Linshang Chemical
PRODUCTS
1-Bromo-5-Chloro-2-Iodobenzene
Linshang Chemical
|
HS Code |
426114 |
| Chemical Formula | C6H3BrClI |
| Molar Mass | 329.35 g/mol |
| Appearance | Solid (usually a white - off - white powder) |
| Physical State At Room Temperature | Solid |
| Melting Point | Data may vary, typically in the range of [specific value if known] °C |
| Boiling Point | Data may vary, typically in the range of [specific value if known] °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Data may vary, typically in the range of [specific value if known] g/cm³ |
| Vapor Pressure | Low vapor pressure at room temperature |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Bromo-5-Chloro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - bromo - 5 - chloro - 2 - iodobenzene packaged in a sealed glass bottle. |
| Storage | 1 - Bromo - 5 - chloro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. Label the storage container clearly with the chemical name and relevant hazard information. |
| Shipping | 1 - bromo - 5 - chloro - 2 - iodobenzene is shipped in sealed, corrosion - resistant containers. It's transported with proper labeling as a chemical. Special care is taken to prevent physical damage during transit to avoid spills and ensure safety. |
Competitive 1-Bromo-5-Chloro-2-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Bromo-5-Chloro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1 - bromo - 5 - chloro - 2 - iodobenzene?
1-Bromo-5-chloro-2-iodobenzene, which is a halogenated aromatic hydrocarbon. It has many unique chemical properties and has a wide range of uses in the field of organic synthesis.
Firstly, its halogen atoms can participate in nucleophilic substitution reactions. Due to the electron-absorbing induction effect of halogen atoms, the electron cloud density of the benzene ring decreases, making the carbon atoms of the phthalene ring more vulnerable to attack by nucleophiles. For example, when encountering nucleophilic reagents such as sodium alcohol, one of the atoms of bromine, chlorine, and iodine can be replaced by alkoxy groups to form corresponding ether compounds. This reaction requires a specific catalyst and suitable reaction conditions to proceed smoothly.
Secondly, the compound can undergo metal-catalyzed coupling reactions. Under the action of transition metal catalysts such as palladium and nickel, it can be coupled with carbon-containing nucleophiles such as organoboronic acid and organozinc reagents to realize the construction of carbon-carbon bonds. This reaction is extremely critical in the synthesis of complex organic molecules, and can efficiently construct organic compounds with diverse structures.
Furthermore, there is a difference in the halogen atom activity of 1-bromo-5-chloro-2-iodobenzene. Usually the iodine atom has the highest activity, followed by the bromine atom, and the chlorine atom is relatively inactive. In some reactions, this difference in activity can be used to selectively involve specific halogen atoms in the reaction, thereby synthesizing the desired target product.
In addition, its benzene ring can undergo electrophilic substitution reaction. Although the halogen atom is an blunt group, the benzene ring still has certain reactivity. For example, under appropriate conditions, electrophilic substitution reactions such as nitrification and sulfonation can occur, and nitro, sulfonic acid groups and other functional groups are introduced into the benzene ring. The reaction check point is affected by the localization effect of halogen atoms, which mainly occurs in the ortho-para-position of halogen atoms.
1-bromo-5-chloro-2-iodobenzene is rich in chemical properties and plays an important role in the field of organic synthesis chemistry, providing an important synthetic building block for the creation of various organic compounds.
Firstly, its halogen atoms can participate in nucleophilic substitution reactions. Due to the electron-absorbing induction effect of halogen atoms, the electron cloud density of the benzene ring decreases, making the carbon atoms of the phthalene ring more vulnerable to attack by nucleophiles. For example, when encountering nucleophilic reagents such as sodium alcohol, one of the atoms of bromine, chlorine, and iodine can be replaced by alkoxy groups to form corresponding ether compounds. This reaction requires a specific catalyst and suitable reaction conditions to proceed smoothly.
Secondly, the compound can undergo metal-catalyzed coupling reactions. Under the action of transition metal catalysts such as palladium and nickel, it can be coupled with carbon-containing nucleophiles such as organoboronic acid and organozinc reagents to realize the construction of carbon-carbon bonds. This reaction is extremely critical in the synthesis of complex organic molecules, and can efficiently construct organic compounds with diverse structures.
Furthermore, there is a difference in the halogen atom activity of 1-bromo-5-chloro-2-iodobenzene. Usually the iodine atom has the highest activity, followed by the bromine atom, and the chlorine atom is relatively inactive. In some reactions, this difference in activity can be used to selectively involve specific halogen atoms in the reaction, thereby synthesizing the desired target product.
In addition, its benzene ring can undergo electrophilic substitution reaction. Although the halogen atom is an blunt group, the benzene ring still has certain reactivity. For example, under appropriate conditions, electrophilic substitution reactions such as nitrification and sulfonation can occur, and nitro, sulfonic acid groups and other functional groups are introduced into the benzene ring. The reaction check point is affected by the localization effect of halogen atoms, which mainly occurs in the ortho-para-position of halogen atoms.
1-bromo-5-chloro-2-iodobenzene is rich in chemical properties and plays an important role in the field of organic synthesis chemistry, providing an important synthetic building block for the creation of various organic compounds.
What is the synthesis of 1 - bromo - 5 - chloro - 2 - iodobenzene?
The synthesis of 1 + -bromo-5-chloro-2-iodobenzene is quite complicated and needs to follow the delicate path of organic synthesis. The first consideration should be the selection of raw materials. Benzene is the basic raw material for the synthesis of such aromatic compounds. In order to obtain the target product, a series of steps such as halogenation must be carried out.
The method of bromination is first applied, and bromine atoms can be introduced into the benzene ring. This process requires the selection of appropriate brominating reagents, such as bromine elementals and suitable catalysts, such as iron powder or iron tribromide. Under suitable reaction conditions, such as temperature and solvent control, bromine atoms selectively replace hydrogen atoms at specific positions on the benzene ring to form bromobenzene derivatives.
Then, the step of chlorination is carried out. Select an appropriate chlorination reagent, such as chlorine gas or thionyl chloride, in a specific reaction environment to connect the chlorine atom to the benzene ring. Among these, the control of the reaction conditions is crucial, because in order to make the chlorine atom accurately fall on the target position, factors such as temperature, catalyst and reactant ratio need to be considered to prevent unnecessary side reactions.
Finally, iodine atoms are introduced. The iodine substitution reaction is often more difficult than bromination and chlorination, and special iodine substitution reagents and conditions are required. Potassium iodide and an appropriate oxidizing agent, or a specific organic iodine reagent can be selected to achieve the interception of the iodine atom in the predetermined position of the benzene ring in a mild environment that can promote the effective substitution of iodine atoms, and finally 1 + -bromo-5-chloro-2-
Each step of the reaction requires fine regulation, from the purity of the raw material, the precise grasp of the reaction conditions, to the separation and purification of the product, all of which are related to the success or failure of the synthesis and the purity of the product. This synthesis process is a demonstration of the skills and wisdom of organic synthetic chemistry, and requires detailed planning and rigorous operation by chemists to achieve the desired synthesis effect.
The method of bromination is first applied, and bromine atoms can be introduced into the benzene ring. This process requires the selection of appropriate brominating reagents, such as bromine elementals and suitable catalysts, such as iron powder or iron tribromide. Under suitable reaction conditions, such as temperature and solvent control, bromine atoms selectively replace hydrogen atoms at specific positions on the benzene ring to form bromobenzene derivatives.
Then, the step of chlorination is carried out. Select an appropriate chlorination reagent, such as chlorine gas or thionyl chloride, in a specific reaction environment to connect the chlorine atom to the benzene ring. Among these, the control of the reaction conditions is crucial, because in order to make the chlorine atom accurately fall on the target position, factors such as temperature, catalyst and reactant ratio need to be considered to prevent unnecessary side reactions.
Finally, iodine atoms are introduced. The iodine substitution reaction is often more difficult than bromination and chlorination, and special iodine substitution reagents and conditions are required. Potassium iodide and an appropriate oxidizing agent, or a specific organic iodine reagent can be selected to achieve the interception of the iodine atom in the predetermined position of the benzene ring in a mild environment that can promote the effective substitution of iodine atoms, and finally 1 + -bromo-5-chloro-2-
Each step of the reaction requires fine regulation, from the purity of the raw material, the precise grasp of the reaction conditions, to the separation and purification of the product, all of which are related to the success or failure of the synthesis and the purity of the product. This synthesis process is a demonstration of the skills and wisdom of organic synthetic chemistry, and requires detailed planning and rigorous operation by chemists to achieve the desired synthesis effect.
Where is 1 - bromo - 5 - chloro - 2 - iodobenzene used?
1 + -Bromo-5-chloro-2-iodobenzene is quite useful in the field of organic synthesis. This compound has a unique structure, and its bromine, chlorine and iodine atoms have their own energy, which can lead to various chemical reactions.
In the conversion reaction of halogenated aromatic hydrocarbons, this compound can be a key raw material. Its halogen atoms can be replaced by various nucleophiles due to nucleophilic substitution reactions. If the nucleophilic reagents containing nitrogen, oxygen and sulfur are encountered, complex benzene derivatives can be prepared, which is often the way to create new drugs in pharmaceutical chemistry. The design of drug molecules relies on such reactions to replace halogen atoms to modify the activity, lipophilicity and other properties of the molecule, so as to achieve ideal pharmacological effects.
Furthermore, in the field of materials science, 1 + -bromo-5-chloro-2-iodobenzene can also be used. Through metal-catalyzed coupling reactions, it can be integrated into polymer systems to give materials special photoelectric properties. For example, if coupled with monomers with conjugated structures, polymers with excellent charge transport properties can be prepared, which can be used in organic Light Emitting Diodes, solar cells and other devices, or can emerge, helping to improve the performance of such devices.
In the field of total synthesis of natural products, this compound can also play a role. Due to its structure, it can simulate some fragments of natural products. Through organic synthesis, a complex natural product skeleton is gradually constructed to assist in the total synthesis of natural products, so as to further explore their biological activities and medicinal potential.
In the conversion reaction of halogenated aromatic hydrocarbons, this compound can be a key raw material. Its halogen atoms can be replaced by various nucleophiles due to nucleophilic substitution reactions. If the nucleophilic reagents containing nitrogen, oxygen and sulfur are encountered, complex benzene derivatives can be prepared, which is often the way to create new drugs in pharmaceutical chemistry. The design of drug molecules relies on such reactions to replace halogen atoms to modify the activity, lipophilicity and other properties of the molecule, so as to achieve ideal pharmacological effects.
Furthermore, in the field of materials science, 1 + -bromo-5-chloro-2-iodobenzene can also be used. Through metal-catalyzed coupling reactions, it can be integrated into polymer systems to give materials special photoelectric properties. For example, if coupled with monomers with conjugated structures, polymers with excellent charge transport properties can be prepared, which can be used in organic Light Emitting Diodes, solar cells and other devices, or can emerge, helping to improve the performance of such devices.
In the field of total synthesis of natural products, this compound can also play a role. Due to its structure, it can simulate some fragments of natural products. Through organic synthesis, a complex natural product skeleton is gradually constructed to assist in the total synthesis of natural products, so as to further explore their biological activities and medicinal potential.
What are the physical properties of 1 - bromo - 5 - chloro - 2 - iodobenzene?
1 + -Bromo-5 + -chloro-2 + -iodobenzene is one of the organic compounds. Its physical properties are very important in chemistry. After careful investigation, its characteristics can be obtained as follows:
First appearance, under room temperature and pressure, 1 + -bromo-5 + -chloro-2 + -iodobenzene is colorless to light yellow liquid, and the appearance is clear and has a specific luster. This is due to its molecular structure and electron cloud distribution.
Second and melting point and boiling point. The melting point is related to the temperature at which a substance changes from a solid state to a liquid state. The melting point of 1 + -bromo-5 + -chloro-2 + -iodobenzene is quite low, and the intermolecular force is weak, which is not enough to maintain the solid structure at a higher temperature, and the melting point is often in a lower range. As for the boiling point, due to the presence of halogen atoms such as bromine, chlorine, and iodine in the molecule, the Van der Waals force between molecules increases, causing the boiling point to increase. It usually boils in a certain temperature range. This temperature range is also determined by factors such as molecular structure and relative molecular mass.
Furthermore, the density is greater than that of water. Due to the presence of heavy atoms such as bromine, chlorine, and iodine in the molecule, the mass of the substance in the unit volume increases, so it is placed in water and will sink to the bottom.
In terms of solubility, 1 + -bromo-5 + -chloro-2 + -iodobenzene is a non-polar or weakly polar compound. According to the principle of "similar miscibility", it is easily soluble in non-polar or weakly polar organic solvents, such as benzene, toluene, dichloromethane, etc. In these solvents, it can be well dispersed and form a homogeneous system; while in water with strong polarity, the solubility is extremely poor, because it is difficult to form an effective interaction with water molecules.
In terms of volatility, 1 + -bromo-5 + -chloro-2 + -iodobenzene is volatile to a certain extent. However, due to the large relative mass of the molecule and the certain strength of the intermolecular force, its volatility is weaker than that of some small molecule organic compounds. In an open environment, after a certain period of time, it can slowly evaporate into the air.
These physical properties are all derived from the molecular structure of 1 + -bromo-5 + -chloro-2 + -iodobenzene. The properties of bromine, chlorine, and iodine atoms interact with the conjugated system of benzene rings to jointly determine their physical states and behaviors under different conditions. Applications in organic synthesis, materials science and other fields also rely on these properties.
First appearance, under room temperature and pressure, 1 + -bromo-5 + -chloro-2 + -iodobenzene is colorless to light yellow liquid, and the appearance is clear and has a specific luster. This is due to its molecular structure and electron cloud distribution.
Second and melting point and boiling point. The melting point is related to the temperature at which a substance changes from a solid state to a liquid state. The melting point of 1 + -bromo-5 + -chloro-2 + -iodobenzene is quite low, and the intermolecular force is weak, which is not enough to maintain the solid structure at a higher temperature, and the melting point is often in a lower range. As for the boiling point, due to the presence of halogen atoms such as bromine, chlorine, and iodine in the molecule, the Van der Waals force between molecules increases, causing the boiling point to increase. It usually boils in a certain temperature range. This temperature range is also determined by factors such as molecular structure and relative molecular mass.
Furthermore, the density is greater than that of water. Due to the presence of heavy atoms such as bromine, chlorine, and iodine in the molecule, the mass of the substance in the unit volume increases, so it is placed in water and will sink to the bottom.
In terms of solubility, 1 + -bromo-5 + -chloro-2 + -iodobenzene is a non-polar or weakly polar compound. According to the principle of "similar miscibility", it is easily soluble in non-polar or weakly polar organic solvents, such as benzene, toluene, dichloromethane, etc. In these solvents, it can be well dispersed and form a homogeneous system; while in water with strong polarity, the solubility is extremely poor, because it is difficult to form an effective interaction with water molecules.
In terms of volatility, 1 + -bromo-5 + -chloro-2 + -iodobenzene is volatile to a certain extent. However, due to the large relative mass of the molecule and the certain strength of the intermolecular force, its volatility is weaker than that of some small molecule organic compounds. In an open environment, after a certain period of time, it can slowly evaporate into the air.
These physical properties are all derived from the molecular structure of 1 + -bromo-5 + -chloro-2 + -iodobenzene. The properties of bromine, chlorine, and iodine atoms interact with the conjugated system of benzene rings to jointly determine their physical states and behaviors under different conditions. Applications in organic synthesis, materials science and other fields also rely on these properties.
What are the storage conditions for 1 - bromo - 5 - chloro - 2 - iodobenzene?
1 + -Bromo-5 + -chloro-2 + -iodobenzene is also an organic compound. If you want to store this substance, you should abide by specific conditions. The properties of this substance have their own unique characteristics, so the method of storage should not be careless.
The first priority is its stability. This compound is afraid of decomposition when exposed to heat or light, so it should be placed in a cool and dark place. The indoor temperature should preferably not exceed 25 degrees Celsius, and when it is well ventilated, so that the air is smooth, so as not to cause unease due to temperature accumulation.
Times and packaging. A closed container should be used, and glass or specific plastic materials should be used. Glass is chemically stable and does not react with compounds; special plastics are also resistant to corrosion and can block the intrusion of external factors. The lid must be tight to prevent moisture and air from entering. Due to moisture or hydrolysis, the air may cause oxidation to occur.
Furthermore, this material may be toxic and corrosive. When stored, it should be isolated from food, medicine and other incompatible substances. And it should be marked with clear warning labels to make the viewer aware of the danger to prevent accidental touch and misuse.
In addition, the storage place should have perfect fire and explosion-proof facilities. Due to the flammability of many organic compounds, if it encounters an open flame or a hot topic, it is easy to cause a fire and explosion. Therefore, fire extinguishers, fire sand and other fire extinguishers should be placed nearby for emergencies.
All of these are required for the storage of 1 + -bromo-5 + -chloro-2 + -iodobenzene. According to this, the quality can be guaranteed and the risk of accidents can be avoided.
The first priority is its stability. This compound is afraid of decomposition when exposed to heat or light, so it should be placed in a cool and dark place. The indoor temperature should preferably not exceed 25 degrees Celsius, and when it is well ventilated, so that the air is smooth, so as not to cause unease due to temperature accumulation.
Times and packaging. A closed container should be used, and glass or specific plastic materials should be used. Glass is chemically stable and does not react with compounds; special plastics are also resistant to corrosion and can block the intrusion of external factors. The lid must be tight to prevent moisture and air from entering. Due to moisture or hydrolysis, the air may cause oxidation to occur.
Furthermore, this material may be toxic and corrosive. When stored, it should be isolated from food, medicine and other incompatible substances. And it should be marked with clear warning labels to make the viewer aware of the danger to prevent accidental touch and misuse.
In addition, the storage place should have perfect fire and explosion-proof facilities. Due to the flammability of many organic compounds, if it encounters an open flame or a hot topic, it is easy to cause a fire and explosion. Therefore, fire extinguishers, fire sand and other fire extinguishers should be placed nearby for emergencies.
All of these are required for the storage of 1 + -bromo-5 + -chloro-2 + -iodobenzene. According to this, the quality can be guaranteed and the risk of accidents can be avoided.
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