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1-Bromo-4-Tert-Butyl-2-Chlorobenzene
Linshang Chemical
|
HS Code |
212202 |
| Chemical Formula | C10H12BrCl |
| Molecular Weight | 249.56 g/mol |
| Appearance | A colorless to light - yellow liquid |
| Boiling Point | Around 245 - 247 °C |
| Density | Approximately 1.35 - 1.40 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Flash Point | Around 105 - 110 °C |
| Purity Typical Commercial | Often available at 95%+ purity |
As an accredited 1-Bromo-4-Tert-Butyl-2-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 4 - tert - butyl - 2 - chlorobenzene packaged in a sealed glass bottle. |
| Storage | 1 - Bromo - 4 - tert - butyl - 2 - chlorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. Label the storage container clearly with its name and relevant safety information. |
| Shipping | 1 - bromo - 4 - tert - butyl - 2 - chlorobenzene is shipped in sealed, corrosion - resistant containers. These are carefully packed to prevent damage. Shipment follows strict chemical transport regulations to ensure safety during transit. |
Competitive 1-Bromo-4-Tert-Butyl-2-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-Bromo-4-Tert-Butyl-2-Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1 - bromo - 4 - tert - butyl - 2 - chlorobenzene?
1-Bromo-4-tert-butyl-2-chlorobenzene is also an organic compound. Its physical properties are quite important, as detailed below.
Looking at its properties, under normal temperature and pressure, 1-bromo-4-tert-butyl-2-chlorobenzene is a colorless to light yellow liquid, with a clear appearance and no obvious impurities mixed in it.
As for its boiling point, it is about a certain temperature range. Due to the intermolecular force, it contains atoms such as bromine and chlorine, which changes the polarity of the molecule. Coupled with the influence of the spatial structure of tert-butyl, its boiling point is at a specific value. This value is an important symbol of the gasification of a substance, which is related to its physical state transition under different temperature conditions.
Melting point is also a key physical property. The melting point of this compound is determined by factors such as molecular arrangement and interaction. The existence of bromine, chlorine atoms and tert-butyl affects the degree of compactness and force between molecules, and then determines the range of its melting point. Under this temperature, the substance is solid.
In terms of density, 1-bromo-4-tert-butyl-2-chlorobenzene has a specific density value. Density reflects the mass of a substance per unit volume and is restricted by molecular composition and structure. The type and quantity of atoms in the compound, as well as the spatial arrangement, determine its density. This value is of great significance in operations such as separation and mixing of substances.
In terms of solubility, it has better solubility in organic solvents. For example, common organic solvents such as ether and dichloromethane are miscible due to the similar force between 1-bromo-4-tert-butyl-2-chlorobenzene molecules and follow the principle of similar compatibility. However, the solubility in water is poor, because the polarity of molecules and water molecules is quite different, and the interaction force is weak, making it difficult to form a uniform and stable mixture.
In addition, the volatility of this compound is also characterized. Although it is not highly volatile, under appropriate temperature and environmental conditions, some molecules will still escape from the liquid phase and enter the gas phase. This volatility is closely related to factors such as boiling point and intermolecular forces.
Looking at its properties, under normal temperature and pressure, 1-bromo-4-tert-butyl-2-chlorobenzene is a colorless to light yellow liquid, with a clear appearance and no obvious impurities mixed in it.
As for its boiling point, it is about a certain temperature range. Due to the intermolecular force, it contains atoms such as bromine and chlorine, which changes the polarity of the molecule. Coupled with the influence of the spatial structure of tert-butyl, its boiling point is at a specific value. This value is an important symbol of the gasification of a substance, which is related to its physical state transition under different temperature conditions.
Melting point is also a key physical property. The melting point of this compound is determined by factors such as molecular arrangement and interaction. The existence of bromine, chlorine atoms and tert-butyl affects the degree of compactness and force between molecules, and then determines the range of its melting point. Under this temperature, the substance is solid.
In terms of density, 1-bromo-4-tert-butyl-2-chlorobenzene has a specific density value. Density reflects the mass of a substance per unit volume and is restricted by molecular composition and structure. The type and quantity of atoms in the compound, as well as the spatial arrangement, determine its density. This value is of great significance in operations such as separation and mixing of substances.
In terms of solubility, it has better solubility in organic solvents. For example, common organic solvents such as ether and dichloromethane are miscible due to the similar force between 1-bromo-4-tert-butyl-2-chlorobenzene molecules and follow the principle of similar compatibility. However, the solubility in water is poor, because the polarity of molecules and water molecules is quite different, and the interaction force is weak, making it difficult to form a uniform and stable mixture.
In addition, the volatility of this compound is also characterized. Although it is not highly volatile, under appropriate temperature and environmental conditions, some molecules will still escape from the liquid phase and enter the gas phase. This volatility is closely related to factors such as boiling point and intermolecular forces.
What are the chemical properties of 1 - bromo - 4 - tert - butyl - 2 - chlorobenzene?
1 + -Bromo-4-tert-butyl-2-chlorobenzene is also an organic compound. Its chemical properties are quite interesting, and I will describe them in detail today.
The first talk about the activity of its halogen atom. The molecule contains bromine and chlorine dihalogen atoms. The bromine atom is relatively small in carbon-bromine bond energy due to its large atomic radius. Therefore, in the nucleophilic substitution reaction, the bromine atom is more likely to leave than the chlorine atom. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., the carbon position where the bromine atom is located is easily attacked by nucleophilic reagents, and a substitution reaction occurs to generate corresponding substitution products. For example, when reacted with sodium ethanol, ether compounds can be formed.
Furthermore, tert-butyl has a significant effect on molecular properties. Tert-butyl is a large volume group with a steric hindrance effect. This steric hindrance effect can affect the selectivity and rate of the reaction. When the nucleophile attacks the halogen atom, the steric hindrance of tert-butyl can make the nucleophile approach the halogen atom from the direction of the smaller steric hindrance, thereby affecting the configuration and yield of the product. And tert-butyl is the power supply group, which can increase the electron cloud density of the benzene ring through the induction effect, making the benzene ring more prone to electrophilic substitution reaction.
As far as the reactivity of the benzene ring is concerned, because the halogen atom is an ortho-para-localization group, although the electron cloud density of the benzene ring is reduced, the electrophilic substitution reaction activity is slightly reduced, but it guides the electrophilic reagent to attack the ortho-position and para-position of the halogen atom. For example, during nitration, the nitro group mainly enters the ortho-position and para-position of bromine or chlorine.
In addition, 1-bromo-4-tert-butyl-2-chlorobenzene can still undergo reduction reaction, and the halogen atom can be reduced and removed under the action of a specific reducing agent to form the corresponding hydrocarbon compound. And because it is an organic halide, under high temperature or specific catalyst conditions, an elimination reaction can occur to dehalide Overall, the chemical properties of this compound are rich and diverse, and it has considerable application value in the field of organic synthesis.
The first talk about the activity of its halogen atom. The molecule contains bromine and chlorine dihalogen atoms. The bromine atom is relatively small in carbon-bromine bond energy due to its large atomic radius. Therefore, in the nucleophilic substitution reaction, the bromine atom is more likely to leave than the chlorine atom. In case of nucleophilic reagents, such as sodium alcohol, amines, etc., the carbon position where the bromine atom is located is easily attacked by nucleophilic reagents, and a substitution reaction occurs to generate corresponding substitution products. For example, when reacted with sodium ethanol, ether compounds can be formed.
Furthermore, tert-butyl has a significant effect on molecular properties. Tert-butyl is a large volume group with a steric hindrance effect. This steric hindrance effect can affect the selectivity and rate of the reaction. When the nucleophile attacks the halogen atom, the steric hindrance of tert-butyl can make the nucleophile approach the halogen atom from the direction of the smaller steric hindrance, thereby affecting the configuration and yield of the product. And tert-butyl is the power supply group, which can increase the electron cloud density of the benzene ring through the induction effect, making the benzene ring more prone to electrophilic substitution reaction.
As far as the reactivity of the benzene ring is concerned, because the halogen atom is an ortho-para-localization group, although the electron cloud density of the benzene ring is reduced, the electrophilic substitution reaction activity is slightly reduced, but it guides the electrophilic reagent to attack the ortho-position and para-position of the halogen atom. For example, during nitration, the nitro group mainly enters the ortho-position and para-position of bromine or chlorine.
In addition, 1-bromo-4-tert-butyl-2-chlorobenzene can still undergo reduction reaction, and the halogen atom can be reduced and removed under the action of a specific reducing agent to form the corresponding hydrocarbon compound. And because it is an organic halide, under high temperature or specific catalyst conditions, an elimination reaction can occur to dehalide Overall, the chemical properties of this compound are rich and diverse, and it has considerable application value in the field of organic synthesis.
What are the main uses of 1 - bromo - 4 - tert - butyl - 2 - chlorobenzene?
1 + -Bromo-4 -tert-butyl-2 -chlorobenzene is an organic compound with important uses in many fields.
In the field of organic synthesis, it can be called a key intermediate. Due to its structure containing bromine, chlorine and tert-butyl, each group has unique reactivity. Bromine atoms can participate in nucleophilic substitution reactions, and can react with many nucleophilic reagents, such as alkoxides and amines, thereby introducing different functional groups to synthesize organic compounds with diverse structures. For example, when reacted with alkoxides, corresponding ether compounds can be formed; when reacted with amines, nitrogen-containing derivatives can be formed. Chlorine atoms can also participate in similar reactions, and due to the different positions of halogen atoms, the reactivity also varies, which provides more options for the synthesis path. The existence of tert-butyl can affect the electron cloud distribution of the benzene ring, change the reactivity of the benzene ring, and at the same time play a spatial role in positioning resistance, which affects the reaction selectivity. In the field of medicinal chemistry, it is often used as a starting material to construct molecular structures with specific pharmacological activities through a series of reactions.
In materials science, 1 + -bromo-4 -tert-butyl-2 -chlorobenzene is also used. Through specific reactions, it can be connected to the main chain or side chain of the polymer, thus giving the material special properties. For example, if a monomer containing this structure is introduced for polymerization, the resulting polymer may exhibit unique solubility, thermal stability or optical properties due to the steric resistance of tert-butyl and the characteristics of halogen atoms, and can be used to prepare special-purpose polymer materials, such as optoelectronic materials, separation membrane materials, etc.
In addition, it is also an important raw material in the preparation of fine chemical products. It can be used to synthesize fine chemicals such as special fragrances and dyes. For example, after appropriate reaction, its structure is modified, and a specific chromophore group is introduced to make a dye with special color and properties; or through reaction, a compound with a unique aroma structure is constructed for fragrance preparation. In conclusion, 1 + -bromo-4 -tert-butyl-2 -chlorobenzene plays an important role in the fields of organic synthesis, medicinal chemistry, materials science and fine chemistry due to its unique structure, providing a key starting point for the preparation of many compounds and materials.
In the field of organic synthesis, it can be called a key intermediate. Due to its structure containing bromine, chlorine and tert-butyl, each group has unique reactivity. Bromine atoms can participate in nucleophilic substitution reactions, and can react with many nucleophilic reagents, such as alkoxides and amines, thereby introducing different functional groups to synthesize organic compounds with diverse structures. For example, when reacted with alkoxides, corresponding ether compounds can be formed; when reacted with amines, nitrogen-containing derivatives can be formed. Chlorine atoms can also participate in similar reactions, and due to the different positions of halogen atoms, the reactivity also varies, which provides more options for the synthesis path. The existence of tert-butyl can affect the electron cloud distribution of the benzene ring, change the reactivity of the benzene ring, and at the same time play a spatial role in positioning resistance, which affects the reaction selectivity. In the field of medicinal chemistry, it is often used as a starting material to construct molecular structures with specific pharmacological activities through a series of reactions.
In materials science, 1 + -bromo-4 -tert-butyl-2 -chlorobenzene is also used. Through specific reactions, it can be connected to the main chain or side chain of the polymer, thus giving the material special properties. For example, if a monomer containing this structure is introduced for polymerization, the resulting polymer may exhibit unique solubility, thermal stability or optical properties due to the steric resistance of tert-butyl and the characteristics of halogen atoms, and can be used to prepare special-purpose polymer materials, such as optoelectronic materials, separation membrane materials, etc.
In addition, it is also an important raw material in the preparation of fine chemical products. It can be used to synthesize fine chemicals such as special fragrances and dyes. For example, after appropriate reaction, its structure is modified, and a specific chromophore group is introduced to make a dye with special color and properties; or through reaction, a compound with a unique aroma structure is constructed for fragrance preparation. In conclusion, 1 + -bromo-4 -tert-butyl-2 -chlorobenzene plays an important role in the fields of organic synthesis, medicinal chemistry, materials science and fine chemistry due to its unique structure, providing a key starting point for the preparation of many compounds and materials.
What are the synthesis methods of 1 - bromo - 4 - tert - butyl - 2 - chlorobenzene?
The synthesis methods of 1 + -bromo-4 -tert-butyl-2 -chlorobenzene can be as follows.
One is the halogenation reaction method. Using 4-tert-butyl-2 -chloroaniline as the starting material, the diazotization reaction is first carried out. 4-tert-butyl-2 -chloroaniline reacts with hydrochloric acid and sodium nitrite at low temperature to form a diazonium salt. This diazosalt is active and then co-heated with cuprous bromide and hydrobromic acid, resulting in a Sandmeyer reaction. The diazoyl group is replaced by a bromine atom to obtain 1 + -bromo-4 -tert-butyl-2 -chlorobenzene. This process requires precise temperature control. The diazotization reaction proceeds smoothly at low temperature, and high temperature is conducive to the substitution reaction, otherwise the side reactions will increase and the product will be impure.
The second can be achieved by the electrophilic substitution reaction of aromatics. Using p-tert-butyl chlorobenzene as the substrate, in the presence of an appropriate catalyst, such as ferric chloride or iron powder, reacts with bromine elemental. Bromine is polarized under the action of the catalyst to generate bromine positive ions, which attack the benzene ring as an electrophilic reagent. Due to the localization effect of tert-butyl and chlorine atoms, tert-butyl is an ortho-and para-localization group, and chlorine atoms are also ortho-and para-localization groups. The two affect together, so that bromine atoms mainly replace the positions of ortho-chlorine atoms and tert-butyl-2-chlorobenzene to obtain the target product 1 + -bromo-4 -tert-butyl-2 -chlorobenzene. In this reaction, the amount of catalyst, reaction time and temperature have a great impact on the yield of the product. If there is too little catalyst, the reaction rate is slow; if there is too much, unnecessary side reactions may be triggered.
Third, The Grignard reagent is first prepared from p-tert-butyl chlorobenzene, and the p-tert-butyl chlorobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to generate the corresponding Grignard reagent. After that, the Grignard reagent is reacted with brominated reagents, such as bromoethane or copper bromide, to achieve the introduction of bromine atoms. After a series of post-treatments, 1 + -bromo-4-tert-butyl-2-chlorobenzene can be obtained. This process needs to be strictly anhydrous and oxygen-free, otherwise the Grignard reagent is easily destroyed, resulting in the failure of the reaction.
One is the halogenation reaction method. Using 4-tert-butyl-2 -chloroaniline as the starting material, the diazotization reaction is first carried out. 4-tert-butyl-2 -chloroaniline reacts with hydrochloric acid and sodium nitrite at low temperature to form a diazonium salt. This diazosalt is active and then co-heated with cuprous bromide and hydrobromic acid, resulting in a Sandmeyer reaction. The diazoyl group is replaced by a bromine atom to obtain 1 + -bromo-4 -tert-butyl-2 -chlorobenzene. This process requires precise temperature control. The diazotization reaction proceeds smoothly at low temperature, and high temperature is conducive to the substitution reaction, otherwise the side reactions will increase and the product will be impure.
The second can be achieved by the electrophilic substitution reaction of aromatics. Using p-tert-butyl chlorobenzene as the substrate, in the presence of an appropriate catalyst, such as ferric chloride or iron powder, reacts with bromine elemental. Bromine is polarized under the action of the catalyst to generate bromine positive ions, which attack the benzene ring as an electrophilic reagent. Due to the localization effect of tert-butyl and chlorine atoms, tert-butyl is an ortho-and para-localization group, and chlorine atoms are also ortho-and para-localization groups. The two affect together, so that bromine atoms mainly replace the positions of ortho-chlorine atoms and tert-butyl-2-chlorobenzene to obtain the target product 1 + -bromo-4 -tert-butyl-2 -chlorobenzene. In this reaction, the amount of catalyst, reaction time and temperature have a great impact on the yield of the product. If there is too little catalyst, the reaction rate is slow; if there is too much, unnecessary side reactions may be triggered.
Third, The Grignard reagent is first prepared from p-tert-butyl chlorobenzene, and the p-tert-butyl chlorobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to generate the corresponding Grignard reagent. After that, the Grignard reagent is reacted with brominated reagents, such as bromoethane or copper bromide, to achieve the introduction of bromine atoms. After a series of post-treatments, 1 + -bromo-4-tert-butyl-2-chlorobenzene can be obtained. This process needs to be strictly anhydrous and oxygen-free, otherwise the Grignard reagent is easily destroyed, resulting in the failure of the reaction.
1 - bromo - 4 - tert - butyl - 2 - chlorobenzene, what are the precautions during storage and transportation?
1 + -Bromo-4-tert-butyl-2-chlorobenzene requires careful attention when storing and transporting.
The first to bear the brunt, because it has a certain chemical activity, the storage place must be dry and cool. Humid environment is easy to cause its hydrolysis and other reactions, resulting in quality damage. Excessive temperature is also poor, or increases the risk of chemical reactions, so it should be controlled in a suitable low temperature range.
Furthermore, this substance has strict packaging requirements. Packaging materials need to be resistant to its corrosion and have good sealing. To prevent leakage and escape, pollute the environment and endanger personal safety.
When transporting, ensure the stability of the vehicle. Avoid severe turbulence and vibration, otherwise the package may be damaged. At the same time, transport personnel should be familiar with its characteristics and emergency treatment methods, and can respond quickly in case of leakage and other unexpected situations.
In addition, fireworks should be strictly prohibited in storage and transportation places. 1 + -Bromo-4-tert-butyl-2-chlorobenzene may be flammable, and it is easy to cause combustion or even explosion in case of open flames and hot topics. Therefore, fire protection facilities must also be fully equipped and ensure normal use.
At the same time, relevant laws and standards must be strictly followed. Whether it is the setting of storage conditions or the process specifications of transportation, it should not exceed the rules to ensure the safety of the whole process and avoid harm to the surrounding environment and personal health.
The first to bear the brunt, because it has a certain chemical activity, the storage place must be dry and cool. Humid environment is easy to cause its hydrolysis and other reactions, resulting in quality damage. Excessive temperature is also poor, or increases the risk of chemical reactions, so it should be controlled in a suitable low temperature range.
Furthermore, this substance has strict packaging requirements. Packaging materials need to be resistant to its corrosion and have good sealing. To prevent leakage and escape, pollute the environment and endanger personal safety.
When transporting, ensure the stability of the vehicle. Avoid severe turbulence and vibration, otherwise the package may be damaged. At the same time, transport personnel should be familiar with its characteristics and emergency treatment methods, and can respond quickly in case of leakage and other unexpected situations.
In addition, fireworks should be strictly prohibited in storage and transportation places. 1 + -Bromo-4-tert-butyl-2-chlorobenzene may be flammable, and it is easy to cause combustion or even explosion in case of open flames and hot topics. Therefore, fire protection facilities must also be fully equipped and ensure normal use.
At the same time, relevant laws and standards must be strictly followed. Whether it is the setting of storage conditions or the process specifications of transportation, it should not exceed the rules to ensure the safety of the whole process and avoid harm to the surrounding environment and personal health.
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