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1-(Bromomethyl)-2,4-Dichlorobenzene
Linshang Chemical
|
HS Code |
798531 |
| Chemical Formula | C7H5BrCl2 |
| Molar Mass | 239.92 g/mol |
| Appearance | Solid (usually white or off - white) |
| Boiling Point | Approximately 275 - 280 °C |
| Melting Point | Around 60 - 65 °C |
| Density | 1.78 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, and dichloromethane |
| Odor | Pungent |
| Flash Point | Approximately 120 °C |
| Hazard Class | Irritant, may be harmful if swallowed, inhaled or in contact with skin |
As an accredited 1-(Bromomethyl)-2,4-Dichlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(bromomethyl)-2,4 - dichlorobenzene in a sealed, labeled chemical - grade bottle. |
| Storage | 1-(Bromomethyl)-2,4 - dichlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and vapor release. This compound may be harmful if mishandled, so proper storage helps ensure safety and maintain its chemical integrity. |
| Shipping | 1-(Bromomethyl)-2,4 - dichlorobenzene is shipped in accordance with strict chemical regulations. Packed in suitable containers, it's transported by methods ensuring safety, minimizing risk during transit due to its chemical nature. |
Competitive 1-(Bromomethyl)-2,4-Dichlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-(Bromomethyl)-2,4-Dichlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1- (bromomethyl) -2,4-dichlorobenzene?
1 - (bromomethyl) -2,4 -dichlorobenzene, this is an organic compound with a wide range of uses.
First, in the field of organic synthesis, it is often used as a key intermediate. Because its structure contains active bromomethyl and chlorine atoms, it is easy to participate in various chemical reactions. For example, nucleophilic substitution reactions, bromomethyl has a very high bromine atom activity, and many nucleophilic reagents such as alcohols, amines, mercaptans, etc. can react with them to form various carbon-heteroatom bonds and synthesize organic compounds with complex structures. When preparing nitrogen-containing heterocyclic compounds, they can react with amine nucleophilic reagents and undergo a series of transformations to obtain the target product.
Second, in the field of medicinal chemistry, its use should not be underestimated. Some biologically active drug molecules are synthesized with it as a starting material. Through subsequent modifications, specific pharmacological activities are imparted to the molecules. For example, in the research and development of some antibacterial and anti-inflammatory drugs, structural modifications and optimization based on it may lead to new drugs with good efficacy and few side effects.
Third, in the field of materials science, it can be used to prepare functional materials. Through the polymerization reaction it participates in, specific structures can be introduced into polymers, giving the materials unique properties. For example, the preparation of polymer materials with special optical and electrical properties, or materials with good thermal stability and mechanical properties, is used in many fields such as electronics and optics.
Fourth, in terms of pesticide chemistry, it is an important raw material for synthetic pesticides. After rational structure design and reaction, pesticides with insecticidal, weeding, and bactericidal effects can be prepared. For example, by modifying its structure, the synthetic pesticide has high selectivity and activity for specific pests or weeds, while reducing the impact on the environment and non-target organisms.
In short, 1- (bromomethyl) -2,4-dichlorobenzene has important uses in many fields such as organic synthesis, medicine, materials, and pesticides, and plays a key role in promoting the development of various fields.
First, in the field of organic synthesis, it is often used as a key intermediate. Because its structure contains active bromomethyl and chlorine atoms, it is easy to participate in various chemical reactions. For example, nucleophilic substitution reactions, bromomethyl has a very high bromine atom activity, and many nucleophilic reagents such as alcohols, amines, mercaptans, etc. can react with them to form various carbon-heteroatom bonds and synthesize organic compounds with complex structures. When preparing nitrogen-containing heterocyclic compounds, they can react with amine nucleophilic reagents and undergo a series of transformations to obtain the target product.
Second, in the field of medicinal chemistry, its use should not be underestimated. Some biologically active drug molecules are synthesized with it as a starting material. Through subsequent modifications, specific pharmacological activities are imparted to the molecules. For example, in the research and development of some antibacterial and anti-inflammatory drugs, structural modifications and optimization based on it may lead to new drugs with good efficacy and few side effects.
Third, in the field of materials science, it can be used to prepare functional materials. Through the polymerization reaction it participates in, specific structures can be introduced into polymers, giving the materials unique properties. For example, the preparation of polymer materials with special optical and electrical properties, or materials with good thermal stability and mechanical properties, is used in many fields such as electronics and optics.
Fourth, in terms of pesticide chemistry, it is an important raw material for synthetic pesticides. After rational structure design and reaction, pesticides with insecticidal, weeding, and bactericidal effects can be prepared. For example, by modifying its structure, the synthetic pesticide has high selectivity and activity for specific pests or weeds, while reducing the impact on the environment and non-target organisms.
In short, 1- (bromomethyl) -2,4-dichlorobenzene has important uses in many fields such as organic synthesis, medicine, materials, and pesticides, and plays a key role in promoting the development of various fields.
What are the physical properties of 1- (bromomethyl) -2,4-dichlorobenzene
1- (bromomethyl) -2,4-dichlorobenzene is one of the organic compounds. Its physical properties are unique and are related to many fields such as chemical industry and medicine. The detailed analysis is as follows.
First of all, its properties, under room temperature, 1- (bromomethyl) -2,4-dichlorobenzene is often colorless to light yellow liquid, pure or nearly colorless. Looking at its appearance, it is clear and has a special smell, but the smell may be slightly different due to impurities, and the smell can be felt that it is different from common odorless substances.
The melting point is about [X] ℃, and this value may vary slightly depending on the measurement environment and method. When the temperature drops below the melting point, the substance will gradually change from the liquid state to the solid state, and the molecular arrangement will tend to be regular. The boiling point is about [X] ° C. At this temperature, the thermal motion of the molecules intensifies, which is enough to overcome the attractive force between molecules and change from liquid to gaseous state to escape.
Furthermore, when it comes to solubility. 1- (bromomethyl) -2,4-dichlorobenzene has little solubility in water because its molecular structure is dominated by non-polar carbon-carbon bonds and carbon-halogen bonds, which are incompatible with the polar structure of water molecules. However, in organic solvents such as ethanol, ether, benzene, etc., the solubility is quite good. The cap organic solvents are mostly non-polar or weakly polar, similar to the intermolecular forces of the substance, and can be well miscible according to the principle of "similar miscibility".
In addition, density is also one of its important physical properties. Its density is greater than that of water, about [X] g/cm ³. Mix it with water, and after standing, the substance will sink to the bottom of the water, which is quite useful for separation and identification.
1- (bromomethyl) -2,4-dichlorobenzene has unique physical properties, and is a key basis for research and application in many fields such as chemical synthesis and pharmaceutical research and development. Its properties, melting point, solubility and density are interrelated and affect its behavior in different environments and processes.
First of all, its properties, under room temperature, 1- (bromomethyl) -2,4-dichlorobenzene is often colorless to light yellow liquid, pure or nearly colorless. Looking at its appearance, it is clear and has a special smell, but the smell may be slightly different due to impurities, and the smell can be felt that it is different from common odorless substances.
The melting point is about [X] ℃, and this value may vary slightly depending on the measurement environment and method. When the temperature drops below the melting point, the substance will gradually change from the liquid state to the solid state, and the molecular arrangement will tend to be regular. The boiling point is about [X] ° C. At this temperature, the thermal motion of the molecules intensifies, which is enough to overcome the attractive force between molecules and change from liquid to gaseous state to escape.
Furthermore, when it comes to solubility. 1- (bromomethyl) -2,4-dichlorobenzene has little solubility in water because its molecular structure is dominated by non-polar carbon-carbon bonds and carbon-halogen bonds, which are incompatible with the polar structure of water molecules. However, in organic solvents such as ethanol, ether, benzene, etc., the solubility is quite good. The cap organic solvents are mostly non-polar or weakly polar, similar to the intermolecular forces of the substance, and can be well miscible according to the principle of "similar miscibility".
In addition, density is also one of its important physical properties. Its density is greater than that of water, about [X] g/cm ³. Mix it with water, and after standing, the substance will sink to the bottom of the water, which is quite useful for separation and identification.
1- (bromomethyl) -2,4-dichlorobenzene has unique physical properties, and is a key basis for research and application in many fields such as chemical synthesis and pharmaceutical research and development. Its properties, melting point, solubility and density are interrelated and affect its behavior in different environments and processes.
Is 1- (bromomethyl) -2,4-dichlorobenzene chemically stable?
1 - (bromomethyl) - 2,4 - dichlorobenzene is also an organic compound. The stability of its chemical properties is related to various factors and cannot be generalized.
In this compound, bromomethyl is connected to dichlorophenyl. In bromomethyl, the carbon-bromide bond has a certain activity. The bromine atom has a large electronegativity, which makes the carbon-bromide bond electron cloud biased towards bromine, causing the carbon atom to be partially positively charged and vulnerable to attack by nucleophiles. This is the reason for its activity. In case of nucleophiles such as hydroxyl negative ions, a nucleophilic substitution reaction can occur, and the bromine atom is replaced by a hydroxyl group to form a corresponding alcohol compound.
The chlorine atom on the benzene ring, although the electron cloud density of the benzene ring is reduced, the activity of the electrophilic substitution of the benzene ring is slightly reduced, but the molecular stability is enhanced to a certain extent. Because the lone pair electrons of the chlorine atom can be conjugated with the benzene ring, the energy of the dispersed system can be dispersed.
External conditions also have a huge impact on its stability. In high temperature environment, the internal molecular energy increases, the vibration of chemical bonds intensifies, the carbon-bromine bond is easier to break, the stability decreases, or the decomposition and rearrangement are triggered. Under light conditions, especially light irradiation of specific wavelengths, the free radical reaction of bromomethyl can be induced,
In common organic solvents, the solubility of 1- (bromomethyl) -2,4-dichlorobenzene may be different, and some solvents may interact with it to affect its stability. For example, polar solvents or interactions with the compound containing polar bonds change the molecular charge distribution and affect its reactivity and stability.
In summary, the stability of 1- (bromomethyl) -2,4-dichlorobenzene is non-absolute, and it is affected by many factors such as functional group characteristics in its own structure and external temperature, light, solvent, etc. Its stability varies under different situations.
In this compound, bromomethyl is connected to dichlorophenyl. In bromomethyl, the carbon-bromide bond has a certain activity. The bromine atom has a large electronegativity, which makes the carbon-bromide bond electron cloud biased towards bromine, causing the carbon atom to be partially positively charged and vulnerable to attack by nucleophiles. This is the reason for its activity. In case of nucleophiles such as hydroxyl negative ions, a nucleophilic substitution reaction can occur, and the bromine atom is replaced by a hydroxyl group to form a corresponding alcohol compound.
The chlorine atom on the benzene ring, although the electron cloud density of the benzene ring is reduced, the activity of the electrophilic substitution of the benzene ring is slightly reduced, but the molecular stability is enhanced to a certain extent. Because the lone pair electrons of the chlorine atom can be conjugated with the benzene ring, the energy of the dispersed system can be dispersed.
External conditions also have a huge impact on its stability. In high temperature environment, the internal molecular energy increases, the vibration of chemical bonds intensifies, the carbon-bromine bond is easier to break, the stability decreases, or the decomposition and rearrangement are triggered. Under light conditions, especially light irradiation of specific wavelengths, the free radical reaction of bromomethyl can be induced,
In common organic solvents, the solubility of 1- (bromomethyl) -2,4-dichlorobenzene may be different, and some solvents may interact with it to affect its stability. For example, polar solvents or interactions with the compound containing polar bonds change the molecular charge distribution and affect its reactivity and stability.
In summary, the stability of 1- (bromomethyl) -2,4-dichlorobenzene is non-absolute, and it is affected by many factors such as functional group characteristics in its own structure and external temperature, light, solvent, etc. Its stability varies under different situations.
What are the synthesis methods of 1- (bromomethyl) -2,4-dichlorobenzene
The method for synthesizing 1 - (bromomethyl) - 2,4 - dichlorobenzene, usually using 2,4 - dichlorotoluene as the starting material. The first method is to react 2,4 - dichlorotoluene with N - bromosuccinimide (NBS) in the presence of an initiator. This initiator is often benzoyl peroxide (BPO), which is heated and refluxed in a suitable solvent such as carbon tetrachloride. The methyl hydrogen in 2,4-dichlorotoluene has certain activity due to the influence of the benzene ring. The bromine radical provided by NBS will capture the methyl hydrogen and then form a benzyl radical. The radical reacts with NBS to form the target product 1- (bromomethyl) -2,4-dichlorobenzene, and at the same time generates succinimide by-products.
Furthermore, 2,4-dichlorotoluene can also be used to react with bromine (Br ²) under light or heating conditions. Light or heating prompts bromine molecules to split into bromine atoms, and bromine atoms interact with the hydrogen of 2,4-dichlorotoluene methyl to obtain 1- (bromomethyl) -2,4-dichlorobenzene through a free radical reaction mechanism. However, this process needs to pay attention to control the reaction conditions. Due to the high reactivity, if the conditions are improper, it is easy to cause the formation of polybrominated products and affect the purity of the target product.
In addition, 2,4-dichlorobenzoic acid can also be considered as the starting material, and it is first reduced to 2,4-dichlorobenzanol. Commonly used reducing agents such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH). After that, 2,4-dichlorobenzyl alcohol is reacted with hydrobromic acid (HBr) or phosphorus tribromide (PBr), and the hydroxyl group is replaced by the bromine atom to generate 1- (bromomethyl) -2,4-dichlorobenzene. This route has a little more steps, but the reaction selectivity of each step is relatively easy to control, which is beneficial to improve the purity of the product.
Furthermore, 2,4-dichlorotoluene can also be used to react with bromine (Br ²) under light or heating conditions. Light or heating prompts bromine molecules to split into bromine atoms, and bromine atoms interact with the hydrogen of 2,4-dichlorotoluene methyl to obtain 1- (bromomethyl) -2,4-dichlorobenzene through a free radical reaction mechanism. However, this process needs to pay attention to control the reaction conditions. Due to the high reactivity, if the conditions are improper, it is easy to cause the formation of polybrominated products and affect the purity of the target product.
In addition, 2,4-dichlorobenzoic acid can also be considered as the starting material, and it is first reduced to 2,4-dichlorobenzanol. Commonly used reducing agents such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH). After that, 2,4-dichlorobenzyl alcohol is reacted with hydrobromic acid (HBr) or phosphorus tribromide (PBr), and the hydroxyl group is replaced by the bromine atom to generate 1- (bromomethyl) -2,4-dichlorobenzene. This route has a little more steps, but the reaction selectivity of each step is relatively easy to control, which is beneficial to improve the purity of the product.
What are the precautions for 1- (bromomethyl) -2,4-dichlorobenzene during storage and transportation?
1 - (bromomethyl) - 2,4 - dichlorobenzene is also an organic compound. During storage and transportation, pay attention to many matters to ensure its safety.
Temperature and humidity of the first storage environment. This compound should be stored in a cool, dry place away from direct sunlight. If the ambient temperature is too high, it may cause its volatilization to accelerate, or even cause chemical reactions; if the humidity is too high, it will easily cause its moisture absorption and deterioration, which will damage its quality and stability.
Furthermore, the storage place should be well ventilated. 1 - (bromomethyl) - 2,4 - dichlorobenzene may have certain volatility and irritation. If the ventilation is not smooth, its gas will accumulate in the space, which will endanger the health of the storage personnel. Second, it may pose a safety hazard due to high concentration, such as explosion and other risks.
The tightness of the packaging is also crucial. Suitable packaging materials must be used to ensure a good seal to prevent leakage. Leakage will not only cause material loss, but also the compound may cause pollution to the environment. If it comes into contact with human body, it will also damage health.
When transporting, it should be operated in accordance with relevant regulations and standards. Choose qualified means of transportation to ensure a smooth transportation process, avoid violent vibration and collision, and prevent package damage. Transport personnel should also be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods.
Storage and transportation of 1- (bromomethyl) -2,4-dichlorobenzene requires careful treatment in terms of environment, packaging, personnel, etc., in order to ensure the safety of the whole process and avoid accidents.
Temperature and humidity of the first storage environment. This compound should be stored in a cool, dry place away from direct sunlight. If the ambient temperature is too high, it may cause its volatilization to accelerate, or even cause chemical reactions; if the humidity is too high, it will easily cause its moisture absorption and deterioration, which will damage its quality and stability.
Furthermore, the storage place should be well ventilated. 1 - (bromomethyl) - 2,4 - dichlorobenzene may have certain volatility and irritation. If the ventilation is not smooth, its gas will accumulate in the space, which will endanger the health of the storage personnel. Second, it may pose a safety hazard due to high concentration, such as explosion and other risks.
The tightness of the packaging is also crucial. Suitable packaging materials must be used to ensure a good seal to prevent leakage. Leakage will not only cause material loss, but also the compound may cause pollution to the environment. If it comes into contact with human body, it will also damage health.
When transporting, it should be operated in accordance with relevant regulations and standards. Choose qualified means of transportation to ensure a smooth transportation process, avoid violent vibration and collision, and prevent package damage. Transport personnel should also be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods.
Storage and transportation of 1- (bromomethyl) -2,4-dichlorobenzene requires careful treatment in terms of environment, packaging, personnel, etc., in order to ensure the safety of the whole process and avoid accidents.
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