicals such as fragrances, preservatives, and pesticides, providing a variety of products for industrial production and daily life. Its active functional groups enable chemists to use various organic reactions to construct complex molecular structures to meet the needs of different fields. It is an important cornerstone of organic synthetic chemistry.
In the field of materials science, it also has its uses. It can participate in the preparation of polymer materials with special properties. Through its active halogenated hydrocarbon groups, it can react with other monomers to create materials with unique electrical, optical or mechanical properties, such as for organic optoelectronic materials, or to improve the solubility and stability of materials.
Furthermore, in the synthesis of fine chemicals, this compound is also indispensable. It can be used as a starting material through multiple steps to prepare fine chemicals such as fragrances, preservatives, and pesticides, providing a variety of products for industrial production and daily life. Its active functional groups enable chemists to use various organic reactions to construct complex molecular structures to meet the needs of different fields. It is an important cornerstone of organic synthetic chemistry.
What are the synthesis methods of 1 - bromo - 4 - (chloromethyl) -2 - methoxybenzene
The synthesis method of 1 + -bromo-4- (chloromethyl) -2 -methoxybenzene has been around for a long time. There are many methods, so I will describe them here.
First, 2-methoxy-4-methylphenol is used as the starting material. First, this phenol is reacted with bromine in a suitable solvent under mild conditions to obtain 1-bromo-2-methoxy-4-methylbenzene. Then, the product is co-placed in an organic solvent with N-chlorosuccinimide (NCS) and the initiator azobisisobutyronitrile (AIBN), and the reaction is initiated by heating. After the radical substitution process, 1-bromo-4- (chloromethyl) -2-methoxybenzene can be obtained. The beauty of this approach lies in the fact that the starting materials are readily available and the reaction steps are relatively clear. However, free radical reactions may have side reactions, and the reaction conditions need to be carefully regulated.
Second, 2-methoxy-4-chloromethylaniline is used as the raw material. The amine is first treated by diazotization reaction with sodium nitrite and inorganic acid at low temperature to obtain diazonium salts. Then the diazonium salt is reacted with a cuprous halide reagent such as cuprous bromide. After the Sandmeyer reaction, the diazonium group can be replaced with a bromine atom to obtain 1-bromo-4- (chloromethyl) -2-methoxylbenzene. Although this method is slightly complicated, the reaction selectivity is quite high, which can effectively avoid the occurrence of some side reactions.
Third, 2-methoxy-4- (hydroxymethyl) aniline is used as the starting material. First, it is reacted with halogenating agents such as thionyl chloride or phosphorus oxychloride to convert hydroxymethyl into chloromethyl to obtain 2-methoxy-4- (chloromethyl) aniline. Then according to the previous method, bromine atoms are introduced through diazotization and Sandmeier reaction, and 1-bromo-4- (chloromethyl) -2-methoxybenzene can also be formed. This path requires attention to the use of halogenating agents, because they are corrosive, and care should be taken during operation.
All these synthetic methods have advantages and disadvantages. Experimenters should choose the best one according to the actual situation, such as the availability of raw materials, the controllability of reaction conditions, and the purity requirements of the product.
First, 2-methoxy-4-methylphenol is used as the starting material. First, this phenol is reacted with bromine in a suitable solvent under mild conditions to obtain 1-bromo-2-methoxy-4-methylbenzene. Then, the product is co-placed in an organic solvent with N-chlorosuccinimide (NCS) and the initiator azobisisobutyronitrile (AIBN), and the reaction is initiated by heating. After the radical substitution process, 1-bromo-4- (chloromethyl) -2-methoxybenzene can be obtained. The beauty of this approach lies in the fact that the starting materials are readily available and the reaction steps are relatively clear. However, free radical reactions may have side reactions, and the reaction conditions need to be carefully regulated.
Second, 2-methoxy-4-chloromethylaniline is used as the raw material. The amine is first treated by diazotization reaction with sodium nitrite and inorganic acid at low temperature to obtain diazonium salts. Then the diazonium salt is reacted with a cuprous halide reagent such as cuprous bromide. After the Sandmeyer reaction, the diazonium group can be replaced with a bromine atom to obtain 1-bromo-4- (chloromethyl) -2-methoxylbenzene. Although this method is slightly complicated, the reaction selectivity is quite high, which can effectively avoid the occurrence of some side reactions.
Third, 2-methoxy-4- (hydroxymethyl) aniline is used as the starting material. First, it is reacted with halogenating agents such as thionyl chloride or phosphorus oxychloride to convert hydroxymethyl into chloromethyl to obtain 2-methoxy-4- (chloromethyl) aniline. Then according to the previous method, bromine atoms are introduced through diazotization and Sandmeier reaction, and 1-bromo-4- (chloromethyl) -2-methoxybenzene can also be formed. This path requires attention to the use of halogenating agents, because they are corrosive, and care should be taken during operation.
All these synthetic methods have advantages and disadvantages. Experimenters should choose the best one according to the actual situation, such as the availability of raw materials, the controllability of reaction conditions, and the purity requirements of the product.
Precautions for 1 - bromo - 4 - (chloromethyl) -2 - methoxybenzene during storage and transportation
For 1 + -bromo-4- (chloromethyl) -2 -methoxybenzene, be sure to pay attention to many key matters during storage and transportation.
This is an organic halide, which is active in nature and has certain chemical hazards. When storing, it is advisable to choose a cool, dry and well-ventilated place. Because it is sensitive to light and heat, if exposed to high temperature or strong light, it is easy to decompose or deteriorate, so it needs to be stored in a dark container, and the temperature should be controlled at a low level to prevent reactions.
Furthermore, this substance has certain toxicity and irritation, which is harmful to the human body. When storing, be sure to keep away from food, beverages and living areas, and make corresponding warning labels to make the contact clear of its potential hazards. Operators and transportation personnel need to wear appropriate protective equipment, such as gloves, protective glasses and protective clothing, to prevent contact with skin and eyes.
During transportation, ensure that the container is firmly sealed to prevent leakage. Due to its chemical activity, it should not be mixed with strong oxidants, strong alkalis and other substances to avoid severe reactions. Handling process also needs to be handled with care to avoid damage to the container.
In conclusion, when storing and transporting 1 + -bromo-4- (chloromethyl) -2 -methoxybenzene, there are strict requirements for environmental conditions, protective measures and transportation specifications. Only by following strictly can we ensure safety and avoid accidents.
This is an organic halide, which is active in nature and has certain chemical hazards. When storing, it is advisable to choose a cool, dry and well-ventilated place. Because it is sensitive to light and heat, if exposed to high temperature or strong light, it is easy to decompose or deteriorate, so it needs to be stored in a dark container, and the temperature should be controlled at a low level to prevent reactions.
Furthermore, this substance has certain toxicity and irritation, which is harmful to the human body. When storing, be sure to keep away from food, beverages and living areas, and make corresponding warning labels to make the contact clear of its potential hazards. Operators and transportation personnel need to wear appropriate protective equipment, such as gloves, protective glasses and protective clothing, to prevent contact with skin and eyes.
During transportation, ensure that the container is firmly sealed to prevent leakage. Due to its chemical activity, it should not be mixed with strong oxidants, strong alkalis and other substances to avoid severe reactions. Handling process also needs to be handled with care to avoid damage to the container.
In conclusion, when storing and transporting 1 + -bromo-4- (chloromethyl) -2 -methoxybenzene, there are strict requirements for environmental conditions, protective measures and transportation specifications. Only by following strictly can we ensure safety and avoid accidents.
Effects of 1 - bromo - 4 - (chloromethyl) -2 - methoxybenzene on the environment and human health
1 + -Bromo-4- (chloromethyl) -2 -methoxybenzene has a significant impact on the environment and human health. This compound has groups such as haloalkyl and methoxy, which are chemically active, difficult to degrade in the environment, or cause pollution to spread.
In the environment, it may enter the natural environment through wastewater and waste gas. In the soil, or ingested by plants, it affects growth and metabolism, and accumulates through the food chain, endangering high-nutrient organisms. When entering the water body, it affects aquatic organisms, causing changes in population structure and disrupting ecological balance. It volatilizes in the atmosphere, or participates in photochemical reactions, affecting air quality and damaging the atmospheric environment.
It is related to human health. This compound may be ingested into the human body through respiration, skin contact, or diet. Its haloalkyl group is electrophilic, or interacts with biological macromolecules such as DNA and proteins, causing gene mutation, cell damage, and increasing the risk of cancer. Long-term exposure may damage the nervous system, immune system, cognitive impairment, and immunodeficiency.
In summary, 1 + -bromo-4- (chloromethyl) -2 -methoxybenzene has latent risks to the environment and human health. It is necessary to properly control and reduce its release to protect the ecology and human well-being.
In the environment, it may enter the natural environment through wastewater and waste gas. In the soil, or ingested by plants, it affects growth and metabolism, and accumulates through the food chain, endangering high-nutrient organisms. When entering the water body, it affects aquatic organisms, causing changes in population structure and disrupting ecological balance. It volatilizes in the atmosphere, or participates in photochemical reactions, affecting air quality and damaging the atmospheric environment.
It is related to human health. This compound may be ingested into the human body through respiration, skin contact, or diet. Its haloalkyl group is electrophilic, or interacts with biological macromolecules such as DNA and proteins, causing gene mutation, cell damage, and increasing the risk of cancer. Long-term exposure may damage the nervous system, immune system, cognitive impairment, and immunodeficiency.
In summary, 1 + -bromo-4- (chloromethyl) -2 -methoxybenzene has latent risks to the environment and human health. It is necessary to properly control and reduce its release to protect the ecology and human well-being.
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