Linshang Chemical
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1-Bromo-4-(Tert-Butyl)-2-Chlorobenzene
Linshang Chemical
|
HS Code |
338658 |
| Chemical Formula | C10H12BrCl |
| Molecular Weight | 249.56 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Approximately 230 - 240 °C (estimated based on similar compounds) |
| Density | Around 1.3 - 1.4 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Estimated to be in the range of 90 - 100 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 1-Bromo-4-(Tert-Butyl)-2-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - bromo - 4 - (tert - butyl)-2 - chlorobenzene in a sealed, labeled chemical bottle. |
| Storage | 1 - Bromo - 4 - (tert - butyl)-2 - chlorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, bases, and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 1 - Bromo - 4 - (tert - butyl)-2 - chlorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring secure transport to prevent leakage and environmental or safety risks. |
Competitive 1-Bromo-4-(Tert-Butyl)-2-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1 - bromo - 4 - (tert - butyl) -2 - chlorobenzene
1-Bromo-4- (tert-butyl) -2-chlorobenzene is one of the organic compounds. Its chemical properties are quite specific and are related to many organic reactions. It is a key research object in the field of organic chemistry.
First describes its physical properties. This compound is usually in a liquid or solid state, depending on the ambient temperature and pressure. Under normal temperature and pressure, or a colorless to light yellow liquid, it has a special odor. Its physical constants such as melting point and boiling point are determined by the intermolecular forces and structures. The existence of tert-butyl increases the steric resistance of its molecules, which has a great impact on the properties of melting and boiling point.
In terms of chemical activity, both bromine and chlorine atoms in this compound are active functional groups. Bromine atoms have higher activity and are easily replaced by nucleophilic reagents in nucleophilic substitution reactions. Nucleophilic reagents such as alkoxides, amines, etc., can attack the carbon atoms connected to bromine atoms, and generate new organic compounds through SN1 or SN2 reaction mechanisms. For example, when sodium alcohol is used as a nucleophilic reagent, a substitution reaction can occur to obtain corresponding ether compounds.
Although chlorine atoms are slightly less active than bromine atoms, they can also participate in specific reactions. Under appropriate conditions, they can be replaced by more active nucleophilic reagents or cooperate with other functional groups in some reactions.
In addition, the conjugate system of the benzene ring endows this compound with unique electronic properties. The electron cloud density distribution of the benzene ring is changed by the substitution of bromine, chlorine and tert-butyl. Tert-butyl is the donator group, which can increase the electron cloud density of the benzene ring, especially in the ortho and para-positions; while bromine and chlorine are electron-absorbing groups, which can reduce the electron cloud density of the benzene ring. This electronic effect affects the reactivity and selectivity of the compound. For example, in electrophilic substitution reactions, the selectivity of the reaction check point is dominated by the electronic effects of these substituents and the spatial effects. The chemical properties of 1-bromo-4- (tert-butyl) -2-chlorobenzene are complex and interesting, and it has a wide range of applications and research value in the fields of organic synthesis and medicinal chemistry. It provides important basic raw materials and reaction intermediates for the creation of new organic compounds and the development of drugs.
First describes its physical properties. This compound is usually in a liquid or solid state, depending on the ambient temperature and pressure. Under normal temperature and pressure, or a colorless to light yellow liquid, it has a special odor. Its physical constants such as melting point and boiling point are determined by the intermolecular forces and structures. The existence of tert-butyl increases the steric resistance of its molecules, which has a great impact on the properties of melting and boiling point.
In terms of chemical activity, both bromine and chlorine atoms in this compound are active functional groups. Bromine atoms have higher activity and are easily replaced by nucleophilic reagents in nucleophilic substitution reactions. Nucleophilic reagents such as alkoxides, amines, etc., can attack the carbon atoms connected to bromine atoms, and generate new organic compounds through SN1 or SN2 reaction mechanisms. For example, when sodium alcohol is used as a nucleophilic reagent, a substitution reaction can occur to obtain corresponding ether compounds.
Although chlorine atoms are slightly less active than bromine atoms, they can also participate in specific reactions. Under appropriate conditions, they can be replaced by more active nucleophilic reagents or cooperate with other functional groups in some reactions.
In addition, the conjugate system of the benzene ring endows this compound with unique electronic properties. The electron cloud density distribution of the benzene ring is changed by the substitution of bromine, chlorine and tert-butyl. Tert-butyl is the donator group, which can increase the electron cloud density of the benzene ring, especially in the ortho and para-positions; while bromine and chlorine are electron-absorbing groups, which can reduce the electron cloud density of the benzene ring. This electronic effect affects the reactivity and selectivity of the compound. For example, in electrophilic substitution reactions, the selectivity of the reaction check point is dominated by the electronic effects of these substituents and the spatial effects. The chemical properties of 1-bromo-4- (tert-butyl) -2-chlorobenzene are complex and interesting, and it has a wide range of applications and research value in the fields of organic synthesis and medicinal chemistry. It provides important basic raw materials and reaction intermediates for the creation of new organic compounds and the development of drugs.
What are the main uses of 1 - bromo - 4 - (tert - butyl) -2 - chlorobenzene
1 + -Bromo-4- (tert-butyl) -2 -chlorobenzene is also an organic compound. It has a wide range of uses and is used in various fields of chemical industry.
First, in the way of drug synthesis, this compound can be a key intermediate. By using a specific reaction method, other functional groups can be introduced to gradually build a complex drug molecular structure. Because of the bromine, chlorine and tert-butyl groups connected to its benzene ring, they can be combined with other reagents through nucleophilic substitution, coupling and other reactions, and then become compounds with specific pharmacological activities, which can be used to create new drugs and help the development of medicine.
Second, in the field of materials science, 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene can also be used. It can be integrated into the structure of polymer materials by chemical reaction. The presence of bromine and chlorine atoms can change the electronic properties and chemical stability of materials; the steric resistance effect of tert-butyl can also affect the morphology and properties of materials. In this way, materials with special electrical and optical properties, such as organic optoelectronic materials, can be prepared to play a role in electronic devices and display technologies.
Third, in the study of organic synthetic chemistry, this compound is often used as a model substrate. Chemists can explore the various reactions they participate in, gain insight into the reaction mechanism, optimize the reaction conditions, and develop novel synthesis methods. Its structural properties enable many reactions to be carried out, providing experimental and theoretical basis for the progress of organic synthesis methodologies and promoting the development of organic chemistry.
First, in the way of drug synthesis, this compound can be a key intermediate. By using a specific reaction method, other functional groups can be introduced to gradually build a complex drug molecular structure. Because of the bromine, chlorine and tert-butyl groups connected to its benzene ring, they can be combined with other reagents through nucleophilic substitution, coupling and other reactions, and then become compounds with specific pharmacological activities, which can be used to create new drugs and help the development of medicine.
Second, in the field of materials science, 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene can also be used. It can be integrated into the structure of polymer materials by chemical reaction. The presence of bromine and chlorine atoms can change the electronic properties and chemical stability of materials; the steric resistance effect of tert-butyl can also affect the morphology and properties of materials. In this way, materials with special electrical and optical properties, such as organic optoelectronic materials, can be prepared to play a role in electronic devices and display technologies.
Third, in the study of organic synthetic chemistry, this compound is often used as a model substrate. Chemists can explore the various reactions they participate in, gain insight into the reaction mechanism, optimize the reaction conditions, and develop novel synthesis methods. Its structural properties enable many reactions to be carried out, providing experimental and theoretical basis for the progress of organic synthesis methodologies and promoting the development of organic chemistry.
What is the synthesis method of 1 - bromo - 4 - (tert - butyl) -2 - chlorobenzene
The synthesis of 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene can follow the following steps:
The starting material can be 4- (tert-butyl) -2 -chloroaniline. In the first step, 4- (tert-butyl) -2 -chloroaniline needs to be re-nitroded. In this reaction, 4- (tert-butyl) -2 -chloroaniline can be dissolved in an appropriate amount of inorganic acid, such as hydrochloric acid, cooled to a low temperature, usually about 0-5 ° C, and then slowly added dropwise to the aqueous solution of sodium nitrite. In this low temperature environment, the amine group will react with nitrous acid to form a diazonium salt. In this process, the reaction temperature needs to be closely monitored to prevent the decomposition of diazonium salts.
After obtaining diazonium salts, the second step is the bromination reaction. To the reaction system containing diazonium salts, add an appropriate amount of cuprous bromide (CuBr) and hydrobromic acid (HBr) mixed solution. The diazonium group will be replaced by bromine atoms to form 1-bromo-4- (tert-butyl) -2-chlorobenzene. This reaction needs to be carried out at a suitable temperature, usually near room temperature, and stirred evenly to ensure sufficient reaction.
At the end of the reaction, the reaction mixture contains the target product 1-bromo-4- (tert-butyl) -2-chlorobenzene, as well as many by-products and unreacted raw materials. Therefore, further separation and purification are required. The organic phase can be extracted with an organic solvent such as dichloromethane to separate the organic phase from the aqueous phase. The organic phase is dried with anhydrous sodium sulfate to remove the moisture. After that, the pure target product is separated by vacuum distillation according to the boiling point characteristics of 1-bromo-4- (tert-butyl) -2-chlorobenzene.
In another way, the starting material can be 4- (tert-butyl) -2-chlorobenzoic acid. First, it is converted into the corresponding acid chloride, which can be reacted with thionyl chloride (SOCl ²), heated and refluxed for several hours, and acid chloride is formed. Then, through a series of reactions, including reduction, halogenation, etc., 1-bromo-4- (tert-butyl) -2-chlorobenzene can also be obtained. Each step requires fine regulation of the reaction conditions, such as temperature, reactant ratio, and reaction time, to ensure the smooth progress of the reaction and improve the yield and purity of the target product.
The starting material can be 4- (tert-butyl) -2 -chloroaniline. In the first step, 4- (tert-butyl) -2 -chloroaniline needs to be re-nitroded. In this reaction, 4- (tert-butyl) -2 -chloroaniline can be dissolved in an appropriate amount of inorganic acid, such as hydrochloric acid, cooled to a low temperature, usually about 0-5 ° C, and then slowly added dropwise to the aqueous solution of sodium nitrite. In this low temperature environment, the amine group will react with nitrous acid to form a diazonium salt. In this process, the reaction temperature needs to be closely monitored to prevent the decomposition of diazonium salts.
After obtaining diazonium salts, the second step is the bromination reaction. To the reaction system containing diazonium salts, add an appropriate amount of cuprous bromide (CuBr) and hydrobromic acid (HBr) mixed solution. The diazonium group will be replaced by bromine atoms to form 1-bromo-4- (tert-butyl) -2-chlorobenzene. This reaction needs to be carried out at a suitable temperature, usually near room temperature, and stirred evenly to ensure sufficient reaction.
At the end of the reaction, the reaction mixture contains the target product 1-bromo-4- (tert-butyl) -2-chlorobenzene, as well as many by-products and unreacted raw materials. Therefore, further separation and purification are required. The organic phase can be extracted with an organic solvent such as dichloromethane to separate the organic phase from the aqueous phase. The organic phase is dried with anhydrous sodium sulfate to remove the moisture. After that, the pure target product is separated by vacuum distillation according to the boiling point characteristics of 1-bromo-4- (tert-butyl) -2-chlorobenzene.
In another way, the starting material can be 4- (tert-butyl) -2-chlorobenzoic acid. First, it is converted into the corresponding acid chloride, which can be reacted with thionyl chloride (SOCl ²), heated and refluxed for several hours, and acid chloride is formed. Then, through a series of reactions, including reduction, halogenation, etc., 1-bromo-4- (tert-butyl) -2-chlorobenzene can also be obtained. Each step requires fine regulation of the reaction conditions, such as temperature, reactant ratio, and reaction time, to ensure the smooth progress of the reaction and improve the yield and purity of the target product.
1 - bromo - 4 - (tert - butyl) -2 - chlorobenzene in storage and transport
1 + -Bromo-4- (tert-butyl) -2 -chlorobenzene is an organic compound. During storage and transportation, many matters need to be carefully paid attention.
First storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because the compound may be sensitive to heat, high temperature can easily cause it to deteriorate, or even cause dangerous chemical reactions, it should be protected from direct sunlight and high temperature places. At the same time, a dry environment is also very critical, because moisture may promote reactions such as hydrolysis, which affects its quality and stability.
The second is the choice of packaging materials. When storing and transporting, suitable packaging materials should be selected. Packaging that can effectively isolate air and moisture should be used to prevent the compound from interacting with external substances. Such as glass bottles, specific plastic containers, etc., must ensure good sealing performance to avoid leakage.
Furthermore, shock resistance is very important during transportation. 1 + -Bromo-4- (tert-butyl) -2 -chlorobenzene may cause damage to the package when it is subjected to vibration or collision, which may cause leakage and other problems. Therefore, proper shock protection measures must be taken during transportation to ensure that it arrives at the destination safely.
In addition, safety labels are also indispensable. On the storage and transportation containers, the relevant information of the compound, such as name and danger, should be clearly marked. This will help personnel to clarify its characteristics and take appropriate protective measures during disposal to avoid safety accidents caused by ignorance.
When storing and transporting 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene, full consideration should be given to the environment, packaging, shock resistance and labeling to ensure its safety and stability and avoid accidents.
First storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because the compound may be sensitive to heat, high temperature can easily cause it to deteriorate, or even cause dangerous chemical reactions, it should be protected from direct sunlight and high temperature places. At the same time, a dry environment is also very critical, because moisture may promote reactions such as hydrolysis, which affects its quality and stability.
The second is the choice of packaging materials. When storing and transporting, suitable packaging materials should be selected. Packaging that can effectively isolate air and moisture should be used to prevent the compound from interacting with external substances. Such as glass bottles, specific plastic containers, etc., must ensure good sealing performance to avoid leakage.
Furthermore, shock resistance is very important during transportation. 1 + -Bromo-4- (tert-butyl) -2 -chlorobenzene may cause damage to the package when it is subjected to vibration or collision, which may cause leakage and other problems. Therefore, proper shock protection measures must be taken during transportation to ensure that it arrives at the destination safely.
In addition, safety labels are also indispensable. On the storage and transportation containers, the relevant information of the compound, such as name and danger, should be clearly marked. This will help personnel to clarify its characteristics and take appropriate protective measures during disposal to avoid safety accidents caused by ignorance.
When storing and transporting 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene, full consideration should be given to the environment, packaging, shock resistance and labeling to ensure its safety and stability and avoid accidents.
What are the effects of 1 - bromo - 4 - (tert - butyl) -2 - chlorobenzene on the environment and human body?
1 + -Bromo-4- (tert-butyl) -2 -chlorobenzene is also an organic compound. The impact on the environment and human body cannot be ignored.
In the environment, if this compound is released, it is difficult to degrade naturally due to its chemical structure, or it may accumulate in soil and water bodies. Accumulation in soil, or changing soil quality, hinders plant root uptake of nutrients and water, causes plant growth to be trapped, or abnormal development. Retained in water bodies, or affect aquatic organisms. It may be absorbed and enriched by aquatic organisms, interfering with the normal physiological functions of aquatic organisms, such as destroying their nervous system and endocrine system, causing decreased reproductive capacity, larval deformity, endangering the reproduction of aquatic organisms, and disrupting the balance of aquatic ecosystems.
As for the human body, 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene can be invaded through various routes. After respiration, its volatilized particles in the air can enter the human body; after diet, contaminated food and water sources are its mediators. After entering the body, it is easy to accumulate in fat tissue because of its lipid solubility. Or interfere with the human endocrine system, interact with hormone receptors, imitate natural hormones, and cause hormone imbalance. Hormone imbalance can lead to a series of health problems, such as thyroid dysfunction, affecting metabolic rate; abnormal reproductive system, male or sperm count and quality decline, female or menstrual disorders, and reduced fertility. Long-term exposure to this compound may increase the risk of cancer, because it may cause genetic mutations, damage the normal growth regulation mechanism of cells, and cause abnormal cell proliferation, eventually forming tumors.
In summary, 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene poses a potential threat to the environment and human body. It should be treated with caution and strictly controlled in production and use to reduce its harm to the environment and human health.
In the environment, if this compound is released, it is difficult to degrade naturally due to its chemical structure, or it may accumulate in soil and water bodies. Accumulation in soil, or changing soil quality, hinders plant root uptake of nutrients and water, causes plant growth to be trapped, or abnormal development. Retained in water bodies, or affect aquatic organisms. It may be absorbed and enriched by aquatic organisms, interfering with the normal physiological functions of aquatic organisms, such as destroying their nervous system and endocrine system, causing decreased reproductive capacity, larval deformity, endangering the reproduction of aquatic organisms, and disrupting the balance of aquatic ecosystems.
As for the human body, 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene can be invaded through various routes. After respiration, its volatilized particles in the air can enter the human body; after diet, contaminated food and water sources are its mediators. After entering the body, it is easy to accumulate in fat tissue because of its lipid solubility. Or interfere with the human endocrine system, interact with hormone receptors, imitate natural hormones, and cause hormone imbalance. Hormone imbalance can lead to a series of health problems, such as thyroid dysfunction, affecting metabolic rate; abnormal reproductive system, male or sperm count and quality decline, female or menstrual disorders, and reduced fertility. Long-term exposure to this compound may increase the risk of cancer, because it may cause genetic mutations, damage the normal growth regulation mechanism of cells, and cause abnormal cell proliferation, eventually forming tumors.
In summary, 1 + -bromo-4- (tert-butyl) -2 -chlorobenzene poses a potential threat to the environment and human body. It should be treated with caution and strictly controlled in production and use to reduce its harm to the environment and human health.
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