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1-(Bromomethyl)-2-Chloro-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
401728 |
| Chemical Formula | C8H5BrClF3 |
| Molecular Weight | 287.48 |
| Solubility In Water | Low solubility expected, being an organic halide |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Stability | Stable under normal conditions, but reactive towards strong nucleophiles |
As an accredited 1-(Bromomethyl)-2-Chloro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(bromomethyl)-2-chloro-3-(trifluoromethyl)benzene in a sealed, chemical - resistant bottle. |
| Storage | 1-(Bromomethyl)-2-chloro-3-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly closed container to prevent vapor leakage. Since it may be reactive and potentially harmful, store it separately from incompatible substances like oxidizing agents and bases to avoid dangerous reactions. |
| Shipping | 1-(Bromomethyl)-2-chloro-3-(trifluoromethyl)benzene is shipped in accordance with strict chemical regulations. It's typically in well - sealed containers, safeguarded during transit to prevent any spills or exposure due to its potentially hazardous nature. |
Competitive 1-(Bromomethyl)-2-Chloro-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 1-(Bromomethyl)-2-Chloro-3-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene?
1 - (bromomethyl) -2 -chloro-3- (trifluoromethyl) benzene, this compound has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
One of them can be used to build the structure of complex organic molecules. Due to its active properties of bromomethyl, it can react with many nucleophilic reagents, such as alcohols and amines, to form new carbon-oxygen, carbon-nitrogen bonds, etc., and then derive multiple compounds. For example, after nucleophilic substitution reaction with alcohols under the catalysis of bases, corresponding ether products can be obtained. Such products have potential application value in medicine, materials and other fields.
Second, due to the chlorine atom and trifluoromethyl group attached to the benzene ring, the compound is endowed with unique electronic and spatial effects. This makes it exhibit special reactivity and selectivity when participating in aromatic electrophilic substitution reactions, which can be used to prepare aromatic compounds with specific structures, such as in medicinal chemistry, or to assist in the synthesis of lead compounds with specific pharmacological activities.
Third, in the field of materials science, the compound may be introduced into the main chain or side chain of the polymer through subsequent reactions. By virtue of the low surface energy and high chemical stability of trifluoromethyl, the surface properties, thermal stability and chemical resistance of the material can be improved. For example, the preparation of high-performance fluoropolymer materials may have outstanding performance in coatings, plastics and other industries.
One of them can be used to build the structure of complex organic molecules. Due to its active properties of bromomethyl, it can react with many nucleophilic reagents, such as alcohols and amines, to form new carbon-oxygen, carbon-nitrogen bonds, etc., and then derive multiple compounds. For example, after nucleophilic substitution reaction with alcohols under the catalysis of bases, corresponding ether products can be obtained. Such products have potential application value in medicine, materials and other fields.
Second, due to the chlorine atom and trifluoromethyl group attached to the benzene ring, the compound is endowed with unique electronic and spatial effects. This makes it exhibit special reactivity and selectivity when participating in aromatic electrophilic substitution reactions, which can be used to prepare aromatic compounds with specific structures, such as in medicinal chemistry, or to assist in the synthesis of lead compounds with specific pharmacological activities.
Third, in the field of materials science, the compound may be introduced into the main chain or side chain of the polymer through subsequent reactions. By virtue of the low surface energy and high chemical stability of trifluoromethyl, the surface properties, thermal stability and chemical resistance of the material can be improved. For example, the preparation of high-performance fluoropolymer materials may have outstanding performance in coatings, plastics and other industries.
What are the physical properties of 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene
1 - (bromomethyl) -2 -chloro-3- (trifluoromethyl) benzene is one of the organic compounds. Its physical properties are quite important and are relevant in various fields of chemical industry.
First of all, its properties are mostly liquid at room temperature, which is caused by the characteristics of its molecular structure. The intermolecular force is moderate, not enough to solidify it, and it is difficult to make it easily vaporized, so it is in a flowing state, similar to smart water, but it has unique chemical properties.
Looking at its color, it is often colorless and transparent, just like a clear spring. Under sunlight, the light and shadow flow, without any variegation, showing a pure state. This pure color also suggests that its chemical structure is relatively regular, and impurities are rare.
As for the smell, it has a special aroma, but this fragrance is not as pleasant as ordinary flowers, but has a unique smell of organic compounds. Smell, like being in the mysterious world of chemistry, although not pungent, it can also lead people to explore the chemical mysteries behind it.
Its boiling point is also a key physical property. Due to the presence of atoms or groups such as bromine, chlorine and trifluoromethyl in the molecule, the intermolecular force is enhanced, and the boiling point is higher than that of ordinary benzene-based compounds. When heated to a specific temperature, about [X] ° C, the molecule is able to break free from the liquid phase and transform into the gas phase. This temperature is crucial in the process of separation and purification.
In terms of melting point, due to the influence of the above atoms and groups, the lattice energy changes, and the melting point is about [X] ° C. At this temperature, the molecules are arranged in an orderly manner to form a solid lattice structure. If the temperature rises slightly, the lattice disintegrates, and the substance changes from solid to liquid.
Solubility is also the focus of investigation. This compound is difficult to dissolve in water, because its molecular polarity is weak, and the force between it and the water molecule is far less than the hydrogen bond of the water molecule itself, so the two are like incompatible enemies and are distinct. However, in organic solvents, such as ethanol, ether, etc., the solubility is quite good. Due to the similar intermolecular forces between organic solvents and the compound, it follows the principle of "similar miscibility" and can be uniformly mixed. This property is quite useful in the selection of reaction media for organic synthesis.
The density is larger than that of water. When poured into water, such as a stone sinking abyss, it slowly settles to the bottom. Due to the large number of heavy atoms (bromine, chlorine, etc.) in the molecule, the mass per unit volume increases. This physical property can be used in operations such as separating mixtures.
In summary, the physical properties of 1 - (bromomethyl) -2 -chloro-3- (trifluoromethyl) benzene are related to each other, and are all indispensable factors in the research and application of organic chemistry.
First of all, its properties are mostly liquid at room temperature, which is caused by the characteristics of its molecular structure. The intermolecular force is moderate, not enough to solidify it, and it is difficult to make it easily vaporized, so it is in a flowing state, similar to smart water, but it has unique chemical properties.
Looking at its color, it is often colorless and transparent, just like a clear spring. Under sunlight, the light and shadow flow, without any variegation, showing a pure state. This pure color also suggests that its chemical structure is relatively regular, and impurities are rare.
As for the smell, it has a special aroma, but this fragrance is not as pleasant as ordinary flowers, but has a unique smell of organic compounds. Smell, like being in the mysterious world of chemistry, although not pungent, it can also lead people to explore the chemical mysteries behind it.
Its boiling point is also a key physical property. Due to the presence of atoms or groups such as bromine, chlorine and trifluoromethyl in the molecule, the intermolecular force is enhanced, and the boiling point is higher than that of ordinary benzene-based compounds. When heated to a specific temperature, about [X] ° C, the molecule is able to break free from the liquid phase and transform into the gas phase. This temperature is crucial in the process of separation and purification.
In terms of melting point, due to the influence of the above atoms and groups, the lattice energy changes, and the melting point is about [X] ° C. At this temperature, the molecules are arranged in an orderly manner to form a solid lattice structure. If the temperature rises slightly, the lattice disintegrates, and the substance changes from solid to liquid.
Solubility is also the focus of investigation. This compound is difficult to dissolve in water, because its molecular polarity is weak, and the force between it and the water molecule is far less than the hydrogen bond of the water molecule itself, so the two are like incompatible enemies and are distinct. However, in organic solvents, such as ethanol, ether, etc., the solubility is quite good. Due to the similar intermolecular forces between organic solvents and the compound, it follows the principle of "similar miscibility" and can be uniformly mixed. This property is quite useful in the selection of reaction media for organic synthesis.
The density is larger than that of water. When poured into water, such as a stone sinking abyss, it slowly settles to the bottom. Due to the large number of heavy atoms (bromine, chlorine, etc.) in the molecule, the mass per unit volume increases. This physical property can be used in operations such as separating mixtures.
In summary, the physical properties of 1 - (bromomethyl) -2 -chloro-3- (trifluoromethyl) benzene are related to each other, and are all indispensable factors in the research and application of organic chemistry.
What are the synthesis methods of 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene
The synthesis of 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene is an important topic in organic synthetic chemistry. The synthesis paths are different, and each method has its advantages and disadvantages, depending on the specific needs.
First, it can be started from a suitable aromatic compound. For example, using 2-chloro-3- (trifluoromethyl) benzoic acid as a raw material, it is first converted into the corresponding acid chloride, and then reduced to give 2-chloro-3- (trifluoromethyl) benzyl alcohol. This step of reduction can be achieved by strong reducing agents such as lithium aluminum hydride. Subsequently, 2-chloro-3- (trifluoromethyl) benzyl alcohol is reacted with hydrobromic acid or bromine-containing reagents to introduce bromomethyl to obtain the target product 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene.
Second, 2-chloro-3- (trifluoromethyl) toluene is used as the starting material. Bromine atoms are introduced at methyl through radical bromination. This reaction usually needs to be carried out under light or in the presence of an initiator. For example, N-bromosuccinimide (NBS) is used as the bromine source, benzoyl peroxide is used as the initiator, and the reaction in a suitable solvent can realize the bromination of toluene methyl, thereby synthesizing 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene.
Furthermore, the nucleophilic substitution strategy of halogenated aromatics can also be used. If a 2-chloro-3- (trifluoromethyl) benzene derivative containing a suitable leaving group can be found, reacted with a nucleophilic reagent containing bromomethyl, and nucleophilic substitution, it is also expected to obtain the target product. However, this approach requires careful selection of substrates and reagents to ensure the smooth progress of the reaction.
First, it can be started from a suitable aromatic compound. For example, using 2-chloro-3- (trifluoromethyl) benzoic acid as a raw material, it is first converted into the corresponding acid chloride, and then reduced to give 2-chloro-3- (trifluoromethyl) benzyl alcohol. This step of reduction can be achieved by strong reducing agents such as lithium aluminum hydride. Subsequently, 2-chloro-3- (trifluoromethyl) benzyl alcohol is reacted with hydrobromic acid or bromine-containing reagents to introduce bromomethyl to obtain the target product 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene.
Second, 2-chloro-3- (trifluoromethyl) toluene is used as the starting material. Bromine atoms are introduced at methyl through radical bromination. This reaction usually needs to be carried out under light or in the presence of an initiator. For example, N-bromosuccinimide (NBS) is used as the bromine source, benzoyl peroxide is used as the initiator, and the reaction in a suitable solvent can realize the bromination of toluene methyl, thereby synthesizing 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene.
Furthermore, the nucleophilic substitution strategy of halogenated aromatics can also be used. If a 2-chloro-3- (trifluoromethyl) benzene derivative containing a suitable leaving group can be found, reacted with a nucleophilic reagent containing bromomethyl, and nucleophilic substitution, it is also expected to obtain the target product. However, this approach requires careful selection of substrates and reagents to ensure the smooth progress of the reaction.
What to pay attention to when storing and transporting 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene
1 - (bromomethyl) - 2 - chloro - 3 - (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
Safety first. This compound may be toxic, irritating, and flammable. When storing, be sure to store in a cool, well-ventilated place, away from fire and heat sources to prevent the risk of fire. Operators should also wear suitable protective equipment, such as gas masks, protective gloves, etc., to avoid direct contact.
Times and packaging. The packaging materials used must be strong and well sealed to prevent leakage. You can choose glass bottles, plastic bottles, etc., wrapped in cushioning materials to reduce vibration and collision during transportation and ensure that the packaging is not damaged.
Furthermore, this compound is sensitive to humidity, light or. When storing, it should be protected from light and cool to prevent deterioration. Protective measures should also be taken during transportation, such as covering with light-shielding materials, do not expose to strong light.
Also, the storage place should be stored separately from oxidants, acids, alkalis, etc., to avoid chemical reactions. It is also not allowed to be mixed with such substances during transportation.
All of these are to be taken into account when storing and transporting 1 - (bromomethyl) - 2 - chloro - 3 - (trifluoromethyl) benzene, and caution must be exercised to ensure safety.
Safety first. This compound may be toxic, irritating, and flammable. When storing, be sure to store in a cool, well-ventilated place, away from fire and heat sources to prevent the risk of fire. Operators should also wear suitable protective equipment, such as gas masks, protective gloves, etc., to avoid direct contact.
Times and packaging. The packaging materials used must be strong and well sealed to prevent leakage. You can choose glass bottles, plastic bottles, etc., wrapped in cushioning materials to reduce vibration and collision during transportation and ensure that the packaging is not damaged.
Furthermore, this compound is sensitive to humidity, light or. When storing, it should be protected from light and cool to prevent deterioration. Protective measures should also be taken during transportation, such as covering with light-shielding materials, do not expose to strong light.
Also, the storage place should be stored separately from oxidants, acids, alkalis, etc., to avoid chemical reactions. It is also not allowed to be mixed with such substances during transportation.
All of these are to be taken into account when storing and transporting 1 - (bromomethyl) - 2 - chloro - 3 - (trifluoromethyl) benzene, and caution must be exercised to ensure safety.
What is the market price of 1- (bromomethyl) -2-chloro-3- (trifluoromethyl) benzene?
I don't know where the market is for 1 - (bromomethyl) -2 - chloro - 3 - (trifluoromethyl) benzene. This compound, or rare in the market, is affected by factors such as supply and demand, availability, and law.
If it is widely used, the raw materials are rare, and the required equipment is exquisite, it is essential. Or its use is scarce, the demand is scarce, the supply is also scarce, and the supply is also scarce.
If you want to know the market, you can turn it into a supplier's station, or sell it to the seller, so you can do it. Or according to the past transactions of the chemical trading platform, to test. Then this is not determined, the transfer is easy, or there is a problem.
If it is widely used, the raw materials are rare, and the required equipment is exquisite, it is essential. Or its use is scarce, the demand is scarce, the supply is also scarce, and the supply is also scarce.
If you want to know the market, you can turn it into a supplier's station, or sell it to the seller, so you can do it. Or according to the past transactions of the chemical trading platform, to test. Then this is not determined, the transfer is easy, or there is a problem.
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