Linshang Chemical
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1-(Bromomethyl)-2-Chloro-3-Fluorobenzene
Linshang Chemical
|
HS Code |
621731 |
| Chemical Formula | C7H5BrClF |
| Molecular Weight | 223.47 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Data may vary, around 200 - 220°C under normal pressure |
| Density | Approximately 1.7 - 1.9 g/cm³ |
| Solubility In Water | Insoluble in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Hazard Class | Irritant, may cause harm to skin, eyes and respiratory system |
As an accredited 1-(Bromomethyl)-2-Chloro-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(bromomethyl)-2 -chloro-3 -fluorobenzene in a sealed, chemical - resistant bottle. |
| Storage | 1-(Bromomethyl)-2 -chloro-3 -fluorobenzene should be stored in a cool, dry, well -ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. |
| Shipping | 1-(Bromomethyl)-2-chloro-3-fluorobenzene is shipped in accordance with chemical transportation regulations. Packed in appropriate containers to prevent leakage, it is transported under controlled conditions to ensure safety during transit. |
Competitive 1-(Bromomethyl)-2-Chloro-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-(Bromomethyl)-2-Chloro-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 1- (bromomethyl) -2-chloro-3-fluorobenzene?
1- (bromomethyl) -2-chloro-3-fluorobenzene, this compound has a wide range of uses. In the field of organic synthesis, it is a key intermediate. It can react with many nucleophiles, such as alcohols, amines, mercaptan, etc. by nucleophilic substitution reaction, and then form various organic compounds containing bromine, chlorine, and fluorine. Such compounds are of great significance in the fields of medicinal chemistry, pesticide chemistry, and materials science.
In medicinal chemistry, the introduction of fluorine atoms can significantly improve the physiological activity, metabolic stability, and membrane permeability of drug molecules. Chlorine atoms can also affect the biological activity and physicochemical properties of compounds. Bromomethyl provides an activity check point for subsequent structural modifications. With this compound as a starting material, through a series of reactions, new specific drugs may be prepared.
In the field of pesticide chemistry, the halogen-containing organic compounds involved in the synthesis of this compound may have excellent insecticidal, bactericidal and herbicidal activities. Because of its unique structure and electronic properties, it may have significant biological effects on specific pests, bacteria or weeds, thus becoming a key component in the development of new and efficient pesticides.
In the field of materials science, through chemical modification, it may be possible to synthesize organic materials with special optical, electrical or thermal properties. For example, introducing it into the structure of polymer may endow materials with unique properties, making it a key component in the fields of optoelectronic materials, functional coatings, etc.
In medicinal chemistry, the introduction of fluorine atoms can significantly improve the physiological activity, metabolic stability, and membrane permeability of drug molecules. Chlorine atoms can also affect the biological activity and physicochemical properties of compounds. Bromomethyl provides an activity check point for subsequent structural modifications. With this compound as a starting material, through a series of reactions, new specific drugs may be prepared.
In the field of pesticide chemistry, the halogen-containing organic compounds involved in the synthesis of this compound may have excellent insecticidal, bactericidal and herbicidal activities. Because of its unique structure and electronic properties, it may have significant biological effects on specific pests, bacteria or weeds, thus becoming a key component in the development of new and efficient pesticides.
In the field of materials science, through chemical modification, it may be possible to synthesize organic materials with special optical, electrical or thermal properties. For example, introducing it into the structure of polymer may endow materials with unique properties, making it a key component in the fields of optoelectronic materials, functional coatings, etc.
What are the physical properties of 1- (bromomethyl) -2-chloro-3-fluorobenzene
1 - (bromomethyl) - 2 - chloro - 3 - fluorobenzene is one of the organic compounds. Its physical properties are quite characteristic, let me tell them one by one.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, clear and translucent, like a quiet spring, and the view gives people a sense of tranquility. The shape of this state is easy to dump, transfer and mix in many experimental and industrial processes, and it is quite convenient to operate.
To describe its smell, the compound exudes a unique smell. Although it does not resemble the pleasant fragrance of rich flowers, it is also unique and recognizable, just like a subtle chemical smell. However, this smell is not pungent and unbearable. It is still in the acceptable category, but it also reminds the contact of its chemical essence.
As for the melting point and boiling point, the melting point value is low, and it is not presented in a solid state at room temperature, due to the nature of the intermolecular force. The boiling point is relatively moderate, which is of great significance in operations such as separation and purification. When it is under suitable heating conditions, it can be separated from other substances by its boiling point difference, even if it is accurately sieved from thousands of debris, providing great assistance for chemical preparation and analysis.
Furthermore, solubility is also one of the important physical properties. 1- (bromomethyl) -2-chloro-3-fluorobenzene exhibits good solubility in organic solvents, such as common organic solvents such as ethanol and ether, which can be fused with it like water emulsion and blend to form a uniform and stable system. This property makes it an excellent reaction medium in organic synthesis reactions, promoting effective collision between reactant molecules, thereby promoting the smooth progress of the reaction. In water, its solubility is very small, just like oil droplets entering water and floating on the water surface, with clear boundaries. This is due to the non-polar nature of the molecular structure of the compound and the polarity difference between the water molecules.
In terms of density, it is heavier than water. If it is placed in the same container as water, it can be seen that it sinks to the bottom of the water, just like a pearl sinking abyss. This characteristic can be used in operations such as liquid-liquid separation to provide different ideas and methods for the separation and purification of substances.
In conclusion, the physical properties of 1 - (bromomethyl) -2 -chloro-3 -fluorobenzene are of great significance in many fields of chemical research and industrial production, laying a solid foundation for the development of related work.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, clear and translucent, like a quiet spring, and the view gives people a sense of tranquility. The shape of this state is easy to dump, transfer and mix in many experimental and industrial processes, and it is quite convenient to operate.
To describe its smell, the compound exudes a unique smell. Although it does not resemble the pleasant fragrance of rich flowers, it is also unique and recognizable, just like a subtle chemical smell. However, this smell is not pungent and unbearable. It is still in the acceptable category, but it also reminds the contact of its chemical essence.
As for the melting point and boiling point, the melting point value is low, and it is not presented in a solid state at room temperature, due to the nature of the intermolecular force. The boiling point is relatively moderate, which is of great significance in operations such as separation and purification. When it is under suitable heating conditions, it can be separated from other substances by its boiling point difference, even if it is accurately sieved from thousands of debris, providing great assistance for chemical preparation and analysis.
Furthermore, solubility is also one of the important physical properties. 1- (bromomethyl) -2-chloro-3-fluorobenzene exhibits good solubility in organic solvents, such as common organic solvents such as ethanol and ether, which can be fused with it like water emulsion and blend to form a uniform and stable system. This property makes it an excellent reaction medium in organic synthesis reactions, promoting effective collision between reactant molecules, thereby promoting the smooth progress of the reaction. In water, its solubility is very small, just like oil droplets entering water and floating on the water surface, with clear boundaries. This is due to the non-polar nature of the molecular structure of the compound and the polarity difference between the water molecules.
In terms of density, it is heavier than water. If it is placed in the same container as water, it can be seen that it sinks to the bottom of the water, just like a pearl sinking abyss. This characteristic can be used in operations such as liquid-liquid separation to provide different ideas and methods for the separation and purification of substances.
In conclusion, the physical properties of 1 - (bromomethyl) -2 -chloro-3 -fluorobenzene are of great significance in many fields of chemical research and industrial production, laying a solid foundation for the development of related work.
What are the synthesis methods of 1- (bromomethyl) -2-chloro-3-fluorobenzene
There are several common methods for synthesizing 1- (bromomethyl) -2 -chloro-3 -fluorobenzene.
First, the o-chlorofluorobenzene is used as the starting material. First, the o-chlorofluorobenzene is co-placed in a reactor with polyformaldehyde, hydrobromic acid and catalysts (such as zinc salts, etc.). Under a specific temperature and pressure, chloromethylation is performed to obtain 1- (chloromethyl) -2 -chloro-3 -fluorobenzene. This step requires attention to the precise control of the reaction conditions. If the temperature is too high, the side reactions will increase, and if it is too low, the reaction rate will be delayed. Then, 1 - (chloromethyl) - 2 - chloro - 3 - fluorobenzene is reacted with a brominating agent (such as a mixed system of sodium bromide and sulfuric acid), and the target product is obtained through a halogen exchange reaction. The steps of this pathway are relatively clear, but the optimization of the reaction conditions of each step is very critical.
Second, 2 - chloro - 3 - fluorobenzoic acid can also be used as the starting material. First, it is esterified with methanol catalyzed by sulfuric acid to form methyl 2 - chloro - 3 - fluorobenzoate. Subsequently, the ester group is reduced by strong reducing agents such as lithium aluminum hydride to obtain 2-chloro-3-fluorobenzyl alcohol. Then the alcohol hydroxyl group is brominated with brominating reagents such as phosphorus tribromide, and finally 1- (bromomethyl) -2-chloro-3-fluorobenzene is generated. Although this route is a little complicated, the reaction selectivity of each step is acceptable, and high yields can be obtained by optimizing the reaction conditions.
Third, nucleophilic substitution of aryl halides can also be used. In the presence of suitable bromomethyl-containing nucleophiles (such as bromomethyl lithium, etc.) and 2-chloro-3-fluorohalobenzene (such as 2-chloro-3-fluoroiodobenzene) in suitable catalysts (such as palladium catalysts) and ligands, react in an organic solvent. This method requires attention to the preparation and stability of nucleophiles, as well as the anhydrous and anaerobic conditions of the reaction system, in order to improve the reaction efficiency and yield.
First, the o-chlorofluorobenzene is used as the starting material. First, the o-chlorofluorobenzene is co-placed in a reactor with polyformaldehyde, hydrobromic acid and catalysts (such as zinc salts, etc.). Under a specific temperature and pressure, chloromethylation is performed to obtain 1- (chloromethyl) -2 -chloro-3 -fluorobenzene. This step requires attention to the precise control of the reaction conditions. If the temperature is too high, the side reactions will increase, and if it is too low, the reaction rate will be delayed. Then, 1 - (chloromethyl) - 2 - chloro - 3 - fluorobenzene is reacted with a brominating agent (such as a mixed system of sodium bromide and sulfuric acid), and the target product is obtained through a halogen exchange reaction. The steps of this pathway are relatively clear, but the optimization of the reaction conditions of each step is very critical.
Second, 2 - chloro - 3 - fluorobenzoic acid can also be used as the starting material. First, it is esterified with methanol catalyzed by sulfuric acid to form methyl 2 - chloro - 3 - fluorobenzoate. Subsequently, the ester group is reduced by strong reducing agents such as lithium aluminum hydride to obtain 2-chloro-3-fluorobenzyl alcohol. Then the alcohol hydroxyl group is brominated with brominating reagents such as phosphorus tribromide, and finally 1- (bromomethyl) -2-chloro-3-fluorobenzene is generated. Although this route is a little complicated, the reaction selectivity of each step is acceptable, and high yields can be obtained by optimizing the reaction conditions.
Third, nucleophilic substitution of aryl halides can also be used. In the presence of suitable bromomethyl-containing nucleophiles (such as bromomethyl lithium, etc.) and 2-chloro-3-fluorohalobenzene (such as 2-chloro-3-fluoroiodobenzene) in suitable catalysts (such as palladium catalysts) and ligands, react in an organic solvent. This method requires attention to the preparation and stability of nucleophiles, as well as the anhydrous and anaerobic conditions of the reaction system, in order to improve the reaction efficiency and yield.
1- (bromomethyl) -2-chloro-3-fluorobenzene what to pay attention to when storing and transporting
1 - (bromomethyl) -2 -chloro-3 -fluorobenzene is an organic compound. During storage and transportation, many aspects need to be paid special attention.
Bear the brunt and safety is of paramount importance. This compound has certain toxicity and irritation, or causes damage to the human body. Therefore, during operation, operators must wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent skin contact and inhalation. When storing, it should be placed in a cool, ventilated place away from fire and heat sources. It is strictly forbidden to mix with strong reactive substances such as oxidants and strong alkalis to avoid severe chemical reactions, resulting in serious accidents such as fire or explosion.
Secondly, the storage conditions cannot be ignored. The compound is quite sensitive to environmental factors and needs to be stored in a dry environment. Due to moisture or reactions such as hydrolysis, quality and stability are affected. It is recommended to store in a sealed container to prevent contact with air and reduce the risk of oxidation. At the same time, the storage temperature should be strictly controlled. Generally speaking, it is suitable to store in a low temperature environment, usually between - 20 ° C and 25 ° C, depending on its physical and chemical properties and product descriptions.
Furthermore, the transportation process also needs to be cautious. It is necessary to ensure that the packaging is intact to prevent leakage. Choose suitable transportation tools to avoid severe vibration, collision and high temperature environment during transportation. Transportation personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In case of leakage and other accidents, they can respond quickly and properly.
In short, the storage and transportation of 1- (bromomethyl) -2 -chloro-3 -fluorobenzene must strictly follow relevant safety regulations and operating guidelines to ensure the safety of personnel and the environment in an all-round way, and at the same time ensure that the quality of the compound is not affected.
Bear the brunt and safety is of paramount importance. This compound has certain toxicity and irritation, or causes damage to the human body. Therefore, during operation, operators must wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent skin contact and inhalation. When storing, it should be placed in a cool, ventilated place away from fire and heat sources. It is strictly forbidden to mix with strong reactive substances such as oxidants and strong alkalis to avoid severe chemical reactions, resulting in serious accidents such as fire or explosion.
Secondly, the storage conditions cannot be ignored. The compound is quite sensitive to environmental factors and needs to be stored in a dry environment. Due to moisture or reactions such as hydrolysis, quality and stability are affected. It is recommended to store in a sealed container to prevent contact with air and reduce the risk of oxidation. At the same time, the storage temperature should be strictly controlled. Generally speaking, it is suitable to store in a low temperature environment, usually between - 20 ° C and 25 ° C, depending on its physical and chemical properties and product descriptions.
Furthermore, the transportation process also needs to be cautious. It is necessary to ensure that the packaging is intact to prevent leakage. Choose suitable transportation tools to avoid severe vibration, collision and high temperature environment during transportation. Transportation personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In case of leakage and other accidents, they can respond quickly and properly.
In short, the storage and transportation of 1- (bromomethyl) -2 -chloro-3 -fluorobenzene must strictly follow relevant safety regulations and operating guidelines to ensure the safety of personnel and the environment in an all-round way, and at the same time ensure that the quality of the compound is not affected.
1- (bromomethyl) -2-chloro-3-fluorobenzene security risks
1 - (bromomethyl) -2 -chloro-3 -fluorobenzene is also an organic compound. It is quite useful in chemical synthesis, but it also poses safety risks and cannot be ignored.
The first to bear the brunt is the risk of toxicity. This compound may invade the human body by inhalation, ingestion or skin contact. Inhalation, or cause respiratory irritation, mild cough, sore throat, severe asthma, breathing difficulties. Ingestion, or damage the stomach, causing nausea, vomiting, abdominal pain and other symptoms. As for skin contact, or cause contact dermatitis, see redness, swelling, itching. If accidentally splashed into the eyes, the damage to the eyes is especially serious, which can cause eye pain, tears, blurred vision, etc.
Furthermore, it is flammable. In case of open flames and hot topics, this compound has the risk of combustion and explosion. When burned, it will release harmful gases such as bromine, chlorine, and fluorine, which are harmful to the environment and human body. Bromide, chloride or cause air pollution, and have strong irritation to the respiratory tract; fluoride is even more harmful, not only damaging the respiratory tract, but also affecting the health of bones and teeth.
Because of its high chemical activity, it is easy to react with other chemicals under certain conditions. If it encounters with an oxidizing agent or causes a violent reaction, the reaction may not be controlled, resulting in an accident. During storage and use, if mixed with incompatible substances, it is also easy to trigger dangerous chemical reactions.
When handling this compound, it is necessary to strictly abide by safety procedures. Operators should wear appropriate protective equipment, such as protective clothing, gloves, protective glasses and gas masks, to prevent its harm to the human body. In the storage place, it should be cool and ventilated, and it should be separated from oxidants, edible chemicals, etc., and should not be mixed. At the same time, suitable materials should be prepared to deal with possible leakage accidents. In the event of leakage, effective measures should be taken immediately to prevent the harm from expanding.
The first to bear the brunt is the risk of toxicity. This compound may invade the human body by inhalation, ingestion or skin contact. Inhalation, or cause respiratory irritation, mild cough, sore throat, severe asthma, breathing difficulties. Ingestion, or damage the stomach, causing nausea, vomiting, abdominal pain and other symptoms. As for skin contact, or cause contact dermatitis, see redness, swelling, itching. If accidentally splashed into the eyes, the damage to the eyes is especially serious, which can cause eye pain, tears, blurred vision, etc.
Furthermore, it is flammable. In case of open flames and hot topics, this compound has the risk of combustion and explosion. When burned, it will release harmful gases such as bromine, chlorine, and fluorine, which are harmful to the environment and human body. Bromide, chloride or cause air pollution, and have strong irritation to the respiratory tract; fluoride is even more harmful, not only damaging the respiratory tract, but also affecting the health of bones and teeth.
Because of its high chemical activity, it is easy to react with other chemicals under certain conditions. If it encounters with an oxidizing agent or causes a violent reaction, the reaction may not be controlled, resulting in an accident. During storage and use, if mixed with incompatible substances, it is also easy to trigger dangerous chemical reactions.
When handling this compound, it is necessary to strictly abide by safety procedures. Operators should wear appropriate protective equipment, such as protective clothing, gloves, protective glasses and gas masks, to prevent its harm to the human body. In the storage place, it should be cool and ventilated, and it should be separated from oxidants, edible chemicals, etc., and should not be mixed. At the same time, suitable materials should be prepared to deal with possible leakage accidents. In the event of leakage, effective measures should be taken immediately to prevent the harm from expanding.
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