Linshang Chemical
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1-(Bromomethyl)-3-Chloro-2-Fluorobenzene
Linshang Chemical
|
HS Code |
642596 |
| Chemical Formula | C7H5BrClF |
| Molecular Weight | 223.47 |
| Appearance | Typically a colorless to light - colored liquid (estimated, specific appearance may vary based on purity) |
| Density | No standard value found, but estimated to be greater than 1 g/cm³ due to halogen content |
| Solubility In Water | Insoluble or sparingly soluble, as it is an organic halogen - substituted aromatic compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Reactivity | Reactive due to the presence of bromomethyl group which can undergo nucleophilic substitution reactions |
As an accredited 1-(Bromomethyl)-3-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(bromomethyl)-3 -chloro -2 -fluorobenzene in a sealed, chemical - resistant bottle. |
| Storage | 1-(Bromomethyl)-3-chloro-2-fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources, open flames, and oxidizing agents. It should be kept in a tightly sealed container made of suitable materials like glass or corrosion - resistant plastics. Store it in a dedicated chemical storage cabinet, separated from incompatible substances to prevent potential reactions. |
| Shipping | 1-(Bromomethyl)-3 -chloro-2 -fluorobenzene is shipped in accordance with hazardous chemical regulations. It's carefully packaged in corrosion - resistant containers, labeled clearly, and transported by carriers with proper safety training for this type of chemical. |
Competitive 1-(Bromomethyl)-3-Chloro-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What is the main use of 1- (bromomethyl) -3-chloro-2-fluorobenzene?
1 - (bromomethyl) -3 -chloro-2 -fluorobenzene, this is an organic compound with a wide range of uses.
In the field of organic synthesis, it is often used as a key intermediate. Because its structure contains bromomethyl, chlorine and fluorine atoms, these functional groups give it unique reactivity. Bromomethyl can participate in nucleophilic substitution reactions, such as with nucleophiles such as alcohols and amines, to form chemical bonds such as carbon-oxygen and carbon-nitrogen, which lays the foundation for the synthesis of complex organic molecules. For example, when reacted with alcohols under basic conditions, corresponding ether products can be formed, which is of great significance for the preparation of specific structural compounds in drug synthesis and materials science.
In the field of medicinal chemistry, the introduction of fluorine atoms can significantly change the physical and chemical properties and biological activities of compounds. 1- (bromomethyl) -3 -chloro-2 -fluorobenzene can be used to develop new drugs. Through subsequent reaction modification, molecules with specific pharmacological activities can be synthesized, such as designing and synthesizing potential therapeutic drugs for some disease targets, opening up new paths for drug development.
In the field of materials science, it can be used as a raw material to prepare special functional materials. With the help of its functional group reaction, polymer materials with specific structures and properties, such as fluoropolymers, can be constructed. Such materials may have excellent weather resistance, chemical stability and low surface energy, which are very useful in coatings, plastics and other fields.
In conclusion, 1- (bromomethyl) -3 -chloro-2 -fluorobenzene plays an important role in many fields such as organic synthesis, drug development and materials science due to its unique structure and reactivity, and is of great significance to promote the development of related fields.
In the field of organic synthesis, it is often used as a key intermediate. Because its structure contains bromomethyl, chlorine and fluorine atoms, these functional groups give it unique reactivity. Bromomethyl can participate in nucleophilic substitution reactions, such as with nucleophiles such as alcohols and amines, to form chemical bonds such as carbon-oxygen and carbon-nitrogen, which lays the foundation for the synthesis of complex organic molecules. For example, when reacted with alcohols under basic conditions, corresponding ether products can be formed, which is of great significance for the preparation of specific structural compounds in drug synthesis and materials science.
In the field of medicinal chemistry, the introduction of fluorine atoms can significantly change the physical and chemical properties and biological activities of compounds. 1- (bromomethyl) -3 -chloro-2 -fluorobenzene can be used to develop new drugs. Through subsequent reaction modification, molecules with specific pharmacological activities can be synthesized, such as designing and synthesizing potential therapeutic drugs for some disease targets, opening up new paths for drug development.
In the field of materials science, it can be used as a raw material to prepare special functional materials. With the help of its functional group reaction, polymer materials with specific structures and properties, such as fluoropolymers, can be constructed. Such materials may have excellent weather resistance, chemical stability and low surface energy, which are very useful in coatings, plastics and other fields.
In conclusion, 1- (bromomethyl) -3 -chloro-2 -fluorobenzene plays an important role in many fields such as organic synthesis, drug development and materials science due to its unique structure and reactivity, and is of great significance to promote the development of related fields.
What are the physical properties of 1- (bromomethyl) -3-chloro-2-fluorobenzene
1 - (bromomethyl) -3 -chloro-2 -fluorobenzene is one of the organic compounds. Its physical properties are particularly important, and it is related to the behavior of this compound in various situations.
First of all, its appearance is often colorless to light yellow liquid, with clear texture and good light transmission. This appearance characteristic can be used as the primary basis for actual observation and identification. Its smell has a slightly special aromatic aroma, but it is not as strong and pungent as common aromatic hydrocarbons. Although it is mild, it can still be detected by a fine smell.
The boiling point is about [X] degrees Celsius when the atmospheric pressure is the standard condition. The boiling point is the temperature limit required for the compound to transform from liquid to gaseous state. The existence of this value determines the specific conditions in the operation process of distillation and separation. The boiling point is closely related to the intermolecular forces. The intermolecular forces of this compound are moderate, so the boiling point is also in the corresponding range.
In terms of melting point, it is about [Y] degrees Celsius. The melting point characterizes the temperature at which the compound transitions from solid to liquid state. This value reflects the stability of its lattice structure and the strength of intermolecular interactions. The low melting point of this compound indicates that its lattice structure is not extremely stable in the solid state, and the intermolecular forces are relatively weak.
Solubility is also a key physical property. In organic solvents such as ethanol and ether, 1- (bromomethyl) -3-chloro-2-fluorobenzene exhibits good solubility and can be miscible with organic solvents in different proportions. However, in water, its solubility is very small, almost insoluble. This difference in solubility is due to the characteristics of its molecular structure. The proportion of hydrophobic groups in the molecule is large, so the hydrophilicity is poor.
The density is about [Z] g/cm3. The density reflects the mass of the substance per unit volume. This value is important for determining its position in the mixture and its mixing behavior with other substances. Due to the difference in density from water and common organic solvents, its distribution can be inferred based on stratification and other phenomena.
In summary, the physical properties of 1- (bromomethyl) -3 -chloro-2 -fluorobenzene, such as appearance, odor, boiling point, melting point, solubility and density, are independent and interrelated, and together outline the physical properties of this compound, laying the foundation for its application in many fields such as organic synthesis and chemical analysis.
First of all, its appearance is often colorless to light yellow liquid, with clear texture and good light transmission. This appearance characteristic can be used as the primary basis for actual observation and identification. Its smell has a slightly special aromatic aroma, but it is not as strong and pungent as common aromatic hydrocarbons. Although it is mild, it can still be detected by a fine smell.
The boiling point is about [X] degrees Celsius when the atmospheric pressure is the standard condition. The boiling point is the temperature limit required for the compound to transform from liquid to gaseous state. The existence of this value determines the specific conditions in the operation process of distillation and separation. The boiling point is closely related to the intermolecular forces. The intermolecular forces of this compound are moderate, so the boiling point is also in the corresponding range.
In terms of melting point, it is about [Y] degrees Celsius. The melting point characterizes the temperature at which the compound transitions from solid to liquid state. This value reflects the stability of its lattice structure and the strength of intermolecular interactions. The low melting point of this compound indicates that its lattice structure is not extremely stable in the solid state, and the intermolecular forces are relatively weak.
Solubility is also a key physical property. In organic solvents such as ethanol and ether, 1- (bromomethyl) -3-chloro-2-fluorobenzene exhibits good solubility and can be miscible with organic solvents in different proportions. However, in water, its solubility is very small, almost insoluble. This difference in solubility is due to the characteristics of its molecular structure. The proportion of hydrophobic groups in the molecule is large, so the hydrophilicity is poor.
The density is about [Z] g/cm3. The density reflects the mass of the substance per unit volume. This value is important for determining its position in the mixture and its mixing behavior with other substances. Due to the difference in density from water and common organic solvents, its distribution can be inferred based on stratification and other phenomena.
In summary, the physical properties of 1- (bromomethyl) -3 -chloro-2 -fluorobenzene, such as appearance, odor, boiling point, melting point, solubility and density, are independent and interrelated, and together outline the physical properties of this compound, laying the foundation for its application in many fields such as organic synthesis and chemical analysis.
What are the synthesis methods of 1- (bromomethyl) -3-chloro-2-fluorobenzene
There are several common methods for synthesizing 1 - (bromomethyl) - 3 - chloro - 2 - fluorobenzene.
First, it can be started by the corresponding halogenated aromatic hydrocarbon. Take 3 - chloro - 2 - fluorotoluene, under appropriate reaction conditions, use N - bromosuccinimide (NBS) as bromination reagent, azobisisobutyronitrile (AIBN) as initiator, and heat it in an inert solvent such as carbon tetrachloride to carry out free radical substitution reaction. In this process, NBS provides bromine radicals to attack the benzyl position of toluene, thereby introducing bromine atoms at the benzyl position to generate the target product 1- (bromomethyl) -3 -chloro-2 -fluorobenzene.
Second, the Grignard reagent method can also be used. The Grignard reagent is first prepared from 3-chloro-2-fluorobromobenzene, which is reacted with formaldehyde or paraformaldehyde to generate the corresponding alcohol, and then halogenated with an appropriate halogenating reagent, such as phosphorus tribromide or hydrobromic acid, to convert the alcohol hydroxyl group into a bromine atom, and finally obtain 1- (bromomethyl) -3-chloro-2-fluorobenzene.
Third, 2-fluoro-3-chlorobenzoic acid can also be considered as a raw material, and it is first reduced to the corresponding alcohol. Commonly used reducing agents such as lithium aluminum hydride. The obtained alcohol is then halogenated and treated with phosphorus tribromide or hydrobromic acid to convert the alcohol into 1- (bromomethyl) -3 -chloro-2 -fluorobenzene.
All synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product, and choose the appropriate one.
First, it can be started by the corresponding halogenated aromatic hydrocarbon. Take 3 - chloro - 2 - fluorotoluene, under appropriate reaction conditions, use N - bromosuccinimide (NBS) as bromination reagent, azobisisobutyronitrile (AIBN) as initiator, and heat it in an inert solvent such as carbon tetrachloride to carry out free radical substitution reaction. In this process, NBS provides bromine radicals to attack the benzyl position of toluene, thereby introducing bromine atoms at the benzyl position to generate the target product 1- (bromomethyl) -3 -chloro-2 -fluorobenzene.
Second, the Grignard reagent method can also be used. The Grignard reagent is first prepared from 3-chloro-2-fluorobromobenzene, which is reacted with formaldehyde or paraformaldehyde to generate the corresponding alcohol, and then halogenated with an appropriate halogenating reagent, such as phosphorus tribromide or hydrobromic acid, to convert the alcohol hydroxyl group into a bromine atom, and finally obtain 1- (bromomethyl) -3-chloro-2-fluorobenzene.
Third, 2-fluoro-3-chlorobenzoic acid can also be considered as a raw material, and it is first reduced to the corresponding alcohol. Commonly used reducing agents such as lithium aluminum hydride. The obtained alcohol is then halogenated and treated with phosphorus tribromide or hydrobromic acid to convert the alcohol into 1- (bromomethyl) -3 -chloro-2 -fluorobenzene.
All synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product, and choose the appropriate one.
1- (bromomethyl) -3-chloro-2-fluorobenzene what to pay attention to when storing and transporting
1 - (bromomethyl) - 3 - chloro - 2 - fluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
Bear the brunt, because it has a certain chemical activity, the storage place must be dry. Moisture is easy to cause adverse reactions such as hydrolysis, resulting in quality damage. Therefore, it is appropriate to choose a dry and ventilated place for storage, away from water sources and moisture.
Second, temperature is also critical. This compound is more sensitive to temperature, and high temperature may cause it to decompose and deteriorate. The storage temperature should be maintained at a low and stable state, generally in a cool and cool place, but it should not be too low to cause it to solidify and affect the use.
Furthermore, 1- (bromomethyl) -3-chloro-2-fluorobenzene may be toxic and irritating, and protective measures are indispensable during storage and transportation. Containers must be well sealed to prevent leakage. Those who come into contact should wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to avoid contact with skin and eyes, and the operating environment should be well ventilated.
In addition, when transporting, the selected means of transportation should comply with relevant safety regulations and be properly fixed to prevent damage to the container due to vibration and collision. And environmental factors such as temperature and humidity need to be closely monitored during transportation to ensure the stability of this compound.
In short, 1- (bromomethyl) -3 -chloro-2 -fluorobenzene needs to be carefully treated in terms of drying, temperature, protection and transportation tools when storing and transporting, so as to ensure its quality and safety.
Bear the brunt, because it has a certain chemical activity, the storage place must be dry. Moisture is easy to cause adverse reactions such as hydrolysis, resulting in quality damage. Therefore, it is appropriate to choose a dry and ventilated place for storage, away from water sources and moisture.
Second, temperature is also critical. This compound is more sensitive to temperature, and high temperature may cause it to decompose and deteriorate. The storage temperature should be maintained at a low and stable state, generally in a cool and cool place, but it should not be too low to cause it to solidify and affect the use.
Furthermore, 1- (bromomethyl) -3-chloro-2-fluorobenzene may be toxic and irritating, and protective measures are indispensable during storage and transportation. Containers must be well sealed to prevent leakage. Those who come into contact should wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to avoid contact with skin and eyes, and the operating environment should be well ventilated.
In addition, when transporting, the selected means of transportation should comply with relevant safety regulations and be properly fixed to prevent damage to the container due to vibration and collision. And environmental factors such as temperature and humidity need to be closely monitored during transportation to ensure the stability of this compound.
In short, 1- (bromomethyl) -3 -chloro-2 -fluorobenzene needs to be carefully treated in terms of drying, temperature, protection and transportation tools when storing and transporting, so as to ensure its quality and safety.
1- (bromomethyl) -3-chloro-2-fluorobenzene security risks
1 - (bromomethyl) - 3 - chloro - 2 - fluorobenzene is an organic compound with multiple safety risks, which should not be underestimated in terms of health, explosion and the environment.
When it comes to health hazards, the activity of bromomethyl, chlorine and fluorine atoms of this compound is very high. First, it is corrosive. If it is accidentally touched with the skin, it can cause burns, redness, pain, and even tissue necrosis. If it comes into contact with the eyes, the damage is particularly serious, or it can cause redness and swelling of the conjunctiva, corneal damage, and severe cases can cause blindness. Second, inhalation through the respiratory tract can irritate the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term or large-scale inhalation, or affect the nervous system, causing headache, dizziness, fatigue, and even coma. Third, accidental ingestion is also extremely harmful, which can damage the digestive tract, cause nausea, vomiting, abdominal pain, etc., and life-threatening in severe cases.
From the perspective of explosion hazard, although it is not extremely flammable, there is still a risk of combustion and explosion in case of open flames, hot topics, or contact with strong oxidants. Because its structure contains hydrocarbon elements, combustion can produce toxic fumes, such as hydrogen bromide, hydrogen chloride, hydrogen fluoride, etc. These gases are toxic and corrosive, and are very harmful to the human body and the environment.
In terms of environmental hazards, this compound enters the environment and can persist in soil and water for a long time due to chemical stability and bioaccumulation. In soil, it may affect soil microbial activity and plant growth; in water, it may endanger aquatic organisms and destroy the balance of aquatic ecosystems. And because it is difficult to degrade, or is transmitted and enriched through the food chain, it ultimately endangers human health.
When operating 1- (bromomethyl) -3-chloro-2-fluorobenzene, it is necessary to strictly follow safety procedures, take protective measures, and do not take it lightly to ensure personal safety and environmental safety.
When it comes to health hazards, the activity of bromomethyl, chlorine and fluorine atoms of this compound is very high. First, it is corrosive. If it is accidentally touched with the skin, it can cause burns, redness, pain, and even tissue necrosis. If it comes into contact with the eyes, the damage is particularly serious, or it can cause redness and swelling of the conjunctiva, corneal damage, and severe cases can cause blindness. Second, inhalation through the respiratory tract can irritate the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term or large-scale inhalation, or affect the nervous system, causing headache, dizziness, fatigue, and even coma. Third, accidental ingestion is also extremely harmful, which can damage the digestive tract, cause nausea, vomiting, abdominal pain, etc., and life-threatening in severe cases.
From the perspective of explosion hazard, although it is not extremely flammable, there is still a risk of combustion and explosion in case of open flames, hot topics, or contact with strong oxidants. Because its structure contains hydrocarbon elements, combustion can produce toxic fumes, such as hydrogen bromide, hydrogen chloride, hydrogen fluoride, etc. These gases are toxic and corrosive, and are very harmful to the human body and the environment.
In terms of environmental hazards, this compound enters the environment and can persist in soil and water for a long time due to chemical stability and bioaccumulation. In soil, it may affect soil microbial activity and plant growth; in water, it may endanger aquatic organisms and destroy the balance of aquatic ecosystems. And because it is difficult to degrade, or is transmitted and enriched through the food chain, it ultimately endangers human health.
When operating 1- (bromomethyl) -3-chloro-2-fluorobenzene, it is necessary to strictly follow safety procedures, take protective measures, and do not take it lightly to ensure personal safety and environmental safety.
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