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1-(Bromo-Phenyl-Methyl)-4-Chloro-Benzene
Linshang Chemical
|
HS Code |
383515 |
| Chemical Formula | C13H10BrCl |
| Molecular Weight | 281.58 |
| Appearance | Solid (usually a white - off - white powder) |
| Solubility In Water | Low solubility, hydrophobic compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low vapor pressure due to its solid state at room temperature |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-(Bromo-Phenyl-Methyl)-4-Chloro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(bromo - phenyl - methyl)-4 - chloro - benzene in a sealed, labeled bottle. |
| Storage | 1-(Bromo - phenyl - methyl)-4 - chloro - benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to moisture or air, which could potentially cause chemical reactions or degradation. |
| Shipping | 1-(bromo - phenyl - methyl)-4 - chloro - benzene, being a chemical, requires careful shipping. It should be packaged in appropriate, leak - proof containers, following regulations, and shipped via carriers approved for hazardous or chemical goods. |
Competitive 1-(Bromo-Phenyl-Methyl)-4-Chloro-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 1- (bromo-phenyl-methyl) -4-chloro-benzene?
1 - (bromo-phenyl-methyl) - 4 -chloro-benzene, this is the name of an organic compound. To clarify its chemical structure, it can be disassembled and analyzed from the name.
"1 -" shows that the substitution is based on the position of the benzene ring, and a certain carbon position is designated as the No. 1 position based on the benzene ring. " (Bromo-phenyl-methyl) " This substituent can be regarded as methyl linked to the benzene ring, and the hydrogen of methyl is replaced by a bromine atom. "4-chloro" refers to the substitution of a chlorine atom at the No. 4 position of the benzene ring.
According to the ancient saying, the structure of this compound is: the benzene ring is the base, and there is a group attached to the ring. This group is the methyl group connected to the benzene ring, and there is a bromine atom on the methyl group; the four positions of the ring are attached to another chlorine atom. In this way, the chemical structure of 1- (bromo-phenyl-methyl) -4-chloro-benzene is clear. In its structure, the benzene ring is the skeleton, and the bromine, phenyl, methyl, and chlorine atoms are related to each other according to their positions, forming a unique chemical structure, which is a specific molecular configuration in the field of organic chemistry.
"1 -" shows that the substitution is based on the position of the benzene ring, and a certain carbon position is designated as the No. 1 position based on the benzene ring. " (Bromo-phenyl-methyl) " This substituent can be regarded as methyl linked to the benzene ring, and the hydrogen of methyl is replaced by a bromine atom. "4-chloro" refers to the substitution of a chlorine atom at the No. 4 position of the benzene ring.
According to the ancient saying, the structure of this compound is: the benzene ring is the base, and there is a group attached to the ring. This group is the methyl group connected to the benzene ring, and there is a bromine atom on the methyl group; the four positions of the ring are attached to another chlorine atom. In this way, the chemical structure of 1- (bromo-phenyl-methyl) -4-chloro-benzene is clear. In its structure, the benzene ring is the skeleton, and the bromine, phenyl, methyl, and chlorine atoms are related to each other according to their positions, forming a unique chemical structure, which is a specific molecular configuration in the field of organic chemistry.
What are the physical properties of 1- (bromo-phenyl-methyl) -4-chloro-benzene?
1 - (Bromo-phenyl-methyl) -4-chlorobenzene is also an organic compound. It has several physical properties, let me tell them one by one.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state. Due to the intermolecular force, the molecules are arranged in an orderly manner. Its melting point is related to the close accumulation and interaction of molecules. Generally speaking, the melting point is relatively high. Due to the rigidity of the benzene ring structure and the introduction of bromine and chlorine atoms to increase the intermolecular attraction, higher temperatures are required to overcome this force, causing the lattice to disintegrate and melt.
As for the boiling point, it is also higher. The presence of benzene rings and halogen atoms in the caustic molecule increases the intermolecular van der Waals force, and more energy is required to make the molecule break free from the liquid phase and turn into the gas phase, so the boiling point rises.
In terms of solubility, this compound has little solubility in polar solvents such as water. Since its molecular structure is mainly composed of non-polar benzene rings, although bromine and chlorine have certain polarity, it is not enough to form a strong interaction between the whole molecule and water molecules. On the contrary, in non-polar or weakly polar organic solvents, such as toluene and dichloromethane, the solubility is better. Due to the principle of "similar miscibility", non-polar molecules are easily soluble in non-polar solvents.
Its density is higher than that of water, which is caused by the relatively large atomic mass of bromine and chlorine atoms in the molecule, resulting in an increase in mass per unit volume, so the density is higher than that of water.
1- (bromo-phenyl-methyl) -4-chlorobenzene The physical properties such as color state, melting boiling point, solubility and density are determined by its molecular structure, and these properties are crucial in the research and application of organic chemistry.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state. Due to the intermolecular force, the molecules are arranged in an orderly manner. Its melting point is related to the close accumulation and interaction of molecules. Generally speaking, the melting point is relatively high. Due to the rigidity of the benzene ring structure and the introduction of bromine and chlorine atoms to increase the intermolecular attraction, higher temperatures are required to overcome this force, causing the lattice to disintegrate and melt.
As for the boiling point, it is also higher. The presence of benzene rings and halogen atoms in the caustic molecule increases the intermolecular van der Waals force, and more energy is required to make the molecule break free from the liquid phase and turn into the gas phase, so the boiling point rises.
In terms of solubility, this compound has little solubility in polar solvents such as water. Since its molecular structure is mainly composed of non-polar benzene rings, although bromine and chlorine have certain polarity, it is not enough to form a strong interaction between the whole molecule and water molecules. On the contrary, in non-polar or weakly polar organic solvents, such as toluene and dichloromethane, the solubility is better. Due to the principle of "similar miscibility", non-polar molecules are easily soluble in non-polar solvents.
Its density is higher than that of water, which is caused by the relatively large atomic mass of bromine and chlorine atoms in the molecule, resulting in an increase in mass per unit volume, so the density is higher than that of water.
1- (bromo-phenyl-methyl) -4-chlorobenzene The physical properties such as color state, melting boiling point, solubility and density are determined by its molecular structure, and these properties are crucial in the research and application of organic chemistry.
What are the main uses of 1- (bromo-phenyl-methyl) -4-chloro-benzene?
1 - (bromo-phenyl-methyl) -4-chlorobenzene, this is an organic compound with a wide range of uses. In the field of organic synthesis, it can be called a key intermediate. With its unique structure, it can participate in a variety of chemical reactions to build more complex organic molecular structures.
In the field of pharmaceutical chemistry, it can be used as a starting material for the synthesis of specific drugs. Because the design of drug molecules often requires precise structures, the bromine, chlorine and benzene ring structures of this compound can be chemically modified to meet the needs of drugs for specific targets, and then help the development of new drugs.
In the field of materials science, it also has its uses. For example, it can be used as a basic unit for building functional materials. By reacting with other compounds, materials with special optoelectronic properties or mechanical properties are generated, such as applied to organic optoelectronic materials to improve the charge transport capacity of materials.
It is also indispensable in the manufacture of fine chemical products. It can be used to synthesize high-value fine chemicals, such as special fragrances, pigments, etc. Because its structure can give the product unique properties, it can meet the market demand for characteristic fine chemical products.
In the field of pharmaceutical chemistry, it can be used as a starting material for the synthesis of specific drugs. Because the design of drug molecules often requires precise structures, the bromine, chlorine and benzene ring structures of this compound can be chemically modified to meet the needs of drugs for specific targets, and then help the development of new drugs.
In the field of materials science, it also has its uses. For example, it can be used as a basic unit for building functional materials. By reacting with other compounds, materials with special optoelectronic properties or mechanical properties are generated, such as applied to organic optoelectronic materials to improve the charge transport capacity of materials.
It is also indispensable in the manufacture of fine chemical products. It can be used to synthesize high-value fine chemicals, such as special fragrances, pigments, etc. Because its structure can give the product unique properties, it can meet the market demand for characteristic fine chemical products.
What are the preparation methods of 1- (bromo-phenyl-methyl) -4-chloro-benzene?
1 - (Bromo-phenyl-methyl) - 4 - chlorobenzene. To make this substance, there are many methods, each with its own advantages and disadvantages. Those who operate it should choose the best one according to their own conditions.
First, the method of coupling halogenated aromatics. With p-chlorobenzene and bromobenzyl as a base, coupled with a palladium catalyst, such as tetrakis (triphenylphosphine) palladium, in a suitable organic solvent, add a base to promote the reaction. Among these bases, potassium carbonate and sodium carbonate are commonly used. When the reaction is carried out, the temperature needs to be controlled at a moderate level, usually in the state of heating and reflux. This method has good selectivity and good yield. However, the palladium-based catalyst has a high valence, and the reaction conditions are harsh. It requires an anhydrous and anaerobic environment, which may be a cost constraint in the actual preparation.
Second, the Grignard reagent method. First, p-chlorobrombenzene and magnesium chips react in anhydrous ether or tetrahydrofuran to form a Grignard reagent. Next, the Grignard reagent is reacted with bromobenzyl. The Grignard reagent is very active and the reaction is easy to carry out. However, this process is extremely sensitive to water. If there is a slight carelessness, the reaction will fail due to the mixing of water, and the preparation of the Grignard reagent needs to be handled with caution. There is a slight poor pool, which
Third, the Fu-gram alkylation reaction. Using p-chlorobenzene and bromobenzyl as materials, aluminum trichloride and other Lewis acids as catalysts. The reaction is carried out in inert solvents such as dichloromethane and carbon disulfide. This method is slightly simpler to operate and the raw materials are easy to obtain. However, the Fu-gram reaction often produces by-products with multiple substitutions, resulting in damage to the purity of the product. The post-treatment is quite complicated, and the product needs to be purified by various means such as column chromatography.
First, the method of coupling halogenated aromatics. With p-chlorobenzene and bromobenzyl as a base, coupled with a palladium catalyst, such as tetrakis (triphenylphosphine) palladium, in a suitable organic solvent, add a base to promote the reaction. Among these bases, potassium carbonate and sodium carbonate are commonly used. When the reaction is carried out, the temperature needs to be controlled at a moderate level, usually in the state of heating and reflux. This method has good selectivity and good yield. However, the palladium-based catalyst has a high valence, and the reaction conditions are harsh. It requires an anhydrous and anaerobic environment, which may be a cost constraint in the actual preparation.
Second, the Grignard reagent method. First, p-chlorobrombenzene and magnesium chips react in anhydrous ether or tetrahydrofuran to form a Grignard reagent. Next, the Grignard reagent is reacted with bromobenzyl. The Grignard reagent is very active and the reaction is easy to carry out. However, this process is extremely sensitive to water. If there is a slight carelessness, the reaction will fail due to the mixing of water, and the preparation of the Grignard reagent needs to be handled with caution. There is a slight poor pool, which
Third, the Fu-gram alkylation reaction. Using p-chlorobenzene and bromobenzyl as materials, aluminum trichloride and other Lewis acids as catalysts. The reaction is carried out in inert solvents such as dichloromethane and carbon disulfide. This method is slightly simpler to operate and the raw materials are easy to obtain. However, the Fu-gram reaction often produces by-products with multiple substitutions, resulting in damage to the purity of the product. The post-treatment is quite complicated, and the product needs to be purified by various means such as column chromatography.
What are the precautions for using 1- (bromo-phenyl-methyl) -4-chloro-benzene?
1 - (Bromo-Phenyl-Methyl) - 4 - Chloro-Benzene, this is an organic compound. During use, many things need to be paid attention to.
First safety protection. This compound may be toxic and irritating. When handling, be sure to wear protective clothing, gloves and goggles, and beware of skin and eye contact. If it is accidentally touched, rinse with plenty of water immediately, and seek medical attention in a timely manner according to the severity of the injury. Operate in a well-ventilated place or with the help of a fume hood to prevent inhalation of its volatile gas and avoid respiratory irritation or poisoning.
Second words storage conditions. It should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its active chemical properties, it may be dangerous to burn or explode in case of heat, open flame or oxidant. At the same time, ensure that the storage container is well sealed to prevent leakage.
Furthermore, the reaction conditions during use also need to be precisely controlled. The chemical reactions in which this compound participates require strict conditions such as temperature, pH, and reaction time. If the temperature is too high or too low, it may affect the reaction rate and product purity; if the pH is not suitable, the reaction may not be carried out, or by-products may be formed. Therefore, the reaction conditions need to be precisely regulated according to the type and purpose of the reaction, with the help of thermometers, pH test strips and other tools.
In addition, when taking this compound, the measuring tool must be accurate to ensure that the proportion of reaction materials is appropriate. Excessive or too little use will have an adverse effect on the reaction results. After use, properly dispose of the remaining compounds and reaction waste. According to relevant regulations, do not discard them at will to prevent environmental pollution.
In summary, when using 1- (bromo-phenyl-methyl) -4-chloro-benzene, be careful and strictly abide by safety procedures and operating guidelines to ensure the smooth progress of experiments or production, and ensure the safety of personnel and the environment is not damaged.
First safety protection. This compound may be toxic and irritating. When handling, be sure to wear protective clothing, gloves and goggles, and beware of skin and eye contact. If it is accidentally touched, rinse with plenty of water immediately, and seek medical attention in a timely manner according to the severity of the injury. Operate in a well-ventilated place or with the help of a fume hood to prevent inhalation of its volatile gas and avoid respiratory irritation or poisoning.
Second words storage conditions. It should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its active chemical properties, it may be dangerous to burn or explode in case of heat, open flame or oxidant. At the same time, ensure that the storage container is well sealed to prevent leakage.
Furthermore, the reaction conditions during use also need to be precisely controlled. The chemical reactions in which this compound participates require strict conditions such as temperature, pH, and reaction time. If the temperature is too high or too low, it may affect the reaction rate and product purity; if the pH is not suitable, the reaction may not be carried out, or by-products may be formed. Therefore, the reaction conditions need to be precisely regulated according to the type and purpose of the reaction, with the help of thermometers, pH test strips and other tools.
In addition, when taking this compound, the measuring tool must be accurate to ensure that the proportion of reaction materials is appropriate. Excessive or too little use will have an adverse effect on the reaction results. After use, properly dispose of the remaining compounds and reaction waste. According to relevant regulations, do not discard them at will to prevent environmental pollution.
In summary, when using 1- (bromo-phenyl-methyl) -4-chloro-benzene, be careful and strictly abide by safety procedures and operating guidelines to ensure the smooth progress of experiments or production, and ensure the safety of personnel and the environment is not damaged.
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