Linshang Chemical
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1-Bromo-4-(Chloromethyl)-Benzene
Linshang Chemical
|
HS Code |
434284 |
| Chemical Formula | C7H6BrCl |
| Molar Mass | 205.48 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | ~236 - 238 °C |
| Melting Point | ~12 - 14 °C |
| Density | 1.58 g/cm³ (approx.) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | ~101 °C |
| Reactive Group | Bromo and chloromethyl groups, reactive in substitution reactions |
As an accredited 1-Bromo-4-(Chloromethyl)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - bromo - 4 - (chloromethyl) - benzene packaged in a sealed glass bottle. |
| Storage | 1 - Bromo - 4 - (chloromethyl) - benzene should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. It is a hazardous chemical, so store it in a secure location, preferably in a chemical storage cabinet. Keep it separate from oxidizing agents, bases, and reactive materials. Use appropriate containers, such as tightly - sealed glass bottles, to prevent leakage and evaporation. |
| Shipping | 1 - bromo - 4 - (chloromethyl) - benzene is a hazardous chemical. Shipping requires proper packaging in accordance with regulations. It must be labeled clearly, and transported by carriers authorized for such chemicals, ensuring safety during transit. |
Competitive 1-Bromo-4-(Chloromethyl)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 1-Bromo-4-(Chloromethyl)-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1 - bromo - 4 - (chloromethyl) - benzene?
1-Bromo-4- (chloromethyl) benzene is also an organic compound. Its unique chemical properties are quite important to chemists.
First of all, its nucleophilic substitution reaction. Because the molecule contains bromine atoms and chloromethyl, both of which are active and easy to be attacked by nucleophilic reagents. Bromine atoms can be replaced by nucleophilic groups such as hydroxyl and amino groups. In an aqueous solution of sodium hydroxide, after heating, the bromine atom leaves, and the hydroxyl group replaces it to produce 4- (chloromethyl) phenol. The chlorine atom of chloromethyl is also active. Under suitable conditions, it can be replaced by nucleophilic reagents to form other compounds.
has the same properties as halogenated hydrocarbons. In the alcoholic solution of strong bases, elimination reactions can occur. Taking the ethanol solution of sodium ethanol as an example, when heated, hydrogen bromide or hydrogen chloride is removed, and unsaturated bonds are formed in the molecule to form aromatic derivatives containing double bonds. This is the way to construct unsaturated structures.
And the presence of benzene rings in this compound gives it the characteristics of aromatics. The benzene ring has a conjugated system, which is relatively stable and can undergo electrophilic substitution reactions. The hydrogen atom on the benzene ring can be replaced by electrophilic groups such as nitro and sulfonic acid. Under the mixed acid of concentrated sulfuric acid and concentrated nitric acid, nitro groups are introduced into the benzene ring to obtain the product of nitro substitution.
In addition, its chemical properties are affected by the electronic and spatial effects of the substituents. Bromine and chloromethyl are electron-absorbing groups, which reduce the electron cloud density of the benzene ring, slightly reduce the activity of electrophilic substitution reaction, and the substitution position is also dominated by its guiding effect.
1-bromo-4- (chloromethyl) benzene is rich in chemical properties and has a wide range of uses in the field of organic synthesis. It can prepare various organic compounds through various reactions, which are commonly used in organic chemistry research and industrial production.
First of all, its nucleophilic substitution reaction. Because the molecule contains bromine atoms and chloromethyl, both of which are active and easy to be attacked by nucleophilic reagents. Bromine atoms can be replaced by nucleophilic groups such as hydroxyl and amino groups. In an aqueous solution of sodium hydroxide, after heating, the bromine atom leaves, and the hydroxyl group replaces it to produce 4- (chloromethyl) phenol. The chlorine atom of chloromethyl is also active. Under suitable conditions, it can be replaced by nucleophilic reagents to form other compounds.
has the same properties as halogenated hydrocarbons. In the alcoholic solution of strong bases, elimination reactions can occur. Taking the ethanol solution of sodium ethanol as an example, when heated, hydrogen bromide or hydrogen chloride is removed, and unsaturated bonds are formed in the molecule to form aromatic derivatives containing double bonds. This is the way to construct unsaturated structures.
And the presence of benzene rings in this compound gives it the characteristics of aromatics. The benzene ring has a conjugated system, which is relatively stable and can undergo electrophilic substitution reactions. The hydrogen atom on the benzene ring can be replaced by electrophilic groups such as nitro and sulfonic acid. Under the mixed acid of concentrated sulfuric acid and concentrated nitric acid, nitro groups are introduced into the benzene ring to obtain the product of nitro substitution.
In addition, its chemical properties are affected by the electronic and spatial effects of the substituents. Bromine and chloromethyl are electron-absorbing groups, which reduce the electron cloud density of the benzene ring, slightly reduce the activity of electrophilic substitution reaction, and the substitution position is also dominated by its guiding effect.
1-bromo-4- (chloromethyl) benzene is rich in chemical properties and has a wide range of uses in the field of organic synthesis. It can prepare various organic compounds through various reactions, which are commonly used in organic chemistry research and industrial production.
What are the main uses of 1 - bromo - 4 - (chloromethyl) - benzene?
1-Bromo-4- (chloromethyl) benzene is an organic compound. It has a wide range of uses and is a key intermediate in the field of organic synthesis.
First, it is often used in the preparation of various drugs. Due to its unique chemical structure, it can be converted into substances with specific pharmacological activities through many chemical reactions. For example, in the synthesis of some antibacterial drugs and anti-tumor drugs, 1-bromo-4- (chloromethyl) benzene can be used as a starting material. After multi-step reactions, the complex molecular structure required for drugs can be constructed, providing an important material basis for pharmaceutical research and development.
Second, it also has important applications in the field of materials science. It can be used to synthesize special polymer materials. By polymerizing with other monomers, polymer materials are endowed with unique properties, such as improving the heat resistance and mechanical properties of the material. For example, polymer materials with special optical properties can be synthesized and used in optical devices, such as optical fibers, optical lenses, etc., to improve the performance of such devices.
Third, in the field of pesticides, it also plays an important role. It can be used as an intermediate for the synthesis of new pesticides, used to prepare high-efficiency and low-toxicity pesticide products. Through reasonable molecular design and reaction, it has high selectivity and high-efficiency killing ability for specific pests or bacteria, which can help agricultural production and ensure the yield and quality of crops. With its unique chemical properties, 1-bromo-4- (chloromethyl) benzene has shown important application value in many fields such as medicine, materials, and pesticides, providing indispensable support for the development of related industries.
First, it is often used in the preparation of various drugs. Due to its unique chemical structure, it can be converted into substances with specific pharmacological activities through many chemical reactions. For example, in the synthesis of some antibacterial drugs and anti-tumor drugs, 1-bromo-4- (chloromethyl) benzene can be used as a starting material. After multi-step reactions, the complex molecular structure required for drugs can be constructed, providing an important material basis for pharmaceutical research and development.
Second, it also has important applications in the field of materials science. It can be used to synthesize special polymer materials. By polymerizing with other monomers, polymer materials are endowed with unique properties, such as improving the heat resistance and mechanical properties of the material. For example, polymer materials with special optical properties can be synthesized and used in optical devices, such as optical fibers, optical lenses, etc., to improve the performance of such devices.
Third, in the field of pesticides, it also plays an important role. It can be used as an intermediate for the synthesis of new pesticides, used to prepare high-efficiency and low-toxicity pesticide products. Through reasonable molecular design and reaction, it has high selectivity and high-efficiency killing ability for specific pests or bacteria, which can help agricultural production and ensure the yield and quality of crops. With its unique chemical properties, 1-bromo-4- (chloromethyl) benzene has shown important application value in many fields such as medicine, materials, and pesticides, providing indispensable support for the development of related industries.
What are the synthesis methods of 1 - bromo - 4 - (chloromethyl) - benzene?
There are many synthetic methods for 1 + -bromo-4- (chloromethyl) benzene, each with its own advantages and disadvantages, suitable for different situations. The following are common synthetic routes:
First, p-methyl bromobenzene is used as the starting material, and the target product can be obtained by chlorination reaction. Specifically, p-methyl bromobenzene is dissolved in an appropriate inert solvent, such as carbon tetrachloride, an appropriate amount of initiator, such as benzoyl peroxide, is added, and then chlorine gas is introduced under light or heating conditions. This reaction process is a free radical substitution reaction. Under the action of the initiator, chlorine gas generates chlorine radicals, attacks the methyl group of p-methyl bromobenzene, and gradually replaces the hydrogen atom on it, thereby generating 1 + -bromo-4- (chloromethyl) benzene. The advantage of this method is that the raw materials are relatively easy to obtain, the reaction conditions are relatively mild, and the operation is simple; however, the disadvantage is that the selectivity is poor, and polychlorinated by-products may be generated, which makes it more difficult to separate and purify the products.
Second, p-bromobenzyl alcohol is used as a raw material and synthesized by reacting with a chlorination reagent. For example, thionyl chloride can be selected as a chlorination reagent, and p-bromobenzyl alcohol is mixed with thionyl chloride and reacted at an appropriate temperature. This reaction mechanism is a nucleophilic substitution reaction. The chlorine atom in the thionyl chloride attacks the alcohol hydroxyl group as a nucleophilic reagent to form an intermediate, which then eliminates a molecule of sulfur dioxide and hydrogen chloride to generate 1 + -bro The advantage of this method is that the reaction conditions are mild and the product purity is high; the disadvantage is that the raw material cost of p-bromobenzyl alcohol is relatively high, and the thionyl chloride has certain corrosiveness and irritation, which requires more strict operating environment.
Third, p-bromobenzaldehyde is used as the starting material, and the target product is obtained by two-step reaction of reduction and chlorination. First, p-bromobenzaldehyde is reduced to p-bromobenzyl alcohol using a suitable reducing agent, such as sodium borohydride. This reduction reaction conditions are relatively mild and the yield is high. Then, according to the above method of reacting p-bromobenzyl alcohol with chlorination reagents, p-bromobenzyl alcohol is converted into 1 + -bromo-4- (chloromethyl) benzene. There are relatively many steps in this synthesis route, but the reaction selectivity of each step is good, which is conducive to improving the purity of the product; however, the total yield may be reduced due to the multi-step reaction, and the operation process is more complicated and the cost increases.
When synthesizing 1 + -bromo-4- (chloromethyl) benzene, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, product purity and yield and many other factors according to actual needs, and reasonably select the appropriate synthesis method.
First, p-methyl bromobenzene is used as the starting material, and the target product can be obtained by chlorination reaction. Specifically, p-methyl bromobenzene is dissolved in an appropriate inert solvent, such as carbon tetrachloride, an appropriate amount of initiator, such as benzoyl peroxide, is added, and then chlorine gas is introduced under light or heating conditions. This reaction process is a free radical substitution reaction. Under the action of the initiator, chlorine gas generates chlorine radicals, attacks the methyl group of p-methyl bromobenzene, and gradually replaces the hydrogen atom on it, thereby generating 1 + -bromo-4- (chloromethyl) benzene. The advantage of this method is that the raw materials are relatively easy to obtain, the reaction conditions are relatively mild, and the operation is simple; however, the disadvantage is that the selectivity is poor, and polychlorinated by-products may be generated, which makes it more difficult to separate and purify the products.
Second, p-bromobenzyl alcohol is used as a raw material and synthesized by reacting with a chlorination reagent. For example, thionyl chloride can be selected as a chlorination reagent, and p-bromobenzyl alcohol is mixed with thionyl chloride and reacted at an appropriate temperature. This reaction mechanism is a nucleophilic substitution reaction. The chlorine atom in the thionyl chloride attacks the alcohol hydroxyl group as a nucleophilic reagent to form an intermediate, which then eliminates a molecule of sulfur dioxide and hydrogen chloride to generate 1 + -bro The advantage of this method is that the reaction conditions are mild and the product purity is high; the disadvantage is that the raw material cost of p-bromobenzyl alcohol is relatively high, and the thionyl chloride has certain corrosiveness and irritation, which requires more strict operating environment.
Third, p-bromobenzaldehyde is used as the starting material, and the target product is obtained by two-step reaction of reduction and chlorination. First, p-bromobenzaldehyde is reduced to p-bromobenzyl alcohol using a suitable reducing agent, such as sodium borohydride. This reduction reaction conditions are relatively mild and the yield is high. Then, according to the above method of reacting p-bromobenzyl alcohol with chlorination reagents, p-bromobenzyl alcohol is converted into 1 + -bromo-4- (chloromethyl) benzene. There are relatively many steps in this synthesis route, but the reaction selectivity of each step is good, which is conducive to improving the purity of the product; however, the total yield may be reduced due to the multi-step reaction, and the operation process is more complicated and the cost increases.
When synthesizing 1 + -bromo-4- (chloromethyl) benzene, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, product purity and yield and many other factors according to actual needs, and reasonably select the appropriate synthesis method.
What are the precautions for 1 - bromo - 4 - (chloromethyl) - benzene during storage and transportation?
For 1 + -bromo-4- (chloromethyl) benzene, there are several ends that should be paid attention to during storage and transportation.
First words storage, this substance has a certain chemical activity and needs to be placed in a cool, dry and well-ventilated place. It may be damaged by chemical reactions such as hydrolysis due to humidity. And if the temperature is too high, it may also lead to increased molecular activity, which has potential risks. The storage place should be away from fire and heat sources to prevent the danger caused by open flames and hot topics. If this substance is stored with oxidants, strong bases, etc., it is easy to react violently, so it must be stored separately and clearly marked to avoid misuse.
As for transportation, the carrier must have professional qualifications. The transportation equipment must be kept tight to prevent its leakage. When loading and unloading, the staff should be cautious and handle lightly to avoid damage to the packaging. During transportation, regular inspections should be made to see if there are any abnormalities. Vehicles should avoid high temperature periods and densely populated places. In case of accidents, such as leakage, they must be handled according to the established emergency plan, evacuate the surrounding people, prevent the spread of harmful substances, and ensure the safety of the environment and people. In this way, the stability of 1 + -bromo-4- (chloromethyl) benzene storage and transportation can be guaranteed.
First words storage, this substance has a certain chemical activity and needs to be placed in a cool, dry and well-ventilated place. It may be damaged by chemical reactions such as hydrolysis due to humidity. And if the temperature is too high, it may also lead to increased molecular activity, which has potential risks. The storage place should be away from fire and heat sources to prevent the danger caused by open flames and hot topics. If this substance is stored with oxidants, strong bases, etc., it is easy to react violently, so it must be stored separately and clearly marked to avoid misuse.
As for transportation, the carrier must have professional qualifications. The transportation equipment must be kept tight to prevent its leakage. When loading and unloading, the staff should be cautious and handle lightly to avoid damage to the packaging. During transportation, regular inspections should be made to see if there are any abnormalities. Vehicles should avoid high temperature periods and densely populated places. In case of accidents, such as leakage, they must be handled according to the established emergency plan, evacuate the surrounding people, prevent the spread of harmful substances, and ensure the safety of the environment and people. In this way, the stability of 1 + -bromo-4- (chloromethyl) benzene storage and transportation can be guaranteed.
What are the effects of 1 - bromo - 4 - (chloromethyl) - benzene on the environment and human health?
1 + -Bromo-4- (chloromethyl) -benzene, this substance has an impact on both the environment and human health.
It is persistent and bioaccumulative to the environment. If released in the environment, it will migrate between water, soil and atmosphere. In water, it is difficult to degrade or retain for a long time. And because of its good fat solubility, it is easy for aquatic organisms to ingest and accumulate in the body, passing through the food chain, resulting in increasing concentrations in high trophic organisms, destroying ecological balance and endangering the stability and diversity of aquatic ecosystems. In the soil, it will adsorb on soil particles, affect soil microbial activities and plant roots' absorption of nutrients and water, hinder plant growth and development, and if rain initializes into surface water, it will pollute water bodies. In the atmosphere, it may participate in photochemical reactions, generate harmful secondary pollutants, and affect air quality.
It is potentially toxic to human health. It enters the human body through inhalation, ingestion or skin contact. Inhalation of air containing this substance can irritate the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term inhalation may damage lung function and increase the risk of respiratory diseases. After ingestion, it will irritate the gastrointestinal tract, causing nausea, vomiting, abdominal pain, diarrhea, etc. Because of its fat solubility, it easily penetrates the skin barrier. Contact with the skin can cause allergic or irritating reactions such as redness, itching, and tingling. Long-term exposure or absorption through the skin accumulates in the body, damaging organs such as the liver and kidneys, and interfering with normal physiological functions. In addition, it may have genotoxicity and carcinogenicity. Although relevant studies are not fully clear, the latent risk cannot be underestimated.
In summary, 1-bromo-4- (chloromethyl) -benzene poses a threat to the environment and human health. Strict prevention and control are required during production, use, and disposal to reduce its adverse effects on the environment and people.
It is persistent and bioaccumulative to the environment. If released in the environment, it will migrate between water, soil and atmosphere. In water, it is difficult to degrade or retain for a long time. And because of its good fat solubility, it is easy for aquatic organisms to ingest and accumulate in the body, passing through the food chain, resulting in increasing concentrations in high trophic organisms, destroying ecological balance and endangering the stability and diversity of aquatic ecosystems. In the soil, it will adsorb on soil particles, affect soil microbial activities and plant roots' absorption of nutrients and water, hinder plant growth and development, and if rain initializes into surface water, it will pollute water bodies. In the atmosphere, it may participate in photochemical reactions, generate harmful secondary pollutants, and affect air quality.
It is potentially toxic to human health. It enters the human body through inhalation, ingestion or skin contact. Inhalation of air containing this substance can irritate the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term inhalation may damage lung function and increase the risk of respiratory diseases. After ingestion, it will irritate the gastrointestinal tract, causing nausea, vomiting, abdominal pain, diarrhea, etc. Because of its fat solubility, it easily penetrates the skin barrier. Contact with the skin can cause allergic or irritating reactions such as redness, itching, and tingling. Long-term exposure or absorption through the skin accumulates in the body, damaging organs such as the liver and kidneys, and interfering with normal physiological functions. In addition, it may have genotoxicity and carcinogenicity. Although relevant studies are not fully clear, the latent risk cannot be underestimated.
In summary, 1-bromo-4- (chloromethyl) -benzene poses a threat to the environment and human health. Strict prevention and control are required during production, use, and disposal to reduce its adverse effects on the environment and people.
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