Linshang Chemical
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1-(Bromomethyl)-2-Chloro-4-Fluorobenzene
Linshang Chemical
|
HS Code |
115972 |
| Chemical Formula | C7H5BrClF |
| Molecular Weight | 225.47 |
| Appearance | Typically a colorless to pale yellow liquid |
| Boiling Point | Approximately in the range of 200 - 220 °C |
| Density | Around 1.7 - 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | Caution, flammable, flash point around 80 - 90 °C |
| Hazard Class | Harmful if swallowed, inhaled or in contact with skin |
As an accredited 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(bromomethyl)-2 - chloro - 4 - fluorobenzene in sealed, chemical - resistant bottle. |
| Storage | 1-(Bromomethyl)-2-chloro-4-fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Due to its potential reactivity, store it separately from oxidizing agents, bases, and other incompatible substances to prevent chemical reactions and ensure safety. |
| Shipping | 1-(Bromomethyl)-2-chloro-4-fluorobenzene is shipped in sealed, corrosion - resistant containers. Transport follows strict chemical safety regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-(Bromomethyl)-2-Chloro-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (bromomethyl) -2-chloro-4-fluorobenzene?
(Hydroxymethyl) -2-chloro-4-fluorobenzene is its main use, related to many fields, and has important applications in medicine, chemical synthesis, etc.
In the field of medicine, this compound is a key intermediate. Through delicate chemical reactions, it can be cleverly combined with other chemicals to synthesize drugs with specific pharmacological activities. For example, in the creation process of some antibacterial drugs, (hydroxymethyl) -2-chloro-4-fluorobenzene plays an indispensable role in helping to build the core structure of the drug, so that the drug can precisely act on the bacteria, inhibit their growth and reproduction, and escort human health.
In the field of chemical synthesis, it is also an extremely important raw material. With its unique chemical structure and reactivity, it can participate in many complex organic synthesis reactions. For example, when preparing high-performance polymer materials, it can be introduced into the polymer chain as a functional monomer, giving the material unique properties such as special solubility, thermal stability or optical properties. This makes related chemical products exhibit excellent performance in high-end fields such as electronics and aerospace, and promotes the vigorous development of these industries.
Therefore, (hydroxymethyl) -2-chloro-4-fluorobenzene has made great contributions to the progress and development of human society due to its key uses in the fields of medicine and chemical synthesis.
In the field of medicine, this compound is a key intermediate. Through delicate chemical reactions, it can be cleverly combined with other chemicals to synthesize drugs with specific pharmacological activities. For example, in the creation process of some antibacterial drugs, (hydroxymethyl) -2-chloro-4-fluorobenzene plays an indispensable role in helping to build the core structure of the drug, so that the drug can precisely act on the bacteria, inhibit their growth and reproduction, and escort human health.
In the field of chemical synthesis, it is also an extremely important raw material. With its unique chemical structure and reactivity, it can participate in many complex organic synthesis reactions. For example, when preparing high-performance polymer materials, it can be introduced into the polymer chain as a functional monomer, giving the material unique properties such as special solubility, thermal stability or optical properties. This makes related chemical products exhibit excellent performance in high-end fields such as electronics and aerospace, and promotes the vigorous development of these industries.
Therefore, (hydroxymethyl) -2-chloro-4-fluorobenzene has made great contributions to the progress and development of human society due to its key uses in the fields of medicine and chemical synthesis.
What are the physical properties of 1- (bromomethyl) -2-chloro-4-fluorobenzene?
(Chloromethyl) -2-fluoro-4-fluorobenzene is also an organic compound. Its physical properties are as follows:
Under normal temperature and pressure, it is often colorless to light yellow liquid, which is convenient for many chemical operations and reactions.
Its boiling point is about a specific temperature range, but it fluctuates slightly depending on the specific environment and conditions. The characteristics of boiling point are related to its application in separation, purification, etc. The compound can be separated by distillation according to the difference in boiling point.
As for the melting point, there is also a corresponding value. The level of melting point affects the transformation of its solid state and liquid state. When storing and transporting, the effect of external temperature on its physical state needs to be considered.
Its density is also an important physical property. The given density indicates the quality of the substance contained in the unit volume. This parameter is indispensable in chemical calculation and batching.
In terms of solubility, (chloromethyl) -2-fluoro-4-fluorobenzene has a certain solubility in some organic solvents, such as common ether and ester solvents. Moderate dissolution can make it participate in the homogeneous reaction, which is conducive to the full progress and control of the reaction.
In addition, its vapor pressure is also a property that cannot be ignored. The vapor pressure is related to temperature, reflecting the equilibrium relationship between the gas phase and the liquid phase of the compound. It is of great significance for its volatilization degree and safety assessment in confined spaces. Knowing the above physical properties, when synthesizing and applying (chloromethyl) -2-fluoro-4-fluorobenzene, the reaction conditions can be accurately grasped, the process flow can be optimized, and the product quality and yield can be improved.
Under normal temperature and pressure, it is often colorless to light yellow liquid, which is convenient for many chemical operations and reactions.
Its boiling point is about a specific temperature range, but it fluctuates slightly depending on the specific environment and conditions. The characteristics of boiling point are related to its application in separation, purification, etc. The compound can be separated by distillation according to the difference in boiling point.
As for the melting point, there is also a corresponding value. The level of melting point affects the transformation of its solid state and liquid state. When storing and transporting, the effect of external temperature on its physical state needs to be considered.
Its density is also an important physical property. The given density indicates the quality of the substance contained in the unit volume. This parameter is indispensable in chemical calculation and batching.
In terms of solubility, (chloromethyl) -2-fluoro-4-fluorobenzene has a certain solubility in some organic solvents, such as common ether and ester solvents. Moderate dissolution can make it participate in the homogeneous reaction, which is conducive to the full progress and control of the reaction.
In addition, its vapor pressure is also a property that cannot be ignored. The vapor pressure is related to temperature, reflecting the equilibrium relationship between the gas phase and the liquid phase of the compound. It is of great significance for its volatilization degree and safety assessment in confined spaces. Knowing the above physical properties, when synthesizing and applying (chloromethyl) -2-fluoro-4-fluorobenzene, the reaction conditions can be accurately grasped, the process flow can be optimized, and the product quality and yield can be improved.
What are the synthesis methods of 1- (bromomethyl) -2-chloro-4-fluorobenzene?
To prepare 1 - (hydroxymethyl) - 2 - chloro - 4 - bromobenzene, the method is as follows:
First, p-bromophenol is used as the starting material. First, p-bromophenol and formaldehyde are placed in an alkaline environment, and the reaction of hydroxymethylation is carried out according to the appropriate temperature and ratio. At this time, the hydroxymethyl group of formaldehyde can be associated with it, and 4 - bromo - 2 - hydroxymethylphenol can be generated in the para-position due to the steric hindrance and electronic effects. This reaction requires temperature control and timing control, and appropriate alkalis, such as sodium hydroxide, are selected to promote its anterograde. Next, 4-bromo-2-hydroxymethylphenol is chlorinated. Chlorination reagents such as thionyl chloride and phosphorus oxychloride can be used. Taking thionyl chloride as an example, the two are mixed. At an appropriate temperature, the hydroxyl group of the hydroxyl methyl can be replaced by a chlorine atom to obtain 1- (chloromethyl) -2-chloro-4-bromobenzene. This process requires attention to the conditions of the reaction to avoid side effects, such as controlling the temperature and the amount of thionyl chloride.
Another method is to start with p-bromophenyl ether. It is first brominated, and bromine atoms are introduced into the ortho-position to obtain 2-bromo-4-methoxybromobenzene. The bromination method can be catalyzed by bromine, iron filings, or N-bromosuccinimide (NBS) and other reagents, depending on the reaction conditions and needs.
Then, the methoxy group is demethylated, often with hydrobromic acid, boron tribromide and other reagents to obtain 2-bromo-4-hydroxybromobenzene. Then the pre-imitation method is hydroxymethylated with formaldehyde, and then chlorinated, and the target product can also be obtained.
Preparation of this compound, each method has its advantages and disadvantages. The former method starts with p-bromophenol, and the steps are slightly simplified, but there may be by-products when hydroxymethylation; the latter method starts with p-bromophenyl ether, although the steps are slightly complicated, the reaction of each step is easier to control, and the purity of the product may be higher. In actual preparation, when the material is easily available, the cost is high, and the product is required, the appropriate method is selected.
First, p-bromophenol is used as the starting material. First, p-bromophenol and formaldehyde are placed in an alkaline environment, and the reaction of hydroxymethylation is carried out according to the appropriate temperature and ratio. At this time, the hydroxymethyl group of formaldehyde can be associated with it, and 4 - bromo - 2 - hydroxymethylphenol can be generated in the para-position due to the steric hindrance and electronic effects. This reaction requires temperature control and timing control, and appropriate alkalis, such as sodium hydroxide, are selected to promote its anterograde. Next, 4-bromo-2-hydroxymethylphenol is chlorinated. Chlorination reagents such as thionyl chloride and phosphorus oxychloride can be used. Taking thionyl chloride as an example, the two are mixed. At an appropriate temperature, the hydroxyl group of the hydroxyl methyl can be replaced by a chlorine atom to obtain 1- (chloromethyl) -2-chloro-4-bromobenzene. This process requires attention to the conditions of the reaction to avoid side effects, such as controlling the temperature and the amount of thionyl chloride.
Another method is to start with p-bromophenyl ether. It is first brominated, and bromine atoms are introduced into the ortho-position to obtain 2-bromo-4-methoxybromobenzene. The bromination method can be catalyzed by bromine, iron filings, or N-bromosuccinimide (NBS) and other reagents, depending on the reaction conditions and needs.
Then, the methoxy group is demethylated, often with hydrobromic acid, boron tribromide and other reagents to obtain 2-bromo-4-hydroxybromobenzene. Then the pre-imitation method is hydroxymethylated with formaldehyde, and then chlorinated, and the target product can also be obtained.
Preparation of this compound, each method has its advantages and disadvantages. The former method starts with p-bromophenol, and the steps are slightly simplified, but there may be by-products when hydroxymethylation; the latter method starts with p-bromophenyl ether, although the steps are slightly complicated, the reaction of each step is easier to control, and the purity of the product may be higher. In actual preparation, when the material is easily available, the cost is high, and the product is required, the appropriate method is selected.
What are the precautions for 1- (bromomethyl) -2-chloro-4-fluorobenzene during storage and transportation?
Mercury is a highly toxic quality. During the process of storage and loss, it is very serious. It is related to the safety of the people and the peace of heaven and earth, and must not be ignored.
When storing mercury, the first thing is to choose a good place. It is advisable to find a cool, dry and well-ventilated place, away from direct sunlight, so as to prevent it from evaporating due to heat. Because it is easy to evaporate in the air, it will become an invisible harm, enter the lungs and damage people's health. And the reservoir must be tightly sealed to prevent the escape of mercury. Thick glass bottles or special metal utensils are commonly used for it. Among the metals, except for iron, a few who are not afraid of mercury corrosion are carefully selected to prevent it from amalgamating with mercury, causing damage to the reservoir and mercury leakage.
When transporting mercury, also pay more attention. The transport equipment must be strong and well sealed, and the loading and unloading of the truck should be done gently to avoid the leakage of the container due to its shock. The transporter must be professionally trained to understand the nature of mercury and prevent danger. Always check the container for damage on the way, and if there is any leakage, dispose of it quickly.
Mercury leakage is a serious problem. Once the mercury leaks, quickly turn on the wind equipment, dissipate air outside, and reduce the mercury concentration in the room. Everyone leaves quickly, and do not leave the place in danger. Emergency responders wear protective clothing and anti-poison equipment, sprinkle sulfur powder on the mercury stains, turn mercury into mercury sulfide, reduce its toxicity, and then clean up.
When it comes to the storage and loss of mercury, the government should strictly establish rules, and those who are in charge of their duties should be diligently supervised and strictly inspected. The industry should abide by the rules and follow the rules, and there should be no luck. Everyone is single-minded, and the long-term way is to protect the clean environment and the safety of people's livelihood.
When storing mercury, the first thing is to choose a good place. It is advisable to find a cool, dry and well-ventilated place, away from direct sunlight, so as to prevent it from evaporating due to heat. Because it is easy to evaporate in the air, it will become an invisible harm, enter the lungs and damage people's health. And the reservoir must be tightly sealed to prevent the escape of mercury. Thick glass bottles or special metal utensils are commonly used for it. Among the metals, except for iron, a few who are not afraid of mercury corrosion are carefully selected to prevent it from amalgamating with mercury, causing damage to the reservoir and mercury leakage.
When transporting mercury, also pay more attention. The transport equipment must be strong and well sealed, and the loading and unloading of the truck should be done gently to avoid the leakage of the container due to its shock. The transporter must be professionally trained to understand the nature of mercury and prevent danger. Always check the container for damage on the way, and if there is any leakage, dispose of it quickly.
Mercury leakage is a serious problem. Once the mercury leaks, quickly turn on the wind equipment, dissipate air outside, and reduce the mercury concentration in the room. Everyone leaves quickly, and do not leave the place in danger. Emergency responders wear protective clothing and anti-poison equipment, sprinkle sulfur powder on the mercury stains, turn mercury into mercury sulfide, reduce its toxicity, and then clean up.
When it comes to the storage and loss of mercury, the government should strictly establish rules, and those who are in charge of their duties should be diligently supervised and strictly inspected. The industry should abide by the rules and follow the rules, and there should be no luck. Everyone is single-minded, and the long-term way is to protect the clean environment and the safety of people's livelihood.
What are the effects of 1- (bromomethyl) -2-chloro-4-fluorobenzene on the environment and human health?
(Hydroxymethyl) -2-chloro-4-fluorobenzene has many effects on the environment and human health.
In terms of the environment, this substance enters the natural water body. Due to its chemical stability, it is difficult to be rapidly degraded by microorganisms and will remain for a long time. Once it flows into rivers and lakes, it will cause water pollution and interfere with aquatic ecosystems. For aquatic organisms, such as fish and shellfish, it will damage their respiratory system and nervous system, affect normal growth, reproduction and behavior, and even lead to a decrease in population. In the soil environment, if it penetrates into the soil, it will change the chemical properties of the soil, affect the type and activity of soil microorganisms, hinder the absorption of nutrients by plant roots, and then affect the growth and development of plants, reducing crop yield and quality.
As far as human health is concerned, this substance can enter the human body through breathing, skin contact or accidental ingestion of contaminated food and water sources. It may have certain toxicity. Contact with the skin will irritate the skin, cause symptoms such as redness, swelling, itching, and pain. Long-term exposure may also cause skin allergies. If not carefully entered the eyes, it will cause strong irritation to the eyes, damage eye tissue, and affect vision in severe cases. Inhalation of its volatile gases can irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term inhalation may increase the risk of respiratory diseases. After entering the human body, it may interfere with the human body's endocrine system, affect the normal secretion and regulation of hormones, and have adverse effects on the reproductive system, such as affecting the quality and quantity of germ cells, and may have teratogenic risks to fetal development. At the same time, it may also have an impact on the nervous system, causing symptoms such as dizziness, headache, fatigue, and memory loss.
In terms of the environment, this substance enters the natural water body. Due to its chemical stability, it is difficult to be rapidly degraded by microorganisms and will remain for a long time. Once it flows into rivers and lakes, it will cause water pollution and interfere with aquatic ecosystems. For aquatic organisms, such as fish and shellfish, it will damage their respiratory system and nervous system, affect normal growth, reproduction and behavior, and even lead to a decrease in population. In the soil environment, if it penetrates into the soil, it will change the chemical properties of the soil, affect the type and activity of soil microorganisms, hinder the absorption of nutrients by plant roots, and then affect the growth and development of plants, reducing crop yield and quality.
As far as human health is concerned, this substance can enter the human body through breathing, skin contact or accidental ingestion of contaminated food and water sources. It may have certain toxicity. Contact with the skin will irritate the skin, cause symptoms such as redness, swelling, itching, and pain. Long-term exposure may also cause skin allergies. If not carefully entered the eyes, it will cause strong irritation to the eyes, damage eye tissue, and affect vision in severe cases. Inhalation of its volatile gases can irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc. Long-term inhalation may increase the risk of respiratory diseases. After entering the human body, it may interfere with the human body's endocrine system, affect the normal secretion and regulation of hormones, and have adverse effects on the reproductive system, such as affecting the quality and quantity of germ cells, and may have teratogenic risks to fetal development. At the same time, it may also have an impact on the nervous system, causing symptoms such as dizziness, headache, fatigue, and memory loss.
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